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This page shows you the most recent publications within this specialty of the MedWorm directory.

Who am I to judge?
Publication date: Available online 23 September 2016 Source:The Lancet Psychiatry Author(s): Cheryl Lai (Source: The Lancet Psychiatry)
Source: The Lancet Psychiatry - September 24, 2016 Category: Psychiatry Source Type: research

Depression in Early Pregnancy Linked to Gestational Diabetes, Postpartum Depression
Depression early in pregnancy appears to increase the risk for gestational diabetes, which in turn increases the risk for postpartum depression, according to a report appearing online inDiabetologia.Stephanie Hinkle, Ph.D., and colleagues at the National Institute of Child Health and Human Development assessed longitudinal associations between depression early in pregnancy and the risk for gestational diabetes (GDM), as well as GDM and subsequent risk of postpartum depression. They analysed data from the prospective National Institute of Child Health and Human Development Fetal Growth Studies-Singleton cohort (2009 –2013...
Source: Psychiatr News - September 23, 2016 Category: Psychiatry Tags: depression gestational diabetes postpartum depression pregnancy Source Type: research

Guidelines and other things.
PMID: 27650685 [PubMed - in process] (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - September 23, 2016 Category: Psychiatry Authors: Mulder R Tags: Aust N Z J Psychiatry Source Type: research

The RANZCP mood disorders guidelines: An easy step-by-step toolbox for daily practice.
PMID: 27650688 [PubMed - in process] (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - September 23, 2016 Category: Psychiatry Authors: Geoffroy PA, Bellivier F Tags: Aust N Z J Psychiatry Source Type: research

ICD-11 features of a mixed mood state: Bold or simply old?
PMID: 27650690 [PubMed - in process] (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - September 23, 2016 Category: Psychiatry Authors: Malhi GS, Porter RJ Tags: Aust N Z J Psychiatry Source Type: research

An Erudite Encounter with: Sam Gershon.
PMID: 27650691 [PubMed - in process] (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - September 23, 2016 Category: Psychiatry Authors: Gershon S Tags: Aust N Z J Psychiatry Source Type: research

The Royal Australian and New Zealand College of Psychiatrists clinical guidelines for mood disorders: Kudos and quarrels.
PMID: 27650686 [PubMed - in process] (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - September 23, 2016 Category: Psychiatry Authors: Gitlin M Tags: Aust N Z J Psychiatry Source Type: research

Royal Australian and New Zealand College of Psychiatrists clinical practice guideline for the management of deliberate self-harm.
CONCLUSION: The clinical practice guidelines for deliberate self-harm address self-harm within specific population sub-groups and provide up-to-date recommendations and guidance within an evidence-based framework, supplemented by expert clinical consensus. PMID: 27650687 [PubMed - in process] (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - September 23, 2016 Category: Psychiatry Authors: Carter G, Page A, Large M, Hetrick S, Milner AJ, Bendit N, Walton C, Draper B, Hazell P, Fortune S, Burns J, Patton G, Lawrence M, Dadd L, Robinson J, Christensen H Tags: Aust N Z J Psychiatry Source Type: research

Are the Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders meeting the needs of clinicians?
PMID: 27650689 [PubMed - in process] (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - September 23, 2016 Category: Psychiatry Authors: Pai N Tags: Aust N Z J Psychiatry Source Type: research

Effects of smoking status and MADRS retardation factor on response to low frequency repetitive transcranial magnetic stimulation for depression.
CONCLUSION: Low MADRS retardation factor and ex-smoker status is highly prevalent in responders to low frequency rTMS. Further studies are needed to investigate the predictive value of these factors. PMID: 27657664 [PubMed - as supplied by publisher] (Source: Journal of the Association of European Psychiatrists)
Source: Journal of the Association of European Psychiatrists - September 23, 2016 Category: Psychiatry Tags: Eur Psychiatry Source Type: research

Early-adult outcome of child and adolescent mental disorders as evidenced by a national-based case register survey.
CONCLUSIONS: These findings suggest that individuals with psychiatric antecedents in childhood and adolescence had a high risk of being referred for treatment in early adulthood, and many mental disorders for which they required treatment revealed both homotypic and heterotypic continuity. PMID: 27657665 [PubMed - as supplied by publisher] (Source: Journal of the Association of European Psychiatrists)
Source: Journal of the Association of European Psychiatrists - September 23, 2016 Category: Psychiatry Tags: Eur Psychiatry Source Type: research

What are People's Experiences of a Novel Cognitive Behavioural Therapy for Bipolar Disorders? A Qualitative Investigation with Participants on the TEAMS Trial.
Conclusions The present study evaluates participants' therapy experiences in detail, including aspects of therapy viewed as helpful, and meaningful post-therapy outcomes. Copyright © 2016 John Wiley & Sons, Ltd. KEY PRACTITIONER MESSAGE: This is the first paper to qualitatively explore people's experiences of individual psychotherapy for bipolar disorders. It highlights elements of psychotherapy described as particularly helpful or unhelpful and the clinical changes viewed as most impactful. Participants reported benefitting in a number of ways from TEAMS therapy. They valued learning to reappraise and problem-sol...
Source: Clinical Psychology and Psychotherapy - September 23, 2016 Category: Psychiatry Tags: Clin Psychol Psychother Source Type: research

Medial Cranial Fossa Meningioma Diagnosed as Mixed Anxiety Disorder with Dissociative Symptoms and Vertigo.
We present a case of medial cranial fossa meningioma that was first diagnosed as mixed anxiety disorder with dissociative symptoms and vertigo. In light of the intact neurological and vestibular system examination, our patient's vertigo and depersonalization were firstly addressed as psychosomatic symptoms of the psychiatric syndrome. Despite decreased anxiety and improved mood, dissociative symptoms and vertigo were resistant to treatment which prompted further research yielding a left hemisphere localized meningioma. Resection of meningioma resulted in full remission of the patient proving it to be responsible for the et...
Source: Case Reports in Psychiatry - September 23, 2016 Category: Psychiatry Tags: Case Rep Psychiatry Source Type: research

Improvement in verbal memory performance in depressed in ‐patients after treatment with electroconvulsive therapy
ConclusionContrary to the widely feared assumption that ECT has long‐term impact on memory functions, we found evidence that ECT is superior to TAU in improving verbal memory in depressed patients. (Source: Acta Psychiatrica Scandinavica)
Source: Acta Psychiatrica Scandinavica - September 23, 2016 Category: Psychiatry Authors: S. V. Biedermann, J. M. Bumb, T. Demirakca, G. Ende, A. Sartorius Tags: Original Article Source Type: research

How Voting and Consensus Created the Diagnostic and Statistical Manual of Mental Disorders (DSM-III).
Authors: Davies J Abstract This paper examines how Task Force votes were central to the development of Diagnostic and Statistical Manual of Mental Disorders (DSM-III and DSM-III-R). Data were obtained through a literature review, investigation of DSM archival material housed at the American Psychiatric Association (APA), and interviews with key Task Force members of DSM-III and DSM-III-R. Such data indicate that Task Force votes played a central role in the making of DSM-III, from establishing diagnostic criteria and diagnostic definitions to settling questions about the inclusion or removal of diagnostic categorie...
Source: Anthropology and Medicine - September 23, 2016 Category: Global & Universal Tags: Anthropol Med Source Type: research

Subtelomeric Copy Number Variations: The Importance of 4p/4q Deletions in Patients with Congenital Anomalies and Developmental Disability
The most prevalent structural variations in the human genome are copy number variations (CNVs), which appear predominantly in the subtelomeric regions. Variable sizes of 4p/4q CNVs have been associated with several different psychiatric findings and developmental disability (DD). We analyzed 105 patients with congenital anomalies (CA) and developmental and/or intellectual disabilities (DD/ID) using MLPA subtelomeric specific kits (P036 /P070) and 4 of them using microarrays. We found abnormal subtelomeric CNVs in 15 patients (14.3%), including 8 patients with subtelomeric deletions at 4p/4q (53.3%). Additional genomic chan...
Source: Cytogenetic and Genome Research - September 23, 2016 Category: Genetics & Stem Cells Source Type: research

Post-intensive care unit syndrome in gynecologic oncology patients
ConclusionsGiven the preponderance of psychiatric disorders and mechanical ventilation during post-operative ICU care in patients with gynecologic cancer, prospective evaluation of risk factors and utility of risk-reducing interventions for PICS is warranted. Long-term cognitive or physical disability is known to hasten mortality; thus, preventative strategies may increase the survival and quality of life for this patient population. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - September 23, 2016 Category: Cancer & Oncology Source Type: research

New journal structure of child and adolescent psychiatry and mental health
(Source: Child and Adolescent Psychiatry and Mental Health)
Source: Child and Adolescent Psychiatry and Mental Health - September 23, 2016 Category: Psychiatry Authors: Joerg M. Fegert and Benedetto Vitiello Source Type: research

Relative differences in resting-state brain connectivity associated with long term intensive lifestyle intervention
Functional magnetic resonance imaging (fMRI) studies evaluating brain activity at rest using the blood oxygen level dependent (BOLD) technique allows identification and evaluation of several brain networks defined by synchronous activity patterns. The network of brain areas known as the default mode network (DMN), so named due to higher activity in this network when the brain is at rest, contains the posterior cingulate cortex, precuneus, medial temporal lobe, inferior parietal lobe, and medial prefrontal cortex. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - September 23, 2016 Category: Psychiatry Authors: Ramon Casanova, Satoru Hayasaka, Santiago Saldana, Nick R. Bryan, Kathryn E. Demos, Lisa Desiderio, Kirk I. Erickson, Mark A. Espeland, Ilya M. Nasrallah, Thomas Wadden, Paul J. Laurienti, for the Action for Health In Diabetes Brain Magnetic Resonance Ima Source Type: research

Supported employment and education in comprehensive, integrated care for first episode psychosis: Effects on work, school, and disability income
Participation in work and school are central objectives for first episode psychosis (FEP) programs, but evidence effectiveness has been mixed in studies not focused exclusively on supported employment and education (SEE). Requirements for current motivation to work or go to school limit the generalizability of such studies. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 23, 2016 Category: Psychiatry Authors: Robert Rosenheck, Kim T. Mueser, Kyaw Sint, Haiqun Lin, David W. Lynde, Shirley M. Glynn, Delbert G. Robinson, Nina R. Schooler, Patricia Marcy, Somaia Mohamed, John M. Kane Source Type: research

Delusional ideation during the perinatal period in a community sample
Despite the prevalence of mental health problems during the perinatal period, little research has examined psychotic symptoms in a community sample across pregnancy and the postpartum. Exposure to environmental risk factors, and immigration in particular, are associated with increased risk for psychotic disorders. The current investigation examined whether psychosocial risk and immigrant status would predict levels of delusional ideation across the perinatal period when controlling for depression, anxiety, and demographic factors. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 23, 2016 Category: Psychiatry Authors: Anna L. MacKinnon, Mariam Naguib, Helena J. Barr, Anna Levinsson, Stephanie Robins, Nancy Feeley, Barbara Hayton, Phyllis Zelkowitz, Ian Gold Source Type: research

Psychotic-like experiences, trauma and related risk factors among “left-behind” children in China
Large scale migration of workers due to wage differences across regions of China has separated millions of children, called “left-behind children” from their parents. Psychotic-like experiences (PLEs) are thought to be associated with childhood deprivation and may predict later psychotic disorders but have not been studied in this potentially vulnerable population. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 23, 2016 Category: Psychiatry Authors: Meng Sun, Zhimin Xue, Wen Zhang, Rui Guo, Aimin Hu, Yihui Li, Tumbwene Elieza Mwansisya, Li Zhou, Chang Liu, Xudong Chen, Xiaojun Huang, Haojuan Tao, Jingcheng Shi, Zhening Liu, Robert Rosenheck Source Type: research

Communicating about cigarette smoke constituents: an experimental comparison of two messaging strategies
AbstractFederal law now requires FDA to disseminate information on chemicals in cigarette smoke, but it is unclear how best to do so. In a 2  × 2 between-subjects experiment, participants received a message about chemicals in cigarette smoke (e.g., “Cigarette smoke has benzene.”) along with an additional randomly assigned messaging strategy: a “found-in” (e.g., “This is found in gasoline.”), a health effect (e.g., “This causes heart disease.”), both, or neither. Participants were U.S. probability phone samples of 5000 adults and 1123 adolescents, and an online convenience sample of 4130 adults. Adding a ...
Source: Journal of Behavioral Medicine - September 23, 2016 Category: Psychiatry Source Type: research

Electro-physiological changes in the brain induced by caffeine or glucose nasal spray
ConclusionGreater cognitive efficiency was observed with GLUC-NAS. CAF-NAS activated cingulate, insular, and sensorymotor cortices, whereas GLUC-NAS activated sensory, cingulate, and insular cortices. However, no effect on the Stroop task was found. (Source: Psychopharmacology)
Source: Psychopharmacology - September 23, 2016 Category: Psychiatry Source Type: research

Benchmarking Family Therapy for Adolescent Behavior Problems in Usual Care: Fidelity, Outcomes, and Therapist Performance Differences
This study evaluated whether community therapists delivering family therapy for adolescent behavior problems in usual care achieved performance benchmarks established in controlled trials for treatment fidelity and outcomes, with particular focus on individual differences in therapist performance. The study contained N  = 38 adolescents (50 % male; mean age 15 years) whose self-reported race/ethnicity was Hispanic (74 %), African American (11 %), multiracial (11 %), and other (4 %). Clients were treated by 13 therapists in one community mental health clinic that delivered family therapy as the routin e standa...
Source: Administration and Policy in Mental Health and Mental Health Services Research - September 23, 2016 Category: Psychiatry Source Type: research

Depression and anxiety mediate the relationship between temperament and character and psychotic-like experiences in healthy subjects
In this study we examined the hypothesis that depression and anxiety may mediate the relationship between personality traits and both positive and negative psychotic-like experiences (PLEs) in healthy adults. The Community Assessment of Psychic Experiences (CAPE) scale, Temperament and Character Inventory (TCI), Beck Depression Inventory (BDI) and State and Trait Anxiety Inventory (STAI) were administered to 492 healthy individuals. Multiple stepwise regression and mediation analyses were performed to examine whether depressive and anxiety symptoms influence the relationship between the TCI dimensions and positive and nega...
Source: Psychiatry Research - September 23, 2016 Category: Psychiatry Authors: Katarzyna Prochwicz, Łukasz Gawęda Source Type: research

Evidence-based treatments for youths with severely dysregulated mood: a qualitative systematic review of trials for SMD and DMDD
AbstractThe aim of this literature review was to examine the evidence for psychotherapeutic and pharmacological treatments in subjects with severely dysregulated mood and to identify potential areas for improvements in research designs. A literature search was conducted using several databases for published (PubMed, PsycINFO) and ongoing (clinical trial registries) studies conducted in youths who met NIMH ’s criteria for Severe Mood Dysregulation (SMD) or the DSM-5 diagnosis of Disruptive Mood Dysregulation Disorder (DMDD). Eight completed studies were identified: three randomized trials, four open pilot studies and one ...
Source: European Child and Adolescent Psychiatry - September 23, 2016 Category: Psychiatry Source Type: research

Atomoxetine for hoarding disorder: A pre-clinical and clinical investigation
Publication date: December 2016 Source:Journal of Psychiatric Research, Volume 83 Author(s): Giacomo Grassi, Micheli Laura, Di Cesare Mannelli Lorenzo, Compagno Elisa, Righi Lorenzo, Ghelardini Carla, Pallanti Stefano Despite several studies suggested that inattention and impulsivity-compulsivity could represent two core dimensions of hoarding disorder (HD), only a small case series study investigated the effectiveness of attention-deficit-hyperactivity-disorder (ADHD) medications in HD. The aim of the present study was to target attentional and inhibitory control networks in HD patients through the ADHD medication atomox...
Source: Journal of Psychiatric Research - September 23, 2016 Category: Psychiatry Source Type: research

The Change in Facial Emotion Recognition Ability in Inpatients with Treatment Resistant Schizophrenia After Electroconvulsive Therapy
AbstractPeople with schizophrenia have impairments in emotion recognition along with other social cognitive deficits. In the current study, we aimed to investigate the immediate benefits of ECT on facial emotion recognition ability. Thirty-two treatment resistant patients with schizophrenia who have been indicated for ECT enrolled in the study. Facial emotion stimuli were a set of 56 photographs that depicted seven basic emotions: sadness, anger, happiness, disgust, surprise, fear, and neutral faces. The average age of the participants was 33.4  ± 10.5 years. The rate of recognizing the disgusted facial expression incr...
Source: Psychiatric Quarterly - September 23, 2016 Category: Psychiatry Source Type: research

Heightened early-attentional stimulus orienting and impulsive action in men with antisocial personality disorder
AbstractWe tested whether enhanced stimulus orienting operationalized as N1 and P2 auditory evoked potentials to increasing loudness (50 –90 dB clicks) could be associated with trait impulsivity (Barratt Impulsiveness Scale, BIS-11), impulsive action (commission error on the Immediate Memory Task), or impulsive choice (immediate responses on temporal discounting tasks). We measured N1 and P2 loudness sensitivity in a passive liste ning task as linear intensity–sensitivity slopes in 36 men with antisocial personality disorder with a history of conviction for criminal conduct and 16 healthy control men. Across all subje...
Source: European Archives of Psychiatry and Clinical Neuroscience - September 23, 2016 Category: Neuroscience Source Type: research

Use of Intraoperative CT to Predict the Accuracy of Microelectrode Recording During Deep Brain Stimulation Surgery. A Proof of Concept Study
Deep brain stimulation (DBS) is an effective therapy for movement disorders such as Parkinson ’s disease, essential tremor and dystonia [1–4]. Treatment of psychiatric conditions including depression and obsessive compulsive disorder is also gaining momentum as new stimulation-responsive targets are being defined [5,6]. In many centers, microelectrode recording (MER) remains the mainstay of target localization and optimization during DBS surgery [7–9]. Often one or several recording tracks are used to obtain an electrophysiological map of the target before lead insertion. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - September 23, 2016 Category: Neurosurgery Authors: Ryan B. Kochanski, Mena G. Kerolus, Gian Pal, Leo Verhagen Metman, Sepehr Sani Source Type: research

Predictive genetic testing for neurodegenerative conditions: how should conflicting interests within families be managed?
Predictive genetic testing for a neurodegenerative condition in one individual in a family may have implications for other family members, in that it can reveal their genetic status. Herein a complex clinical case is explored where the testing wish of one family member was in direct conflict to that of another. The son of a person at 50% risk of an autosomal dominant neurodegenerative condition requested testing to reveal his genetic status. The main reason for the request was if he had the familial mutation, he and his partner planned to utilise preimplantation genetic diagnosis to prevent his offspring having the conditi...
Source: Journal of Medical Ethics - September 23, 2016 Category: Medical Ethics Authors: Stark, Z., Wallace, J., Gillam, L., Burgess, M., Delatycki, M. B. Tags: Clinical genetics, Suicide (psychiatry), Ethics of reproduction, Suicide (public health) Clinical ethics Source Type: research

Analysis of Genome-Wide Monoallelic Expression Patterns in Three Major Cell Types of Mouse Visual Cortex Using Laser Capture Microdissection
by Chia-Yi Lin, Shih-Chuan Huang, Chun-Che Tung, Chih-Hsuan Chou, Susan Shur-Fen Gau, Hsien-Sung Huang Genomic imprinting is an epigenetic mechanism causing monoallelic expression in a parent-of-origin-specific manner. Disruption of imprinted genes causes various neurological and psychiatric disorders. However, the role of imprinted genes in the brain is largely unknown. Different cell types within distinct brain regions can influence the genomic imprinting status, but imprinted genes in single cell types within distinct brain regions have not been characterized on a genome-wide scale. To address this critical question, w...
Source: PLoS One - September 23, 2016 Category: Biomedical Science Authors: Chia-Yi Lin Source Type: research

Risk score developed from routinely collected data by primary healthcare practitioners is useful to rule out dementia in 60-79 year-olds
Commentary on: Walters K, Hardoon S, Petersen I, et al.. Predicting dementia risk in primary care: development and validation of the Dementia Risk Score using routinely collected data. BMC Medicine 2016;14:6 . Context In spite of major repercussions on the life of patients and caregivers, dementia remains a neglected domain in primary care setting. Previous studies have shown that only a third of new dementia cases occurring in the general population were referred to a specialist1 and that too at a severe stage of the disease, 25% of cases were ignored.2 A great proportion of primary care practitioners (PCPs) consider deme...
Source: Evidence-Based Medicine - September 23, 2016 Category: Internal Medicine Authors: Dartigues, J. F., Helmer, C. Tags: EBM Diagnosis, Health policy, General practice / family medicine, Drugs: cardiovascular system, Dementia, Drugs: CNS (not psychiatric), Stroke, Memory disorders (psychiatry), Psychiatry of old age, Health service research Source Type: research

An unusually long retrocaecal appendix
Case report An 11-year-old boy presented with a 1-day history of a generalised lower abdominal pain extending from the right to the left iliac fossa. His symptoms were associated with nausea, anorexia and a mild fever. On physical examination, deep tenderness and guarding were elicited at McBurney's point, as well as the hypogastrium and the left iliac fossa. Haematological investigations revealed normal ranges of both white cell count and C reactive protein. Urinalysis and abdominal ultrasound were also both normal. Due to the unclear nature of the initial clinical picture, the patient was monitored overnight; unfortunate...
Source: Postgraduate Medical Journal - September 23, 2016 Category: Journals (General) Authors: Kim, I., Chitnis, A., Sabri, S., Muhammad, K. Tags: Journalology, Pain (neurology), Child and adolescent psychiatry, Eating disorders, Radiology, Clinical diagnostic tests, Gastrointestinal surgery, Radiology (diagnostics), Ethics Images in medicine Source Type: research

Decline in Consultant Availability in Massachusetts Emergency Departments: 2005 to 2014
Conclusion In Massachusetts EDs between 2005 and 2014, ED consultant availability significantly declined despite accounting for other ED characteristics. (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - September 23, 2016 Category: Emergency Medicine Source Type: research

Can we accelerate autism discoveries through crowdsourcing?
Publication date: December 2016 Source:Research in Autism Spectrum Disorders, Volume 32 Author(s): Maude M. David, Brooke A. Babineau, Dennis P. Wall Autism is a dramatically expanding public health challenge. The search for genomic variants underlying the disease concomitantly accelerated over the last 5 years, leading to a general consensus that genetics can explain between 40% and 60% of the symptomatic variability seen in autism. This stresses both an urgent need to continue devoting resources to the search for genetic etiologies that define the forms of autism, and an equal need for attention to the interactive r...
Source: Research in Autism Spectrum Disorders - September 23, 2016 Category: Psychiatry Source Type: research

Short term, low dose fluoxetine blocks estrous cycle-linked changes in responsiveness to diazepam in female rats
Anxiety behavior in female Wistar rats was assessed at different stages of the estrous cycle using the elevated plus maze (EPM). No differences were observed at any cycle stage. Pretreatment with diazepam (1 mg kg–1 intraperitoneal (i.p.)) 30 min before testing produced an anxiolytic effect (significant increase in percentage of time in the open arms compared to control group in the same cycle phase) in animals in proestrus, estrus, and early diestrus but had no effect in rats in late diestrus. Locomotor activity (total arm entries) was unchanged at any cycle phase. When rats in the late diestrus phase were pretreate...
Source: Journal of Psychopharmacology - September 23, 2016 Category: Psychiatry Authors: Soares-Rachetti, V. d. P., de Sousa Pinto, I. A., Santos, R. O., Andre, E., Gavioli, E. C., Lovick, T. Tags: Original Papers Source Type: research

Mineralocorticoid receptor haplotype moderates the effects of oral contraceptives and menstrual cycle on emotional information processing
Conclusion: MR-haplotype 1/3 carriers may be more sensitive to the influence of their female hormonal status. MR-haplotype 2 carriers showed more risky decision-making. As this may reflect optimistic expectations, this finding may support previous observations in female carriers of MR-haplotype 2 in a naturalistic cohort study. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - September 23, 2016 Category: Psychiatry Authors: Hamstra, D. A., de Kloet, E. R., Tollenaar, M., Verkuil, B., Manai, M., Putman, P., Van der Does, W. Tags: Original Papers Source Type: research

Slow subcutaneous infusion of flumazenil for the treatment of long-term, high-dose benzodiazepine users: a review of 214 cases
Despite the first reports concerning benzodiazepine dependence being published in the early 1960s literature, the risk of benzodiazepine addiction is still greatly debated. The severe discomfort and life threatening complications usually experienced by long-term benzodiazepine users who suddenly interrupt benzodiazepine intake have led to the development of several detoxification protocols. A successful strategy used by our Addiction Unit is abrupt benzodiazepine cessation by administering flumazenil slow subcutaneous infusion (FLU-SSI) with an elastomeric pump. Although some studies proved the efficacy of flumazenil infus...
Source: Journal of Psychopharmacology - September 23, 2016 Category: Psychiatry Authors: Faccini, M., Leone, R., Opri, S., Casari, R., Resentera, C., Morbioli, L., Conforti, A., Lugoboni, F. Tags: Original Papers Source Type: research

Acute anxiety and social inference: An experimental manipulation with 7.5% carbon dioxide inhalation
Conclusions: Positive self-bias (i.e. fewer errors learning self-like than self-dislike) seemed robust to changes in state anxiety. In contrast, learning other-referential evaluation was impaired as state anxiety increased. This suggested that the previously observed variations in self-bias arise due to trait, rather than state, characteristics. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - September 23, 2016 Category: Psychiatry Authors: Button, K. S., Karwatowska, L., Kounali, D., Munafo, M. R., Attwood, A. S. Tags: Original Papers Source Type: research

Serotonin synthesis rate and the tryptophan hydroxylase-2: G-703T polymorphism in social anxiety disorder
It is disputed whether anxiety disorders, like social anxiety disorder, are characterized by serotonin over- or underactivity. Here, we evaluated whether our recent finding of elevated neural serotonin synthesis rate in patients with social anxiety disorder could be reproduced in a separate cohort, and whether allelic variation in the tryptophan hydroxylase-2 (TPH2) G-703T polymorphism relates to differences in serotonin synthesis assessed with positron emission tomography. Eighteen social anxiety disorder patients and six healthy controls were scanned during 60 minutes in a resting state using positron emission tomography...
Source: Journal of Psychopharmacology - September 23, 2016 Category: Psychiatry Authors: Furmark, T., Marteinsdottir, I., Frick, A., Heurling, K., Tillfors, M., Appel, L., Antoni, G., Hartvig, P., Fischer, H., Langström, B., Eriksson, E., Fredrikson, M. Tags: Original Papers Source Type: research

Lithium intoxication: Incidence, clinical course and renal function - a population-based retrospective cohort study
In this study, we examined a cohort of patients exposed to lithium between 1997 and 2013. The aims of this study were to determine the frequency of lithium intoxication and to evaluate the clinical course and changes in renal function. Of 1340 patients, 96 had experienced at least one episode of lithium levels >=1.5 mmol/L, yielding an incidence of 0.01 per patient-year. Seventy-seven patients available for review had experienced 91 episodes, of whom 34% required intensive care and 13% were treated with haemodialysis. There were no fatalities. Acute kidney injury occurred, but renal function at baseline was not differen...
Source: Journal of Psychopharmacology - September 23, 2016 Category: Psychiatry Authors: Ott, M., Stegmayr, B., Salander Renberg, E., Werneke, U. Tags: Original Papers Source Type: research

Comparing episodes of antidepressants use with intermittent episodes of no use: A higher relative risk of suicide attempts but not of suicide at young age
The Food and Drug Administration has issued a number of advisories regarding a possible causal link between antidepressants and suicide behaviour among young persons. We investigated the age dependency of (fatal) suicide attempts associated with antidepressants (N=232,561). By linking insurance claims with the death register of Statistics Netherlands (2002–2011), rates of (fatal) suicide attempts were estimated during antidepressant use and intermittent episodes without use. The age dependency of the relative risk of attempts and of suicide during episodes with compared with episodes without antidepressants was inves...
Source: Journal of Psychopharmacology - September 23, 2016 Category: Psychiatry Authors: Termorshuizen, F., Smeets, H. M., Boks, M. P., Heerdink, E. R. Tags: Original Papers Source Type: research

The NMDA receptor partial agonist d-cycloserine does not enhance motor learning
Conclusion: The results suggest that d-cycloserine does not exert beneficial effects on psychological treatments via mechanisms involved in motor learning. Further studies are needed to clarify the influence on other cognitive mechanisms. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - September 23, 2016 Category: Psychiatry Authors: Günthner, J., Scholl, J., Favaron, E., Harmer, C. J., Johansen-Berg, H., Reinecke, A. Tags: Original Papers Source Type: research

Pharmacokinetics, pharmacodynamics and safety of CEP-26401, a high-affinity histamine-3 receptor antagonist, following single and multiple dosing in healthy subjects
CEP-26401 is a novel orally active, brain-penetrant, high-affinity histamine H3 receptor (H3R) antagonist, with potential therapeutic utility in cognition enhancement. Two randomized, double-blind, placebo-controlled dose escalation studies with single (0.02 to 5 mg) or multiple administration (0.02 to 0.5 mg once daily) of CEP-26401 were conducted in healthy subjects. Plasma and urine samples were collected to investigate CEP-26401 pharmacokinetics. Pharmacodynamic endpoints included a subset of tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB) and nocturnal polysomnography. Population pharmacoki...
Source: Journal of Psychopharmacology - September 23, 2016 Category: Psychiatry Authors: Spiegelstein, O., Stevens, J., Van Gerven, J., Nathan, P. J., Maynard, J. P., Mayleben, D. W., Hellriegel, E., Yang, R. Tags: Original Papers Source Type: research

Sarcosine treatment for oppositional defiant disorder symptoms of attention deficit hyperactivity disorder children
This study aimed to assess the efficacy of sarcosine in treating children with ADHD. We conducted a six-week, randomized, double-blind, placebo-controlled clinical trial. The primary outcome measures were those on the Inattention, Hyperactivity/impulsivity, and oppositional defiant disorder (ODD) subscales of the Swanson, Nolan, and Pelham, version IV scale. Efficacy and safety were measured bi-weekly. A total of 116 children with ADHD were enrolled. Among them, 48 (83%) of the 58 sarcosine recipients and 44 (76%) of the 58 placebo recipients returned for the first post-treatment visit. The missing data values were imputed...
Source: Journal of Psychopharmacology - September 23, 2016 Category: Psychiatry Authors: Tzang, R.-F., Chang, Y.-C., Tsai, G. E., Lane, H.-Y. Tags: Original Papers Source Type: research

Pharmacotherapy of conduct disorder: Challenges, options and future directions
There is a critical need for evaluation of the pharmacotherapies used in conduct disorder (CD), due to the high incidence of off-label prescribing. The aim of this review was to identify concerns associated with the safety, efficacy and impact on quality of life (QOL) that pharmacotherapy has in children and adolescents with CD. A systematic review was undertaken using pre-defined search criteria and four databases, including reference searches. We assessed these studies using the Strength of Recommendation Taxonomy, Grading of Recommendations Assessment, Development and Evaluation, and Review Manager Risk of Bias (RevMan&...
Source: Journal of Psychopharmacology - September 23, 2016 Category: Psychiatry Authors: Hambly, J. L., Khan, S., McDermott, B., Bor, W., Haywood, A. Tags: Reviews Source Type: research

Neural signals of 'intensity but not 'wanting or 'liking of rewards may be trait markers for depression
We have shown previously that participants ‘at risk’ of depression have decreased neural processing of reward suggesting this might be a neural biomarker for depression. However, how the neural signal related to subjective experiences of reward (wanting, liking, intensity) might differ as trait markers for depression is as yet unknown. Using SPM8 parametric modulation analysis the neural signal related to the subjective report of wanting, liking and intensity was compared between 25 young people with a biological parent with depression (FH) and 25 age/gender matched controls. In a second study the neural signal...
Source: Journal of Psychopharmacology - September 23, 2016 Category: Psychiatry Authors: McCabe, C. Tags: Original Papers Source Type: research

A neurological perspective on the enhancement debate: Lessons learned from Parkinsons disease
Cognitive enhancement is signified by adaptive behavioural change following an intervention that targets the brain. Although much of the discussion and research into cognitive enhancement focuses on the effects of neural interventions in healthy individuals, it is useful to consider evidence from clinical populations. Diseases of the central nervous system represent the primary and richest source of evidence on the effects of brain manipulations, which are in the first instance therapeutic. Parkinson’s disease (PD) is used as a model for understanding the effects of pharmacological agents that target systems with a c...
Source: Journal of Psychopharmacology - September 23, 2016 Category: Psychiatry Authors: Kehagia, A. A. Tags: Reviews Source Type: research