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Dexmedetomidine Oral Mucosa Patch for Sedation Suppresses Apoptosis in Hippocampus of Normal Rats.
CONCLUSIONS: A dexmedetomidine oral mucosa patch can be used as a convenient tool for sedation, and is of therapeutic value due to its antiapoptotic effects under normal conditions. PMID: 28446017 [PubMed - in process] (Source: International Neurourology Journal)
Source: International Neurourology Journal - April 29, 2017 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Motor neurone disease: progress and challenges.
Authors: Dharmadasa T, Henderson RD, Talman PS, Macdonell RA, Mathers S, Schultz DW, Needham M, Zoing M, Vucic S, Kiernan MC Abstract Major progress has been made over the past decade in the understanding of motor neurone disease (MND), changing the landscape of this complex disease. Through identifying positive prognostic factors, new evidence-based standards of care have been established that improve patient survival, reduce burden of disease for patients and their carers, and enhance quality of life. These factors include early management of respiratory dysfunction with non-invasive ventilation, maintenance of w...
Source: Medical Journal of Australia - April 29, 2017 Category: Journals (General) Tags: Med J Aust Source Type: research

Granulicatella adiacens Vertebral Osteomyelitis: A Case Report and Review of the Literature
We report the case of a patient who developed Granulicatella adiacens vertebral osteomyelitis. It is the eighth reported case of NVS vertebral osteomyelitis in the literature and represents the first case of Granulicatella vertebral osteomyelitis in a patient without concomitant bacteremia. We review the literature about reported cases of NVS vertebral osteomyelitis. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - April 29, 2017 Category: Infectious Diseases Tags: Review Articles Source Type: research

Genetic polymorphisms of Bcl-2 promoter in cancer susceptibility and prognosis: a meta-analysis.
Authors: Yao Z, Yang B, Liu Z, Li W, He Q, Peng X Abstract Bcl-2 is critical for tumorigenesis. However, previous studies on the association of Bcl-2 promoter polymorphisms with predisposition to different cancer types are somewhat contradictory. Therefore, we performed this meta-analysis regarding the relationship between Bcl-2 promoter single nucleotide polymorphisms (SNPs) and cancer susceptibility and prognosis. Up to August 2016, 32 original publications were identified covering two Bcl-2 promoter SNPs (rs2279115 and rs1801018). Our results showed statistically significant association between rs2279115 and can...
Source: Oncotarget - April 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Advanced glycation end products ‑induced mitochondrial energy metabolism dysfunction alters proliferation of human umbilical vein endothelial cells.
In conclusion, the results of the present study indicated that AGEs exhibited an inhibitory effect on the proliferation in HUVECs potentially by mediating the dysfunction of mitochondrial energy metabolism and glycolysis. This may provide a new consideration for therapeutic methods in diabetic vascular complications. PMID: 28447727 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - April 29, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Respiratory Sinus Arrhythmia and Ventromedial Prefrontal Function in Veterans with Posttraumatic Stress Symptoms
Adaptive emotional responding requires flexible regulatory control of autonomic response systems, thought to involve the ventromedial prefrontal cortex (vmPFC). Individuals with posttraumatic stress disorder (PTSD) show compromised vmPFC function and parasympathetic tone —as reflected by reduced respiratory sinus arrhythmia (RSA)—yet previous studies have not drawn a direct link between these deficits. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2017 Category: Psychiatry Authors: Daniel Grupe, Joseph Wielgosz, Jack Nitschke, Richard Davidson Source Type: research

Novel Complementary and Alternative Mindfulness Based Intervention: Therapeutic Approach to Manage Substance Use Disorders and Posttraumatic Stress Disorder
Relapse is a core feature of substance use disorders (SUD). Intentional slower breathing or "intentional respiratory rate variability" (IRRV) by the aid of Rhemercise (a new exercise manual) may be an effective therapeutic approach for well-being. IRRV can increase Heart Rate Variability (HRV) and that HRV is the biomarker of overall well-being. We hypothesize that increased HRV could decrease craving creating relapse prevention strategy. We hypothesize that IRRV increases HRV. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2017 Category: Psychiatry Authors: Sajoy Varghese, Sheena Varghese, Anish Chackochan, Maju Koola, Sandeep Saini, Alex Zachariah Source Type: research

Management of Pyogenic Liver Abscess in Neonates
To the Editor:A 35-day-old Saudi boy developed respiratory distress from bilateral pneumonitis due to meconium aspiration. He required ventilation for 8 days, and an umbilical vein catheterization for 2 days. He had thrombocytopenia of 16× 103/cmm. Leukocytosis of 32× 103/cmm and Hgb of 15.3× g/L. Two days later he developed fresh signs of sepsis with hepatosplenomegaly, abdominal distension, and generalized erythematous rash. At this stage he had Hgb 15.3 g/L, WBC 45× 103/cmm and platelet count of 32× 103; liver enzymes were within normal limits, and PT and PTT were prolonged> 100 sec. Cul...
Source: Annals of Saudi Medicine - April 29, 2017 Category: Journals (General) Tags: ISSUE 4 Source Type: research

Blunt chest trauma: is there a place for rib stabilization?
Authors: Mitchell JD Abstract Rib fractures are a common and highly morbid finding in patients with blunt chest trauma. Over the past decade, a renewed interest in (and instrumentation for) rib fixation in this cohort has occurred. Stabilization of the chest wall in this setting, particularly when a flail segment is present, is associated with significant reductions in the rates of respiratory failure, pneumonia, ICU stay, and mortality. Thoracic surgeons should remain actively involved in this evolving area of our specialty to further optimize patient outcomes. PMID: 28446987 [PubMed - in process] (Source: Jou...
Source: Journal of Thoracic Disease - April 28, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Thoracic surgery training in Europe-the perspective of a trainee.
Authors: Frick AE, Massard G Abstract Duration and content of Thoracic surgery training differs considerably across Europe, leading to unequal levels of knowledge, skills and attitudes at the time of graduation as a specialist. The European Board of Thoracic Surgery examination strives to overcome these regional differences by offering a diploma to achieve harmonization and equal qualified certification. The HERMES initiative, driven by a joint task force from European Society of Thoracic Surgeons (ESTS) and European Respiratory Society (ERS) is currently establishing a consensual syllabus and curriculum for Thorac...
Source: Journal of Thoracic Disease - April 28, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Sa1040 A Comparison of Adequacy of Ventilation With a Non-Invasive Ventilator System vs. Standard O2 With a Nasal Cannula for Colonoscopy With Moderate Sedation Using Propofol and Fentanyl
The American Society of Anesthesiology found drug-induced respiratory depression and airway obstruction to be the primary cause of morbidity associated with moderate and deep sedation[KB1] [MF2]. We have developed a prototype non-invasive ventilator (NIV) system. It provides CPAP (continuous positive airway pressure) with accurate monitoring of ventilation, regardless of whether there is a poor mask fit or excessive leak. Because the system monitors respiratory rate and tidal volume during CPAP, the clinician is aware of slowed respiratory rate and/or of upper airway obstruction caused by sedative medication. (Source: Gast...
Source: Gastrointestinal Endoscopy - April 28, 2017 Category: Gastroenterology Authors: Mike Fogarty, Kai Kuck, Joseph A. Orr, Derek Sakata, Lara Brewer, Ken B. Johnson, John C. Fang Tags: Saturday – ASGE poster Source Type: research

868 Endoscopic Management of a Large Esophageal Duplication Cyst Causing Respiratory Compromise
A 69 year old woman was admitted with pneumonia with ventilator dependent respiratory failure. The patient ’s medical history included bipolar disorder, chronic kidney disease, and a thyroidectomy for thyroid malakoplakia (a rare granulomatous disease). On 2 separate occasions, after extubation, she required re-intubation for respiratory failure and eventually underwent tracheostomy tube placement. A n on-contrast chest CT was obtained, revealing a 10 cm by 4 cm mediastinal mass, appearing to arise from the esophagus. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - April 28, 2017 Category: Gastroenterology Authors: Paul Korc, Nikolai A. Bildzukewicz, John C. Lipham, Phuong T. Nguyen Tags: Oral abstract Source Type: research

Sa1383 Outcomes of Endoscopic Retrograde Cholangiopancreatography (ERCP) Performed Under General Anesthesia Compared to Moderate Anesthesia Care
Endoscopic retrograde cholangiopancreatography (ERCP) is a complex procedure requiring deep sedation. ERCP can be performed under general anesthesia (GA) or Monitored Anesthesia Care (MAC). GA is associated with prolonged recovery time and subsequent decreased efficiency in endoscopy units. Barriers to MAC are a theoretical increased risk of respiratory complications and premature procedure termination due to inadequate sedation. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - April 28, 2017 Category: Gastroenterology Authors: Clara Antoury, Shyam Thakkar, Manish Dhawan, Katie Farah, Abhijit Kulkarni Tags: Saturday – ASGE poster Source Type: research

Tu1215 Predictive Factors Affecting the Technical Difficulty in Endoscopic Submucosal Dissection of Superficial Esophageal Cancer
Endoscopic submucosal dissection (ESD) is widely accepted as a standard treatment for superficial esophageal cancer (SEC) in Japan and Asian countries. ESD for SEC is sometimes technically difficult because esophageal lumen is narrow and its wall is thin, and it is significantly affected by respiratory fluctuation and cardiac pulsation. The aim of this study was to assess the predictive factors affecting the technical difficulty in ESD of SEC. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - April 28, 2017 Category: Gastroenterology Authors: Hiromasa Hazama, Masaki Tanaka, Kohei Takizawa, Naomi Kakushima, Noboru Kawata, Sayo Ito, Kenichiro Imai, Kinichi Hotta, Hirotoshi Ishiwatari, Hiroyuki Matsubayashi, Hiroyuki Ono Tags: Tuesday – ASGE poster Source Type: research

Inhaled Glucocorticoids and Pneumonia in Preterm Infants: Post Hoc Results from the NEuroSIS Trial
Conclusion: The current analysis does not support the assumption that respiratory tract infections explain the increased mortality seen in the glucocorticoid group in the NEuroSIS trial.Neonatology 2017;112:110-113 (Source: Neonatology)
Source: Neonatology - April 28, 2017 Category: Perinatology & Neonatology Source Type: research

Prevalence of Major Comorbidities in Chronic Obstructive Pulmonary Disease Caused by Biomass Smoke or Tobacco
Conclusions: The prevalence of ischemic heart disease is significantly lower in B-COPD than in T-COPD, suggesting a different systemic effect of both types of smoke in COPD patients.Respiration (Source: Respiration)
Source: Respiration - April 28, 2017 Category: Respiratory Medicine Source Type: research

Meditation in Stressed Older Adults: Improvements in Self-Rated Mental Health Not Paralleled by Improvements in Cognitive Function or Physiological Measures
AbstractTo determine if mindfulness meditation (MM) in older adults improves cognition and, secondarily, if MM improves mental health and physiology, 134 at least mildly stressed 50 –85-year olds were randomized to a 6-week MM intervention or a waitlist control. Outcome measures were assessed at baseline and 2 months later at visit 2. The primary outcome measure was an executive function/attentional measure (flanker task). Other outcome measures included additional cognitive assessments, salivary cortisol, respiratory rate, heart rate variability, Positive and Negative Affect Schedule (PANAS), Center for Epidemiologic S...
Source: Mindfulness - April 28, 2017 Category: Psychiatry & Psychology Source Type: research

Efficacy of Extracorporeal Photopheresis in Patients With Bronchiolitis Obliterans Syndrome After Lung Transplantation
Lung transplantation (LT) is only therapeutic option for patients affected by chronic respiratory failure. Chronic rejection, also known as bronchiolitis obliterans syndrome (BOS), is still the main cause of death and the most important factor that influences post-transplantation quality of life. Currently available therapies have not been proven to result in significant benefit in the prevention or treatment of BOS. Extracorporeal photopheresis (ECP) seems to reduce the rate of lung function decline in transplant recipients with progressive BOS. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - April 28, 2017 Category: Transplant Surgery Authors: Y. Pecoraro, C. Carillo, D. Diso, S. Mantovani, G. Cimino, T. De Giacomo, P. Troiani, M. Shafii, L. Gherzi, D. Amore, E.A. Rendina, F. Venuta, M. Anile Tags: 40th Congress of the Italian Transplantation Society Source Type: research

Selection of Candidates for Lung Transplantation: The First Italian Consensus Statement
Lung transplantation is a well-established treatment for selected patients with advanced chronic respiratory insufficiency. Recognizing those patients with end-stage lung disease who might benefit from lung transplantation is a crucial task. Considering the presence of inadequate evidence-based practice, international and national scientific societies provided  consensus opinions regarding the appropriate timing of listing. The Study Group for Thoracic Organs Transplantation (branch of the Italian Society for Organs Transplantation) promoted and realized a Delphi conference among the Italian lung transplantation centers ...
Source: Transplantation Proceedings - April 28, 2017 Category: Transplant Surgery Authors: M. Nosotti, A. Dell'Amore, D. Diso, T. Oggionni, S. Aliberti, Study Group for Thoracic Organs Transplantation Tags: 40th Congress of the Italian Transplantation Society Source Type: research

Later Evaluation of Ischemia and Reperfusion by the Pringle Maneuver in Wistar Rats, Demonstrating That Hepatic Lesions Can Be Reversible
There has been much research on hepatic ischemia and reperfusion by means of short or longer interruption of the portal triad. The aim of this work was to evaluate the mitochondrial respiratory activity and liver histology at 2 different times after the Pringle maneuver. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - April 28, 2017 Category: Transplant Surgery Authors: G. de Lourdes Jorge, R. dos Reis T ártaro, C.A. Fazzio Escanhoela, I.F.S.F. Boin Tags: 15th Portuguese-Brazilian Congress, 13th Portuguese Transplant Congress, and 2nd Iberic Transplant Meeting Source Type: research

[Evaluation and treatment of sleep problems in children diagnosed with attention deficit hyperactivity disorder: an update of the evidence].
CONCLUSIONS: It is important to evaluate sleep in children who present symptoms suggestive of ADHD, since problems during sleep can play a causal role or exacerbate the clinical features of ADHD. Correct evaluation and treatment of sleep disorders increase the family's and the child's quality of life and can lessen the severity of the symptoms of ADHD. PMID: 28444684 [PubMed - in process] (Source: Revista de Neurologia)
Source: Revista de Neurologia - April 28, 2017 Category: Neurology Authors: Chamorro M, Lara JP, Insa I, Espadas M, Alda-Diez JA Tags: Rev Neurol Source Type: research

Monitoring Hospitalized Adult Patients for Opioid-Induced Sedation and Respiratory Depression: Erratum
No abstract available (Source: AJN)
Source: AJN - April 28, 2017 Category: Nursing Tags: Erratum Source Type: research

Genetics and biological property analysis of Korea lineage of influenza A H9N2 viruses
The objective of this study was to characterize the genetic and biological properties of 22 Korean H9N2 viruses and assess their potential risks to mammals. Their complete genomes were analyzed. Some Korean H9N2 viruses were found to carry mammalian host-specific mutations. Based on genomic diversities, these H9N2 viruses were divided into 12 genotypes. All 22 showed preferential binding to human-like receptor. Two of eight H9N2 viruses were highly lethal to mice, causing 90–100% mortality without prior adaptation and severe respiratory syndromes associated with diffuse lung injury, severe pneumonia, and alveolar damage....
Source: Veterinary Microbiology - April 28, 2017 Category: Veterinary Research Source Type: research

Modeling Monogenic Human Nephrotic Syndrome in the Drosophila Garland Cell Nephrocyte
In conclusion, Drosophila garland cell nephrocytes provide a model with which to study the pathogenesis of nephrotic syndrome, and ROS formation may be a pathomechanism of COQ2-nephropathy. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - April 28, 2017 Category: Urology & Nephrology Authors: Hermle, T., Braun, D. A., Helmstädter, M., Huber, T. B., Hildebrandt, F. Tags: Basic Research Source Type: research

The great simulator: A historical presentation involving miliary tuberculosis and Pott ’s disease in an immunocompetent young female patient aged 25
We report the case of an immunocompetent woman aged 25, suffering from inflammatory back pain associated with fever and weight loss in postpartum. Chest CT-scan showed a miliary and spine CT-scan revealed the presence of staged spondylodiscitis with epiduritis. The diagnosis of tuberculosis was made by the detection of bacillus in the pus of paravertebral abscess. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - April 28, 2017 Category: Respiratory Medicine Source Type: research

An uncommon cause of miliary pattern of pulmonary nodules —diffuse pulmonary meningotheliomatosis
We present the case of a 74‐year‐old asymptomatic female referred to the pulmonary clinic for evaluation of incidentally detected diffuse bilateral pulmonary nodules. A transbronchial biopsy established a diagnosis of diffuse pulmonary meningotheliomatosis, obviating the need for further invasive workup. She remains stable after more than 2 years of follow‐up. We present the case of a 74‐year‐old asymptomatic female referred to the pulmonary clinic for evaluation of incidentally detected diffuse bilateral pulmonary nodules. A transbronchial biopsy established a diagnosis of diffuse pulmonary meningotheliomatosis...
Source: Respirology Case Reports - April 28, 2017 Category: Respiratory Medicine Authors: Vivek Jayaschandran, Sandra Gjorgova ‐Gjeorgjievski, Haamid Siddique Tags: Case Report Source Type: research

Standardized Treatment of Pulmonary Exacerbations (STOP) study: Observations at the initiation of intravenous antibiotics for cystic fibrosis pulmonary exacerbations
The objective of this analysis was to describe the clinical presentations of patients admitted for intravenous (IV) antibiotics and enrolled in a prospective observational PEx study as well as to understand physician treatment goals at the start of the intervention. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - April 28, 2017 Category: Respiratory Medicine Authors: Don B. Sanders, George M. Solomon, Valeria V. Beckett, Natalie E. West, Cori L. Daines, Sonya L. Heltshe, Donald R. VanDevanter, Jonathan E. Spahr, Ronald L. Gibson, Jerry A. Nick, Bruce C. Marshall, Patrick A. Flume, Christopher H. Goss, on behalf of the Tags: Original Article Source Type: research

Clinical Features of Patients with Diffuse Alveolar Hemorrhage due to Negative-Pressure Pulmonary Edema
ConclusionNPPE-related DAH is a rare life-threatening condition occurring primarily after tonic –clonic generalized seizure or generalized anesthesia. Clinical circumstances are a key to its diagnosis. Early diagnosis and recognition likely allow for successful management of this potentially serious complication, whereas ictal-DAH appears ominous in epileptic patients. (Source: Lung)
Source: Lung - April 28, 2017 Category: Respiratory Medicine Source Type: research

Extended-release guaifenesin/pseudoephedrine hydrochloride for symptom relief in support of a ‘wait and see’ approach for the treatment of acute upper respiratory tract infections: A randomized, double-blind, placebo-controlled study
This study was not designed to assess the effects of guaifenesin or pseudoephedrine individually. Other limitations include the need for better clinical methods to assess the effectiveness of treatments for acute symptoms of patients with URTIs. Trial registration: ClinicalTrials.gov NCT01202279. Registered 13 September 2010. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 28, 2017 Category: Drugs & Pharmacology Source Type: research

Cost of porcine reproductive and respiratory syndrome virus at individual farm level – an economic disease model
Publication date: Available online 27 April 2017 Source:Preventive Veterinary Medicine Author(s): H. Nathues, P. Alarcon, J. Rushton, R. Jolie, K. Fiebig, M. Jimenez, V. Geurts, C. Nathues Porcine reproductive and respiratory syndrome (PRRS) is reported to be among the diseases with the highest economic impact in modern pig production worldwide. Yet, the economic impact of the disease at farm level is not well understood as, especially in endemically infected pig herds, losses are often not obvious. It is therefore difficult for farmers and veterinarians to appraise whether control measures such as virus elimination or va...
Source: Preventive Veterinary Medicine - April 28, 2017 Category: Veterinary Research Source Type: research

The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure [Bioenergetics]
The protein optic atrophy 1 (OPA1) is a dynamin-related protein associated with the inner mitochondrial membrane and functions in mitochondrial inner membrane fusion and cristae maintenance. Inner membrane-anchored long OPA1 (L-OPA1) undergoes proteolytic cleavage resulting in short OPA1 (S-OPA1). It is often thought that S-OPA1 is a functionally insignificant proteolytic product of L-OPA1 because the accumulation of S-OPA1 due to L-OPA1 cleavage is observed in mitochondrial fragmentation and dysfunction. However, cells contain a mixture of both L- and S-OPA1 in normal conditions, suggesting the functional significance of ...
Source: Journal of Biological Chemistry - April 28, 2017 Category: Chemistry Authors: Hakjoo Lee, Sylvia B. Smith, Yisang Yoon Tags: Cell Biology Source Type: research

Outpatient drainage for patients with spontaneous pneumothorax over 50 years of age
Conclusions: Outpatient drainage therapy is useful for patients with spontaneous pneumothorax over 50 years of age, because outpatient drainage therapy alone was successful in 4 of 11 patients and admission for drainage was avoided in 9 of 11 patients. However, prolonged air leakage occurs more frequently in this age group. (Source: Lung India)
Source: Lung India - April 28, 2017 Category: Respiratory Medicine Authors: Atsushi Sano Takuma Yotsumoto Takehiro Tsuchiya Source Type: research

A prospective study of ventilator-associated tracheobronchitis: Incidence and etiology in intensive care unit of a tertiary care hospital
Conclusions: VAT is a common healthcare-associated infection caused mostly by MDR Gram-negative bacteria. Monitoring and active surveillance are required to detect VAT at the earliest to institute appropriate isolation measures and therapy. (Source: Lung India)
Source: Lung India - April 28, 2017 Category: Respiratory Medicine Authors: Ujjwayini Ray Suresh Ramasubban Chandrashish Chakravarty Lawni Goswami Soma Dutta Source Type: research

Nasal airflow monitoring during swallowing: Evidences for respiratory-swallowing incoordination in individuals with chronic obstructive pulmonary disease
Conclusion: The results of the present study gave an insight into the pattern of respiratory-swallowing coordination in individuals with COPD. (Source: Lung India)
Source: Lung India - April 28, 2017 Category: Respiratory Medicine Authors: Calida Frieda Pinto Radish Kumar Balasubramanium Vishak Acharya Source Type: research

Squat-to-stand test in functional assessment of stable chronic obstructive pulmonary disease patients
Conclusion: SqTST is a feasible and effective tool to assess functional status of COPD patients residing in rural areas. BMI is an important surrogate marker of the functional status in these patients. (Source: Lung India)
Source: Lung India - April 28, 2017 Category: Respiratory Medicine Authors: Prahlad Rai Gupta Asif Feroz Sachet Dawar Harshdeep Bhangoo Shivani Swami TK Khublani Source Type: research

Poor sleep quality has an adverse effect on childhood asthma control and lung function measures
ConclusionWe found that the SRBD is an independent risk factor for partly‐controlled/uncontrolled asthma and have an adverse effect on lung function measures in children. Further research is warranted to determine whether the improvement of sleep quality may also enhance level of asthma control and lung function in children.This article is protected by copyright. All rights reserved. (Source: Pediatrics International)
Source: Pediatrics International - April 28, 2017 Category: Pediatrics Authors: Youn Ho Sheen, Sun Hee Choi, Sun Jung Jang, Ji Hyeon Baek, Hye Mi Jee, Mi Ae Kim, Kyu Young Chae, Man Yong Han Tags: Original Article Source Type: research

RPC4046, A Novel Anti-interleukin-13 Antibody, Blocks IL-13 Binding to IL-13 α1 and α2 Receptors: A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation First-in-Human Study
ConclusionRPC4046 is a novel anti-IL-13 antibody that blocks IL-13 binding to both receptors and more fully blocks the asthma phenotype. These results support further investigation of RPC4046 for IL-13-related allergic/inflammatory diseases (e.g., asthma and eosinophilic esophagitis).FundingAbbVie Inc. sponsored the studies and contributed to the design and conduct of the studies, data management, data analysis, interpretation of the data, and in the preparation and approval of the manuscript. (Source: Advances in Therapy)
Source: Advances in Therapy - April 28, 2017 Category: Drugs & Pharmacology Source Type: research

Morbidity in extreme low birth weight newborns hospitalized in a high risk public maternity
Conclusions: the morbidities from respiratory tract, cardiac, neurological and infectious were the most prevalent, whilst PDA, intraventricular hemorrhage and sepsis were the morbidities that significantly influenced the time of hospitalization.Resumo Objetivos: determinar a preval ência das morbidades mais comuns em recém-nascidos de extremo baixo peso (RNEBP) internados em uma unidade de terapia intensiva neonatal (UTIN) e avaliar a influência dessas morbidades no tempo de internamento. Métodos: estudo observacional, longitudinal, prospectivo e analítico, na UTIN de um a maternidade publica referência em alto risco...
Source: Revista Brasileira de Saude Materno Infantil - April 27, 2017 Category: Midwifery Source Type: research

Prevalence of Complement-Mediated Cell Lysis-like Gene (sicG) in Streptococcus dysgalactiae subsp. equisimilis Isolates From Japan (2014-2016).
CONCLUSIONS: CC17 SDSE harboring sicG might have spread into three closely-related prefectures in central Japan during 2014-2016. Clonal analysis of isolates from other areas might be needed to monitor potentially virulent strains in humans and animals. PMID: 28445008 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - April 27, 2017 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Overview of procalcitonin assays and procalcitonin-guided protocols for the management of patients with infections and sepsis.
Authors: Schuetz P, Bretscher C, Bernasconi L, Mueller B Abstract INTRODUCTION: Procalcitonin is a surrogate infection blood marker whose levels help estimate the likelihood of bacterial infections and correlate with their resolution. Recent trials have revealed the benefits of inclusion of procalcitonin in antibiotic stewardship protocols for initiation and discontinuation of antimicrobial therapy. Areas covered: Procalcitonin-guided antibiotic stewardship protocols have shown appreciable reductions in antibiotic use and duration of therapy in respiratory infections, sepsis, and other infections, with positive eff...
Source: Expert Review of Molecular Diagnostics - April 27, 2017 Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research

Dexmedetomidine attenuates acute paroxysmal sympathetic hyperactivity.
Authors: Peng Y, Zhu H, Chen H, Zhu Z, Zhou H, Zhang S, Gao L, Shi L, Li X, Luo Z Abstract We evaluated the curative effect of dexmedetomidine on paroxysmal sympathetic hyperactivity (PSH) in a retrospective study of 72 PSH patients after neurosurgery. Our results showed that dexmedetomidine was superior to propofol for treatment of PSH with respect to: average time needed to reduce paroxysmal hypertension (PH) to <140/90 mmHg (29.03±8.86 vs. 42.0±14.77 min), average remission time of PH (3.97±1.73 vs. 5.65±1.51 min), PH remission rate (61.22±10.8% vs. 41.52±14.15%), PH duration (9.31±2.66 vs. 13.05±4.19...
Source: Oncotarget - April 27, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Safety and Efficacy of a Fully Covered Self-Expandable Metallic Stent in Benign Airway Stenosis
Conclusion: Third-generation SEMS are a safe treatment option for complex benign airway stenosis, but complications requiring stent removal are frequent. Further studies are needed to compare the performance of third-generation SEMS and silicone stents in benign airway stenosis.Respiration (Source: Respiration)
Source: Respiration - April 27, 2017 Category: Respiratory Medicine Source Type: research

Pneumonia Severity Assessment Tools for Predicting Mortality in Patients with Healthcare-Associated Pneumonia: A Systematic Review and Meta-Analysis
Conclusions: The PORT score and CURB-65 do not have substantial power compared with the tools for CAP patients, although the PORT score is more useful than CURB-65 for predicting mortality in HCAP patients. According to our results, however, these tools, especially the PORT score, can be more useful when limited to nonimmunocompromised patients.Respiration (Source: Respiration)
Source: Respiration - April 27, 2017 Category: Respiratory Medicine Source Type: research

Bronchopulmonary Infection Due to Moraxella (Branhamella) Catarrhalis at Qatif Central Hospital
Moraxella (Branhamella) catarrhalis is now recognized as an important cause of respiratory tract infections. Over a two year period,Moraxella (Branhamella) catarrhalis was isolated in pure culture from 3.4% of the sputums collected from patients with symptoms of acute respiratory tract infections. It was the third most important pathogen isolated afterHaemophilus influenzae andStreptococcus pneumoniae; 77% of the patients had an underlying chronic pulmonary condition. Prevalence, antibiotic sensitivity, and treatment options, will be discussed. (Source: Annals of Saudi Medicine)
Source: Annals of Saudi Medicine - April 27, 2017 Category: Journals (General) Tags: ISSUE 6 Source Type: research

Acute Renal Failure in Neonates: A Prospective Study
Babies admitted to a neonatal intensive care unit in whom acute renal failure developed were studied prospectively to determine the etiology, course, and outcome of the disorder, as well as the reliability of renal indices in distinguishing intrinsic from prerenal renal failure. The incidence of neonatal acute renal failure was 3.6% (22/603). The most frequent causes were hypotension (86%), respiratory distress syndrome (41%), sepsis (32%), and asphyxia (27%). Half of the patients were born at less than 32 weeks' gestation and had a birth weight of less than 1500 gm. There was intrinsic renal failure in 15 neonates and pre...
Source: Annals of Saudi Medicine - April 27, 2017 Category: Journals (General) Tags: ISSUE 3 Source Type: research

First reported enterovirus D68 infection in pediatric patients from the Caribbean region: evidence of spread from the U.S. outbreak.
The objective of this study was to provide rapid evidence of the introduction of EV-D68 strains in the Caribbean region during the 2014 outbreak in the United States, using a relatively simple phylogenetic approach. From October 2014 to May 2015, four EV-D68 cases from two countries (Bermuda and Dominica) were detected at the regional referral laboratory at the Caribbean Public Health Agency (Port of Spain, Trinidad and Tobago) based on molecular testing of respiratory specimens. All cases were children presenting to hospitals with moderate respiratory distress. No cases of acute flaccid paralysis were detected. Phylogenet...
Source: Pan American Journal of Public Health - April 27, 2017 Category: Global & Universal Tags: Rev Panam Salud Publica Source Type: research

[Antituberculosis-drug resistance in the border of Brazil with Paraguay and Bolivia].
Conclusions: In the border region, the state should investigate drug resistance in all patients with respiratory symptoms, determine the pattern of resistance in confirmed cases, adopt directly observed treatment for cases of PTB, and develop health actions together with neighboring countries. Across the state, the levels of acquired resistance should be monitored, with investigation of resistance in all treated cases and implementation of directly observed treatment especially among patients with diabetes or alcoholism. PMID: 28444009 [PubMed - in process] (Source: Pan American Journal of Public Health)
Source: Pan American Journal of Public Health - April 27, 2017 Category: Global & Universal Tags: Rev Panam Salud Publica Source Type: research

Noninvasive Respiratory Metabolite Analysis Associated with Clinical Disease in Cetaceans: A Deepwater Horizon Oil Spill Study
Environmental Science& TechnologyDOI: 10.1021/acs.est.6b06482 (Source: Environmental Science and Technology)
Source: Environmental Science and Technology - April 27, 2017 Category: Environmental Health Authors: managing.editor at est.acs.org (American Chemical Society) Source Type: research

The safety of ustekinumab for the treatment of psoriatic arthritis.
Authors: López-Ferrer A, Laiz A, Puig L Abstract INTRODUCTION: The cytokines interleukin (IL)-12 and IL-23 have been involved in the pathogenesis of psoriasis and psoriatic arthritis. Ustekinumab is a fully human monoclonal antibody targeting the p40 subunit shared by IL-12 and IL-23. Ustekinumab prevents the interaction of IL-12 and IL-23 binding to its receptor, blocking the T1 and T17 inflammatory pathways. Ustekinumab has been evaluated for the treatment of various chronic immune mediated diseases including psoriasis and psoriatic arthritis (PsA). Most of the data regarding the safety of ustekinumab come from ...
Source: Expert Opinion on Drug Safety - April 27, 2017 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

Perspectives on advance care planning among patients recently requiring non-invasive ventilation for acute respiratory failure: A qualitative study using thematic analysis.
CONCLUSION: This study suggests opportunities and barriers for advance care planning in individuals with chronic disease. Patients' understanding of their prognosis and their attitudes to cardiopulmonary resuscitation suggests an opportunity for advance care planning. Structuring discussions around patients' preferences for care during future exacerbations may foster a sense of control over the future despite illness. The diversity of familial responses to patients' concerns about their future health has implications for advance care planning. These findings have the potential to improve care for patients with respiratory ...
Source: Palliative Medicine - April 27, 2017 Category: Palliative Care Authors: Smith TA, Disler RT, Jenkins CR, Ingham JM, Davidson PM Tags: Palliat Med Source Type: research