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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 16.

Perioperative considerations in infantile neuroaxonal dystrophy
Summary Infantile neuroaxonal dystrophy is a rare neurological disorder that is universally fatal with life expectancy under 10 years. A 10‐year‐old boy with infantile neuroaxonal dystrophy and severe neuromuscular scoliosis underwent posterior spinal fusion following halo traction. He was successfully extubated to bilevel positive airway pressure on postoperative day 3 and discharged home on postoperative day 11. Infantile neuroaxonal dystrophy presents several perioperative challenges including concerns for difficult intubation and respiratory dysfunction. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - February 8, 2017 Category: Anesthesiology Authors: Jina L. Sinskey, Robert S. Holzman Tags: Case Report Source Type: research

Role of Parp Activity in Lung Cancer ‐induced Cachexia: Effects on Muscle Oxidative Stress, Proteolysis, Anabolic Markers and Phenotype
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - February 8, 2017 Category: Cytology Authors: Alba Chacon ‐Cabrera, Mercè Mateu‐Jimenez, Klaus Langohr, Clara Fermoselle, Elena García‐Arumí, Antoni L. Andreu, Jose Yelamos, Esther Barreiro Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Hydroxysafflor Yellow A Alleviates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Mice.
Abstract Hydroxysafflor yellow A (HSYA) is an effective ingredient of the Chinese herb Carthamus tinctorius L. The present study investigated the protective effect of HSYA on lipopolysaccharide (LPS)-induced acute respiratory distress syndrome in mice, and the underlying mechanisms involved. HSYA (14, 28, 56 mg/kg) was intraperitoneally injected to mice once daily from day 1 to 10 after LPS administration. HSYA attenuated the body weight loss, the augmented left index and the increase of pathologic changes in pulmonary inflammation caused by LPS. Treatment with HSYA also alleviated increased expressions of tumor...
Source: Biological and Pharmaceutical Bulletin - February 7, 2017 Category: Drugs & Pharmacology Authors: Zhang Y, Song L, Pan R, Gao J, Zang BX, Jin M Tags: Biol Pharm Bull Source Type: research

A new real ‐time RT‐PCR targeting VP4‐VP2 to detect and quantify enterovirus D68 in respiratory samples
This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - February 7, 2017 Category: Virology Authors: L éna Royston, Johan Geiser, Laurence Josset, Isabelle Schuffenecker, Caroline Tapparel Tags: Short Communication Source Type: research

TC2 C776G polymorphism studies in patients with oral cancer in the Polish population.
Authors: Malinowska K, Morawiec-Sztandera A, Majsterek I, Kaczmarczyk D Abstract The first signs of oral cancer may resemble developing infections in the mucous membranes, with throat cancer symptoms being similar to those of upper respiratory tract infections. This greatly hinders rapid diagnosis and treatment. Better knowledge of the changes occurring in the metabolism of folic acid can help in understanding the carcinogenesis affecting DNA methylation and genome stability. Polymorphisms in genes encoding enzymes involved in this pathway may influence enzyme activity and thereby interfere with the concentrations ...
Source: Polish Journal of Pathology - February 7, 2017 Category: Pathology Tags: Pol J Pathol Source Type: research

Complete mesocolic excision an assessment of feasibility and outcome.
Authors: Bertelsen CA Abstract Surgery is the most important factor for radical treatment of colon cancer, and the long-term prognosis can be improved by improving the surgical treatment without increased risk of perioperative mortality. Complete mesocolic excision (CME), in which more extensive lymph node (LN) dissection is performed, has been shown in single-centre studies with historical controls to be associated with better oncological outcome. However, better evidence is needed. The main purpose of this PhD thesis was to investigate whether CME could be implemented in a colorectal surgical department in Denmar...
Source: Danish Medical Journal - February 7, 2017 Category: Journals (General) Tags: Dan Med J Source Type: research

The Safety of Laryngeal Mask Airway-Assisted Bronchoscopy versus Standard Nasal Bronchoscopy
Background: The use of laryngeal mask airway (LMA) for fiberoptic bronchoscopy was first described in 1982. The LMA was found to be beneficial in operator view, flexibility, and also in maintaining stable oxygen saturation. Despite its advantages, the use of LMA has not become widespread.Objective: The aim of this paper was to evaluate the safety of LMA-assisted bronchoscopy compared to standard nasal bronchoscopy.Methods: We conducted a prospective randomized trial. The study group included 105 patients prospectively randomized to undergo either LMA-assisted (53 patients) or standard nasal bronchoscopy (52 patients). The ...
Source: Respiration - February 7, 2017 Category: Respiratory Medicine Source Type: research

Sarcoidosis: Treatments Beyond Prednisone and Methotrexate.
Authors: Ribeiro Neto ML, Culver DA PMID: 28157433 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - February 7, 2017 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Toward Respiratory Assessment Using Depth Measurements from a Time-of-Flight Sensor
Charles Sharp, Vahid Soleimani, Sion Hannuna, Massimo Camplani, Dima Damen, Jason Viner, Majid Mirmehdi, James W. Dodd (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - February 7, 2017 Category: Physiology Source Type: research

Children in Greenland: disease patterns and contacts to the health care system.
Conclusions In this first study of its kind, the health care contact pattern in Greenlandic children showed a relatively high hospitalisation rate and duration per admission, and a low primary health care contact rate. The overall contact rate and disease pattern resembled those in Denmark, except for tuberculosis screening. Adherence to the vaccination programme was low. These findings may be helpful for the organisation and dimensioning of the Greenlandic health care system for children. PMID: 28156369 [PubMed - in process] (Source: International Journal of Circumpolar Health)
Source: International Journal of Circumpolar Health - February 7, 2017 Category: Global & Universal Tags: Int J Circumpolar Health Source Type: research

Food insecurity, vitamin D insufficiency and respiratory infections among Inuit children.
Conclusions Using a large cross-sectional survey of Inuit children, we found that household crowding, but not food security or vitamin D levels, was associated with adverse respiratory outcomes. Further studies are warranted to examine the impact of decreasing household crowding on the respiratory health of these children. PMID: 28156414 [PubMed - in process] (Source: International Journal of Circumpolar Health)
Source: International Journal of Circumpolar Health - February 7, 2017 Category: Global & Universal Tags: Int J Circumpolar Health Source Type: research

PM10 Air Pollution and Acute Hospital Admissions for Cardiovascular and Respiratory Causes in Ostrava.
CONCLUSIONS: The observed significant relationship between hospital admissions for respiratory causes was consistent with the results of large European and American studies. PMID: 28160535 [PubMed - in process] (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - February 7, 2017 Category: Global & Universal Tags: Cent Eur J Public Health Source Type: research

GSE94555 Single Cell RNA-Sequencing Identifies Diverse Roles of Epithelial Cells in Idiopathic Pulmonary Fibrosis
Contributors : Y Xu ; J Whitsett ; BR Stripp ; T Mizuno ; Y DuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIdiopathic pulmonary fibrosis (IPF) is a lethal interstitial lung disease causing alveolar remodeling, inflammation, and fibrosis. We utilized single cell RNA-sequencing (scRNA-Seq) to identify epithelial cell types and associated biological processes involved in the pathogenesis of IPF. Transcriptomic analysis of epithelial cells from normal human lung defined gene expression patterns associated with highly differentiated alveolar type 2 (AT2) cells, indicated by enrichment o...
Source: GEO: Gene Expression Omnibus - February 7, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

"J Thorac Dis"[ta]; +109 new citations
109 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "J Thorac Dis"[ta] These pubmed results were generated on 2017/02/06PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - February 7, 2017 Category: Respiratory Medicine Tags: Report Source Type: research

Effect of inhaled corticosteroid particle size on asthma efficacy and safety outcomes: a systematic literature review and meta-analysis
Inhaled corticosteroids (ICS) are the primary treatment for persistent asthma. Currently available ICS have differing particle size due to both formulation and propellant, and it has been postulated that this ... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - February 7, 2017 Category: Respiratory Medicine Authors: C éline El Baou, Rachael L. Di Santostefano, Rafael Alfonso-Cristancho, Elizabeth A Suarez, David Stempel, Mark L Everard and Neil Barnes Source Type: research

Combined cumulative sum (CUSUM) and chronological environmental analysis as a tool to improve the learning environment for linear-probe endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) trainees: a pilot study
Cumulative sum (CUSUM) analysis can be used to continuously monitor the performance of an individual or process and detect deviations from a preset or standard level of achievement. However, no previous study ... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - February 7, 2017 Category: Respiratory Medicine Authors: Yasuhiro Norisue, Yasuharu Tokuda, Mayrol Juarez, Ryo Uchimido, Shigeki Fujitani and David A. Stoeckel Source Type: research

First time identification of Pandoraea sputorum from a patient with cystic fibrosis in Argentina: a case report
Pandoraea species are considered emerging pathogens in the context of cystic fibrosis (CF) and are difficult to identify by conventional biochemical methods. These multidrug resistant ... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - February 7, 2017 Category: Respiratory Medicine Authors: Pablo F. Martina, M ónica Martínez, Guillermo Frada, Florencia Alvarez, Lorena Leguizamón, Claudia Prieto, Carolina Barrias, Marisa Bettiol, Antonio Lagares, Alejandra Bosch, Julián Ferreras and Martha Von Specht Source Type: research

Gender differences in patients starting long-term home mechanical ventilation due to obesity hypoventilation syndrome
In a letter to the editor, Santos and Cruz [1] had some highly relevant considerations about our study, “Gender differences in patients starting long-term home mechanical ventilation (LTMV) due to obesity hypoventilation syndrome (OHS)” [2]. They asked for information about ventilator parameters, apnea-hypopnea index (AHI) and more details about reasons for discontinuation of LTMV among patients w ith OHS on LTMV. In addition, they asked for information about patients with OHS treated with continuous positive airway pressure (CPAP) only. (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 7, 2017 Category: Respiratory Medicine Authors: Andreas Palm, Bengt Midgren, Christer Janson, Eva Lindberg Source Type: research

Chronic obstructive pulmonary disease and atrial fibrillation: An unknown relationship.
Abstract Chronic obstructive pulmonary disease (COPD) is independently associated with atrial fibrillation (AF). Decreased oxygenation, hypercapnia, pulmonary hypertension, diastolic dysfunction, oxidative stress, inflammation, changes in atrial size by altered respiratory physiology, increased arrhythmogenicity from nonpulmonary vein foci commonly located in the right atrium, and respiratory drugs have been implicated in the pathogenesis of AF in COPD. The understanding of the relationship between COPD and AF is of particular importance, as the presence of the arrhythmia has significant impact on mortality, espec...
Source: Journal of Cardiology - February 7, 2017 Category: Cardiology Authors: Goudis CA Tags: J Cardiol Source Type: research

Suplatast tosilate protects the lung against hyperoxic lung injury by scavenging hydroxyl radicals.
Abstract Prolonged exposure to hyperoxia produces extraordinary amounts of reactive oxygen species (ROS) in the lung and causes hyperoxic lung injury. Although supraphysiological oxygen is routinely administered for the management of respiratory failure, there is no effective strategy to prevent hyperoxic lung injury. In our previous study, we showed that suplatast tosilate, an asthma drug that inhibits T helper 2 (Th2) cytokines, ameliorated bleomycin-induced lung injury and fibrosis through Th2-independent mechanisms. Because bleomycin also generates ROS, we hypothesized that suplatast tosilate might have antiox...
Source: Free Radical Biology and Medicine - February 7, 2017 Category: Biology Authors: Fukuhara K, Nakashima T, Abe M, Masuda T, Hamada H, Iwamoto H, Fujitaka K, Kohno N, Hattori N Tags: Free Radic Biol Med Source Type: research

Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release.
CONCLUSIONS: XN exemplifies a promising new class of antiplatelet agents that are highly effective at inhibiting platelet activation by decreasing ROS accumulation and platelet mtDNA release without incurring a bleeding risk. This study has also provided novel insights into mechanisms of thrombotic diseases with possible therapeutic implications. PMID: 28188927 [PubMed - as supplied by publisher] (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - February 7, 2017 Category: Biology Authors: Xin G, Wei Z, Ji C, Zheng H, Gu J, Ma L, Huang W, Morris-Natschke SL, Yeh JL, Zhang R, Qin C, Wen L, Xing Z, Cao Y, Xia Q, Li K, Niu H, Lee KH, Huang W Tags: Free Radic Biol Med Source Type: research

Lung liquid clearance in preterm lambs assessed by magnetic resonance imaging.
CONCLUSION: FRC expansion results mainly from an increase in lung volume rather than a decrease in lung liquid in preterm and late preterm lambs. Antenatal steroids promote FRC expansion through increases in lung volume and liquid clearance.Pediatric Research (2017); doi:10.1038/pr.2017.31. PMID: 28170388 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - February 7, 2017 Category: Pediatrics Authors: Houeijeh A, Tourneux P, Mur S, Aubry E, Viard R, Sharma D, Storme L Tags: Pediatr Res Source Type: research

Continuous Lidocaine Infusion as Adjunctive Analgesia in Intensive Care Unit Patients.
This report suggests that IVLI as an adjunctive agent in the treatment of acute pain may be a potential option in ICU patients who are refractory to opioids or those in whom opioid-induced respiratory depression is a concern. PMID: 28168730 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Pharmacology)
Source: The Journal of Clinical Pharmacology - February 7, 2017 Category: Drugs & Pharmacology Authors: Mo Y, Thomas MC, Antigua AD, Ebied AM, Karras GE Tags: J Clin Pharmacol Source Type: research

Forensic Considerations in Cases of Myotonic Dystrophy at Autopsy.
Abstract Myotonic dystrophy (DM) is a chronic, slowly progressive, autosomal-dominant disorder with delayed muscle relaxation after contraction, distal skeletal muscle weakness, and atrophy. It has a reduced life expectancy due predominantly to respiratory failure or sudden cardiac death. The mortality rate is approximately 7.3 times greater than the general population with a mean age at death of 53 years. Degeneration of the cardiac conduction system causes atrioventricular block, arrhythmias, and ventricular failure. A case of sudden death in a 44-year-old woman with DM type 1 is reported to demonstrate an alter...
Source: Journal of Forensic Sciences - February 7, 2017 Category: Forensic Medicine Authors: Omond KJ, Byard RW Tags: J Forensic Sci Source Type: research

Cause of death and potentially avoidable deaths in Australian adults with intellectual disability using retrospective linked data
Conclusions Adults with ID experience premature mortality and over-representation of potentially avoidable deaths. A national system of reporting of deaths in adults with ID is required. Inclusion in health policy and services development and in health promotion programmes is urgently required to address premature deaths and health inequalities for adults with ID. (Source: BMJ Open)
Source: BMJ Open - February 7, 2017 Category: Journals (General) Authors: Trollor, J., Srasuebkul, P., Xu, H., Howlett, S. Tags: Open access, Epidemiology, Public health Research Source Type: research

Polycyclic aromatic hydrocarbons exposure, oxidative stress, and asthma in children
ConclusionExposure to PAH may enhance oxidative stress and may induce asthma. The effect of PAH exposure on asthma may be mediated by oxidative stress. (Source: International Archives of Occupational and Environmental Health)
Source: International Archives of Occupational and Environmental Health - February 7, 2017 Category: Occupational Health Source Type: research

GESAP trial rationale and methodology: management of patients with suspected obstructive sleep apnea in primary care units compared to sleep units
npj Primary Care Respiratory Medicine, Published online: 7 February 2017; doi:10.1038/s41533-016-0010-x (Source: npj Primary Care Respiratory Medicine)
Source: npj Primary Care Respiratory Medicine - February 7, 2017 Category: Primary Care Authors: N úria Tarraubella Jordi de Batlle N úria Nadal Anabel L. Castro-Grattoni Silvia G ómez Manuel S ánchez-de-la-Torre Ferran Barb é Source Type: research

Pharmacokinetics of Salbutamol Delivered from the Unit Dose Dry Powder Inhaler: Comparison with the Metered Dose Inhaler and Diskus Dry Powder Inhaler
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - February 7, 2017 Category: Respiratory Medicine Authors: Alison Moore Kylie Riddell Shashidhar Joshi Robert Chan Rashmi Mehta Source Type: research

Validation of multiple breath washout devices
To the editor, (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - February 7, 2017 Category: Respiratory Medicine Authors: Lena Raaijmakers, Renee Jensen, Sanja Stanojevic, Felix Ratjen Tags: Letter to the Editor Source Type: research

The 1-min sit-to-stand test in cystic fibrosis — Insights into cardiorespiratory responses
We aimed to characterize the cardiopulmonary response during a 1-min sit-to-stand (STS) test and compare peak exercise cardiorespiratory variables to a maximal cardiopulmonary exercise test (CPET) in cystic fibrosis (CF). We further aimed to assess the validity of the STS power index (PowerSTS) as a measure of exercise capacity. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - February 7, 2017 Category: Respiratory Medicine Authors: Thomas Radtke, Helge Hebestreit, Milo A. Puhan, Susi Kriemler Tags: Original Article Source Type: research

Effect of posture on lung ventilation distribution and associations with structure in children with cystic fibrosis
We assessed the effect of posture on ventilation distribution and the impact on associations with structural lung disease. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - February 7, 2017 Category: Respiratory Medicine Authors: Kathryn A. Ramsey, Caroline McGirr, Stephen M. Stick, Graham L. Hall, Shannon J. Simpson, on behalf of AREST CF Tags: Original Article Source Type: research

Once daily aerosolised tobramycin in adult patients with cystic fibrosis in the management of Pseudomonas aeruginosa chronic infection
AbstractIt is estimated that about 60 –70% of Cystic Fibrosis patients developPseudomonas aeruginosa chronic infection, with progressive loss of lung function, as well as increased antibiotic resistance and mortality.The current strategy is to maintain lung function by chronic suppressive antipseudomonas antibiotic therapy. Tobramycin inhalation solution was the first approved aerosolised antibiotic to be used againstP. aeruginosa; inhalatory tobramycin frequency of administration is twice daily and inhalation time is estimated to be 15 to 20  min.From the pharmacokinetic point of view, aminoglycosides are dose-dependen...
Source: Multidisciplinary Respiratory Medicine - February 7, 2017 Category: Respiratory Medicine Source Type: research

Response to paper: Long-term home mechanical ventilation due to obesity hypoventilation syndrome
In a letter to the editor, Santos and Cruz (1) had some highly relevant considerations about our study, “Gender differences in patients starting long-term home mechanical ventilation (LTMV) due to obesity hypoventilation syndrome (OHS)” (2). They asked for information about ventilator parameters, apnea-hypopnea index (AHI) and more details about reasons for discontinuation of LTMV among patients w ith OHS on LTMV. In addition, they asked for information about patients with OHS treated with continuous positive airway pressure (CPAP) only. (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 7, 2017 Category: Respiratory Medicine Authors: Andreas Palm, Bengt Midgren, Christer Janson, Eva Lindberg Source Type: research

Multicenter study of cigarette smoking among adults with asthma exacerbations in the emergency department, 2011 –2012
Previous studies demonstrated a high prevalence of cigarette smoking in patients presenting to the emergency department (ED) with acute asthma. Despite the clinical and public health importance, there have been no recent multicenter efforts to characterize this patient population. We aimed to update the prevalence of cigarette smoking among ED patients with asthma exacerbations. (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 7, 2017 Category: Respiratory Medicine Authors: Robert A. Silverman, Kohei Hasegawa, Daniel J. Egan, Kirk A. Stiffler, Ashley F. Sullivan, Carlos A. Camargo Tags: Short communication Source Type: research

Women treated for epilepsy during pregnancy: outcomes from a nationwide population ‐based cohort study
ConclusionsWWE are at an increased risk of complications and hospitalizations during pregnancy and delivery. However, the majority of WWE have normal pregnancy and delivery.This article is protected by copyright. All rights reserved. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 7, 2017 Category: OBGYN Authors: Miia Artama, Jemina Ahola, Jani Raitanen, Jukka Uotila, Mika Gissler, Jouko Isoj ärvi, Anssi Auvinen Tags: Original Research Article Source Type: research

Abnormal FLAIR Signal in the Internal Capsule: A Novel Brain MRI Finding in a Child with Acute Flaccid Myelitis
A previously healthy 12-year-old girl presented with three days of left arm weakness eight days following a presumed upper respiratory tract infection. On examination she had proximal greater than distal left arm weakness and absent reflexes throughout the left arm. Cerebrospinal fluid examination demonstrated 200 white blood cells (normal 0-6) and 20,000 red blood cells (normal=0) with normal protein and glucose. Enterovirus and herpes group viruses were not detected in cerebrospinal fluid, no viruses were detected in a nasopharyngeal swab specimen, and enterovirus was not detected in stool. (Source: Pediatric Neurology)
Source: Pediatric Neurology - February 7, 2017 Category: Neurology Authors: Naila Makhani, Amit Mahajan Tags: Visual Diagnosis Source Type: research

Should We Prescribe Antibiotics to This Patient With Persistent Upper Respiratory Symptoms?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center.
Discussion From Beth Israel Deaconess Medical Center. Ann Intern Med. 2017 Feb 07;166(3):201-208 Authors: Libman H, Brockmeyer DM, Gold HS Abstract The American College of Physicians (ACP) and the Centers for Disease Control and Prevention (CDC) recently published advice for high-value care on the appropriate use of antibiotics for acute respiratory tract infections. They conducted a narrative literature review of evidence for antibiotic use in this setting that included recent clinical guidelines from professional societies supplemented by randomized, controlled trials; meta-analyses; and systematic ...
Source: Annals of Internal Medicine - February 7, 2017 Category: Internal Medicine Authors: Libman H, Brockmeyer DM, Gold HS Tags: Ann Intern Med Source Type: research

Middle East respiratory syndrome (MERS) coronavirus: Putting one health principles into practice?
Publication date: Available online 7 February 2017 Source:The Veterinary Journal Author(s): Janet M. Daly (Source: The Veterinary Journal)
Source: The Veterinary Journal - February 7, 2017 Category: Veterinary Research Source Type: research

Metastable radical state, nonreactive with oxygen, is inherent to catalysis by respiratory and photosynthetic cytochromes bc1/b6f [Biochemistry]
Oxygenic respiration and photosynthesis based on quinone redox reactions face a danger of wasteful energy dissipation by diversion of the productive electron transfer pathway through the generation of reactive oxygen species (ROS). Nevertheless, the widespread quinone oxido-reductases from the cytochrome bc family limit the amounts of released ROS to a... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 7, 2017 Category: Science Authors: Marcin Sarewicz, Łukasz Buȷnowicz, Satarupa Bhaduri, Sandeep K. Singh, William A. Cramer, Artur Osyczka Tags: Biological Sciences Source Type: research

Is obstructive sleep apnea associated with the presence of intracranial cerebral atherosclerosis?
ConclusionsOur findings suggest that moderate to severe OSA is associated with the presence of ICAS in patients with suspected OSA. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 7, 2017 Category: Respiratory Medicine Source Type: research

Rapid strip tests as a decision-making tool about antibiotic treatment in children – A prospective study
Conclusions Rapid diagnostic tests used by the family physicians in initial diagnostics of seasonal upper respiratory tract infections in children allowed to differentiate between the type of infection as well as reduce the number of follow-up visits. Also, the antibiotic spending reimbursed by the insurer decreased by 17%. (Source: Pediatria Polska)
Source: Pediatria Polska - February 7, 2017 Category: Pediatrics Source Type: research

Starplasty tracheostomy: case series and literature review
ConclusionsIn our series, pediatric SPT was not associated with any major complications. Therefore, we conclude that SPT should be considered as a safe and advantageous alternative for traditional tracheotomy, especially in patients with low probability of future decannulation, and, therefore, at low risk of a persistent tracheocutaneous fistula. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - February 7, 2017 Category: ENT & OMF Source Type: research

Massive left atrial calcification: a case report and review of the literature
We report a case of LA calcification in a 69-year-old woman presented with dyspnea and cyanosis. Admission electrocardiogram showed atrial fibrillation and biventricular hypertrophy. Her chest roentgenogram revealed cardiomegaly and a curvilinear whitish shadow in the area of LA. Transthoracic echocardiography revealed severe mitral stenosis and massive LA thrombosis. The patient underwent an emergent surgery, during which the whitish line on chest roentgenogram proved to be a calcified LA inner wall. During an on-pump surgery with cardioplegic arrest, she underwent open MV commissurotomy along with the excision of calcifi...
Source: General Thoracic and Cardiovascular Surgery - February 7, 2017 Category: Cardiovascular & Thoracic Surgery Source Type: research

Effect of tobacco and electronic cigarette use on cough reflex sensitivity
Publication date: Available online 6 February 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Peter V. Dicpinigaitis Multiple previous studies have shown that otherwise healthy tobacco cigarette smokers have suppressed cough reflex sensitivity compared with nonsmokers and furthermore, that smoking cessation, even after years of tobacco use, leads to prompt enhancement of cough reflex sensitivity. Thus, cough reflex sensitivity is demonstrated to be a dynamic phenomenon, responding to the presence or absence of influences such as tobacco smoke. These studies, however, were unable to identify whether it...
Source: Pulmonary Pharmacology and Therapeutics - February 7, 2017 Category: Respiratory Medicine Source Type: research

The obesity paradox: validity and clinical implications
AbstractPurpose of reviewObesity has been associated with increased incidence of diabetes, atherosclerotic disease, numerous cancers, and other comorbidities. Given the increased comorbidities and challenges associated with bedside care of the critically ill obese patient, the expectation would be worse overall clinical outcomes. However, it has been noted that there are improved outcomes in critically ill patients who are overweight or mildly obese compared to their underweight and morbidly obese counterparts. This has been termed the obesity paradox. The purpose of this article is to discuss the validity of the obesity p...
Source: Current Respiratory Care Reports - February 7, 2017 Category: Respiratory Medicine Source Type: research

Immunoglobulin (Ig)M antibodies to proteinase 3 in granulomatosis with polyangiitis and microscopic polyangiitis
Summary Anti‐neutrophil cytoplasmic antibodies (ANCA) appear to play an important role in the pathogenesis of ANCA‐associated vasculitis (AAV). However, ANCA alone are not sufficient to generate disease, and some evidence suggests that infectious triggers may serve as inciting events for AAV disease activity. Antibodies of the immunoglobulin (Ig)M isotype often serve as markers of recent infection, and IgM ANCA have been identified previously in patients with AAV, although the frequency and clinical relevance of IgM ANCA is not well established. We sought to characterize IgM ANCA more clearly by creating a novel enzyme...
Source: Clinical and Experimental Immunology - February 7, 2017 Category: Allergy & Immunology Authors: J. M. Clain, A. M. Hummel, J. H. Stone, F. C. Fervenza, G. S. Hoffman, C. G. M. Kallenberg, C. A. Langford, W. J. McCune, P. A. Merkel, P. A. Monach, P. Seo, R. F. Spiera, E. W. St Clair, S. R. Ytterberg, U. Specks, Tags: Original Article Source Type: research

Increased systemic cytokine/chemokine expression in asthmatic and non ‐asthmatic patients with bacterial, viral or mixed lung infection
This study was aimed to determine the profiles of serum cytokines (IL‐1β, TNF‐α, IL‐4, IL‐5) and chemokines (MCP‐1: monocyte chemoattract protein‐1 and RANTES: regulated on activation normal T cell expressed and secreted) in individuals with an asthmatic versus a non‐asthmatic background with bacterial, viral or mixed acute respiratory infection. Asthmatic (n=14) and non‐ asthmatic (n=29) patients with acute viral, bacterial or mixed (bacterial and viruses) respiratory infection were studied. Patients were also analyzed as individuals with pneumonia or bronchitis. Healthy individuals with similar age and ...
Source: Scandinavian Journal of Immunology - February 7, 2017 Category: Allergy & Immunology Authors: Maria J Giuffrida, Nereida Valero, Jesus Mosquera, Anyelo Duran, Francisco Arocha, Betulio Chac ín, Luz Marina Espina, Jenifer Gotera, John Bermudez, Alibeth Mavarez, Melchor Alvarez‐Mon Tags: Regular Article Source Type: research

Validation of the Japanese Severe Respiratory Insufficiency Questionnaire in hypercapnic patients with noninvasive ventilation
Conclusions The Japanese SRI Questionnaire was produced using a standardized procedure and an equivalency study. It has high psychometric properties with internal consistency and concurrent validity. The Japanese SRI Questionnaire can be used to assess HRQL in patients on NIV for CHRF. (Source: Respiratory Investigation)
Source: Respiratory Investigation - February 7, 2017 Category: Respiratory Medicine Source Type: research

[Prevention and treatment of skin lesions associated with non-invasive mechanical ventilation. Recommendations of experts].
CONCLUSIONS: The mask of choice is the facial, always using foam or hydrocolloid dressings on the nasal bridge. Evaluate the condition of the skin under the interface and harness every 4hours (recommended) and 11hours (maximum). Evaluate the rotation strategy of the interface at 24hours if the NIV is still needed on an ongoing basis. PMID: 28153465 [PubMed - as supplied by publisher] (Source: Enfermeria Intensiva)
Source: Enfermeria Intensiva - February 6, 2017 Category: Nursing Tags: Enferm Intensiva Source Type: research

Near-fatal Anorexia Nervosa in a Middle-aged Woman.
Authors: Foppiani L, Massobrio B, Cascio C, Antonucci G Abstract Anorexia nervosa (AN) is a serious psychiatric disorder which typically occurs in young women; however, more and more cases in middle-aged women are being reported. The management of this complex disease requires a team approach, and full recovery occurs only in 50% of patients. Endocrine and metabolic complications are commonly observed, the latter of which may even be life-threatening, and require prompt and proper management. Infections, albeit reported, are not usually a major clinical problem in these patients. We herein report the case of a seve...
Source: Internal Medicine - February 6, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research