Insights into binding molecular mechanism of hemagglutinin H3N2 of influenza virus complexed with arbidol and its derivative: A molecular dynamics simulation perspective
Comput Biol Chem. 2022 Aug 28;101:107764. doi: 10.1016/j.compbiolchem.2022.107764. Online ahead of print.ABSTRACTRecently, the H3N2 influenza outbreak has caused serious global public health concern for future control of the next influenza pandemic. Since using current anti-influenza drugs targeting neuraminidase (oseltamivir and zanamivir) and the proton M2 channel (amantadine and rimantadine) leads to drug resistance, it is essential to seek new anti-viral agents that act on additional viral targets. Hemagglutinin (HA), a glycoprotein embedded in the viral surface and playing a critical role in influenza the viral replic...
Source: Computational Biology and Chemistry - September 1, 2022 Category: Bioinformatics Authors: Thitiya Boonma Nattharuja Soikudrua Bodee Nutho Thanyada Rungrotmongkol Nadtanet Nunthaboot Source Type: research
Insights into binding molecular mechanism of hemagglutinin H3N2 of influenza virus complexed with arbidol and its derivative: A molecular dynamics simulation perspective
Comput Biol Chem. 2022 Aug 28;101:107764. doi: 10.1016/j.compbiolchem.2022.107764. Online ahead of print.ABSTRACTRecently, the H3N2 influenza outbreak has caused serious global public health concern for future control of the next influenza pandemic. Since using current anti-influenza drugs targeting neuraminidase (oseltamivir and zanamivir) and the proton M2 channel (amantadine and rimantadine) leads to drug resistance, it is essential to seek new anti-viral agents that act on additional viral targets. Hemagglutinin (HA), a glycoprotein embedded in the viral surface and playing a critical role in influenza the viral replic...
Source: Computational Biology and Chemistry - September 1, 2022 Category: Bioinformatics Authors: Thitiya Boonma Nattharuja Soikudrua Bodee Nutho Thanyada Rungrotmongkol Nadtanet Nunthaboot Source Type: research
Insights into binding molecular mechanism of hemagglutinin H3N2 of influenza virus complexed with arbidol and its derivative: A molecular dynamics simulation perspective
Comput Biol Chem. 2022 Aug 28;101:107764. doi: 10.1016/j.compbiolchem.2022.107764. Online ahead of print.ABSTRACTRecently, the H3N2 influenza outbreak has caused serious global public health concern for future control of the next influenza pandemic. Since using current anti-influenza drugs targeting neuraminidase (oseltamivir and zanamivir) and the proton M2 channel (amantadine and rimantadine) leads to drug resistance, it is essential to seek new anti-viral agents that act on additional viral targets. Hemagglutinin (HA), a glycoprotein embedded in the viral surface and playing a critical role in influenza the viral replic...
Source: Computational Biology and Chemistry - September 1, 2022 Category: Bioinformatics Authors: Thitiya Boonma Nattharuja Soikudrua Bodee Nutho Thanyada Rungrotmongkol Nadtanet Nunthaboot Source Type: research
Insights into binding molecular mechanism of hemagglutinin H3N2 of influenza virus complexed with arbidol and its derivative: A molecular dynamics simulation perspective
Comput Biol Chem. 2022 Aug 28;101:107764. doi: 10.1016/j.compbiolchem.2022.107764. Online ahead of print.ABSTRACTRecently, the H3N2 influenza outbreak has caused serious global public health concern for future control of the next influenza pandemic. Since using current anti-influenza drugs targeting neuraminidase (oseltamivir and zanamivir) and the proton M2 channel (amantadine and rimantadine) leads to drug resistance, it is essential to seek new anti-viral agents that act on additional viral targets. Hemagglutinin (HA), a glycoprotein embedded in the viral surface and playing a critical role in influenza the viral replic...
Source: Computational Biology and Chemistry - September 1, 2022 Category: Bioinformatics Authors: Thitiya Boonma Nattharuja Soikudrua Bodee Nutho Thanyada Rungrotmongkol Nadtanet Nunthaboot Source Type: research
Insights into binding molecular mechanism of hemagglutinin H3N2 of influenza virus complexed with arbidol and its derivative: A molecular dynamics simulation perspective
Comput Biol Chem. 2022 Aug 28;101:107764. doi: 10.1016/j.compbiolchem.2022.107764. Online ahead of print.ABSTRACTRecently, the H3N2 influenza outbreak has caused serious global public health concern for future control of the next influenza pandemic. Since using current anti-influenza drugs targeting neuraminidase (oseltamivir and zanamivir) and the proton M2 channel (amantadine and rimantadine) leads to drug resistance, it is essential to seek new anti-viral agents that act on additional viral targets. Hemagglutinin (HA), a glycoprotein embedded in the viral surface and playing a critical role in influenza the viral replic...
Source: Computational Biology and Chemistry - September 1, 2022 Category: Bioinformatics Authors: Thitiya Boonma Nattharuja Soikudrua Bodee Nutho Thanyada Rungrotmongkol Nadtanet Nunthaboot Source Type: research
Characterization of influenza B viruses with reduced susceptibility to influenza neuraminidase inhibitors
Antiviral Res. 2022 Mar 15;200:105280. doi: 10.1016/j.antiviral.2022.105280. Online ahead of print.ABSTRACTA total of 3425 influenza B viruses collected from the Asia-Pacific region were tested against the four registered neuraminidase inhibitors (NAIs) (oseltamivir carboxylate, zanamivir, peramivir and laninamivir) as part of the routine surveillance work at the WHO Collaborating Centre for Research and Reference on Influenza, Melbourne between 2016 and 2020. Forty-five influenza B viruses with reduced susceptibility to one or more NAIs were identified. While the majority of these had neuraminidase (NA) mutations that wer...
Source: Antiviral Research - March 19, 2022 Category: Virology Authors: Sook Kwan Brown Yeu-Yang Tseng Ammar Aziz Mariana Baz Ian G Barr Source Type: research
Characterization of influenza B viruses with reduced susceptibility to influenza neuraminidase inhibitors
Antiviral Res. 2022 Mar 15;200:105280. doi: 10.1016/j.antiviral.2022.105280. Online ahead of print.ABSTRACTA total of 3425 influenza B viruses collected from the Asia-Pacific region were tested against the four registered neuraminidase inhibitors (NAIs) (oseltamivir carboxylate, zanamivir, peramivir and laninamivir) as part of the routine surveillance work at the WHO Collaborating Centre for Research and Reference on Influenza, Melbourne between 2016 and 2020. Forty-five influenza B viruses with reduced susceptibility to one or more NAIs were identified. While the majority of these had neuraminidase (NA) mutations that wer...
Source: Antiviral Research - March 19, 2022 Category: Virology Authors: Sook Kwan Brown Yeu-Yang Tseng Ammar Aziz Mariana Baz Ian G Barr Source Type: research
Characterization of influenza B viruses with reduced susceptibility to influenza neuraminidase inhibitors
Antiviral Res. 2022 Mar 15:105280. doi: 10.1016/j.antiviral.2022.105280. Online ahead of print.ABSTRACTA total of 3425 influenza B viruses collected from the Asia-Pacific region were tested against the four registered neuraminidase inhibitors (NAIs) (oseltamivir carboxylate, zanamivir, peramivir and laninamivir) as part of the routine surveillance work at the WHO Collaborating Centre for Research and Reference on Influenza, Melbourne between 2016 and 2020. Forty-five influenza B viruses with reduced susceptibility to one or more NAIs were identified. While the majority of these had neuraminidase (NA) mutations that were kn...
Source: Antiviral Research - March 19, 2022 Category: Virology Authors: Sook Kwan Brown Yeu-Yang Tseng Ammar Aziz Mariana Baz Ian G Barr Source Type: research
Characterization of influenza B viruses with reduced susceptibility to influenza neuraminidase inhibitors
Antiviral Res. 2022 Mar 15;200:105280. doi: 10.1016/j.antiviral.2022.105280. Online ahead of print.ABSTRACTA total of 3425 influenza B viruses collected from the Asia-Pacific region were tested against the four registered neuraminidase inhibitors (NAIs) (oseltamivir carboxylate, zanamivir, peramivir and laninamivir) as part of the routine surveillance work at the WHO Collaborating Centre for Research and Reference on Influenza, Melbourne between 2016 and 2020. Forty-five influenza B viruses with reduced susceptibility to one or more NAIs were identified. While the majority of these had neuraminidase (NA) mutations that wer...
Source: Antiviral Research - March 19, 2022 Category: Virology Authors: Sook Kwan Brown Yeu-Yang Tseng Ammar Aziz Mariana Baz Ian G Barr Source Type: research
Characterization of influenza B viruses with reduced susceptibility to influenza neuraminidase inhibitors
Antiviral Res. 2022 Mar 15;200:105280. doi: 10.1016/j.antiviral.2022.105280. Online ahead of print.ABSTRACTA total of 3425 influenza B viruses collected from the Asia-Pacific region were tested against the four registered neuraminidase inhibitors (NAIs) (oseltamivir carboxylate, zanamivir, peramivir and laninamivir) as part of the routine surveillance work at the WHO Collaborating Centre for Research and Reference on Influenza, Melbourne between 2016 and 2020. Forty-five influenza B viruses with reduced susceptibility to one or more NAIs were identified. While the majority of these had neuraminidase (NA) mutations that wer...
Source: Antiviral Research - March 19, 2022 Category: Virology Authors: Sook Kwan Brown Yeu-Yang Tseng Ammar Aziz Mariana Baz Ian G Barr Source Type: research
Characterization of influenza B viruses with reduced susceptibility to influenza neuraminidase inhibitors
Antiviral Res. 2022 Mar 15;200:105280. doi: 10.1016/j.antiviral.2022.105280. Online ahead of print.ABSTRACTA total of 3425 influenza B viruses collected from the Asia-Pacific region were tested against the four registered neuraminidase inhibitors (NAIs) (oseltamivir carboxylate, zanamivir, peramivir and laninamivir) as part of the routine surveillance work at the WHO Collaborating Centre for Research and Reference on Influenza, Melbourne between 2016 and 2020. Forty-five influenza B viruses with reduced susceptibility to one or more NAIs were identified. While the majority of these had neuraminidase (NA) mutations that wer...
Source: Antiviral Research - March 19, 2022 Category: Virology Authors: Sook Kwan Brown Yeu-Yang Tseng Ammar Aziz Mariana Baz Ian G Barr Source Type: research
National FluWatch mid-season report, 2021-2022: Sporadic influenza activity returns
Can Commun Dis Rep. 2022 Jan 26;48(1):39-45. doi: 10.14745/ccdr.v48i01a06. eCollection 2022 Jan 26.ABSTRACTSurveillance for Canada's 2021-2022 seasonal influenza epidemic began in epidemiological week 35 (the week starting August 29, 2021) during the ongoing coronavirus disease 2019 (COVID-19) global public health emergency. In the 2021-2022 surveillance season to date, there has been a return of persistent sporadic influenza activity, and the first influenza-associated hospitalizations since mid-2020 have been reported. However, as of week 52 (week ending 01/01/2022) activity has remained sporadic, and no influenza-confir...
Source: Can Commun Dis Rep - March 11, 2022 Category: Infectious Diseases Authors: Christina Bancej Abbas Rahal Liza Lee Steven Buckrell Kara Schmidt Nathalie Bastien Source Type: research
National FluWatch mid-season report, 2021-2022: Sporadic influenza activity returns
Can Commun Dis Rep. 2022 Jan 26;48(1):39-45. doi: 10.14745/ccdr.v48i01a06. eCollection 2022 Jan 26.ABSTRACTSurveillance for Canada's 2021-2022 seasonal influenza epidemic began in epidemiological week 35 (the week starting August 29, 2021) during the ongoing coronavirus disease 2019 (COVID-19) global public health emergency. In the 2021-2022 surveillance season to date, there has been a return of persistent sporadic influenza activity, and the first influenza-associated hospitalizations since mid-2020 have been reported. However, as of week 52 (week ending 01/01/2022) activity has remained sporadic, and no influenza-confir...
Source: Can Commun Dis Rep - March 11, 2022 Category: Infectious Diseases Authors: Christina Bancej Abbas Rahal Liza Lee Steven Buckrell Kara Schmidt Nathalie Bastien Source Type: research
National FluWatch mid-season report, 2021-2022: Sporadic influenza activity returns
Can Commun Dis Rep. 2022 Jan 26;48(1):39-45. doi: 10.14745/ccdr.v48i01a06. eCollection 2022 Jan 26.ABSTRACTSurveillance for Canada's 2021-2022 seasonal influenza epidemic began in epidemiological week 35 (the week starting August 29, 2021) during the ongoing coronavirus disease 2019 (COVID-19) global public health emergency. In the 2021-2022 surveillance season to date, there has been a return of persistent sporadic influenza activity, and the first influenza-associated hospitalizations since mid-2020 have been reported. However, as of week 52 (week ending 01/01/2022) activity has remained sporadic, and no influenza-confir...
Source: Can Commun Dis Rep - March 11, 2022 Category: Infectious Diseases Authors: Christina Bancej Abbas Rahal Liza Lee Steven Buckrell Kara Schmidt Nathalie Bastien Source Type: research
National FluWatch mid-season report, 2021-2022: Sporadic influenza activity returns
Can Commun Dis Rep. 2022 Jan 26;48(1):39-45. doi: 10.14745/ccdr.v48i01a06. eCollection 2022 Jan 26.ABSTRACTSurveillance for Canada's 2021-2022 seasonal influenza epidemic began in epidemiological week 35 (the week starting August 29, 2021) during the ongoing coronavirus disease 2019 (COVID-19) global public health emergency. In the 2021-2022 surveillance season to date, there has been a return of persistent sporadic influenza activity, and the first influenza-associated hospitalizations since mid-2020 have been reported. However, as of week 52 (week ending 01/01/2022) activity has remained sporadic, and no influenza-confir...
Source: Can Commun Dis Rep - March 11, 2022 Category: Infectious Diseases Authors: Christina Bancej Abbas Rahal Liza Lee Steven Buckrell Kara Schmidt Nathalie Bastien Source Type: research
