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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 18.

Bitter pills: care givers navigating stigma, stock outs, and unfriendly formulations in Botswana
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - September 12, 2016 Category: Respiratory Medicine Authors: Mitchell, Ellen M. H. Tags: EDITORIALS Source Type: research

Using bedaquiline and delamanid in combination and safely
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - September 12, 2016 Category: Respiratory Medicine Authors: Dedicoat, Martin Tags: EDITORIALS Source Type: research

State-of-the-art series on tuberculosis and migration
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - September 12, 2016 Category: Respiratory Medicine Authors: L önnroth, Knut Shah, N. Sarita Lange, Christoph Tags: EDITORIALS Source Type: research

Primary care physicians ' ability to diagnose the most prevalent respiratory diseases
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - September 12, 2016 Category: Respiratory Medicine Authors: de S ão José, B. P. Camargos, P. A. M. Bateman, E. D. Botelho, C. M. A. de Seixas Maciel, J. G. F. Mancuzo, E. V. de Amorim Corr êa, R. Tags: ORIGINAL ARTICLES Source Type: research

Coronary Stenting and Dyspnea in a Patient With Severe Lung Disease
This Teachable Moment describes a patient who died from respiratory failure after a cardiologist chose an individualized treatment approach rather than a more conservative, evidence-based approach. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - September 12, 2016 Category: Internal Medicine Source Type: research

Self-micellizing solid dispersion of cyclosporine A for pulmonary delivery: Physicochemical, pharmacokinetic and safety assessments.
Abstract The present study aimed to develop an inhalable self-micellizing solid dispersion of cyclosporine A (SMSD/CsA) for the direct delivery to the respiratory system with improved therapeutic efficacy and minimized systemic exposure.SMSD/CsA was obtained by wet-milling, and then jet-milled SMSD/CsA was blended with lactose carrier, producing a respirable powder of SMSD/CsA (SMSD/CsA-RP).The physicochemical, pharmacological, and pharmacokinetic properties of SMSD/CsA-RP were characterized, and the hepatotoxic and nephrotoxic potentials were investigated by biomarker analysis.Cascade impactor analysis demonstrat...
Source: European Journal of Pharmaceutical Sciences - September 12, 2016 Category: Drugs & Pharmacology Authors: Suzuki H, Ueno K, Mizumoto T, Seto Y, Sato H, Onoue S Tags: Eur J Pharm Sci Source Type: research

Elucidation of the therapeutic role of mitochondrial biogenesis transducers NRF-1 in the regulation of renal fibrosis.
DISCUSSION: These finding suggest that NRF-1 plays a pivotal role on renal cellular fibrosis. Moreover, NRF-1 might act as a novel renal fibrosis antagonist by down-regulating fibrosis signaling in renal fibroblast cells. PMID: 27634749 [PubMed - as supplied by publisher] (Source: Experimental Cell Research)
Source: Experimental Cell Research - September 12, 2016 Category: Cytology Authors: Hsieh PF, Liu SF, Hung TJ, Hung CY, Liu GZ, Chuang LY, Chen MF, Wang JL, Shi MD, Hsu CH, Shiue YL, Yang YL Tags: Exp Cell Res Source Type: research

Pharmacological inhibition of NOX4 ameliorates alcohol-induced liver injury in mice through improving oxidative stress and mitochondrial function.
CONCLUSION: Pharmacological inhibition of NOX4 activity protects against alcohol-induced fat accumulation and activation of intrinsic apoptosis via improving mitochondrial function. GENERAL SIGNIFICANCE: Pharmacological inhibition of NOX4 could be a promising treatment for ALD. PMID: 27634671 [PubMed - as supplied by publisher] (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - September 12, 2016 Category: Biochemistry Authors: Sun Q, Zhang W, Zhong W, Sun X, Zhou Z Tags: Biochim Biophys Acta Source Type: research

Probing the proton channels in subunit N of Complex I from Escherichia coli through intra-subunit cross-linking.
In this study of the enzyme from Escherichia coli, subunit N, containing one of the sites, was targeted. Pairs of cysteine residues were introduced into neighboring α-helices along the proposed proton pathways. In an effort to constrain conformational changes that might occur during proton translocation, we attempted to form disulfide bonds or methanethiosulfonate bridges between two engineered cysteine residues. Cysteine modification was inferred by the inability of PEG-maleimide to shift the electrophoretic mobility of subunit N, which will occur upon reaction with free sulfhydryl groups. After the cross-linking treatme...
Source: Biochimica et Biophysica Acta - September 12, 2016 Category: Biochemistry Authors: Tursun A, Zhu S, Vik SB Tags: Biochim Biophys Acta Source Type: research

In Vitro Activity of Solithromycin against Bordetella pertussis - An Emerging Respiratory Pathogen.
This study reports the potent in vitro activity of solithromycin against a collection of recent isolates of Bordetella pertussis. PMID: 27620481 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - September 12, 2016 Category: Microbiology Authors: Hardy DJ, Vicino D, Fernandes P Tags: Antimicrob Agents Chemother Source Type: research

Uliginosibacterium paludis sp. nov., isolated from a marsh.
Abstract A bacterial strain designated KBP-13T was isolated from a water sample taken from the Banping Lake Wetland Park in Taiwan and characterized using the polyphasic taxonomic approach. Cells of strain KBP-13T were Gram-staining-negative, aerobic, poly--hydroxybutyrate-accumulating, motile rods and forming light yellow-colored colonies. Growth occurred at 15-40 oC (optimum, 30-40 °C), at pH 6.0-8.0 (optimum, pH 6.0) and with 0-2 % NaCl (optimum, 0 %). Phylogenetic analyses based on 16S rRNA gene sequences showed that strain KBP-13T belonged to the genus Uliginosibacterium within the family Rhodocyclaceae o...
Source: International Journal of Systematic and Evolutionary Microbiology - September 12, 2016 Category: Microbiology Authors: Chen WM, Li YS, Chen ZH, Young CC, Sheu SY Tags: Int J Syst Evol Microbiol Source Type: research

Deinococcus persicinus, a new species of radiation-resistant bacteria from soil.
Abstract Two Gram-negative, oxidase-negative, catalase-positive, aerobic, and coccus shaped bacterial strains, KSY3-6T and JSH6-18, were isolated from soil in South Korea. Strains KSY3-6T and JSH6-18 showed high resistance to gamma-ray and UVC irradiation. The 16S rRNA gene sequences of strains KSY3-6T and JSH6-18 showed a novel subline within the genus Deinococcus in family Deinococcaceae. They shared 94.8~86.4% nucleotide similarities with other Deinococcus species. Strain KSY3-6T exhibited high levels of DNA-DNA hybridization values with JSH6-18 (77 ± 0.8%). The two strains showed typical chemotaxonomic charac...
Source: International Journal of Systematic and Evolutionary Microbiology - September 12, 2016 Category: Microbiology Authors: Jeon SH, Kang MS, Joo ES, Kim EB, Lim S, Jeong SW, Jung HY, Srinivasan S, Kim MK Tags: Int J Syst Evol Microbiol Source Type: research

[Pulmonary fibrosis in rheumatic diseases].
Abstract Rheumatic diseases are frequently complicated by secondary pulmonary diseases, which often impair the quality of life and increase the mortality of patients. A correct classification of such pulmonary complications is important to ensure appropriate treatment and optimal prognosis. The diagnostic and therapeutic challenge is to find the precise diagnosis and appropriate therapy among the multitude of potential causes for respiratory symptoms. It is important to maintain a cautious approach to invasive diagnostics, even though the differential diagnostics of infections or toxic lung disease might be crucia...
Source: Zeitschrift fur Rheumatologie - September 12, 2016 Category: Rheumatology Authors: Grund D, Siegert E Tags: Z Rheumatol Source Type: research

Tyrosine kinase 2 is not limiting human antiviral type III interferon responses.
This article is protected by copyright. All rights reserved. PMID: 27615517 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
Source: European Journal of Immunology - September 12, 2016 Category: Allergy & Immunology Authors: Fuchs S, Kaiser-Labusch P, Bank J, Ammann S, Kolb-Kokocinski A, Edelbusch C, Omran H, Ehl S Tags: Eur J Immunol Source Type: research

Impact of Infection Control Measures to Control an Outbreak of Multidrug-Resistant Tuberculosis in a Human Immunodeficiency Virus Ward, Peru.
We reported the effect of tuberculosis infection control measures that were introduced in 2001 and that consisted of 1) building a respiratory isolation ward with mechanical ventilation, 2) triage segregation of patients, 3) relocation of waiting room to outdoors, 4) rapid sputum smear microscopy, and 5) culture/drug-susceptibility testing with the microscopic-observation drug-susceptibility assay. Records pertaining to patients attending the study site between 1997 and 2004 were reviewed. Six hundred and fifty five HIV/TB-coinfected patients (mean age 33 years, 79% male) who attended the service during the study period we...
Source: The American Journal of Tropical Medicine and Hygiene - September 12, 2016 Category: Tropical Medicine Authors: Ticona E, Huaroto L, Kirwan DE, Chumpitaz M, Munayco CV, Maguiña M, Tovar MA, Evans CA, Escombe R, Gilman RH Tags: Am J Trop Med Hyg Source Type: research

Genome-wide association studies identify susceptibility loci affecting respiratory disease in Chinese Erhualian pigs under natural conditions.
In this study, a categorical trait of enzootic pneumonia-like (EPL) score representing the infection gradient of a respiratory disease, more likely enzootic pneumonia, was recorded in a herd of 332 Chinese Erhualian pigs. According to their EPL scores and the disease effect on weight gains, these pigs were grouped into controls (EPL score ≤ 1) and cases (EPL score > 1). The weight gain of the case group reduced significantly at days 180, 210, 240 and 300 as compared to the control group. The heritability of EPL score was estimated to be 0.24 based on the pedigree information using a linear mixed model. All 332 Erh...
Source: Animal Genetics - September 12, 2016 Category: Genetics & Stem Cells Authors: Huang X, Huang T, Deng W, Yan G, Qiu H, Huang Y, Ke S, Hou Y, Zhang Y, Zhang Z, Fang S, Zhou L, Yang B, Ren J, Ai H, Huang L Tags: Anim Genet Source Type: research

The long road to steady state in gas exchange: metabolic and ventilatory responses to hypercapnia and hypoxia in Cuviers dwarf caiman [RESEARCH ARTICLE]
Christian Lind Malte, Hans Malte, and Tobias Wang Animals with intermittent lung ventilation and those exposed to hypoxia and hypercapnia will experience fluctuations in the bodily O2 and CO2 stores, but the magnitude and temporal duration of these changes are not well understood amongst ectotherms. Using the changes in the respiratory exchange ratio (RER, CO2 excretion divided by O2 uptake) as a proxy for changes in bodily gas stores, we quantified time constants in response to hypoxia and hypercapnia in Cuvier’s dwarf caiman. We confirm distinct and prolonged changes in RER during and after exposure to hypoxia or h...
Source: Journal of Experimental Biology - September 12, 2016 Category: Biology Authors: Malte, C. L., Malte, H., Wang, T. Tags: RESEARCH ARTICLE Source Type: research

Mitochondrial physiology in the skeletal and cardiac muscles is altered in torrent ducks, Merganetta armata, from high altitudes in the Andes [RESEARCH ARTICLE]
We examined the mitochondrial physiology that facilitates performance over this altitudinal cline by comparing the respiratory capacities of permeabilized fibers, the activities of 16 key metabolic enzymes, and the myoglobin content in muscles between high- and low-altitude populations of this species. Mitochondrial respiratory capacities (assessed using substrates of mitochondrial complexes I, II, and/or IV) were higher in highland ducks in the gastrocnemius muscle – the primary muscle used to support swimming and diving – but were similar between populations in the pectoralis muscle and the left ventricle. Th...
Source: Journal of Experimental Biology - September 12, 2016 Category: Biology Authors: Dawson, N. J., Ivy, C. M., Alza, L., Cheek, R., York, J. M., Chua, B., Milsom, W. K., McCracken, K. G., Scott, G. R. Tags: RESEARCH ARTICLE Source Type: research

Assessment of diaphragmatic dysfunction in the critically ill patient with ultrasound: a systematic review
ConclusionsCurrent literature suggests that DU could be a useful and accurate tool to detect diaphragmatic dysfunction in critically ill patients, to predict extubation success or failure, to monitor respiratory workload, and to assess atrophy in patients who are mechanically ventilated. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - September 12, 2016 Category: Intensive Care Source Type: research

Understanding the kidney during acute respiratory failure
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - September 12, 2016 Category: Intensive Care Source Type: research

Ventilator-related causes of lung injury: the mechanical power
ConclusionsThe mechanical power equation may help estimate the contribution of the different ventilator-related causes of lung injury and of their variations. The equation can be easily implemented in every ventilator ’s software. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - September 12, 2016 Category: Intensive Care Source Type: research

An adverse immune-endocrine profile in patients with tuberculosis and type 2 diabetes
Diabetes is a risk factor for the development of pulmonary tuberculosis (TB) and both diseases present endocrine alterations likely to play a role in certain immuno-endocrine-metabolic associated disorders. Patients with TB, or with TB and type 2 diabetes (TB+T2DM) and healthy controls (HCo) were assessed for plasma levels of cortisol, dehydroepiandrosterone (DHEA), estradiol, testosterone, growth hormone (GH), prolactin, insulin-like growth factor-1 (IGF-1), cytokines (IL-6, IL-10, IFN- γ) and the specific lymphoproliferative capacity of peripheral blood mononuclear cells. (Source: Tuberculosis)
Source: Tuberculosis - September 12, 2016 Category: Respiratory Medicine Authors: R. Fern ández, A. Díaz, L. D’Attilio, B. Bongiovanni, N. Santucci, D. Bertola, H. Besedovsky, A. del Rey, M.L. Bay, O. Bottasso Tags: Immunological Aspects Source Type: research

Is the knowledge and attitude of physicians in Nigeria adequate for the diagnosis and management of obstructive sleep apnea?
ConclusionThe knowledge of obstructive sleep apnea among resident doctors and general practitioners in Nigeria is inadequate. There is need to improve training on sleep disorders in Nigeria both at continuing medical education programs and during residency training. (Source: Sleep and Breathing)
Source: Sleep and Breathing - September 12, 2016 Category: Respiratory Medicine Source Type: research

Respiratory-motion artefacts in liver MRI following injection of gadoxetate disodium and gadobenate dimeglumine: an intra-individual comparative study in cirrhotic patients
To perform an intra-individual comparison of the frequency of respiratory-motion artefacts on magnetic resonance imaging (MRI) in cirrhotic patients following injection of gadoxetate disodium and gadobenate dimeglumine. (Source: Clinical Radiology)
Source: Clinical Radiology - September 12, 2016 Category: Radiology Authors: A. Furlan, O.N. Close, A.A. Borhani, Y.H. Wu, M.T. Heller Source Type: research

W. Ritchie Russell, A.B. Baker, and Fred Plum: Pioneers of ventilatory management in poliomyelitis
Historically, neurologists were not involved in the day-to-day management of critically ill patients with bulbar poliomyelitis, but some were. The major contributions of 3 neurologists—W. Ritchie Russell, A.B. Baker, and Fred Plum—in the respiratory management of poliomyelitis have not been recognized. Russell's work was instrumental in identifying multiple types of poliomyelitis defined by their respiratory needs, and he advised treatment that varied from simple postural drainage to use of respirators. He participated in the development of the Radcliffe respiratory pump. Baker recognized the essential involvem...
Source: Neurology - September 12, 2016 Category: Neurology Authors: Wijdicks, E. F. M. Tags: History of Neurology, Clinical neurology history, Critical care HISTORICAL NEUROLOGY Source Type: research

Middle East Respiratory Syndrome Coronavirus Infection During Pregnancy: A Report of 5 Cases From Saudi Arabia
Little is known about the effects of Middle East respiratory syndrome coronavirus (MERS-CoV) during pregnancy. In Saudi Arabia, 5 cases of MERS-CoV infection among pregnant women were reviewed, and all cases resulted in adverse outcomes. MERS-CoV infection during pregnancy may be associated with maternal and perinatal disease and death. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - September 12, 2016 Category: Infectious Diseases Authors: Assiri, A., Abedi, G. R., Al Masri, M., Bin Saeed, A., Gerber, S. I., Watson, J. T. Tags: BRIEF REPORTS Source Type: research

Executive Summary: Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America Clinical Practice Guidelines: Treatment of Drug-Susceptible Tuberculosis
The American Thoracic Society, Centers for Disease Control and Prevention, and Infectious Diseases Society of America jointly sponsored the development of this guideline for the treatment of drug-susceptible tuberculosis, which is also endorsed by the European Respiratory Society and the US National Tuberculosis Controllers Association. Representatives from the American Academy of Pediatrics, the Canadian Thoracic Society, the International Union Against Tuberculosis and Lung Disease, and the World Health Organization also participated in the development of the guideline. This guideline provides recommendations on the clin...
Source: Clinical Infectious Diseases - September 12, 2016 Category: Infectious Diseases Authors: Nahid, P., Dorman, S. E., Alipanah, N., Barry, P. M., Brozek, J. L., Cattamanchi, A., Chaisson, L. H., Chaisson, R. E., Daley, C. L., Grzemska, M., Higashi, J. M., Ho, C. S., Hopewell, P. C., Keshavjee, S. A., Lienhardt, C., Menzies, R., Merrifield, C., N Tags: IDSA GUIDELINE Source Type: research

Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America Clinical Practice Guidelines: Treatment of Drug-Susceptible Tuberculosis
The American Thoracic Society, Centers for Disease Control and Prevention, and Infectious Diseases Society of America jointly sponsored the development of this guideline for the treatment of drug-susceptible tuberculosis, which is also endorsed by the European Respiratory Society and the US National Tuberculosis Controllers Association. Representatives from the American Academy of Pediatrics, the Canadian Thoracic Society, the International Union Against Tuberculosis and Lung Disease, and the World Health Organization also participated in the development of the guideline. This guideline provides recommendations on the clin...
Source: Clinical Infectious Diseases - September 12, 2016 Category: Infectious Diseases Authors: Nahid, P., Dorman, S. E., Alipanah, N., Barry, P. M., Brozek, J. L., Cattamanchi, A., Chaisson, L. H., Chaisson, R. E., Daley, C. L., Grzemska, M., Higashi, J. M., Ho, C. S., Hopewell, P. C., Keshavjee, S. A., Lienhardt, C., Menzies, R., Merrifield, C., N Tags: IDSA GUIDELINE Source Type: research

Remifentanil for labor analgesia: a comprehensive review
This article provides an overview of knowledge and principles of using remifentanil IVPCA for labor analgesia and introduces its potential usage in Japan. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - September 12, 2016 Category: Anesthesiology Source Type: research

Nitrobenzodiazepines: Postmortem brain and blood reference concentrations
The nitrobenzodiazepines (NBZDs) clonazepam, flunitrazepam, and nitrazepam are used as anxiolytics, anticonvulsants, and sedatives. However, long-term use can cause tolerance and dependence [1,2], and they are commonly used as recreational drugs [3 –5]. When combined with other drugs, serious complications can occur, such as enhanced sedative effects and respiratory depression [1,6]. As a result, they all frequently occur in polydrug overdose cases as well as postmortem cases related to drug abuse [7–9], and flunitrazepam as well as nitraz epam have been reported as some of the most toxic benzodiazepines (BZDs) causing...
Source: Forensic Science International - September 12, 2016 Category: Forensic Medicine Authors: Louise Skov, Karen Marie Dollerup Holm, Kristian Linnet Source Type: research

Enhancement of cell growth and glycolic acid production by overexpression of membrane-bound alcohol dehydrogenase in Gluconobacter oxydans DSM 2003
Publication date: 10 November 2016 Source:Journal of Biotechnology, Volume 237 Author(s): Huan Zhang, Lulu Shi, Xinlei Mao, Jinping Lin, Dongzhi Wei Membrane-bound alcohol dehydrogenase (mADH) was overexpressed in Gluconobacter oxydans DSM 2003, and the effects on cell growth and glycolic acid production were investigated. The transcription levels of two terminal ubiquinol oxidases (bo3 and bd) in the respiratory chain of the engineered strain G. oxydans-adhABS were up-regulated by 13.4- and 3.8-fold, respectively, which effectively enhanced the oxygen uptake rate, resulting in higher resistance to acid. The cell biomass ...
Source: Journal of Biotechnology - September 12, 2016 Category: Biotechnology Source Type: research

Quantifying cerebrovascular reactivity in anterior and posterior cerebral circulations during voluntary breath holding
This article is protected by copyright. All rights reserved (Source: Experimental Physiology)
Source: Experimental Physiology - September 12, 2016 Category: Physiology Authors: Christina D. Bruce, Craig D. Steinback, Uday V. Chauhan, Jamie R. Pfoh, Maria Abrosimova, Emily R. Vanden Berg, Rachel J. Skow, Margie H. Davenport, Trevor A. Day Tags: Research Paper Source Type: research

Inspiratory modulation of sympathetic activity is increased in female rats exposed to chronic intermittent hypoxia
This study revealed a specific respiratory‐related mechanism for sympathetic overactivity linked to inspiration that explains, at least in part, the hypertensive phenotype in female rats exposed to CIH. This article is protected by copyright. All rights reserved (Source: Experimental Physiology)
Source: Experimental Physiology - September 12, 2016 Category: Physiology Authors: George Miguel P. R. Souza, Leni G.H. Bonagamba, Mateus R. Amorim, Davi J.A. Moraes, Benedito H. Machado Tags: Research Paper Source Type: research

Shared responsibility: the political will to end TB
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - September 12, 2016 Category: Respiratory Medicine Authors: Herbert, Nick Tags: EDITORIALS Source Type: research

Assessment and management of viral croup in children
This article discusses the approach to clinical assessment and evidence‐based management of childhood croup in both hospital and primary care settings. (Source: Prescriber)
Source: Prescriber - September 12, 2016 Category: Primary Care Authors: Marie Wright, Andrew Bush Tags: Prescribing in Children Source Type: research

Electrophysiological observations in critically ill Guillain & #8211;Barre syndrome
Conclusion: Distinct patterns of electrophysiological abnormalities are noted in patients and they correlate with the duration of mechanical ventilation. Future studies to unravel the underlying pathophysiological processes that govern the patterns of progression and recovery in the critically ill patients with GBS will pave way for the development of better and more potent therapies that will hasten recovery, when combined with the prevalent treatment modalities including plasmapheresis and intravenous immunoglobulin. (Source: Neurology India)
Source: Neurology India - September 12, 2016 Category: Neurology Authors: Madhu Nagappa Archana B Netto Arun B Taly Girish Baburao Kulkarni GS Umamaheshwara Rao Sunder Periyavan Shivaji Rao Source Type: research

Pathogenesis of amyotrophic lateral sclerosis
Introduction Amyotrophic lateral sclerosis (ALS) or motor neuron disease is a rapidly progressive neurodegenerative disorder. The primary involvement is of motor neurons in the brain, spinal cord and peripherally. There is secondary weakness of muscles and primary involvement of other brain regions, especially involving cognition. Sources of data Peer-reviewed journal articles and reviews. PubMed.gov Areas of agreement The pathogenesis of ALS remains largely unknown. There are a wide range of potential mechanisms related to neurodegeneration. An increasing number of genetic factors are recognized. Areas of controversy ...
Source: British Medical Bulletin - September 12, 2016 Category: Journals (General) Authors: Morgan, S., Orrell, R. W. Tags: Invited review Source Type: research

Multiple unusual lung etiologies in a child with acute lymphocytic leukemia
Abstract Granulomatous lung disease is a rare and perplexing differential in pediatrics. Pulmonary Cryptococcus falls into the differential but is not high on the list, particularly in a non‐AIDS patient. Methotrexate (MTX) is a commonly used agent for chemotherapy in oncology and has been documented to cause lung injury in both patients with rheumatologic and oncologic diseases. Our patient had chronic cough and then developed an opportunistic infection resulting in respiratory failure. Lung biopsy showed two underlying unusual diagnoses: MTX lung injury and cryptococcal pneumonia. His case is presented with particular ...
Source: Pediatric Blood and Cancer - September 12, 2016 Category: Cancer & Oncology Authors: Allison Bechtel, Michael Joyce, Christopher J. Dudek, John J. Sarandria, Chetan Shah, Ali G. Saad Tags: Brief Report Source Type: research

Nonallergic rhinitis and lower airway disease
Abstract In the past years, several investigators have demonstrated the existence of local nasal responses in some patients with typical allergic rhinitis symptoms but without atopy and have defined a new phenotype called local allergic rhinitis (LAR) or ‘entopy’. In a percentage of LAR subjects, the upper airway disease is also associated with lower airway symptoms. After the description of this phenotype, the differential diagnosis between LAR and nonallergic rhinitis (NAR) has become a challenge for the clinician. To correctly identify LAR patients is of high importance for treatment and management of these patients...
Source: Allergy - September 12, 2016 Category: Allergy & Immunology Authors: C. Rond ón, G. Bogas, E. Barrionuevo, M. Blanca, M. J. Torres, P. Campo Tags: Review Article Source Type: research

GlyT2-Dependent Preservation of MECP2-Expression in Inhibitory Neurons Improves Early Respiratory Symptoms but Does Not Rescue Survival in a Mouse Model of Rett Syndrome
Swen H ülsmann, Guillaume Mesuret, Julia Dannenberg, Mauricio Arnoldt, Marcus Niebert (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - September 12, 2016 Category: Physiology Source Type: research

An autotuning respiration compensation system based on ultrasound image tracking.
This study designed a UITA for tracking the motion of a specific target, such as the human diaphragm. Simulated diaphragm motion driven by a respiration simulation system was observed with an ultrasound imaging system, and then the induced diaphragm displacements were calculated by our proposed UITA. These signals were used to adjust the gain of the RCS so that the amplitudes of the compensation signals were close to the target movements. The inclination angle of the ultrasound probe with respect to the surface of the abdomen affects the results of ultrasound image displacement tracking. Therefore, the displacement of the ...
Source: Journal of X-Ray Science and Technology - September 11, 2016 Category: Radiology Tags: J Xray Sci Technol Source Type: research

An update on technical and methodological aspects for cardiac PET applications.
Authors: Presotto L, Busnardo E, Gianolli L, Bettinardi V Abstract Positron emission tomography (PET) is indicated for a large number of cardiac diseases: perfusion and viability studies are commonly used to evaluate coronary artery disease; PET can also be used to assess sarcoidosis and endocarditis, as well as to investigate amyloidosis. Furthermore, a hot topic for research is plaque characterization. Most of these studies are technically very challenging. High count rates and short acquisition times characterize perfusion scans while very small targets have to be imaged in inflammation/infection and plaques exa...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - September 11, 2016 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Microbiome Changes during Tuberculosis and Antituberculous Therapy.
Abstract The critical role of commensal microbiota in the human body has been increasingly recognized, and our understanding of its implications in human health and disease has expanded rapidly. The lower respiratory tract contains diverse communities of microbes known as lung microbiota, which are present in healthy individuals and in individuals with respiratory diseases. The dysbiosis of the airway microbiota in pulmonary tuberculosis (TB) may play a role in the pathophysiological processes associated with TB disease. Recent studies of the lung microbiome have pointed out changes in lung microbial communities a...
Source: Clinical Microbiology Reviews - September 11, 2016 Category: Microbiology Authors: Hong BY, Maulén NP, Adami AJ, Granados H, Balcells ME, Cervantes J Tags: Clin Microbiol Rev Source Type: research

Effect of a Multi-Nutrient Over-the-Counter Supplement on Changes in Metabolic Rate and Markers of Lipolysis.
In conclusion, ingestion of a single dose of TS increased oxygen consumption, epinephrine and energy levels, while substrate oxidation tended to change in comparison to a placebo. No adverse responses were reported. PMID: 27611657 [PubMed - as supplied by publisher] (Source: Journal of Dietary Supplements)
Source: Journal of Dietary Supplements - September 11, 2016 Category: Nutrition Tags: J Diet Suppl Source Type: research

The introduction of emergency cricothyroidotomy simulation training in Zimbabwe contributed to the saving of two lives.
CONCLUSION: Emergency cricothyroidotomy training should be considered for all surgeons, anaesthetists and, eventually, emergency and recovery room personnel in developing countries. A video-guided simulation training programme on emergency cricothyroidotomy in Zimbabwe proved its value in this regard. PMID: 27608941 [PubMed - as supplied by publisher] (Source: Journal of Laryngology and Otology)
Source: Journal of Laryngology and Otology - September 11, 2016 Category: ENT & OMF Tags: J Laryngol Otol Source Type: research

Unconstrained Measurement of Respiration Motions of Chest and Abdomen Using a Tactile Sensor Sheet in Supine Position on Bed
In this study, a flexible and stretchable tactile sensor sheet was developed to measure the static body pressure of a subject who lies on it and measure the pressure fluctuations induced by respiration or respiratory efforts. The results were compared with the measurements by band sensors that are widely used for measuring chest and abdominal movements in clinic. It was demonstrated that the sensor sheet can distinguish chest and abdominal movements in a supine position. The reasons why the pressure fluctuations measured by the sensor sheet are antiphase with the outputs of band sensors are discussed using a simple dynamic...
Source: Journal of Medical Devices, Transactions of the ASME - September 11, 2016 Category: Medical Equipment Source Type: research

Isolation of yeast complex IV in native lipid nanodiscs.
Abstract We used the amphipathic styrene maleic acid (SMA) co-polymer to extract cytochrome c oxidase (CytcO) in its native lipid environment from S. cerevisiae mitochondria. Native nanodiscs containing one CytcO per disc were purified using affinity chromatography. The longest cross-sections of the native nanodiscs were 11nm×14nm. Based on this size we estimated that each CytcO was surrounded by ~100 phospholipids. The native nanodiscs contained the same major phospholipids as those found in the mitochondrial inner membrane. Even though CytcO forms a supercomplex with cytochrome bc1 in the mitochondrial membrane...
Source: Biochimica et Biophysica Acta - September 11, 2016 Category: Biochemistry Authors: Smirnova IA, Sjöstrand D, Li F, Björck M, Schäfer J, Östbye H, Högbom M, von Ballmoos C, Lander G, Ädelroth P, Brzezinski P Tags: Biochim Biophys Acta Source Type: research

Association Between Carbohydrate Nutrition and Successful Aging Over 10 Years
Conclusions: Consumption of dietary fiber from breads/cereals and fruits independently influenced the likelihood of aging successfully over 10 years. These findings suggest that increasing intake of fiber-rich foods could be a successful strategy in reaching old age disease free and fully functional. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - September 11, 2016 Category: Geriatrics Authors: Gopinath, B., Flood, V. M., Kifley, A., Louie, J. C. Y., Mitchell, P. Tags: Research Article Source Type: research

Impact of micro ‐environmental changes on respiratory tract infections with intracellular bacteria
Community‐acquired pneumonia is caused by intra‐ and extracellular bacteria, with some of these bacteria also being linked to the pathogenesis of chronic lung diseases, including asthma and chronic obstructive pulmonary disease. Chlamydia pneumoniae is an obligate intracellular pathogen that is highly sensitive to micro‐environmental conditions controlling both pathogen growth and host immune responses. The availability of nutrients, as well as changes in oxygen, pH and interferon‐γ levels, have been shown to directly influence the chlamydial life cycle and clearance. Although the lung has been traditionally rega...
Source: FEBS Letters - September 11, 2016 Category: Biochemistry Authors: Kensuke Shima, Jonas Coopmeiners, Simon Graspeuntner, Klaus Dalhoff, Jan Rupp Tags: Review Article Source Type: research

The antiviral effect of mollusk mucus on measles virus
In this study, the antiviral activity of the mucus of the land slug P. boraceiensis was demonstrated in vitro using Vero cells infected with measles virus. The crude sample and four fractions were tested in cultures infected with measles virus and the antiviral activity was assessed by the cytopathic effect in infected cell cultures as well as by immunofluorescence and qPCR. Fractions 39 and 50 of the mucus from P. boraceiensis were analyzed by HPLC-DAD-ESI-MS/MS and infrared spectroscopy. A mixture of polyunsaturated fatty acids was found in the two fractions. A reduction in the growth of the measles virus was observed, m...
Source: Antiviral Therapy - September 11, 2016 Category: Virology Source Type: research