Introducing rotavirus vaccination in Nigeria highly cost effective
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - January 1, 2021 Category: Drugs & Pharmacology Source Type: news

Fiji's vaccine program reduces childhood death and illness: study
(University of Melbourne) Fiji's national vaccine program against pneumonia, a serious lung condition, and rotavirus, a common disease which causes severe diarrhoea and vomiting, has reduced illness and death, new research shows. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 25, 2020 Category: Infectious Diseases Source Type: news

How rotavirus causes severe gastrointestinal disease
(Baylor College of Medicine) Using intercellular calcium waves, rotavirus amplifies its ability to cause disease beyond the cells it directly infects. This is the first virus identified to activate ADP-mediated intercellular calcium waves. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 19, 2020 Category: International Medicine & Public Health Source Type: news

Rotavirus induces intercellular calcium waves through ADP signaling
Rotavirus causes severe diarrheal disease in children by broadly dysregulating intestinal homeostasis. However, the underlying mechanism(s) of rotavirus-induced dysregulation remains unclear. We found that rotavirus-infected cells produce paracrine signals that manifested as intercellular calcium waves (ICWs), observed in cell lines and human intestinal enteroids. Rotavirus ICWs were caused by the release of extracellular adenosine 5'-diphosphate (ADP) that activated P2Y1 purinergic receptors on neighboring cells. ICWs were blocked by P2Y1 antagonists or CRISPR-Cas9 knockout of the P2Y1 receptor. Blocking the ADP signal re...
Source: ScienceNOW - November 19, 2020 Category: Science Authors: Chang-Graham, A. L., Perry, J. L., Engevik, M. A., Engevik, K. A., Scribano, F. J., Gebert, J. T., Danhof, H. A., Nelson, J. C., Kellen, J. S., Strtak, A. C., Sastri, N. P., Estes, M. K., Britton, R. A., Versalovic, J., Hyser, J. M. Tags: Microbiology, Molecular Biology, Online Only r-articles Source Type: news

The origin of diarrhea in rotavirus infection
(Source: ScienceNOW)
Source: ScienceNOW - November 19, 2020 Category: Science Authors: Stanifer, M., Boulant, S. Tags: perspective Source Type: news

Investigator at Children's Hospital Los Angeles awarded $3.4M to study rotavirus vaccine
(Children's Hospital Los Angeles) The rotavirus vaccine--which protects against diarrhea and resulting dehydration-- is less effective in children in middle- and low-income countries. Investigators will use genomics to optimize effectiveness of the vaccine in order to decrease hospitalizations and deaths in young children worldwide. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 9, 2020 Category: Infectious Diseases Source Type: news

Revenge against rotavirus
(Source: ScienceNOW)
Source: ScienceNOW - October 8, 2020 Category: Science Authors: Fogg, C. N. Tags: twis Source Type: news

Biomedical sciences researchers find new way to prevent and cure rotavirus, other viral infections
(Georgia State University) A combination of two substances secreted by the immune system can cure and prevent rotavirus infection, as well as potentially treat other viral infections that target epithelial cells, which cover body surfaces such as skin, blood vessels, organs and the urinary tract, according to researchers in the Institute for Biomedical Sciences at Georgia State University. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 2, 2020 Category: Infectious Diseases Source Type: news

Slow-growing rotavirus mutant reveals early steps of viral assembly
(Baylor College of Medicine) A serendipitous observation led researchers at Baylor College of Medicine to uncover new insights into the formation of rotavirus viroplasms. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 23, 2020 Category: Biology Source Type: news

Mystery solved, rotavirus VP3 is a unique capping machine
(Baylor College of Medicine) After eluding researchers for more than 30 years, the VP3 protein of rotavirus has finally revealed its unique structure and function to a team led by scientists at Baylor College of Medicine. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 16, 2020 Category: Infectious Diseases Source Type: news

Rotavirus Vaccination, Type 1 Diabetes Not Linked in Children
MONDAY, March 9, 2020 -- Rotavirus vaccination seems not to be associated with type 1 diabetes in children, according to a study published online March 9 in JAMA Pediatrics. Jason M. Glanz, Ph.D., from Kaiser Permanente Colorado in Aurora, and... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 9, 2020 Category: Pharmaceuticals Source Type: news

Rotavirus May Be Overdiagnosed Due to Vaccine Virus Shedding Rotavirus May Be Overdiagnosed Due to Vaccine Virus Shedding
Nearly half of infants with rotavirus in their stool test positive due to vaccine virus shedding, new findings show.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - January 2, 2020 Category: Pathology Tags: Infectious Diseases News Source Type: news

Immune mystery solved in mice points to better protection from rotavirus in humans
(University of Toronto) Researchers at the University of Toronto have discovered how a brief disruption to a molecular pathway in the guts of mice before they are born can compromise adult immunity to a common and often deadly intestinal virus. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 20, 2019 Category: International Medicine & Public Health Source Type: news

Rotavirus Vaccination: 5 Things to Know Rotavirus Vaccination: 5 Things to Know
With rotavirus vaccination rates lagging behind those of other childhood vaccines, many children still suffer from severe rotavirus disease. Here are five things to know.CDC Expert Commentary (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 2, 2019 Category: Consumer Health News Tags: Pediatrics Commentary Source Type: news

Rotavirus, Hib, PCV immunisation large economic benefits in India
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - October 31, 2019 Category: Drugs & Pharmacology Source Type: news