GSE234049 Cardiotoxic effects of mycotoxin citrinin on mammalian cells revealed by transcriptome profiling
In this study, we performed RNA-seq experiments in order to investigate the transcriptomic alterations induced by CTN-exposed rat H9c2 cardiomyocytes. The transcriptome profiling we obtained may reveal some evidence regarding the toxic effects of CTN on cardiac phenotypes, chromosome segregation, tubulin arrangement, mitochondrial functioning, and stress responses, etc. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - January 31, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus Source Type: research

Extraction process, physicochemical properties, and digestive performance of red yeast rice starch
AbstractIn the present study, taking red yeast rice (RYR) as the raw material, the optimum extraction process of RYR starch was investigated through a single-factor experiment and the Box –Behnken design: The liquid–to-solid ratio was 5 mL/g, the concentration of sodium hydroxide solution was 0.075 mol/L, and the extraction time was 3.1 h. Under these extraction conditions, the extraction rate of starch reached 90.077%. To explore the influence of solid-state fermentation on R YR starch, three different fermentation stages of RYR starch, raw rice starch, semi-gelatinized rice starch, and RYR starch were used as test...
Source: Biotechnology and Applied Biochemistry - December 22, 2023 Category: Biochemistry Authors: Mengting Bai, Kai Liu, Yulin Wang, Shuguang Hou, Xiaofang Li, Jia Luo Tags: ORIGINAL ARTICLE Source Type: research

The antihyperlipidemic effect of a combined supplement of standardized dry extracts of amla (Emblica officinalis), walnut (Juglans regia), olive (Olea europaea) and red yeast rice (Monascus purpureus) powder: Reduction in circulatory low-density lipoprotein-cholesterol (LDL-C) and remnant cholesterol (RC) levels in patients with hypercholesterolemia
Conclusion: According to the results of this study, a combined supplementation of amla, walnut, and olive extracts, and RYR powder exerts a significant antihyperlipidemic effect, leading to a decrease in circulatory LDL-C and RC levels in patients with hypercholesterolemia. The supplementation bears excellent safety and tolerability, and is rated as satisfactory and pursuable, even among patients with statin intolerance.Clinical Trial Registration: clinicaltrials.gov; identifier number: NCT06002893 (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 27, 2023 Category: Drugs & Pharmacology Source Type: research

Alternative lipid lowering strategies: State-of-the-art review of red yeast rice
Fitoterapia. 2023 Nov 4:105719. doi: 10.1016/j.fitote.2023.105719. Online ahead of print.ABSTRACTRed yeast rice (RYR) is an entirely natural product that originates from the fermentation of white rice (Oryza sativa) with a yeast, mainly Monascus Purpureus, and has been part of traditional Chinese medicine and diet since ancient times. It has generated great interest in recent years in the context of cardiovascular (CV) prevention due to its ability to inhibit endogenous cholesterol production, helping to achieve and maintain optimal plasma lipid concentrations. This review aims to make an extensive 360-degree assessment an...
Source: Fitoterapia - November 6, 2023 Category: Biochemistry Authors: Lorenzo Buzzelli Andrea Segreti Daniela Di Gioia Erika Lemme Maria Rosaria Squeo Antonio Nenna Giuseppe Di Gioia Source Type: research

Rhabdomyolysis or Severe Acute Hepatitis Associated with the Use of Red Yeast Rice Extracts: an Update from the Adverse Event Reporting Systems
AbstractPurpose of ReviewElevated plasma levels of low-density lipoprotein cholesterol (LDL-C) are a major risk factor for atherosclerotic cardiovascular disease (ASCVD), and lowering LDL-C reduces the risk of cardiovascular adverse events. Among natural approaches known for their lipid-lowering properties, red yeast rice (RYR) has a cholesterol-lowering effect due to the presence of bioactive components (monacolins) that act by inhibiting the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. In August 2018, the European Food Safety Authority (EFSA) concluded in its assessment of the use of RYR (furthe...
Source: Current Atherosclerosis Reports - October 13, 2023 Category: Cardiology Source Type: research

Three arms, double-blind, non-inferiority, randomized clinical study testing the lipid-lowering effect of a novel dietary supplement containing red yeast rice and artichoke extracts compared to Armolipid Plus < sup > ® < /sup > and placebo
CONCLUSIONS: Patients with polygenic hypercholesterolemia experienced a significant improvement in several cardiovascular risk factors in both ATC and Armolipid Plus® groups.PMID:37732047 | PMC:PMC10507752 | DOI:10.5114/aoms/167969 (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 21, 2023 Category: General Medicine Authors: Arrigo F G Cicero Federica Fogacci Giuliano Tocci Sergio D'Addato Elisa Grandi Maciej Banach Claudio Borghi Source Type: research