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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 10.

Catheter-Based Approaches for the Treatment of Acute Pulmonary Embolism
Semin Respir Crit Care Med 2017; 38: 073-083 DOI: 10.1055/s-0036-1597971Except when contraindicated, anticoagulation should be initiated when pulmonary embolism (PE) is strongly suspected and the bleeding risk is perceived to be low, even if the evaluation has not been completed. Low-risk patients with acute PE are simply continued on anticoagulation. Severely ill patients with high-risk (massive) PE require aggressive therapy, and if the bleeding risk is acceptable, systemic thrombolysis should be considered. However, despite clear evidence that parenteral thrombolytic therapy leads to more rapid clot resolution than anti...
Source: Seminars in Respiratory and Critical Care Medicine - February 16, 2017 Category: Respiratory Medicine Authors: Tapson, Victor F. Jimenez, David Tags: Review Article Source Type: research

Massive Pulmonary Embolism: Extracorporeal Membrane Oxygenation and Surgical Pulmonary Embolectomy
Semin Respir Crit Care Med 2017; 38: 066-072 DOI: 10.1055/s-0036-1597559Massive pulmonary embolism (PE) refers to large emboli that cause hemodynamic instability, right ventricular failure, and circulatory collapse. According to the 2016 ACCP Antithrombotic Guidelines, therapy for massive PE should include systemic thrombolytic therapy in conjunction with anticoagulation and supportive care. However, in patients with a contraindication to systemic thrombolytics or in those who fail the above interventions, extracorporeal membrane oxygenation (ECMO) and/or surgical embolectomy may be used to improve oxygenation, achieve hem...
Source: Seminars in Respiratory and Critical Care Medicine - February 16, 2017 Category: Respiratory Medicine Authors: Weinberg, Aaron Tapson, Victor F. Ramzy, Danny Tags: Review Article Source Type: research

Systemic Thrombolytic Therapy for Acute Pulmonary Embolism: Who Is a Candidate?
Semin Respir Crit Care Med 2017; 38: 056-065 DOI: 10.1055/s-0036-1597560Pulmonary embolism (PE) is a major cause of both acute and long-term morbidity for a large number of patients worldwide, and massive PE is frequently fatal. Right ventricular (RV) dysfunction is a key determinant of prognosis in the acute phase of PE. Patients with clinically overt RV failure, that is, with cardiogenic shock or persistent hypotension at presentation (acute high-risk PE), are clearly in need of immediate reperfusion treatment with systemic thrombolysis or, alternatively, surgical or catheter-directed techniques. On the other hand, withi...
Source: Seminars in Respiratory and Critical Care Medicine - February 16, 2017 Category: Respiratory Medicine Authors: Konstantinides, Stavros V. Barco, Stefano Tags: Review Article Source Type: research

The Pulmonary Embolism Response Team: What Is the Ideal Model?
Semin Respir Crit Care Med 2017; 38: 051-055 DOI: 10.1055/s-0036-1597561Treatment of patients with intermediate- and high-risk pulmonary embolism (PE) is a controversial area. Many therapeutic options exist, and deciding on appropriate treatment can be difficult. In addition, multiple specialties are often involved in the care of PE patients. To better organize the response to serious PE patients, several hospitals and academic centers across the United States, spearheaded by Massachusetts General Hospital, have created pulmonary embolism response teams (PERTs). The goal of a PERT is to have a single multidisciplinary team...
Source: Seminars in Respiratory and Critical Care Medicine - February 16, 2017 Category: Respiratory Medicine Authors: Rodriguez-Lopez, Josanna Channick, Richard Tags: Review Article Source Type: research

Reversal of Direct Oral Anticoagulants: Current Status and Future Directions
Semin Respir Crit Care Med 2017; 38: 040-050 DOI: 10.1055/s-0036-1597831Direct oral anticoagulants (DOACs) are increasingly used for prevention and treatment of venous thromboembolism and for prevention of stroke in patients with nonvalvular atrial fibrillation. In phase III clinical trials that included more than 100,000 patients, the DOACs were at least as effective as vitamin K antagonists (VKAs) and were associated with less serious bleeding, particularly less intracranial bleeding. Real-world evidence supports these outcomes. Despite this, some physicians and patients are concerned about serious bleeding or emergencie...
Source: Seminars in Respiratory and Critical Care Medicine - February 16, 2017 Category: Respiratory Medicine Authors: Weitz, Jeffrey I. Tags: Review Article Source Type: research

The Novel Oral Anticoagulants for Acute Venous Thromboembolism: Is Warfarin Dead?
Semin Respir Crit Care Med 2017; 38: 029-039 DOI: 10.1055/s-0036-1597562The direct oral anticoagulants (DOACs) have been compared with parenteral anticoagulants and vitamin K antagonists (VKAs) for the treatment of venous thromboembolism (VTE) in several robust studies. DOACs have shown similar efficacy in preventing recurrent VTE and significant reductions in critical site (intracranial) bleeding, fatal bleeding, major and nonmajor bleeding. Warfarin and other VKAs are not dead as treatment modalities for VTE. A better way to describe the current situation is to use a boxing expression, “down but not out.” VKAs and pa...
Source: Seminars in Respiratory and Critical Care Medicine - February 16, 2017 Category: Respiratory Medicine Authors: Cohen, Alexander T. Granziera, Serena Veronese, Nicola Zoppellaro, Giacomo Tags: Review Article Source Type: research

Risk Stratification for Proven Acute Pulmonary Embolism: What Information Is Needed?
Semin Respir Crit Care Med 2017; 38: 011-017 DOI: 10.1055/s-0036-1597556Classification of risk drives treatment decisions for patients with acute symptomatic pulmonary embolism (PE). High-risk patients with acute symptomatic PE have hemodynamic instability (i.e., shock or hypotension present), and treatment guidelines suggest systemically administered thrombolytic therapy in this setting. Normotensive PE patients at low risk for early complications (low-risk PE) might benefit from treatment at home or early discharge, while normotensive patients with preserved systemic arterial pressure deemed as having a high risk for PE-...
Source: Seminars in Respiratory and Critical Care Medicine - February 16, 2017 Category: Respiratory Medicine Authors: Barrios, Deisy Yusen, Roger D. Jim énez, David Tags: Review Article Source Type: research

Echocardiography in the Risk Assessment of Acute Pulmonary Embolism
Semin Respir Crit Care Med 2017; 38: 018-028 DOI: 10.1055/s-0036-1597563Acute pulmonary embolism (PE) is a major cause of morbidity and mortality and is classified as massive (high risk), submassive (intermediate risk), or nonmassive (low risk) based on the hemodynamic status and clinical characteristics of the patient. At this time, the management of patients with submassive PE remains controversial and approaches for improving risk assessment are critical. In this review, we discuss several echocardiographic methods to assess right heart function that may aid in the risk assessment of patients with acute PE. They range f...
Source: Seminars in Respiratory and Critical Care Medicine - February 16, 2017 Category: Respiratory Medicine Authors: Dahhan, Talal Alenezi, Fawaz Samad, Zainab Rajagopal, Sudarshan Tags: Review Article Source Type: research

Approach to Suspected Acute Pulmonary Embolism: Should We Use Scoring Systems?
Semin Respir Crit Care Med 2017; 38: 003-010 DOI: 10.1055/s-0036-1597555Modern diagnostic strategies for pulmonary embolism diagnosis almost all rely on an initial assessment of the pretest probability. Clinical prediction rules are decision-making tools using combinations of easily available clinical predictors to define the probability of a disease. The assessment of the clinical probability of pulmonary embolism has an important impact on the diagnostic strategy and on therapeutic management. Clinical prediction rules provide accurate and reproducible estimates of clinical probability. They should be derived and validat...
Source: Seminars in Respiratory and Critical Care Medicine - February 16, 2017 Category: Respiratory Medicine Authors: Righini, Marc Gal, Gr égoire Le Bounameaux, Henri Tags: Review Article Source Type: research

Controversies and Evolving Concepts in Acute Pulmonary Embolism
Semin Respir Crit Care Med 2017; 38: 001-002 DOI: 10.1055/s-0036-1597554 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Respiratory and Critical Care Medicine)
Source: Seminars in Respiratory and Critical Care Medicine - February 16, 2017 Category: Respiratory Medicine Authors: Tapson, Victor F. Jimenez, David Tags: Preface Source Type: research

The Post-mortem Examination in Ruminants and its Possible Benefit to Ruminant Clinical Medicine
This study highlighted the abiding importance of the post-mortem examination in modern ruminant medicine, despite technical advances in clinical technologies, both as a diagnostic tool and for quality control. (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - February 16, 2017 Category: Pathology Source Type: research

Respiratory disease in pregnancy
Breathlessness in pregnancy is a very common symptom. We discuss in this review, the physiological changes to the respiratory system in pregnancy and the commonly seen respiratory ailments like asthma, pneumonia and tuberculosis. Treatments for most conditions are similar to those administered to non-pregnant women. However, conditions may sometimes deteriorate rapidly in pregnancy and hence prompt recognition and treatment is crucial.Investigations should be appropriately used and should not be withheld in pregnancy if indicated. (Source: Obstetrics, Gynaecology and Reproductive Medicine)
Source: Obstetrics, Gynaecology and Reproductive Medicine - February 16, 2017 Category: OBGYN Authors: Himabindu Annamraju, Lucy Mackillop Tags: Review Source Type: research

Laboratory-based surveillance of hospital-acquired respiratory virus infection in a tertiary care hospital
Publication date: Available online 15 February 2017 Source:American Journal of Infection Control Author(s): Hye-Suk Choi, Mi-Na Kim, Heungsup Sung, Jeong-Young Lee, Hee-Youn Park, Sun-Hee Kwak, Young-Ju Lim, Min-Jee Hong, Sun-Kyung Kim, So-Yeon Park, Hyeon-Jeong Kim, Kyu-Ri Kim, Hye-Ran Choi, Jae Sim Jeong, Sang-Ho Choi Of 7,772 laboratory-confirmed cases of respiratory viral infection among hospitalized patients, 22.8% were categorized as having hospital-acquired infection. The overall incidence of hospital-acquired respiratory viral infection was 3.9 (95% confidence interval, 3.7-4.1) cases per 1,000 admitted patients. ...
Source: American Journal of Infection Control - February 16, 2017 Category: Infectious Diseases Source Type: research

Thoracic Complications in Chronic Lymphocytic Leukemia (Thoracic Diseases in CLL)
Chronic Lymphocytic Leukemia (CLL) is the most common adult leukemia. Patients with CLL often present with pulmonary symptoms and diagnoses. We performed a retrospective, single center, chart review evaluating all patients with CLL admitted with a thoracic symptom or diagnosis. Although pneumonia is frequent, there are an increasing number of non-infectious complications, which often require lower respiratory tract sampling. (Source: Clinical Lymphoma, Myeloma and Leukemia)
Source: Clinical Lymphoma, Myeloma and Leukemia - February 16, 2017 Category: Hematology Authors: Sameer Khanijo, Pragati Tandon, Cristina P. Sison, Seth Koenig Tags: Original Study Source Type: research

The effect of preexisting respiratory co-morbidities on burn outcomes
Conclusion Preexisting chronic respiratory disease significantly increases the hazard of progression to mechanical ventilation and mortality in patients following burn. Given the increasing number of Americans with chronic respiratory diseases, there will likely be a greater number of individuals at risk for worse outcomes following burn. (Source: Burns)
Source: Burns - February 16, 2017 Category: Dermatology Source Type: research

Cardiorespiratory fitness and exercise-induced ST segment depression in assessing the risk of sudden cardiac death in men
Conclusions The combination of low CRF and exercise-induced ST segment depression was associated with a markedly increased risk of SCD in men. (Source: Heart)
Source: Heart - February 16, 2017 Category: Cardiology Authors: Hagnäs, M. J., Lakka, T. A., Kurl, S., Rauramaa, R., Mäkikallio, T. H., Savonen, K., Laukkanen, J. A. Tags: Drugs: cardiovascular system Coronary artery disease Source Type: research

Prospective evaluation of respiratory health benefits from reduced exposure to airborne particulate matter
. (Source: International Journal of Environmental Health Research)
Source: International Journal of Environmental Health Research - February 16, 2017 Category: Environmental Health Authors: Yanhui Hao Guanghui Zhang Bin Han Xiaowen Xu Nannan Feng Yong Li Wei Wang Haidong Kan Zhipeng Bai Yiliang Zhu William Au Zhao-lin Xia Source Type: research

Pulmonary hypertension in connective tissue diseases: an update
Abstract Pulmonary hypertension (PH) is a relatively commoner complication of systemic sclerosis (SSc) with estimated prevalence ranging between 8% and 12% as compared to much lower figures in other connective tissue diseases (CTD). It is a major cause of morbidity and mortality in CTDs. PH is classified into five major groups. CTD‐associated PH belongs to group 1 PH, also known as pulmonary arterial hypertension (PAH). Around 30% of scleroderma‐related deaths are due to PAH. Underlying pathogenesis is related to pulmonary vasculopathy involving small vessels. The Evidence‐based Detection of Pulmonary Arterial Hypert...
Source: APLAR Journal of Rheumatology - February 16, 2017 Category: Rheumatology Authors: Ramya Aithala, Anoop G. Alex, Debashish Danda Tags: Review Article Source Type: research

Continuous Positive Airway Pressure Adherence In Patients with Obstructive Sleep Apnea & amp; Symptomatic BPH
Conclusions BPH or diuretic use did not affect adherence with CPAP therapy in obstructive sleep apnea. Severity of nocturia did not have any influence on adherence among the cases. BPH, regardless of the severity of nocturia, and diuretic use does not influence CPAP adherence in patients with OSA. (Source: Lung)
Source: Lung - February 16, 2017 Category: Respiratory Medicine Source Type: research

New biomarkers in community ‐acquired pneumonia: Another step in improving outcome prediction
(Source: Respirology)
Source: Respirology - February 16, 2017 Category: Respiratory Medicine Authors: Paola Faverio, Oriol Sibila Tags: Editorial Source Type: research

Medullary neuropathology in sleep apnoea
(Source: Respirology)
Source: Respirology - February 16, 2017 Category: Respiratory Medicine Authors: J.Howard Jaster Tags: Correspondence Source Type: research

The uncertain science of predicting tuberculosis
Publication date: Available online 16 February 2017 Source:The Lancet Respiratory Medicine Author(s): Toyin Togun, Madhukar Pai (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - February 16, 2017 Category: Respiratory Medicine Source Type: research

Serial QuantiFERON testing and tuberculosis disease risk among young children: an observational cohort study
Publication date: Available online 16 February 2017 Source:The Lancet Respiratory Medicine Author(s): Jason R Andrews, Elisa Nemes, Michele Tameris, Bernard S Landry, Hassan Mahomed, J Bruce McClain, Helen A Fletcher, Willem A Hanekom, Robin Wood, Helen McShane, Thomas J Scriba, Mark Hatherill Background The value of quantitative interferon-γ release assay results for predicting progression from Mycobacterium tuberculosis infection to active disease is unknown. We aimed to investigate the relation between QuantiFERON-TB Gold In-Tube (QFT) conversion interferon-γ values and risk of subsequent active tuberculosis disease ...
Source: The Lancet Respiratory Medicine - February 16, 2017 Category: Respiratory Medicine Source Type: research

Libby: the long legacy of a public health disaster
Publication date: Available online 16 February 2017 Source:The Lancet Respiratory Medicine Author(s): Aaron van Dorn (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - February 16, 2017 Category: Respiratory Medicine Source Type: research

The effect of sitting and calf activity on leg fluid and snoring
Publication date: Available online 16 February 2017 Source:Respiratory Physiology & Neurobiology Author(s): Bhajan Singh, Azadeh Yadollahi, Owen Lyons, Hisham Alshaer, TDouglas Bradley Prolonged sitting may promote leg fluid retention that redistributes to the neck during sleep and contributes to snoring. This could be attenuated by calf activity while sitting. In 16 healthy non-obese subjects we measured leg fluid volume (LFV) below the knees using bioelectrical impedance while sitting for 4hours, snoring using a portable BresoDx™ device, and Mallampati grade. Using a double cross-over study design, subjects we...
Source: Respiratory Physiology and Neurobiology - February 16, 2017 Category: Respiratory Medicine Source Type: research

The measurement of DLNO and DLCO: A manufacturer's perspective
Publication date: Available online 16 February 2017 Source:Respiratory Physiology & Neurobiology Author(s): X. Giraud, N.N. Le-Dong, K. Hogben, J.B. Martinot The simultaneous measurement of the lung transfer factor for carbon monoxide (DLCO) and nitric oxide (DLNO) is now available as a powerful method for studying the alveolar-capillary gas exchange. However, application of the DLNO-CO technique in daily settings is still limited by some technical drawbacks. This paper provides a manufacturer’s overview of the measuring principles, technical challenges and current available solutions for implementing the DLNO-C...
Source: Respiratory Physiology and Neurobiology - February 16, 2017 Category: Respiratory Medicine Source Type: research

Determinants of cough effectiveness in patients with respiratory muscle weakness
In conclusion, transient glottic closure is necessary to render cough effective in patients with respiratory-muscle weakness, indicating that failure to close the glottis contributes to ineffective cough in weak tracheostomized patients and patients with bulbar disorders. (Source: Respiratory Physiology and Neurobiology)
Source: Respiratory Physiology and Neurobiology - February 16, 2017 Category: Respiratory Medicine Source Type: research

Respiratory load perception in overweight and asthmatic children
Publication date: Available online 16 February 2017 Source:Respiratory Physiology & Neurobiology Author(s): Victoria MacBean, Lorna Wheatley, Alan C. Lunt, Gerrard F. Rafferty Overweight asthmatic children report greater symptoms than normal weight asthmatics, despite comparable airflow obstruction. This has been widely assumed to be due to heightened perception of respiratory effort. Three groups of children (healthy weight controls, healthy weight asthmatics, overweight asthmatics) rated perceived respiratory effort throughout an inspiratory resistive loading protocol. Parasternal intercostal electromyogram was ...
Source: Respiratory Physiology and Neurobiology - February 16, 2017 Category: Respiratory Medicine Source Type: research

A low cost, simplified, and scaleable pneumotachograph and face mask for neonatal mouse respiratory measurements
Discussion The described methods offer a relatively simple and inexpensive approach to constructing a pneumotachograph for non-invasive measurements of neonatal mouse respiration, enhancing accessibility and enabling the high-throughput and parallel characterizations of neonatal respiratory disorders and potential pharmacological therapies. (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - February 16, 2017 Category: Drugs & Pharmacology Source Type: research

Medical research and the ethics of medical treatments: disability-free survival
<span class="paragraphSection">Interest in relevant patient-centred outcomes, instead of surrogate outcomes, continues to increase, and for good reason. An example in the setting of anaesthesia and intensive care is that therapeutic measures that improve oxygenation in the setting of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) (“blood gas cosmetics”), do not translate into improved survival as might be expected. Other measures (e.g. ICU mortality or even 30-day post-ICU discharge survival) do not really reflect what many medical staff and laypeople believe represents valid outcome parameter...
Source: British Journal of Anaesthesia - February 16, 2017 Category: Anesthesiology Source Type: research

Antagonism of moderate neuromuscular block with sugammadex versus neostigmine
<span class="paragraphSection">Editor—Boon and colleagues<a href="#aex014-B1" class="reflinks"><sup>1</sup></a> conclude in their study that “the selection of antagonistic agent has a significant effect on postoperative respiratory conditions”. We suggest, however, that what they have demonstrated is that neuromuscular monitoring is essential in clinical practice and that patients should not be extubated before adequate recovery of neuromuscular function. Residual neuromuscular block has been demonstrated to interfere with pulmonary dynamics and to impair the ventilatory response to hypo...
Source: British Journal of Anaesthesia - February 16, 2017 Category: Anesthesiology Source Type: research

Acute postoperative hypoxemic respiratory failure as a result of Chilaiditi’s syndrome: contribution of high flow oxygen through nasal cannula
<span class="paragraphSection">Editor—A 56 yr old man was admitted in our intensive care unit for acute hypoxaemic respiratory failure after orthopaedic surgery for an infected hygroma of the right knee.</span> (Source: British Journal of Anaesthesia)
Source: British Journal of Anaesthesia - February 16, 2017 Category: Anesthesiology Source Type: research

SponTaneous Respiration using IntraVEnous anaesthesia and Hi-flow nasal oxygen (STRIVE Hi) maintains oxygenation and airway patency during management of the obstructed airway: an observational study
Conclusions.</strong> STRIVE Hi succeeded in preserving adequate oxygen saturation, end-tidal carbon dioxide and airway patency. We suggest that the upper and lower airway benefits attributed to HFNO, are ideally suited to a spontaneous respiration induction, increasing its margin of safety. STRIVE Hi is a modern alternative to the traditional inhalation induction.</span> (Source: British Journal of Anaesthesia)
Source: British Journal of Anaesthesia - February 16, 2017 Category: Anesthesiology Source Type: research

Influence of head and neck position on ventilation using the air-Q ® SP airway in anaesthetized paralysed patients: a prospective randomized crossover study
Conclusions.</strong> Ventilation was not adversely affected in the rotated or flexed head and neck positions, whereas head and neck extension negatively influenced ventilation. Clinically, it is better to avoid head and neck extension during ventilation with an air-Q<sup>®</sup> SP airway.<strong>Clinical trial registration.</strong> NCT02402387.</span> (Source: British Journal of Anaesthesia)
Source: British Journal of Anaesthesia - February 16, 2017 Category: Anesthesiology Source Type: research

Non-Invasive Respiratory Impedance Enhances Cerebral Perfusion in Healthy Adults
Christopher G. Favilla, Ashwin B. Parthasarathy, John A. Detre, Arjun G. Yodh, Michael T. Mullen, Scott E. Kasner, Kimberly Gannon, Steven R. Mess é (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 16, 2017 Category: Neurology Source Type: research

Histopathological background data of the systemic organs of CLAWN miniature swine with coronary artery stent implantation.
In conclusion, this study identified CLAWN miniature swine as a suitable animal model for various experiments. PMID: 28190922 [PubMed - in process] (Source: Journal of Toxicologic Pathology)
Source: Journal of Toxicologic Pathology - February 15, 2017 Category: Toxicology Tags: J Toxicol Pathol Source Type: research

Cathodal trans-spinal direct current stimulation (tsDCS) is harmful in ALS patients: direct evidence from intradiaphragmatic recordings
Introduction: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder typically leading to death because of respiratory failure. In healthy subjects, a single session of cathodal tsDCS applied over C3-C5 spinal segments induces persistent potentiation in the respiratory control system1. Here, we evaluated whether cathodal tsDCS could also modulate intradiaphragmatic EMG in ALS patients implanted with diaphragm pacing. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: M.-C. Nierat, I. Rivals, J. Gonzalez-Bermejo, C. Morelot-Panzini, T. Similowski, J.-C. Lamy Source Type: research

Clinical Course of Enterovirus D68 in Hospitalized Children
Background: Enterovirus D68 (EV-D68) has been sporadically reported as a cause of respiratory tract infections. In 2014, an international outbreak of EV-D68 occurred and caused severe respiratory disease in the pediatric population. Methods: A retrospective chart review was performed of children admitted to Children’s Mercy Hospital from August 1, 2014, to September 15, 2014, with positive multiplex polymerase chain reaction testing for EV/rhinovirus (RV). Specimens were subsequently tested for EV-D68, and clinical data were obtained from the medical records. Patients with EV-D68 were compared with children presenting s...
Source: The Pediatric Infectious Disease Journal - February 15, 2017 Category: Infectious Diseases Tags: Original Studies Source Type: research

Intensive Care Admissions for Children With Enterovirus and Human Parechovirus Infections in the United Kingdom and The Republic of Ireland, 2010–2014
Enteroviruses and human parechoviruses usually cause mild, self-limiting illnesses in children but can occasionally cause severe disease. During 2010–2014, 104 children in the United Kingdom and the Republic of Ireland were admitted to a pediatric intensive care unit with severe enterovirus and human parechovirus infection; 40% had neurologic symptoms, 20% respiratory failure, 16% cardiac complications and 11% septic shock. Annual number of cases and incidence increased in the 5-year period, from 0.6/1000 pediatric intensive care unit admissions (12 cases) in 2010 to 1.8/1000 (36 cases) in 2014. Most cases (n = 86, 83%) ...
Source: The Pediatric Infectious Disease Journal - February 15, 2017 Category: Infectious Diseases Tags: Brief Reports Source Type: research

Statistical Power to Detect an Association Between Guideline-based Palivizumab Administration and Hospitalizations for Respiratory Syncytial Virus Infections
No abstract available (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - February 15, 2017 Category: Infectious Diseases Tags: Letters to the Editors Source Type: research

In Reply: Statistical Power to Detect an Association Between Guideline-based Palivizumab Administration and Hospitalizations for Respiratory Syncytial Virus Infections
No abstract available (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - February 15, 2017 Category: Infectious Diseases Tags: Letters to the Editors Source Type: research

Adenovirus type 4 respiratory infections with a concurrent outbreak of coxsackievirus A21 among United States army basic trainees, a retrospective viral etiology study using next ‐generation sequencing
ConclusionsHAdV4 is the predominant respiratory pathogen in unvaccinated military trainee. HAdV4 has temporal and demographic variability. CAV21 is a significant respiratory pathogen and needs to be evaluated for its current significance in military basic trainees. This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - February 15, 2017 Category: Virology Authors: Jun Hang, Todd J. Vento, Erica A. Norby, Richard G. Jarman, Paul B. Keiser, Robert A. Kuschner, Leonard N. Binn Tags: Research Article Source Type: research

Laser tracheobronchoplasty: a novel technique for the treatment of symptomatic tracheobronchomalacia
This study aims to evaluate the outcomes of a novel surgical treatment for membranous tracheobronchomalacia. A consecutive series of patients with tracheobronchomalacia were treated with two to three holmium laser scarring surgeries of the hyperdynamic tracheal and bronchial walls for the purpose of stiffening them through fibrosis. Patients filled out a Dyspnea Index questionnaire before and after treatment. Ten patients were treated for their tracheobronchomalacia with a mean age of 54  years. Symptoms included severe dyspnea, dry cough, recurrent pulmonary infections, and respiratory failure. Fifty percent of patients ...
Source: European Archives of Oto-Rhino-Laryngology - February 15, 2017 Category: ENT & OMF Source Type: research

Effect of Mahuang Gancao Ganjiang Decoction on Fusion and Fission of Mitochondria and Apoptosis of Lymphocytes in Mice under Cold Stress.
This study was designed to investigate the effect of MGGD on the apoptosis of lymphocytes induced by cold stress in mice. The model mice were randomly divided into four groups: the normal control group (no handling mice), cold stress group, MGGD + cold stress group, and MGGD group. Lymphocytes of the mice were isolated from the peripheral blood. Electron microscopy analysis revealed cold stress resulted in mitochondrial fragmentation. Accompanied with the change of morphology of mitochondria, ATP production and the activity of respiratory chain complex decreased in these cells. Western blot analysis showed that these cells...
Source: Evidence-based Complementary and Alternative Medicine - February 15, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Expression of NKp46 Splice Variants in Nasal Lavage Following Respiratory Viral Infection: Domain 1-Negative Isoforms Predominate and Manifest Higher Activity
Yonat Shemer-Avni, Kiran Kundu, Avishai Shemesh, Michael Brusilovsky, Rami Yossef, Mesfin Meshesha, Semaria Solomon-Alemayehu, Shai Levin, Orly Gershoni-Yahalom, Kerry S. Campbell, Angel Porgador (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - February 15, 2017 Category: Allergy & Immunology Source Type: research

GSE92754 TP53 modulates oxidative stress in Gata1+ erythroid cells
In this report, we have found that gata1 expressing erythroid cells contribute to a significant proportion of total body oxidative stress when animals were exposed to a strong pro-oxidant. RNA-seq of zebrafish under oxidative stress revealed the induction of tp53. Zebrafish carrying tp53 with mutation in its DNA binding domain were acutely sensitive to pro-oxidant exposure and displayed significant reactive oxygen species (ROS) and tp53-independent erythroid cell death resulting in an edematous phenotype. We found that a major contributing factor to ROS was increased basal mitochondrial respiratory rate without reserve. Th...
Source: GEO: Gene Expression Omnibus - February 15, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Danio rerio Source Type: research

Validation of Polyvinylidene Fluoride Impedance Sensor for Respiratory Event Classification during Polysomnography in Children
Conclusions:Based on these findings, PVDF belts appear to be as effective as RIP belts in detection of respiratory effort and events in children.Commentary:A commentary on this article appears in this issue on page 159.Citation:Griffiths AG, Patwari PP, Loghmanee DA, Balog MJ, Trosman I, Sheldon SH. Validation of polyvinylidene fluoride impedance sensor for respiratory event classification during polysomnography in children.J Clin Sleep Med. 2017;13(2):259–265. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - February 15, 2017 Category: Sleep Medicine Source Type: research

Dynamic Volume Computed Tomography Imaging of the Upper Airway in Obstructive Sleep Apnea
Conclusions:A dynamic 3D CT technique of the upper airway is described that can be performed with a clinically reasonable radiation dose and sets a benchmark for future use.Citation:Fleck RJ, Ishman SL, Shott SR, Gutmark EJ, McConnell KB, Mahmoud M, Mylavarapu G, Subramaniam DR, Szczesniak R, Amin RS. Dynamic volume computed tomography imaging of the upper airway in obstructive sleep apnea.J Clin Sleep Med. 2017;13(2):189–196. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - February 15, 2017 Category: Sleep Medicine Source Type: research

Factors Associated with Changes in Invasive and Noninvasive Positive Airway Pressure Therapy Settings during Pediatric Polysomnograms
Conclusions:Children were more likely to have a change in their technology settings during a PSG if there was a shorter period of time from the original technology initiation, if they were using BPAP (as compared to CPAP or IPPV) and/or if they had a primary central nervous system or musculoskeletal diagnosis.Citation:Al-Saleh S, Sayal P, Stephens D, Florence J, Sayal A, Baker A, Syed F, Narang I, Amin R. Factors associated with changes in invasive and noninvasive positive airway pressure therapy settings during pediatric polysomnograms.J Clin Sleep Med. 2017;13(2):183–188. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - February 15, 2017 Category: Sleep Medicine Source Type: research

A Potential Alternative to Respiratory Inductance Plethysmography for Children?
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - February 15, 2017 Category: Sleep Medicine Source Type: research