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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 19.

Starplasty tracheostomy: case series and literature review
ConclusionsIn our series, pediatric SPT was not associated with any major complications. Therefore, we conclude that SPT should be considered as a safe and advantageous alternative for traditional tracheotomy, especially in patients with low probability of future decannulation, and, therefore, at low risk of a persistent tracheocutaneous fistula. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - February 7, 2017 Category: ENT & OMF Source Type: research

Massive left atrial calcification: a case report and review of the literature
We report a case of LA calcification in a 69-year-old woman presented with dyspnea and cyanosis. Admission electrocardiogram showed atrial fibrillation and biventricular hypertrophy. Her chest roentgenogram revealed cardiomegaly and a curvilinear whitish shadow in the area of LA. Transthoracic echocardiography revealed severe mitral stenosis and massive LA thrombosis. The patient underwent an emergent surgery, during which the whitish line on chest roentgenogram proved to be a calcified LA inner wall. During an on-pump surgery with cardioplegic arrest, she underwent open MV commissurotomy along with the excision of calcifi...
Source: General Thoracic and Cardiovascular Surgery - February 7, 2017 Category: Cardiovascular & Thoracic Surgery Source Type: research

Effect of tobacco and electronic cigarette use on cough reflex sensitivity
Publication date: Available online 6 February 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Peter V. Dicpinigaitis Multiple previous studies have shown that otherwise healthy tobacco cigarette smokers have suppressed cough reflex sensitivity compared with nonsmokers and furthermore, that smoking cessation, even after years of tobacco use, leads to prompt enhancement of cough reflex sensitivity. Thus, cough reflex sensitivity is demonstrated to be a dynamic phenomenon, responding to the presence or absence of influences such as tobacco smoke. These studies, however, were unable to identify whether it...
Source: Pulmonary Pharmacology and Therapeutics - February 7, 2017 Category: Respiratory Medicine Source Type: research

The obesity paradox: validity and clinical implications
AbstractPurpose of reviewObesity has been associated with increased incidence of diabetes, atherosclerotic disease, numerous cancers, and other comorbidities. Given the increased comorbidities and challenges associated with bedside care of the critically ill obese patient, the expectation would be worse overall clinical outcomes. However, it has been noted that there are improved outcomes in critically ill patients who are overweight or mildly obese compared to their underweight and morbidly obese counterparts. This has been termed the obesity paradox. The purpose of this article is to discuss the validity of the obesity p...
Source: Current Respiratory Care Reports - February 7, 2017 Category: Respiratory Medicine Source Type: research

Immunoglobulin (Ig)M antibodies to proteinase 3 in granulomatosis with polyangiitis and microscopic polyangiitis
Summary Anti‐neutrophil cytoplasmic antibodies (ANCA) appear to play an important role in the pathogenesis of ANCA‐associated vasculitis (AAV). However, ANCA alone are not sufficient to generate disease, and some evidence suggests that infectious triggers may serve as inciting events for AAV disease activity. Antibodies of the immunoglobulin (Ig)M isotype often serve as markers of recent infection, and IgM ANCA have been identified previously in patients with AAV, although the frequency and clinical relevance of IgM ANCA is not well established. We sought to characterize IgM ANCA more clearly by creating a novel enzyme...
Source: Clinical and Experimental Immunology - February 7, 2017 Category: Allergy & Immunology Authors: J. M. Clain, A. M. Hummel, J. H. Stone, F. C. Fervenza, G. S. Hoffman, C. G. M. Kallenberg, C. A. Langford, W. J. McCune, P. A. Merkel, P. A. Monach, P. Seo, R. F. Spiera, E. W. St Clair, S. R. Ytterberg, U. Specks, Tags: Original Article Source Type: research

Increased systemic cytokine/chemokine expression in asthmatic and non ‐asthmatic patients with bacterial, viral or mixed lung infection
This study was aimed to determine the profiles of serum cytokines (IL‐1β, TNF‐α, IL‐4, IL‐5) and chemokines (MCP‐1: monocyte chemoattract protein‐1 and RANTES: regulated on activation normal T cell expressed and secreted) in individuals with an asthmatic versus a non‐asthmatic background with bacterial, viral or mixed acute respiratory infection. Asthmatic (n=14) and non‐ asthmatic (n=29) patients with acute viral, bacterial or mixed (bacterial and viruses) respiratory infection were studied. Patients were also analyzed as individuals with pneumonia or bronchitis. Healthy individuals with similar age and ...
Source: Scandinavian Journal of Immunology - February 7, 2017 Category: Allergy & Immunology Authors: Maria J Giuffrida, Nereida Valero, Jesus Mosquera, Anyelo Duran, Francisco Arocha, Betulio Chac ín, Luz Marina Espina, Jenifer Gotera, John Bermudez, Alibeth Mavarez, Melchor Alvarez‐Mon Tags: Regular Article Source Type: research

Validation of the Japanese Severe Respiratory Insufficiency Questionnaire in hypercapnic patients with noninvasive ventilation
Conclusions The Japanese SRI Questionnaire was produced using a standardized procedure and an equivalency study. It has high psychometric properties with internal consistency and concurrent validity. The Japanese SRI Questionnaire can be used to assess HRQL in patients on NIV for CHRF. (Source: Respiratory Investigation)
Source: Respiratory Investigation - February 7, 2017 Category: Respiratory Medicine Source Type: research

[Prevention and treatment of skin lesions associated with non-invasive mechanical ventilation. Recommendations of experts].
CONCLUSIONS: The mask of choice is the facial, always using foam or hydrocolloid dressings on the nasal bridge. Evaluate the condition of the skin under the interface and harness every 4hours (recommended) and 11hours (maximum). Evaluate the rotation strategy of the interface at 24hours if the NIV is still needed on an ongoing basis. PMID: 28153465 [PubMed - as supplied by publisher] (Source: Enfermeria Intensiva)
Source: Enfermeria Intensiva - February 6, 2017 Category: Nursing Tags: Enferm Intensiva Source Type: research

Near-fatal Anorexia Nervosa in a Middle-aged Woman.
Authors: Foppiani L, Massobrio B, Cascio C, Antonucci G Abstract Anorexia nervosa (AN) is a serious psychiatric disorder which typically occurs in young women; however, more and more cases in middle-aged women are being reported. The management of this complex disease requires a team approach, and full recovery occurs only in 50% of patients. Endocrine and metabolic complications are commonly observed, the latter of which may even be life-threatening, and require prompt and proper management. Infections, albeit reported, are not usually a major clinical problem in these patients. We herein report the case of a seve...
Source: Internal Medicine - February 6, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Fulminant Laryngeal-tracheobronchial-pulmonary Aspergillosis: A Rare and Fatal Complication in Allogeneic Hematopoietic Stem Cell Transplantation Recipients.
Authors: Tao T, Zhang YH, Xue SL, Wu DP, Chen F Abstract A 23-year-old man who had previously undergone allogeneic hematopoietic stem cell transplantation (allo-HSCT) for severe aplastic anemia was diagnosed with invasive laryngeal-tracheobronchial-pulmonary aspergillosis after presenting with a persistent dry cough at six months post-transplantation based on the findings of laryngoscopy and fiberoptic bronchoscopy. A fiberoptic bronchoscope was used to remove the obstructive material from the patient's airway and posaconazole plus caspofungin were administered to successfully to treat the patient. Our report sugge...
Source: Internal Medicine - February 6, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Effect of tiotropium and olodaterol on symptoms and patient-reported outcomes in patients with COPD: results from four randomised, double-blind studies.
Abstract Chronic obstructive pulmonary disease is associated with significant morbidity and mortality. Trials of maintenance chronic obstructive pulmonary disease treatments focus on improvement in lung function and reductions in exacerbations, while patients are much more concerned about symptoms and health status. Our aim was to investigate the effects of tiotropium + olodaterol on patient-reported health outcomes, breathlessness and night-time rescue medication use in patients with chronic obstructive pulmonary disease, compared to placebo, tiotropium or olodaterol monotherapy. Two pairs of replicate, phase...
Source: Primary Care - February 6, 2017 Category: Primary Care Authors: Ferguson GT, Karpel J, Bennett N, Clerisme-Beaty E, Grönke L, Voß F, Buhl R Tags: NPJ Prim Care Respir Med Source Type: research

Health Consequences of Typhoon Haiyan in the Eastern Visayas Region Using a Syndromic Surveillance Database
Conclusions The predominance of primary care conditions seen in the study may be used for planning for future disasters and signals disaster managers to focus on basic health care and public health measures. The trends observed for consultation rates across time may be used as guides for disaster response and recovery. Interventions targeting young, elderly, and impoverished populations are recommended. Community health centers should be prioritized in recovery and rehabilitation efforts. Competing Interests The authors have declared that no competing interests exist. Corresponding Author Miguel Antonio Salazar: miguel.s...
Source: PLOS Currents Disasters - February 6, 2017 Category: Global & Universal Authors: Miguel Antonio Salazar Source Type: research

Molecular point-of-care testing for respiratory viruses versus routine clinical care in adults with acute respiratory illness presenting to secondary care: a pragmatic randomised controlled trial protocol (ResPOC)
Respiratory viruses are associated with a huge socio-economic burden and are responsible for a large proportion of acute respiratory illness in hospitalised adults. Laboratory PCR is accurate but takes at leas... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - February 6, 2017 Category: Infectious Diseases Authors: Nathan J. Brendish, Ahalya K. Malachira and Tristan W. Clark Source Type: research

Hemosiderin-laden macrophages are an independent factor correlated with pulmonary vascular resistance in idiopathic pulmonary fibrosis: a case control study
Increases in hemosiderin-laden macrophages (HLM) are reported to be observed in idiopathic pulmonary fibrosis (IPF). According to a recent study, significant correlation between hemosiderin deposition in the l... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - February 6, 2017 Category: Respiratory Medicine Authors: Jun Fukihara, Hiroyuki Taniguchi, Masahiko Ando, Yasuhiro Kondoh, Tomoki Kimura, Kensuke Kataoka, Taiki Furukawa, Takeshi Johkoh, Junya Fukuoka, Koji Sakamoto and Yoshinori Hasegawa Source Type: research

Associations between chronic comorbidity and exacerbation risk in primary care patients with COPD
COPD often coexists with chronic conditions that may influence disease prognosis. We investigated associations between chronic (co)morbidities and exacerbations in primary care COPD patients. (Source: Respiratory Research)
Source: Respiratory Research - February 6, 2017 Category: Respiratory Medicine Authors: Janine A. M. Westerik, Esther I. Metting, Job F. M. van Boven, Waling Tiersma, Janwillem W. H. Kocks and Tjard R. Schermer Source Type: research

Impact of Weight Loss Management in OSA.
Abstract The interaction between obesity and obstructive sleep apnea (OSA) is complex. Whilst it is often assumed that obesity is the major cause of OSA, and that treatment of the OSA might mitigate further weight gain, new evidence is emerging that suggest these statements may not be the case. Obesity explains about 60% of the variance of the apnea hypopnea index definition of OSA, mainly in those < 50 years and less so in the elderly. Moreover, long term treatment of OSA with continuous positive airway pressure is associated with small but significant weight gain. This weight gain effect may result from aboli...
Source: Chest - February 6, 2017 Category: Respiratory Medicine Authors: Joosten SA, Hamilton GS, Naughton MT Tags: Chest Source Type: research

Association of Gene Polymorphisms in Interleukin 6 in Infantile Bronchial Asthma.
CONCLUSIONS: Interleukin 6 polymorphism is associated with bronchial asthma, particularly its atopic phenotype. Expression and secretion of interleukins in asthmatic patients may be affected by genetic polymorphisms, and could have a disease-modifying effect in the asthmatic airway and modify the therapeutic response. PMID: 28185773 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - February 6, 2017 Category: Respiratory Medicine Authors: Babusikova E, Jurecekova J, Jesenak M, Evinova A Tags: Arch Bronconeumol Source Type: research

Mitochondrial Complex II: At the Crossroads.
Abstract Mitochondrial complex II (CII), also called succinate dehydrogenase (SDH), is a central purveyor of the reprogramming of metabolic and respiratory adaptation in response to various intrinsic and extrinsic stimuli and abnormalities. In this review we discuss recent findings regarding SDH biogenesis, which requires four known assembly factors, and modulation of its enzymatic activity by acetylation, succinylation, phosphorylation, and proteolysis. We further focus on the emerging role of both genetic and epigenetic aberrations leading to SDH dysfunction associated with various clinical manifestations. This ...
Source: Trends in Biochemical Sciences - February 6, 2017 Category: Biochemistry Authors: Bezawork-Geleta A, Rohlena J, Dong L, Pacak K, Neuzil J Tags: Trends Biochem Sci Source Type: research

Detecting Pulmonary Edema in Obstetric Patients Through Point-of-Care Lung Ultrasonography.
CONCLUSION: Lung ultrasonography has potential to be used in obstetrics for detecting pulmonary edema in preeclampsia. It is a well-established tool in critical care settings and use in obstetric patients should be studied given the availability of ultrasonography on labor and delivery and the importance of timely care for critically ill pregnant patients. It is a safe modality to evaluate pregnant women with respiratory symptoms and the necessary skills can be easily acquired by obstetric practitioners familiar with obstetric ultrasonography. Training of obstetric practitioners in this application of ultrasonography is ne...
Source: Obstetrics and Gynecology - February 6, 2017 Category: OBGYN Authors: Pachtman S, Koenig S, Meirowitz N Tags: Obstet Gynecol Source Type: research

Acute Respiratory Distress Syndrome in Pregnant Women.
CONCLUSION: In this nationwide study, the overall mortality rate for pregnant patients mechanically ventilated for ARDS was 9%. The rate of ARDS requiring mechanical ventilation increased from 36.5 cases (95% CI 33.5-41.8) per 100,000 live births in 2006 to 59.6 cases (95% CI 54.3-65.3) per 100,000 live births in 2012. PMID: 28178046 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - February 6, 2017 Category: OBGYN Authors: Rush B, Martinka P, Kilb B, McDermid RC, Boyd JH, Celi LA Tags: Obstet Gynecol Source Type: research

Incidences and Costs of Illness for Diarrhea and Acute Respiratory Infections for Children < 5 Years of Age in Rural Bangladesh.
This study aimed to determine incidence of childhood diarrhea and ARI and costs of homecare, hospitalization, and outpatient treatment by practitioner type in rural Bangladesh. From each of 100 randomly selected population clusters we sampled 17 households with at least one child < 5 years of age. Childhood diarrhea incidence was 3,451 and ARI incidence was 5,849/1,000 child-years. For diarrhea and ARI outpatient care per 1,000 child-years, parents spent more on unqualified ($2,361 and $4,822) than qualified health-care practitioners ($113 and $947). For outpatient care, visits to unqualified health-care practitioners w...
Source: The American Journal of Tropical Medicine and Hygiene - February 6, 2017 Category: Tropical Medicine Authors: Halder AK, Luby SP, Akhter S, Ghosh PK, Johnston RB, Unicomb L Tags: Am J Trop Med Hyg Source Type: research

Patient Characteristics, Management, and Predictors of Outcome from Severe Community-Onset Staphylococcal Sepsis in Northeast Thailand: A Prospective Multicenter Study.
Abstract Staphylococcus aureus infection is a persistent threat in resource-restricted settings in southeast Asia but informative data about this disease remain limited. We analyzed characteristics, management, and predictors of outcome in severely septic patients with community-onset S. aureus infection in northeast Thailand. We performed a prospective, multicenter observational cohort study of community-onset S. aureus sepsis in four referral hospitals recruiting patients at least 14 years of age admitted between March 2010 and December 2013. One hundred and nineteen patients with severe staphylococcal sepsis we...
Source: The American Journal of Tropical Medicine and Hygiene - February 6, 2017 Category: Tropical Medicine Authors: West TE, Wikraiphat C, Tandhavanant S, Ariyaprasert P, Suntornsut P, Okamoto S, Mahavanakul W, Srisamang P, Phiphitaporn S, Anukunananchai J, Chetchotisakd P, Peacock SJ, Chantratita N Tags: Am J Trop Med Hyg Source Type: research

Chikungunya and Neonatal Immunity: Fatal Vertically Transmitted Chikungunya Infection.
This report summarizes two severe cases of vertically transmitted neonatal chikungunya infection. One case was confirmed by real-time reverse transcription polymerase chain reaction and the other fulfilled clinical and epidemiological criteria. Both infants presented on day 3 with abdominal distension, reduced perfusion pressure, and hypotension; acrocyanosis progressing to ischemic digits; and respiratory distress. Both died within 24-48 hours of presentation. The severity of symptoms observed is likely due to a combination of contamination of the fetal blood from highly viremic mothers during delivery and a low innate an...
Source: The American Journal of Tropical Medicine and Hygiene - February 6, 2017 Category: Tropical Medicine Authors: Evans-Gilbert T Tags: Am J Trop Med Hyg Source Type: research

In Vitro Activity of Delafloxacin When Tested Against Contemporary Bacterial Pathogens from the United States and Europe, 2014.
Abstract The in vitro activities of delafloxacin and comparator antimicrobial agents were tested against 6,485 bacterial isolates from medical centers in Europe (EU) and the United States (US) in 2014. Delafloxacin was the most potent agent tested against methicillin-susceptible S. aureus (MSSA), MRSA, Streptococcus pneumoniae, viridans group streptococci, and β-hemolytic streptococci and had activity similar to that of ciprofloxacin and levofloxacin against certain members of the Enterobacteriaceae. Overall the broadest coverage of tested pathogens (Gram-positive cocci and Gram-negative bacilli) was observed wit...
Source: Antimicrobial Agents and Chemotherapy - February 6, 2017 Category: Microbiology Authors: Pfaller MA, Sader HS, Rhomberg PR, Flamm RK Tags: Antimicrob Agents Chemother Source Type: research

Intravenous Poison Hemlock Injection Resulting in Prolonged Respiratory Failure and Encephalopathy.
CONCLUSION: Intravenous injection of poison hemlock alkaloids can result in significant toxicity, including cardiopulmonary arrest, prolonged weakness, and encephalopathy. PMID: 28168558 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - February 6, 2017 Category: Toxicology Authors: Brtalik D, Stopyra J, Hannum J Tags: J Med Toxicol Source Type: research

Mortality among Coast Guard Shipyard workers: a retrospective cohort study of specific exposures.
Abstract In a previous analysis of a cohort of shipyard workers, we found excess mortality from all causes, lung cancer, and mesothelioma for longer work durations and in specific occupations. Here, we expand the previous analyses by evaluating mortality associated with five chemical exposures: asbestos, solvents, lead, oils/greases, and wood dust. Data were gathered retrospectively for 4,702 workers employed at the Coast Guard Shipyard, Baltimore, MD (1950-1964). The cohort was traced through 2001 for vital status. Associations between mortality and these five exposures were calculated via standardized mortality ...
Source: Archives of Environmental and Occupational Health - February 6, 2017 Category: Environmental Health Authors: Rusiecki J, Stewart P, Lee D, Alexander M, Krstev S, Silverman D, Blair A Tags: Arch Environ Occup Health Source Type: research

Stability of Blood Eosinophils in COPD and Controls and the Impact of Gender, Age, Smoking and Baseline Counts.
PMID: 28165763 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 6, 2017 Category: Respiratory Medicine Authors: Oshagbemi OA, Burden AM, Braeken DC, Henskens Y, Wouters EF, Driessen JH, Maitland-van der Zee AH, de Vries F, Franssen FM Tags: Am J Respir Crit Care Med Source Type: research

Exercise-induced Hypoxemia in Juvenile Thyroid Carcinoma With Lung Metastases.
CONCLUSION: EIAH in patients with thyroid carcinoma and pulmonary metastases is not related to ventilation-perfusion mismatch but to alveolar hypoventilation, possibly related to an increased work of breathing with pulmonary fibrosis. PMID: 28165859 [PubMed - as supplied by publisher] (Source: Pediatric Exercise Science)
Source: Pediatric Exercise Science - February 6, 2017 Category: Pediatrics Authors: Segerer FJ, Biko J, Reiners C, Wirth C, Hebestreit H Tags: Pediatr Exerc Sci Source Type: research

Randomised controlled trial examining the effect of an outpatient exercise training programme on haemodynamics and cardiac MR parameters of right ventricular function in patients with pulmonary arterial hypertension: the ExPAH study protocol
This study will assess the effect of an outpatient rehabilitation programme on haemodynamics and cardiac right ventricular function in patients with pulmonary arterial hypertension (PAH), a subgroup of PH. Methods and analysis This randomised controlled trial involves both a major urban tertiary and smaller regional hospital in New South Wales, Australia. The intervention will compare an outpatient rehabilitation programme with a control group (home exercise programme). Participants will be stable on oral PAH-specific therapy. The primary outcome measure will be right ventricular ejection fraction measured by cardiac MRI....
Source: BMJ Open - February 6, 2017 Category: Journals (General) Authors: Chia, K. S. W., Faux, S. G., Wong, P. K. K., Holloway, C., Assareh, H., McLachlan, C. S., Kotlyar, E. Tags: Open access, Cardiovascular medicine, Rehabilitation medicine, Respiratory medicine Protocol Source Type: research

Disturbed mitochondrial function restricts glutamate uptake in the human M üller glia cell line, MIO-M1
Publication date: Available online 6 February 2017 Source:Mitochondrion Author(s): Rupali Vohra, Iswariyaraja Sridevi Gurubaran, Ulrik Henriksen, Linda Hildegaard Bergersen, Lene Juel Rasmussen, Claus Desler, Dorte Marie Skytt, Miriam Kolko Using the human Müller cell line, MIO-M1, the aim was to study the impact of mitochondrial inhibition in Müller glia through antimycin A treatment. MIO-M1 cell survival, levels of released lactate, mitochondrial function, and glutamate uptake were studied in response to mitochondrial inhibition and glucose restriction. Lactate release decreased in response to glucose restriction. Com...
Source: Mitochondrion - February 6, 2017 Category: Biochemistry Source Type: research

Emergency surgery for lung cancer with abscess formation after transbronchial biopsy
We describe an instructive case of lung cancer which developed into an abscess after TBB. An 80‐year‐old man with poorly controlled diabetes mellitus underwent TBB for diagnosing a mass lesion in the left upper lobe. The TBB specimen confirmed a diagnosis of lung cancer, and he was scheduled for radical surgery. However, the tumour was revealed to have progressed into an enlarged abscess 24 days after TBB. Prompt use of meropenem failed to relieve the infection, hence we performed emergency left upper lobectomy. Poorly controlled diabetes mellitus was considered to be a risk for the formation of a tumour abscess after ...
Source: Respirology Case Reports - February 6, 2017 Category: Respiratory Medicine Authors: Yusuke Takanashi, Koichi Miyashita, Shogo Tajima, Takamitsu Hayakawa, Hiroshi Neyatani, Kazuhito Funai Tags: Case Report Source Type: research

Fatal disseminated Rasamsonia infection in cystic fibrosis post-lung transplantation
Disseminated fungal infections are a known serious complication in individuals with cystic fibrosis (CF) following orthotopic lung transplantation. Aspergillus fumigatus and Scedosporium species are among the more common causes of invasive fungal infection in this population. However, it is also important for clinicians to be aware of other emerging fungal species which may require markedly different antifungal therapies. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - February 6, 2017 Category: Respiratory Medicine Authors: Gina Hong, Marissa White, Noah Lechtzin, Natalie E. West, Robin Avery, Heather Miller, Richard Lee, Robert J. Lovari, Christian Massire, Lawrence B. Blyn, Xinglun Liang, Deanna A. Sutton, Jianmin Fu, Brian L. Wickes, Nathan P. Wiederhold, Sean X. Zhang Tags: Case Report Source Type: research

Macronutrient intake in preschoolers with cystic fibrosis and the relationship between macronutrients and growth
Adequate nutrition is essential for growth in children with cystic fibrosis (CF). The new CF Foundation Clinical Practice Guidelines bring attention to monitoring macronutrient intake as well as total energy. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - February 6, 2017 Category: Respiratory Medicine Authors: Stephanie S. Filigno, Shannon M. Robson, Rhonda D. Szczesniak, Leigh A. Chamberlin, Meredith A. Baker, Stephanie M. Sullivan, John Kroner, Scott W. Powers Tags: Original Article Source Type: research

Spontaneous pneumomediastinum in a healthy young female: A case report and literature review
We report the case of a 22-year-old female presented with SPM diagnosed by chest x-ray and chest CT scan who was treated conservatively with subsequent spontaneous resolution. (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - February 6, 2017 Category: Respiratory Medicine Source Type: research

A case of mixed dust pneumoconiosis with desquamative interstitial pneumonia-like reaction in an aluminum welder
Publication date: Available online 6 February 2017 Source:Respiratory Medicine Case Reports Author(s): Yuki Iijima, Masashi Bando, Hideaki Yamasawa, Hiroshi Moriyama, Tamiko Takemura, Toshiro Niki, Yukihiko Sugiyama A 60-year-old man presented with an 18-month history of gradually worsening cough and a 12-month history of dyspnea on exertion. High-resolution computed tomography showed bilateral uniform ground grass opacity in the lower lung fields, partially resolved by smoking cessation. A tentative diagnosis of desquamative interstitial pneumonia (DIP) was made. Video-assisted thoracic surgery was performed and patholog...
Source: Respiratory Medicine Case Reports - February 6, 2017 Category: Respiratory Medicine Source Type: research

Dyspnea following intravenous drug use
Publication date: Available online 6 February 2017 Source:Respiratory Medicine Case Reports Author(s): E. Matrosovich, R. Brodmann, S. Lampert, G. Lehnert, A. Hartmann, J.H. Ficker (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - February 6, 2017 Category: Respiratory Medicine Source Type: research

Health ‐related quality of life in idiopathic pulmonary fibrosis: Data from the Australian IPF Registry
ConclusionCough, dyspnoea and depression are major symptomatic determinants of HRQoL in IPF. FVC decline is associated with worsening HRQoL. (Source: Respirology)
Source: Respirology - February 6, 2017 Category: Respiratory Medicine Authors: Ian N. Glaspole, Sally A. Chapman, Wendy A. Cooper, Samantha J. Ellis, Nicole S. Goh, Peter M. Hopkins, Sacha Macansh, Annabelle Mahar, Yuben P. Moodley, Eldho Paul, Paul N. Reynolds, E.Haydn. Walters, Christopher J. Zappala, Tamera J. Corte Tags: Original Article Source Type: research

Managing the Precarious Hemostatic Balance during Extracorporeal Life Support: Implications for Coagulation Laboratories
Semin Thromb Hemost DOI: 10.1055/s-0036-1593414For the past four decades, extracorporeal life support (ECLS) has been used to treat critically ill adult and pediatric patients with cardiac and/or respiratory failure unresponsive to medical management, and there are increasing numbers of centers performing ECLS for numerous indications worldwide. Despite the progress with advancing technology, hemorrhagic and thrombotic complications occur frequently and are associated with worse outcomes, but the exact cause is often elusive or multifactorial. As a result of the interaction between blood and a nonendothelialized circuit, t...
Source: Seminars in Thrombosis and Hemostasis - February 6, 2017 Category: Hematology Authors: Winkler, Anne M. Tags: Review Article Source Type: research

Pulmonary innate inflammatory responses to agricultural occupational contaminants
AbstractAgricultural workers are exposed to many contaminants and suffer from respiratory and other symptoms. Dusts, gases, microbial products and pesticide residues from farms have been linked to effects on the health of agricultural workers. Growing sets of data from in vitro and in vivo models demonstrate the role of the innate immune system, especially Toll-like receptor 4 (TLR4) and TLR9, in lung inflammation induced following exposure to contaminants in agricultural environments. Interestingly, inflammation and lung function changes appear to be discordant indicating the complexity of inflammatory responses to exposu...
Source: Cell and Tissue Research - February 6, 2017 Category: Cytology Source Type: research

Enterovirus D68 detection in respiratory specimens: Association with severe disease
In conclusion, use of an EV‐specific‐RT‐PCR allowed us to detect EV‐D68 circulation in autumn 2014 that was not detected by the multiplex RT‐PCR and was associated with severe disease. This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - February 6, 2017 Category: Virology Authors: I. Engelmann, M. Fatoux, M. Lazrek, E. K. Alidjinou, A. Mirand, C. Henquell, A. Dewilde, D. Hober Tags: Research Article Source Type: research

Frequency of Th17 cells correlates with the presence of lung lesions in pigs chronically infected with Actinobacillus pleuropneumoniae
AbstractPorcine contagious pleuropneumonia caused byActinobacillus pleuropneumoniae (APP) remains one of the major causes of poor growth performance and respiratory disease in pig herds. While the role of antibodies against APP has been intensely studied, the porcine T cell response remains poorly characterized. To address this, pigs were intranasally infected with APP serotype 2 and euthanized during the acute phase [6 –10 days post-infection (dpi)] or the chronic phase of APP infection (27–31 dpi). Lymphocytes isolated from blood, tonsils, lung tissue and tracheobronchial lymph nodes were analyzed by intracellular ...
Source: Veterinary Research - February 6, 2017 Category: Veterinary Research Source Type: research

Fetal Right Aortic Arch: Associated Anomalies, Genetic Anomalies with Chromosomal Microarray Analysis and Postnatal Outcome
ConclusionsA right aortic arch is associated with 22q11.2 deletion syndrome in approximately 5% of cases and, therefore, prenatal testing, preferably using CMA, should be offered. (Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - February 6, 2017 Category: Perinatology & Neonatology Authors: Ruan Peng, Hong ‐Ning Xie, Ju Zheng, Yi Zhou, Mei‐Fang Lin Tags: Original Article Source Type: research

Neonatal Abstinence Syndrome: Trend and Expenditure in Louisiana Medicaid, 2003 –2013
Conclusions for Practice Over an 11-year period, NAS rate among Louisiana ’s Medicaid infants quadrupled and the cost for caring for the affected infants increased six-fold. Medicaid, as the predominant payer for pregnant women and children affected by substance use disorders, must play a more active role in expanding access to comprehensive substance abuse treatment pr ograms. (Source: Maternal and Child Health Journal)
Source: Maternal and Child Health Journal - February 6, 2017 Category: Health Management Source Type: research

CNS-targeted autoimmunity leads to increased influenza mortality in mice
In this study, to investigate the mechanisms responsible for this enhanced susceptibility, we established a comorbid model system in which mice with experimental autoimmune encephalomyelitis (EAE) were administered a sublethal dose of influenza. Whereas mice with either EAE alone or influenza alone survived, 70% of comorbid mice died as a result of uncontrolled viral replication. Immunological analyses revealed that the induction of EAE led to a surprising alteration of the lung milieu, converting an effective stimulatory influenza-reactive environment into a suppressive one. These results provide mechanistic information t...
Source: The Journal of Experimental Medicine - February 6, 2017 Category: Internal Medicine Authors: Glenn, J. D., Smith, M. D., Xue, P., Chan-Li, Y., Collins, S., Calabresi, P. A., Horton, M. R., Whartenby, K. A. Tags: Autoimmunity, Neuroinflammation, Infectious Disease and Host Defense Brief Definitive Reports Source Type: research

Intratracheal Administration of Budesonide ‐Surfactant in Prevention of Bronchopulmonary Dysplasia in Very Low Birth Weight Infants: A Systematic Review and Meta‐Analysis
Abstract Despite the near universal adaptation of gentle mechanical ventilation, surfactant use and non‐invasive respiratory support, bronchopulmonary dysplasia (BPD) remains one of the most common respiratory morbidities in very low birth weight (VLBW) infants. Thus, the objective of this review was to evaluate the efficacy of intra‐tracheal administration of budesonide‐surfactant mixture in preventing bronchopulmonary dysplasia (BPD) in very low birth weight (VLBW) infants. MEDLINE, EMBASE, and PubMed were searched for randomized clinical trials in which intra‐tracheal administration of budesonide‐surfactant wa...
Source: Pediatric Pulmonology - February 6, 2017 Category: Respiratory Medicine Authors: Rohini Venkataraman, Majeeda Kamaluddeen, Shabih U. Hasan, Helen Lee Robertson, Abhay Lodha Tags: REVIEW Source Type: research

Predictors for critical care admission among children presenting to emergency department with recurrent wheezing
Conclusion: The present cross-sectional study with limited sample size revealed incomplete immunization status of children to be a significant risk factor that determined the need for critical care admission among children below 2 years of age presenting to ED with recurrent wheezing. (Source: Journal of Emergencies, Trauma and Shock)
Source: Journal of Emergencies, Trauma and Shock - February 6, 2017 Category: Emergency Medicine Authors: Aman Saini Jaya Shankar Kaushik Vandana Arya Geeta Gathwala Source Type: research

Flexible polygon ‐mirror based laser scanning microscope platform for multiphoton in‐vivo imaging
Commercial microscopy systems make use of tandem scanning i.e. either slow or fast scanning. We constructed, for the first time, an advanced control system capable of delivering a dynamic line scanning speed ranging from 2.7 kHz to 27 kHz and achieve variable frame rates from 5 Hz to 50 Hz (512 × 512). The dynamic scanning ability is digitally controlled by a new customized open‐source software named PScan1.0. This permits manipulation of scanning rates either to gain higher fluorescence signal at slow frame rate without increasing laser power or increase frame rates to capture high speed events. By adjusting imagin...
Source: Journal of Biophotonics - February 6, 2017 Category: Physics Authors: Y. X. Li, V. Gautam, A. Br üstle, I. A. Cockburn, V. R. Daria, C. Gillespie, K. Gaus, C. Alt, W. M. Lee Tags: Full Article Source Type: research

Occurrence of Chlamydophila felis, feline herpesvirus 1 and calcivirus in domestic cats of Iran.
CONCLUSION: These results confirm the presence and show the prevalence of three major pathogens associated with upper respiratory tract disease for the first time in Iran. PMID: 28149490 [PubMed - in process] (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - February 5, 2017 Category: Microbiology Tags: Iran J Microbiol Source Type: research

Prevalence of colonization and mitochondrial large subunit rRNA mutation of Pneumocystis jiroveci among Iranian children.
CONCLUSION: Colonized person as an environmental reservoir might play an important role in the progression of infection in immunocompromised patients. Diagnosis of the reservoir and genotyping can be essential for the prevention of nosocomial infections. PMID: 28149493 [PubMed - in process] (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - February 5, 2017 Category: Microbiology Tags: Iran J Microbiol Source Type: research

Evidence of human coroanvirus (229E), in patients with respiratory infection, Iran, 2015: the first report.
CONCLUSION: It is the first comprehensive study on determination of the role of human coronaviruses in respiratory infections in Iran. Our data provide a novel insight into the epidemiology of HCoVs in Iran. Further studies are needed and should include the isolation and molecular characterization of HCoVs in Iran. PMID: 28149491 [PubMed - in process] (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - February 5, 2017 Category: Microbiology Tags: Iran J Microbiol Source Type: research