Two phytocompounds from Schinopsis brasiliensis show promising antiviral activity with multiples targets in Influenza A virus
An Acad Bras Cienc. 2021 Nov 22;93(suppl 4):e20210964. doi: 10.1590/0001-3765202120210964. eCollection 2021.ABSTRACTInfluenza A virus, the main flu agent, affects billions of people worldwide. Conventional treatments still present limitations related to drug-resistance and severe side effects. As a result, natural product-derived molecules have been increasingly investigated as prospect drug candidates. Therefore, the aim of this study was to investigate the possible anti-flu activity and to evaluate the toxicity and pharmacokinetic parameters, by in silico approaches, of the Schinopsis brasiliensis Engl. phytochemical com...
Source: An Acad Bras Cienc - November 24, 2021 Category: Science Authors: Pedro Henrique Sette-DE-Souza Moan J F Costa F ábio A C Araújo Everton N Alencar Lucas Amaral-Machado Source Type: research
Two phytocompounds from Schinopsis brasiliensis show promising antiviral activity with multiples targets in Influenza A virus
An Acad Bras Cienc. 2021 Nov 22;93(suppl 4):e20210964. doi: 10.1590/0001-3765202120210964. eCollection 2021.ABSTRACTInfluenza A virus, the main flu agent, affects billions of people worldwide. Conventional treatments still present limitations related to drug-resistance and severe side effects. As a result, natural product-derived molecules have been increasingly investigated as prospect drug candidates. Therefore, the aim of this study was to investigate the possible anti-flu activity and to evaluate the toxicity and pharmacokinetic parameters, by in silico approaches, of the Schinopsis brasiliensis Engl. phytochemical com...
Source: An Acad Bras Cienc - November 24, 2021 Category: Science Authors: Pedro Henrique Sette-DE-Souza Moan J F Costa F ábio A C Araújo Everton N Alencar Lucas Amaral-Machado Source Type: research
Two phytocompounds from Schinopsis brasiliensis show promising antiviral activity with multiples targets in Influenza A virus
An Acad Bras Cienc. 2021 Nov 22;93(suppl 4):e20210964. doi: 10.1590/0001-3765202120210964. eCollection 2021.ABSTRACTInfluenza A virus, the main flu agent, affects billions of people worldwide. Conventional treatments still present limitations related to drug-resistance and severe side effects. As a result, natural product-derived molecules have been increasingly investigated as prospect drug candidates. Therefore, the aim of this study was to investigate the possible anti-flu activity and to evaluate the toxicity and pharmacokinetic parameters, by in silico approaches, of the Schinopsis brasiliensis Engl. phytochemical com...
Source: An Acad Bras Cienc - November 24, 2021 Category: Science Authors: Pedro Henrique Sette-DE-Souza Moan J F Costa F ábio A C Araújo Everton N Alencar Lucas Amaral-Machado Source Type: research
Two phytocompounds from Schinopsis brasiliensis show promising antiviral activity with multiples targets in Influenza A virus
An Acad Bras Cienc. 2021 Nov 22;93(suppl 4):e20210964. doi: 10.1590/0001-3765202120210964. eCollection 2021.ABSTRACTInfluenza A virus, the main flu agent, affects billions of people worldwide. Conventional treatments still present limitations related to drug-resistance and severe side effects. As a result, natural product-derived molecules have been increasingly investigated as prospect drug candidates. Therefore, the aim of this study was to investigate the possible anti-flu activity and to evaluate the toxicity and pharmacokinetic parameters, by in silico approaches, of the Schinopsis brasiliensis Engl. phytochemical com...
Source: An Acad Bras Cienc - November 24, 2021 Category: Science Authors: Pedro Henrique Sette-DE-Souza Moan J F Costa F ábio A C Araújo Everton N Alencar Lucas Amaral-Machado Source Type: research
Two phytocompounds from Schinopsis brasiliensis show promising antiviral activity with multiples targets in Influenza A virus
An Acad Bras Cienc. 2021 Nov 22;93(suppl 4):e20210964. doi: 10.1590/0001-3765202120210964. eCollection 2021.ABSTRACTInfluenza A virus, the main flu agent, affects billions of people worldwide. Conventional treatments still present limitations related to drug-resistance and severe side effects. As a result, natural product-derived molecules have been increasingly investigated as prospect drug candidates. Therefore, the aim of this study was to investigate the possible anti-flu activity and to evaluate the toxicity and pharmacokinetic parameters, by in silico approaches, of the Schinopsis brasiliensis Engl. phytochemical com...
Source: An Acad Bras Cienc - November 24, 2021 Category: Science Authors: Pedro Henrique Sette-DE-Souza Moan J F Costa F ábio A C Araújo Everton N Alencar Lucas Amaral-Machado Source Type: research
Two phytocompounds from Schinopsis brasiliensis show promising antiviral activity with multiples targets in Influenza A virus
An Acad Bras Cienc. 2021 Nov 22;93(suppl 4):e20210964. doi: 10.1590/0001-3765202120210964. eCollection 2021.ABSTRACTInfluenza A virus, the main flu agent, affects billions of people worldwide. Conventional treatments still present limitations related to drug-resistance and severe side effects. As a result, natural product-derived molecules have been increasingly investigated as prospect drug candidates. Therefore, the aim of this study was to investigate the possible anti-flu activity and to evaluate the toxicity and pharmacokinetic parameters, by in silico approaches, of the Schinopsis brasiliensis Engl. phytochemical com...
Source: An Acad Bras Cienc - November 24, 2021 Category: Science Authors: Pedro Henrique Sette-DE-Souza Moan J F Costa F ábio A C Araújo Everton N Alencar Lucas Amaral-Machado Source Type: research
[ASAP] Zanamivir –Cholesterol Conjugate: A Long-Acting Neuraminidase Inhibitor with Potent Efficacy against Drug-Resistant Influenza Viruses
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01531 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 19, 2021 Category: Chemistry Authors: Xun Lv, Pengfei Wang, Chenning Li, Shuihong Cheng, Yuhai Bi, and Xuebing Li Source Type: research
A Liquid Chromatography with Tandem Mass Spectrometry BioAnalytical Method Development and Validation for the Quantification of Zanamivir in Biological Matrices
A. S. Mohammad* and Jayanthi Bangaru (Source: Indian Journal of Pharmaceutical Sciences)
Source: Indian Journal of Pharmaceutical Sciences - November 8, 2021 Category: Drugs & Pharmacology Source Type: research
The use of antiviral drugs in children
J Chemother. 2021 Oct 11:1-14. doi: 10.1080/1120009X.2021.1979746. Online ahead of print.ABSTRACTViral infections are particularly common among children. They often have a mild course, are self-limiting and do not need any specific treatment. However, in some cases, the disease can be severe and lead to permanent disabilities. A variety of antiviral drugs are available for the treatments of certain infectious agents: for instance, acyclovir is used to treat herpes simplex virus encephalitis. Recommendations for flu treatment may change according to the current epidemiological surveillance data, on the basis of which antivi...
Source: Journal of Chemotherapy - October 11, 2021 Category: Cancer & Oncology Authors: Marco Antonio Motisi Agnese Tamborino Sara Parigi Luisa Galli Maurizio de Martino Elena Chiappini Source Type: research
Influenza polymerase inhibitor resistance: Assessment of the current state of the art - A report of the isirv Antiviral group
Antiviral Res. 2021 Aug 4:105158. doi: 10.1016/j.antiviral.2021.105158. Online ahead of print.ABSTRACTIt is more than 20 years since the neuraminidase inhibitors, oseltamivir and zanamivir were approved for the treatment and prevention of influenza. Guidelines for global surveillance and methods for evaluating resistance were established initially by the Neuraminidase Inhibitor Susceptibility Network (NISN), which merged 10 years ago with the International Society for influenza and other Respiratory Virus Diseases (isirv) to become the isirv-Antiviral Group (isirv-AVG). With the ongoing development of new influenza polymer...
Source: Antiviral Research - August 7, 2021 Category: Virology Authors: Michael G Ison Frederick G Hayden Alan J Hay Larisa V Gubareva Elena A Govorkova Emi Takashita Jennifer L McKimm-Breschkin Source Type: research
Influenza polymerase inhibitor resistance: Assessment of the current state of the art - A report of the isirv Antiviral group
Antiviral Res. 2021 Aug 4:105158. doi: 10.1016/j.antiviral.2021.105158. Online ahead of print.ABSTRACTIt is more than 20 years since the neuraminidase inhibitors, oseltamivir and zanamivir were approved for the treatment and prevention of influenza. Guidelines for global surveillance and methods for evaluating resistance were established initially by the Neuraminidase Inhibitor Susceptibility Network (NISN), which merged 10 years ago with the International Society for influenza and other Respiratory Virus Diseases (isirv) to become the isirv-Antiviral Group (isirv-AVG). With the ongoing development of new influenza polymer...
Source: Antiviral Research - August 7, 2021 Category: Virology Authors: Michael G Ison Frederick G Hayden Alan J Hay Larisa V Gubareva Elena A Govorkova Emi Takashita Jennifer L McKimm-Breschkin Source Type: research
Influenza polymerase inhibitor resistance: Assessment of the current state of the art - A report of the isirv Antiviral group
Antiviral Res. 2021 Aug 4:105158. doi: 10.1016/j.antiviral.2021.105158. Online ahead of print.ABSTRACTIt is more than 20 years since the neuraminidase inhibitors, oseltamivir and zanamivir were approved for the treatment and prevention of influenza. Guidelines for global surveillance and methods for evaluating resistance were established initially by the Neuraminidase Inhibitor Susceptibility Network (NISN), which merged 10 years ago with the International Society for influenza and other Respiratory Virus Diseases (isirv) to become the isirv-Antiviral Group (isirv-AVG). With the ongoing development of new influenza polymer...
Source: Antiviral Research - August 7, 2021 Category: Virology Authors: Michael G Ison Frederick G Hayden Alan J Hay Larisa V Gubareva Elena A Govorkova Emi Takashita Jennifer L McKimm-Breschkin Source Type: research
