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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 13.

Radiological findings of unilateral tuberculous lung destruction
ConclusionsTotal unilateral post-tuberculous lung destruction is an irreversible complication with the following main radiological features: predominantly left-sided location, decreases in the diameter of the ipsilateral pulmonary vessels, herniation of the contralateral lung and hypertrophy of the ribs and/or thickening of extrapleural fat.Teaching Points•Unilateral tuberculous lung destruction is an irreversible complication of tuberculosis.•Left-side predominance and herniation of the contralateral lung are characteristic.•Decreased diameter of the ipsilateral pulmonary vessels occurred in all patients.•The patt...
Source: Insights into Imaging - February 14, 2017 Category: Radiology Source Type: research

Reactive oxygen: a novel antimicrobial mechanism for targeting biofilm-associated infection
Publication date: Available online 14 February 2017 Source:Journal of Global Antimicrobial Resistance Author(s): Matthew S. Dryden, Jonathan Cooke, Rami J. Salib, Rebecca E. Holding, Timothy Biggs, Ali A. Salamat, Raymond N. Allan, Rachel S. Newby, Fenella Halstead, Beryl Oppenheim, Thomas Hall, Sophie C. Cox, Liam M. Grover, Zain Al-hindi, Lilyann Novak-Frazer, Malcolm D. Richardson Reactive oxygen species (ROS) is a novel therapeutic strategy for topical or local application to wounds, mucosa or internal structures where there may be heavy bacterial bioburden with biofilm and chronic inflammation. Bacterial biofilms are...
Source: Journal of Global Antimicrobial Resistance - February 14, 2017 Category: Infectious Diseases Source Type: research

A cross-sectional survey to study the relationship of periodontal disease with cardiovascular disease, respiratory disease, and diabetes mellitus
Conclusion: From the findings of the present study, it can be concluded that diabetes mellitus, CVD, and respiratory disease are associated with a higher severity of periodontal disease. (Source: Journal of Indian Society of Periodontology)
Source: Journal of Indian Society of Periodontology - February 14, 2017 Category: Dentistry Authors: Sukhvinder Singh Oberoi Yashoda Harish Shivalingaswamy Hiremath Manjunath Puranik Source Type: research

Effect of adjuvanted and standard sublingual immunotherapy on respiratory function in pure rhinitis due to house dust mite over a 5-year period
ConclusionIn the real life setting, considering a 5-year period, aSLIT and sSLIT reduced the onset of new sensistizations and maintained intact the pulmonary function, as compared to patients receiving drug treatment alone. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - February 14, 2017 Category: Allergy & Immunology Source Type: research

Clinical Manifestations and Genetic Analysis of 17 Patients with Autosomal Dominant Hyper-IgE Syndrome in Mainland China: New Reports and a Literature Review
ConclusionsWe here retrospectively report the largest Chinese cohort of AD-HIES patients with STAT3 mutation. Unique features, when compared to existing literature reports, include (1) later age of diagnosis, (2) significantly higher rate of BCG complications, and (3) lower rate of candidiasis and chronic otitis media. (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - February 14, 2017 Category: Allergy & Immunology Source Type: research

Physicochemical changes of ‘Phulae’ pineapple fruit treated with short-term anoxia during ambient storage
In conclusion, the short-term anoxia exposure for 16h maintained postharvest quality, retarded physiological disorder and enhanced nutritional values of the pineapple fruit stored at ambient temperature (25±2°C). (Source: Food Chemistry)
Source: Food Chemistry - February 14, 2017 Category: Food Science Source Type: research

Rheumatoid arthritis associated pulmonary hypertension: Clinical challenges reflecting the diversity of pathophysiology
Publication date: Available online 13 February 2017 Source:Respiratory Medicine Case Reports Author(s): Evangelia Panagiotidou, Evdokia Sourla, Serafim Xrisovalantis Kotoulas, Sofia Akritidou, Vasileios Mpikos, Vasileios Mpagalas, Ioannis Stanopoulos, Georgia Pitsiou The present article reports three clinical cases in order to elucidate the diversity of the pathophysiological mechanisms that underlie rheumatoid arthritis associated pulmonary hypertension. The condition's three major causes are: interstitial lung disease, vasculitis, and chronic thromboembolic disease, but it should be noted that the multiple pulmonary man...
Source: Respiratory Medicine Case Reports - February 14, 2017 Category: Respiratory Medicine Source Type: research

A fatal endocarditis case due to an emerging bacterium: Moraxella nonliquefaciens
We report a fatal case of endocarditis due to M. nonliquefaciens whose identification was confirmed by 16S rRNA, and we review the literature on this pathogen in endocarditis. (Source: IDCases)
Source: IDCases - February 14, 2017 Category: Infectious Diseases Source Type: research

Long ‐Term Safety and Efficacy of Bixalomer in Hyperphosphatemic Patients With Chronic Kidney Disease Not on Dialysis
This study examined the long‐term effectiveness and safety of bixalomer in predialysis patients with hyperphosphatemia. This was a 48‐week, multicenter, open‐label, phase 3 study in Japanese predialysis patients with hyperphosphatemia. Patients received bixalomer at an initial dose of 1500 mg/day, which was titrated to a maximum of 7500 mg/day depending on patients’ serum phosphorus responses to bixalomer. A total of 105 patients received bixalomer treatment, and 39 completed the study. The most common reason for discontinuation was initiation of dialysis. Mean serum phosphorus concentrations decreased from 5.1...
Source: Therapeutic Apheresis and Dialysis - February 14, 2017 Category: Hematology Authors: Tadao Akizawa, Junko Tsukada, Chisato Kameoka, Kentarou Kuroishi, Yusuke Yamaguchi Tags: Original Article Source Type: research

Juvenile generalized pustular psoriasis is a chronic recalcitrant disease: an analysis of 27 patients seen in a tertiary hospital in Johor, Malaysia
ConclusionsJuvenile GPP is a chronic recalcitrant disease. IL36RN‐positive patients have more severe disease. (Source: International Journal of Dermatology)
Source: International Journal of Dermatology - February 14, 2017 Category: Dermatology Authors: Bi ‐Wen Lau, Dee‐Zhen Lim, Francesca Capon, Jonathan N. Barker, Siew‐Eng Choon Tags: Report Source Type: research

Atrial natriuretic peptide: a novel mediator for TGF- β1-induced epithelial-mesenchymal transition in 16HBE-14o and A549 cells
In conclusion, ANP inhibits TGF-β1-induced EMT in 16HBE-14o and A549 cells through cGMP/PKG signaling, by which it targets TGF-β1/Smad3 via attenuating phosphorylation of Smad3. These findings suggest the potential of ANP in the treatment on pulmonary diseases with airway remodeling. (Source: Peptides)
Source: Peptides - February 14, 2017 Category: Biochemistry Source Type: research

Omalizumab in severe asthma: Evaluation of the clinical impact after its withdrawal
Publication date: Available online 13 February 2017 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): M. D. de Sousa, C. Ferreira, A. Arrobas (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - February 14, 2017 Category: Respiratory Medicine Source Type: research

Extracorporeal Membrane Oxygenation Outcomes in Acute Respiratory Distress Treatment: Case Study in a Chinese Referral Center.
CONCLUSIONS ECMO is an effective alternative option for severe ARDS. APACHE II score on admission, onset of acute kidney injury, and membrane oxygenator replacement, and the evolution of levels of urea nitrogen, platelet, and fibrinogen during hospitalization may help to determine the in-hospital patient prognosis. By establishing a well-trained mobile ECMO team, a long-distance, inter-hospital transport can be administered safely. PMID: 28184033 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 13, 2017 Category: Research Tags: Med Sci Monit Source Type: research

[Systemic lupus erythematosus presenting as severe alveolar hypoventilation and the shrinking lung syndrome].
CONCLUSION: The interesting features of this case report consist of: 1) the presentation of the SLS as an alveolar hypoventilation with a fatal outcome, 2) the presentation of systemic lupus as SLS. PMID: 28189434 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - February 13, 2017 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

Interpatient mutational spectrum of human coronavirus ‐OC43 revealed by illumina sequencing
This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - February 13, 2017 Category: Virology Authors: Geoffrey J. Gorse, Gira B. Patel, Xiaofeng Fan Tags: Research Article Source Type: research

Lactic Acidosis with Chloramphenicol Treatment in a Child with Cystic Fibrosis.
We describe the case of a 15-year-old female with terminal cystic fibrosis who required intravenous (IV) chloramphenicol treatment for a Burkholderia cepacia (B. cepacia) exacerbation. The child subsequently developed lactic acidosis and secondary respiratory compensation adding to her baseline respiratory distress. Based on the Naranjo scale, the probability of chloramphenicol being the cause of the hyperlactatemia and associated respiratory distress was rated as probable, as the adverse effects resolved upon discontinuation of the drug. Subsequent genotyping for mitochondrial polymorphism (G3010A) confirmed a possible su...
Source: Journal of Population Therapeutics and Clinical Pharmacology - February 13, 2017 Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research

Postoperative negative pressure pulmonary edema following repetitive laryngospasm even after reversal of neuromuscular blockade by sugammadex: a case report.
Authors: Lee JH, Lee JH, Lee MH, Cho HO, Park SE Abstract Laryngospasm, an occlusion of the glottis, can occur at any time during anesthesia, and is associated with serious perioperative complications such as hypoxia, hypercabia, aspiration, bronchospasm, arrhythmia, prolonged recovery, cardiac collapse, and eventually catastrophic death. Importantly, postoperative negative pressure pulmonary edema (NPPE) is a rare, but well described life-threatening complication related to acute and chronic upper airway obstruction. Sugammadex well known for affirmatively reducing the postoperative pulmonary complications associa...
Source: Korean Journal of Anesthesiology - February 13, 2017 Category: Anesthesiology Tags: Korean J Anesthesiol Source Type: research

A high-flow nasal cannula system set at relatively low flow effectively washes out CO2 from the anatomical dead space of a respiratory-system model.
Authors: Onodera Y, Akimoto R, Suzuki H, Masaki N, Kawamae K PMID: 28184277 [PubMed - in process] (Source: Korean Journal of Anesthesiology)
Source: Korean Journal of Anesthesiology - February 13, 2017 Category: Anesthesiology Tags: Korean J Anesthesiol Source Type: research

Effect of titanium dioxide nanoparticles (TiO2 NPs) on the expression of mucin genes in human airway epithelial cells.
CONCLUSIONS: These results demonstrate for the first time that TiO2 NPs induce MUC5B expression via TLR4-dependent ERK1/2 and p38 MAPK signaling pathways in respiratory epithelium. PMID: 28183201 [PubMed - in process] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - February 13, 2017 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Adverse respiratory effects in rats following inhalation exposure to ammonia: respiratory dynamics and histopathology.
Authors: Perkins MW, Wong B, Tressler J, Rodriguez A, Sherman K, Andres J, Devorak J, L Wilkins W, Sciuto AM Abstract Acute respiratory dynamics and histopathology of the lungs and trachea following inhaled exposure to ammonia were investigated. Respiratory dynamic parameters were collected from male Sprague-Dawley rats (300-350 g) during (20 min) and 24 h (10 min) after inhalation exposure for 20 min to 9000, 20,000, and 23,000 ppm of ammonia in a head-only exposure system. Body weight loss, analysis of blood cells, and lungs and trachea histopathology were assessed 1, 3, and 24 h following inhalatio...
Source: Inhalation Toxicology - February 13, 2017 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Effective inhibition of MERS-CoV infection by resveratrol
Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that causes severe morbidity and mortality. Up to date, there is no approved or licensed vaccine or antiviral medicines can... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - February 13, 2017 Category: Infectious Diseases Authors: Shih-Chao Lin, Chi-Tang Ho, Wen-Ho Chuo, Shiming Li, Tony T. Wang and Chi-Chen Lin Source Type: research

Observation management of pulmonary embolism and agreement with claims-based and clinical risk stratification criteria in United States patients: a retrospective analysis
Guidelines suggest observation stays are appropriate for pulmonary embolism (PE) patients at low-risk for early mortality. We sought to assess agreement between United States (US) observation management of PE ... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - February 13, 2017 Category: Respiratory Medicine Authors: Elaine Nguyen, Craig I. Coleman, W. Frank Peacock, Philip S. Wells, Erin R. Weeda, Veronica Ashton, Concetta Crivera, Peter Wildgoose, Jeff R. Schein, Thomas J. Bunz and Gregory J. Fermann Source Type: research

Malondialdehyde-acetaldehyde (MAA) adducted surfactant protein induced lung inflammation is mediated through scavenger receptor a (SR-A1)
Co-exposure to cigarette smoke and alcohol leads to the generation of high concentrations of acetaldehyde and malondialdehyde in the lung. These aldehydes being highly electrophilic in nature react with biolog... (Source: Respiratory Research)
Source: Respiratory Research - February 13, 2017 Category: Respiratory Medicine Authors: Muna Sapkota, Jane M. DeVasure, Kusum K. Kharbanda and Todd A. Wyatt Source Type: research

Using theory to explore facilitators and barriers to delayed prescribing in Australia: a qualitative study using the Theoretical Domains Framework and the Behaviour Change Wheel
Delayed antibiotic prescribing reduces antibiotic use for acute respiratory infections in trials in general practice, but the uptake in clinical practice is low. The aim of the study was to identify facilitato... (Source: BMC Family Practice)
Source: BMC Family Practice - February 13, 2017 Category: Primary Care Authors: Lucy Sargent, Amanda McCullough, Chris Del Mar and John Lowe Source Type: research

Adaptive Servoventilation Device Software in the Assessment of Residual Respiratory Events in Patients With Central or Complex Apnoeas.
PMID: 28209445 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - February 13, 2017 Category: Respiratory Medicine Authors: Silveira MG, Sampol G, Cambrodi R, Ferre À, Lloberes P Tags: Arch Bronconeumol Source Type: research

Selective inhibition of phosphodiesterases 4A, B, C and D isoforms in chronic respiratory diseases: current and future evidences.
Abstract Chronic respiratory diseases affect millions of people every day. According to World Health Organization estimates, ~235 million people suffer from asthma, ~64 million suffer from chronic obstructive pulmonary disease (COPD), and millions more suffer from allergic rhinitis around the world. In recent last years, the first phosphodiesterase 4 (PDE4) inhibitor, roflumilast, was approved as a treatment to reduce the risk of exacerbations in stable and severe COPD associated with chronic bronchitis and a history of exacerbations. PDE4 exists as four subtypes (A, B, C, and D) each with a capacity to degrade cA...
Source: Current Pharmaceutical Design - February 13, 2017 Category: Drugs & Pharmacology Authors: Contreras S, Milara J, Morcillo E, Cortijo J Tags: Curr Pharm Des Source Type: research

Efficacy, safety and pharmacokinetics of biosimilars of anti-tumor necrosis factor- α agents in rheumatic diseases; A systematic review and meta-analysis.
CONCLUSION: In the present study, biosimilars of anti-TNF-α agents had an overall comparable efficacy and safety profile compared to their reference agents in RA and AS supporting their use for these conditions. PMID: 28209290 [PubMed - as supplied by publisher] (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - February 13, 2017 Category: Allergy & Immunology Authors: Komaki Y, Yamada A, Komaki F, Kudaravalli P, Micic D, Ido A, Sakuraba A Tags: J Autoimmun Source Type: research

A Multisite Benchmarking Trial of Capnometry Guided Respiratory Intervention for Panic Disorder in Naturalistic Treatment Settings.
Abstract Panic disorder (PD) is associated with hyperventilation. The efficacy of a brief respiratory feedback program for PD has been established. The aim of the present study was to expand these results by testing a similar program with more clinically representative patients and settings. Sixty-nine adults with PD received 4 weeks of Capnometry Guided Respiratory Intervention (CGRI) using Freespira, which provides feedback of end-tidal CO2 (PETCO2) and respiration rate (RR), in four non-academic clinical settings. This intervention is delivered via home use following initial training by a clinician and provides...
Source: Applied Psychophysiology and Biofeedback - February 13, 2017 Category: Psychiatry & Psychology Authors: Tolin DF, McGrath PB, Hale LR, Weiner DN, Gueorguieva R Tags: Appl Psychophysiol Biofeedback Source Type: research

Multiple Perspectives of Symptoms and Suffering at End of Life in the NICU.
Abstract BACKGROUND: Despite technological advances in the neonatal intensive care unit, not all infants survive. Limited research has focused on infants' symptoms and suffering at end of life (EOL) from multiple perspectives. PURPOSE: To compare retrospective parent report and electronic medical record (EMR) documentation of symptoms and to examine associations with parent perceptions of infants suffering at EOL. METHODS/SEARCH STRATEGY: Bereaved parents of 40 infants (40 mothers and 27 fathers) retrospectively reported on their perceptions of infant symptoms and suffering during the last week of life. ...
Source: Advances in Neonatal Care - February 13, 2017 Category: Nursing Authors: Shultz EL, Switala M, Winning AM, Keim MC, Baughcum AE, Gerhardt CA, Fortney CA Tags: Adv Neonatal Care Source Type: research

IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity.
In conclusion, IL-25 can stimulate M2 macrophage polarization and thereby promote lipolysis and mitochondrial respiratory capacity, highlighting the potential for IL-25 to be used as a therapeutic agent against obesity and associated metabolic syndromes.Cellular & Molecular Immunology advance online publication, 13 February 2017; doi:10.1038/cmi.2016.71. PMID: 28194019 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - February 13, 2017 Category: Molecular Biology Authors: Feng J, Li L, Ou Z, Li Q, Gong B, Zhao Z, Qi W, Zhou T, Zhong J, Cai W, Yang X, Zhao A, Gao G, Yang Z Tags: Cell Mol Immunol Source Type: research

Results from a patient-based health education intervention in reducing antibiotic use for acute upper respiratory tract infections in the private sector primary care setting in Singapore.
Abstract We investigated the efficacy of patient-targeted education in reducing antibiotic prescriptions for upper respiratory tract infections (URTIs) amongst adults in the private primary care setting in Singapore. Our randomized controlled trial enrolled patients aged 21 years and above presenting at GP (general practitioner) clinics with URTI symptoms for 7 days or less. Intervention arm patients were verbally educated via pamphlets about the aetiology of URTIs, role of antibiotics in treating URTIs, and consequences of inappropriate antibiotic use. Control arm patients were educated on influenza vaccinations....
Source: Antimicrobial Agents and Chemotherapy - February 13, 2017 Category: Microbiology Authors: Lee MH, Pan DS, Huang JH, Chen MI, Chong JW, Goh EH, Jiang L, Leo YS, Lee TH, Wong CS, Loh VW, Lim FS, Poh AZ, Tham TY, Wong WM, Yu Y Tags: Antimicrob Agents Chemother Source Type: research

A Multisite Benchmarking Trial of Capnometry Guided Respiratory Intervention for Panic Disorder in Naturalistic Treatment Settings
AbstractPanic disorder (PD) is associated with hyperventilation. The efficacy of a brief respiratory feedback program for PD has been established. The aim of the present study was to expand these results by testing a similar program with more clinically representative patients and settings. Sixty-nine adults with PD received 4 weeks of Capnometry Guided Respiratory Intervention (CGRI) using Freespira, which provides feedback of end-tidal CO2 (PETCO2) and respiration rate (RR), in four non-academic clinical settings. This intervention is delivered via home use following initial training by a clinician and provides remote mo...
Source: Applied Psychophysiology and Biofeedback - February 13, 2017 Category: Psychiatry Source Type: research

NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection.
This article is protected by copyright. All rights reserved. PMID: 28191644 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
Source: European Journal of Immunology - February 13, 2017 Category: Allergy & Immunology Authors: Diab M, Glasner A, Issacson B, Bar-On Y, Drori Y, Yamin R, Duev-Cohen A, Danziger O, Zamostiano R, Mandelboim M, Jonjic S, Bacharach E, Mandelboim O Tags: Eur J Immunol Source Type: research

Retrospective observational study of trends in hospital admissions for idiopathic pulmonary fibrosis in Spain (2004-2013) using administrative data
Conclusions The frequency of hospital admissions for IPF increased during the study period, as did healthcare costs. However, IHM and LOHS decreased. (Source: BMJ Open)
Source: BMJ Open - February 13, 2017 Category: Journals (General) Authors: Pedraza-Serrano, F., Lopez de Andres, A., Jimenez-Garcia, R., Jimenez-Trujillo, I., Hernandez-Barrera, V., Sanchez-Munoz, G., Puente-Maestu, L., de Miguel-Diez, J. Tags: Open access, Epidemiology, Respiratory medicine Research Source Type: research

Pharmacokinetics and safety of cavosonstat (N91115) in healthy and cystic fibrosis adults homozygous for F508DEL-CFTR
Cavosonstat (N91115), an orally bioavailable inhibitor of S-nitrosoglutathione reductase, promotes cystic fibrosis transmembrane conductance regulator (CFTR) maturation and plasma membrane stability, with a mechanism of action complementary to CFTR correctors and potentiators. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - February 13, 2017 Category: Respiratory Medicine Authors: Scott H. Donaldson, George M. Solomon, Pamela L. Zeitlin, Patrick A. Flume, Alicia Casey, Karen McCoy, Edith T. Zemanick, Arun Mandagere, Janice M. Troha, Steven A. Shoemaker, James F. Chmiel, Jennifer L. Taylor-Cousar Tags: Original Article Source Type: research

The diacylglycerol acyltransferase Rv3371 of Mycobacterium tuberculosis is required for growth arrest and involved in stress-induced cell wall alterations
We report that one of these genes, Rv3371, specific to pathogenic mycobacteria, when expressed in M. smegmatis leads to modifications in colony morphotype, bacterial architecture, cell surface properties and elevated TAG levels. Rv3371 was found to largely localize in the cell membrane. The Rv3371 promoter is minimally active during exponential growth in vitro, however, is up-regulated under stationary phase, hypoxia, nutrient starvation, nitrosative stress, low iron, in IFN- γ activated macrophages and infected mice. (Source: Tuberculosis)
Source: Tuberculosis - February 13, 2017 Category: Respiratory Medicine Authors: Shivangi Rastogi, Amit Kumar Singh, Gyan Chandra, Pragati Kushwaha, Garima Pant, Kavita Singh, Kalyan Mitra, Koneni V. Sashidhara, Manju Y. Krishnan Source Type: research

Amygdala and hippocampus are symptomatogenic zones for central apneic seizures
Conclusions: These findings confirm that hippocampus and amygdala are limbic breathing control sites in humans, as well as the symptomatogenic zone for central apneic seizures. (Source: Neurology)
Source: Neurology - February 13, 2017 Category: Neurology Authors: Lacuey, N., Zonjy, B., Londono, L., Lhatoo, S. D. Tags: EEG; see Epilepsy/Seizures ARTICLE Source Type: research

Application of high-flow nasal cannula to heterogeneous condition in the emergency department
To date, there is limited evidence on the use of HFNC (high-flow nasal cannula) in adult patients presenting to the ED (emergency department) and on which patients benefit most from the therapy. There have been large-scale studies published which compared HFNC with COT (conventional oxygen therapy) regarding escalation to invasive ventilation, and the results seem conflicting until now. According to the HOT-ER study from New Zealand, HFNC was not shown to reduce the need for mechanical ventilation for subjects with acute respiratory distress compared to COT [1]. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - February 13, 2017 Category: Emergency Medicine Authors: Areum Durey, Soo Kang, Young Ju Suh, Seung Baik Han, Ah Jin Kim Source Type: research

Evaluation of the agreement of tidal breathing parameters measured simultaneously using pneumotachography and structured light plethysmography
This study compared tidal breathing parameters measured simultaneously using the gold standard method, pneumotachography (PNT), and a novel, noncontact and light‐based technique called structured light plethysmography (SLP). The repeatability of the agreement between the two devices, and the impact of a change in respiratory rate (RR) on this agreement was also assessed. Agreement of all tidal breathing parameters examined was good, both for breath‐by‐breath and when averaged over 45 sec. There was no significant difference in agreement between devices for any of the parameters between two resting breathing measurem...
Source: Physiological Reports - February 13, 2017 Category: Physiology Authors: Shayan Motamedi ‐Fakhr, Richard Iles, Anna Barney, Willem Boer, Jenny Conlon, Amna Khalid, Rachel C. Wilson Tags: Original Research Source Type: research

Comparative assessment of patient care expenses among intensive care units of a tertiary care teaching hospital using cost block method
Conclusion: Costing of intensive care service is essential for controlled operations and to provide efficient patient care. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - February 13, 2017 Category: Intensive Care Authors: Kanakavalli Kiranmai Kundury HK Mamatha Divya Rao Source Type: research

Pulmonary function and airway inflammation among dairy parlor workers after exposure to inhalable aerosols
ConclusionsInhalation exposures during parlor tasks, which were lower than previously reported and were not associated with cross‐shift measures of pulmonary health among dairy workers. Modern milking parlor designs may be contributing to lower inhalation exposure. Am. J. Ind. Med. 60:255–263, 2017. © 2017 Wiley Periodicals, Inc. (Source: American Journal of Industrial Medicine)
Source: American Journal of Industrial Medicine - February 13, 2017 Category: Occupational Health Authors: Matthew W. Nonnenmann, David Gimeno Ruiz de Porras, Jeffrey Levin, David Douphrate, Vijay Boggaram, Joshua Schaffer, Michael Gallagher, Madeleine Hornick, Stephen Reynolds Tags: Research Article Source Type: research

Acute respiratory distress syndrome: An unusual presentation of chikungunya fever viral infection
Abhijeet SinghJournal of Global Infectious Diseases 2017 9(1):33-34 (Source: Journal of Global Infectious Diseases)
Source: Journal of Global Infectious Diseases - February 13, 2017 Category: Infectious Diseases Authors: Abhijeet Singh Source Type: research

The epidemiologic characteristics, temporal trends, predictors of death, and discharge disposition in patients with a diagnosis of sepsis: A cross-sectional retrospective cohort study
Conclusion Certain comorbidities and organ failures were associated with death and discharge to a skilled outpatient facility. (Source: Journal of Critical Care)
Source: Journal of Critical Care - February 13, 2017 Category: Gastroenterology Source Type: research

Does Diurnal Variation in Cough Reflex Testing Exist in Healthy Young Adults?
Publication date: Available online 12 February 2017 Source:Respiratory Physiology & Neurobiology Author(s): Sarah Perry, Maggie-Lee Huckabee The aim of this study was to investigate whether diurnal variation in cough reflex sensitivity exists in healthy young adults when a tidal-breathing method is used. Fifty-three participants (19–37 years) underwent cough reflex testing on two occasions: once in the morning (between 9am − midday) and once in the afternoon (between 2–5pm). The order of testing was counter-balanced. Within each assessment, participants inhaled successively higher citric acid concentrations ...
Source: Respiratory Physiology and Neurobiology - February 13, 2017 Category: Respiratory Medicine Source Type: research

Preserving brain function in a comatose patient with septic hyperpyrexia (41.6  °C): a case report
ConclusionsWe propose that a combination of levetiracetam and amantadine may provide neuroprotective and neurorestorative properties when administered during a period of hyperpyrexia accompanied by any form of mental status changes, particularly if there is a decline in Glasgow Coma Score. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - February 13, 2017 Category: Journals (General) Source Type: research

Excessive Respiratory Modulation of Blood Pressure Triggers Hypertension.
Abstract The etiology of hypertension, the world's biggest killer, remains poorly understood, with treatments targeting the established symptom, not the cause. The development of hypertension involves increased sympathetic nerve activity that, in experimental hypertension, may be driven by excessive respiratory modulation. Using selective viral and cell lesion techniques, we identify adrenergic C1 neurons in the medulla oblongata as critical for respiratory-sympathetic entrainment and the development of experimental hypertension. We also show that a cohort of young, normotensive humans, selected for an exaggerated...
Source: Cell Metabolism - February 12, 2017 Category: Cytology Authors: Menuet C, Le S, Dempsey B, Connelly AA, Kamar JL, Jancovski N, Bassi JK, Walters K, Simms AE, Hammond A, Fong AY, Goodchild AK, McMullan S, Allen AM Tags: Cell Metab Source Type: research

SARS-CoV-Encoded Small RNAs Contribute to Infection-Associated Lung Pathology.
Abstract Severe acute respiratory syndrome coronavirus (SARS-CoV) causes lethal disease in humans, which is characterized by exacerbated inflammatory response and extensive lung pathology. To address the relevance of small non-coding RNAs in SARS-CoV pathology, we deep sequenced RNAs from the lungs of infected mice and discovered three 18-22 nt small viral RNAs (svRNAs). The three svRNAs were derived from the nsp3 (svRNA-nsp3.1 and -nsp3.2) and N (svRNA-N) genomic regions of SARS-CoV. Biogenesis of CoV svRNAs was RNase III, cell type, and host species independent, but it was dependent on the extent of viral repl...
Source: Cell Host and Microbe - February 12, 2017 Category: Microbiology Authors: Morales L, Oliveros JC, Fernandez-Delgado R, tenOever BR, Enjuanes L, Sola I Tags: Cell Host Microbe Source Type: research

Association between chronic exposure to air pollution and mortality in the acute respiratory distress syndrome.
Abstract The impact of chronic exposure to air pollution and outcomes in the acute respiratory distress syndrome (ARDS) is unknown. The Nationwide Inpatient Sample (NIS) from 2011 was utilized for this analysis. The NIS is a national database that captures 20% of all US in-patient hospitalizations from 47 states. Patients with ARDS who underwent mechanical ventilation from the highest 15 ozone pollution cities were compared with the rest of the country. Secondary analyses assessed outcomes of ARDS patients for ozone pollution and particulate matter pollution on a continuous scale by county of residence. A total of...
Source: Environmental Pollution - February 12, 2017 Category: Environmental Health Authors: Rush B, McDermid RC, Celi LA, Walley KR, Russell JA, Boyd JH Tags: Environ Pollut Source Type: research

Air pollution, PM2.5 composition, source factors, and respiratory symptoms in asthmatic and nonasthmatic children in Santiago, Chile.
In conclusion, exposure to air pollutants, especially PM2.5, NO2, and O3, were found to exacerbate respiratory symptoms in both asthmatic and nonasthmatic children. Some of the results suggest that PM2.5 components associated with a secondary sulfate source may have a greater impact on some symptoms than PM2.5. In general, the results of this study show important associations at concentrations close or below current air quality standards. PMID: 28202226 [PubMed - as supplied by publisher] (Source: Environment International)
Source: Environment International - February 12, 2017 Category: Environmental Health Authors: Prieto-Parra L, Yohannessen K, Brea C, Vidal D, Ubilla CA, Ruiz-Rudolph P Tags: Environ Int Source Type: research

The impact of statin use on all-cause mortality in patients with COPD: a population based cohort study.
CONCLUSIONS: This study shows that statin use in a population-based cohort of COPD patients may confer benefits in terms of reduced pulmonary-related and all-cause mortality. PMID: 28202342 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 12, 2017 Category: Respiratory Medicine Authors: Raymakers AJ, Sadatsafavi M, Sin DD, De Vera MA, Lynd LD Tags: Chest Source Type: research