Metabolomic profiling of wild rooibos (Aspalathus linearis) ecotypes and their antioxidant-derived phytopharmaceutical potential
AbstractIntroductionAspalathus linearis (commonly known as rooibos) is endemic to the Cape Floristic Region of South Africa and is a popular herbal drink and skin phytotherapeutic ingredient, with health benefits derived primarily from its unique phenolic content. Several, seemingly habitat-specific ecotypes from the Cederberg (Western Cape) and Northern Cape have morphological, ecological, genetic and biochemical differences.Objectives and methodsDespite the commercial popularity of the cultivated variety, the uncultivated ecotypes are largely understudied. To address gaps in knowledge about the biochemical constituency, ...
Source: Metabolomics - April 14, 2024 Category: Biology Source Type: research
Fermented Rooibos tea (Aspalathus linearis) Ameliorates Sodium Fluoride-Induced Cardiorenal Toxicity, Oxidative Stress, and Inflammation via Modulation of NF- κB/IκB/IκKB Signaling Pathway in Wistar Rats
This study evaluated the potential protective effect of fermented rooibos tea (RTE) on sodium fluoride (NaF)-induced cardiorenal toxicity in rats. Male Wistar rats (n = 56) were randomly allocated into one of seven equal groups: control, NaF (100 mg/kg orally), NaF + RTE (2%, w/v), NaF + RTE (4%, w/v), NaF + lisinopril (10 mg/kg orally), 2% RTE, and 4% RTE. The experiment lasted for 14 days and RTE was administered to the rats as their sole source of drinking fluid. NaF induced cardiorenal toxicity indicated by elevated level of urea, creatinine, LDH, creatinine kinase-MB, and cardiac troponin I in the serum, accompanied b...
Source: Cardiovascular Toxicology - February 5, 2024 Category: Cardiology Authors: Olawale Razaq Ajuwon Toyosi Abiodun Adeleke Basiru Olaitan Ajiboye Akeem Olalekan Lawal Ibukun Folorunso Bartholomew Brai Fisayo Abraham Bamisaye John Adeolu Falode Ikenna Maximillian Odoh Kabirat Iyabode Adegbite Oluwasayo Bosede Adegoke Source Type: research
Translation of preclinical ethnomedicine data in LMICs: the example of rooibos
All disease, but especially non-communicable diseases, are related to dysfunction of one or more regulatory systems. In developing countries, long-term management of patients with chronic diseases has many challenges and is generally not financially viable, but Africa in particular, which is rich in diverse ethnomedicines presents a more feasible long-term therapeutic approach in this niche. However, despite comprehensive preclinical investigations on numerous plant-derived candidate medicines, only a small portion of these reach the patient as recognised medicines. In this review, we use the example of rooibos (Aspalathus...
Source: Frontiers in Pharmacology - December 19, 2023 Category: Drugs & Pharmacology Source Type: research
Breast cancer and obesity: Impact of rooibos on the inflammatory adipose microenvironment during hormonotherapy
Rationale: Obesity is associated with a chronic inflammatory state and adipocytes participate in the installation of the tumor inflammatory environment. Breast cancer BC patients have the highest prevalence of uncontrolled food supplement consumption. The effect of rooibos extract (ExRob), rich in polyphenols, was evaluated to clarify its impact on adipocytes, inflammation and hormonotherapy, in a situation of BC associated with obesity. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: R. Nehme Source Type: research
Evaluation of chemical constituents of Rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia) as adenosine A1/A2A receptor ligands
AbstractRooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia) are popular tisanes in South Africa and are of growing interest due to the wide variety of flavonoids and other phytochemicals they contain. Despite their history as herbal teas and traditional medicines, the chemical constituents of these tisanes have yet to be studied for their effects on adenosine receptors. A series of 30 commercially available chemical constituents of Rooibos and Honeybush were investigated via radioligand binding studies to determine their adenosine A1 and A2A receptor affinity at both rat and human subtypes in order to establi...
Source: Medicinal Chemistry Research - October 5, 2023 Category: Chemistry Source Type: research
Rare blue dye faces risky path from rainforest to product
Polines, Colombia—
The road ends in Luz del Mundo. A few kilometers’ walk from here, just across the Chigorodó River, lies Polines, a scattering of open-sided houses on the edge of the forest. It’s a settlement of Indigenous Emberá people, about 80,000 of whom live in communities across Colombia and Panama. On a recent hot day, an Emberá man named Alirio Niaza scaled a large tree. Standing on one of the lower branches, he wielded a long pole with shears at the end. He carefully positioned the tip against a tiny branch, then pulled a cord that closed the blades. With a thud, a green, fist-size fruit landed in ...
Source: Science of Aging Knowledge Environment - June 15, 2023 Category: Geriatrics Source Type: research
The effect of Aspalathin linearis, Cyclopia intermedia and Sutherlandia frutescene on sperm functional parameters of healthy male wistar rats
Conclusion: In summary, animals treated with the respective infusions presented with a percentage increase in SOD activity but have reduced sperm motility and decreased normal morphology. Paradoxically, they presented with increased sperm concentration. Hence, it is presumed that rooibos, honeybush and sutherlandia may enhance sperm quantity (concentration) but may impair sperm quality (motility morphology) when consumed by healthy animals. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - June 7, 2023 Category: Physiology Source Type: research
Rooibos (Aspalathus linearis) and its constituent quercetin can suppress ovarian cell functions and their response to FSH
Physiol Res. 2023 Apr 30;72(2):269-280.ABSTRACTRooibos (Aspalathus linearis Brum. f) can directly influence female reproduction, but whether rooibos can influence the response of ovarian cells to FSH and whether the rooibos effects are due to the presence of quercetin remain unknown. We compared the influence of rooibos extract and quercetin (both at 10 µg/ml-1) on porcine ovarian granulosa cells cultured with and without FSH (0, 1, 10 or 100 ng/ml-1). The expression of intracellular proliferation (PCNA, cyclin B1) and apoptosis (bax, caspase 3) markers in the cells was detected by immunocytochemistry. The release of prog...
Source: Physiological Research - May 9, 2023 Category: Physiology Authors: A V Sirotkin Z Fabova W Aldahmash A Alshamrani A H Harrath Source Type: research
Rooibos (Aspalathus linearis) and its constituent quercetin can suppress ovarian cell functions and their response to FSH
Physiol Res. 2023 Apr 30;72(2):269-280.ABSTRACTRooibos (Aspalathus linearis Brum. f) can directly influence female reproduction, but whether rooibos can influence the response of ovarian cells to FSH and whether the rooibos effects are due to the presence of quercetin remain unknown. We compared the influence of rooibos extract and quercetin (both at 10 µg/ml-1) on porcine ovarian granulosa cells cultured with and without FSH (0, 1, 10 or 100 ng/ml-1). The expression of intracellular proliferation (PCNA, cyclin B1) and apoptosis (bax, caspase 3) markers in the cells was detected by immunocytochemistry. The release of prog...
Source: Physiological Research - May 9, 2023 Category: Physiology Authors: A V Sirotkin Z Fabova W Aldahmash A Alshamrani A H Harrath Source Type: research
Rooibos (Aspalathus linearis) and its constituent quercetin can suppress ovarian cell functions and their response to FSH
Physiol Res. 2023 Apr 30;72(2):269-280.ABSTRACTRooibos (Aspalathus linearis Brum. f) can directly influence female reproduction, but whether rooibos can influence the response of ovarian cells to FSH and whether the rooibos effects are due to the presence of quercetin remain unknown. We compared the influence of rooibos extract and quercetin (both at 10 µg/ml-1) on porcine ovarian granulosa cells cultured with and without FSH (0, 1, 10 or 100 ng/ml-1). The expression of intracellular proliferation (PCNA, cyclin B1) and apoptosis (bax, caspase 3) markers in the cells was detected by immunocytochemistry. The release of prog...
Source: Physiological Research - May 9, 2023 Category: Physiology Authors: A V Sirotkin Z Fabova W Aldahmash A Alshamrani A H Harrath Source Type: research
Rooibos (Aspalathus linearis) and its constituent quercetin can suppress ovarian cell functions and their response to FSH
Physiol Res. 2023 Apr 30;72(2):269-280.ABSTRACTRooibos (Aspalathus linearis Brum. f) can directly influence female reproduction, but whether rooibos can influence the response of ovarian cells to FSH and whether the rooibos effects are due to the presence of quercetin remain unknown. We compared the influence of rooibos extract and quercetin (both at 10 µg/ml-1) on porcine ovarian granulosa cells cultured with and without FSH (0, 1, 10 or 100 ng/ml-1). The expression of intracellular proliferation (PCNA, cyclin B1) and apoptosis (bax, caspase 3) markers in the cells was detected by immunocytochemistry. The release of prog...
Source: Physiological Research - May 9, 2023 Category: Physiology Authors: A V Sirotkin Z Fabova W Aldahmash A Alshamrani A H Harrath Source Type: research
Rooibos (Aspalathus linearis) and its constituent quercetin can suppress ovarian cell functions and their response to FSH
Physiol Res. 2023 Apr 30;72(2):269-280.ABSTRACTRooibos (Aspalathus linearis Brum. f) can directly influence female reproduction, but whether rooibos can influence the response of ovarian cells to FSH and whether the rooibos effects are due to the presence of quercetin remain unknown. We compared the influence of rooibos extract and quercetin (both at 10 µg/ml-1) on porcine ovarian granulosa cells cultured with and without FSH (0, 1, 10 or 100 ng/ml-1). The expression of intracellular proliferation (PCNA, cyclin B1) and apoptosis (bax, caspase 3) markers in the cells was detected by immunocytochemistry. The release of prog...
Source: Physiological Research - May 9, 2023 Category: Physiology Authors: A V Sirotkin Z Fabova W Aldahmash A Alshamrani A H Harrath Source Type: research
Rooibos (Aspalathus linearis) and its constituent quercetin can suppress ovarian cell functions and their response to FSH
Physiol Res. 2023 Apr 30;72(2):269-280.ABSTRACTRooibos (Aspalathus linearis Brum. f) can directly influence female reproduction, but whether rooibos can influence the response of ovarian cells to FSH and whether the rooibos effects are due to the presence of quercetin remain unknown. We compared the influence of rooibos extract and quercetin (both at 10 µg/ml-1) on porcine ovarian granulosa cells cultured with and without FSH (0, 1, 10 or 100 ng/ml-1). The expression of intracellular proliferation (PCNA, cyclin B1) and apoptosis (bax, caspase 3) markers in the cells was detected by immunocytochemistry. The release of prog...
Source: Cell Research - May 9, 2023 Category: Cytology Authors: A V Sirotkin Z Fabova W Aldahmash A Alshamrani A H Harrath Source Type: research
Rooibos (Aspalathus linearis) and its constituent quercetin can suppress ovarian cell functions and their response to FSH
Physiol Res. 2023 Apr 30;72(2):269-280.ABSTRACTRooibos (Aspalathus linearis Brum. f) can directly influence female reproduction, but whether rooibos can influence the response of ovarian cells to FSH and whether the rooibos effects are due to the presence of quercetin remain unknown. We compared the influence of rooibos extract and quercetin (both at 10 µg/ml-1) on porcine ovarian granulosa cells cultured with and without FSH (0, 1, 10 or 100 ng/ml-1). The expression of intracellular proliferation (PCNA, cyclin B1) and apoptosis (bax, caspase 3) markers in the cells was detected by immunocytochemistry. The release of prog...
Source: Physiological Research - May 9, 2023 Category: Physiology Authors: A V Sirotkin Z Fabova W Aldahmash A Alshamrani A H Harrath Source Type: research
