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Varian inks deal with Bionix
Radiation therapy firm Varian Medical Systems has signed a distribution agreement...Read more on AuntMinnie.comRelated Reading: Varian treats 1st patient with HyperArc Philips, Varian, IBA partner on Singapore cancer center FDA clears Varian's Halcyon rad therapy system AccuBoost names U.S. distributor Bionix launches radiation therapy tattoo system Bionix adds Medspira's Breath Hold (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - August 9, 2017 Category: Radiology Source Type: news

Varian Medical Systems Signs Brachytherapy Applicator Distribution Agreement with Bionix Radiation Therapy
PALO ALTO, Calif., Aug. 9, 2017 -- (Healthcare Sales & Marketing Network) -- Varian Medical Systems (NYSE: VAR) today announced it has signed an agreement with Bionix® Radiation Therapy to distribute Bionix brachytherapy applicators. Varian will marke... Devices, Oncology, Distribution Varian Medical Systems, Bionix Radiation Therapy, brachytherapy applicators (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - August 9, 2017 Category: Pharmaceuticals Source Type: news

Moffitt Cancer Center and Cvergenx partner to personalize radiation therapy
(H. Lee Moffitt Cancer Center& Research Institute) Moffitt's Radiation Oncology Department will utilize Cvergenx's Genomic-Adjusted Radiation Dose (GARD) model. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 9, 2017 Category: International Medicine & Public Health Source Type: news

ViewRay sees Q2 sales grow, net loss narrows
Image-guided radiation therapy developer ViewRay announced a boost in revenues...Read more on AuntMinnie.comRelated Reading: ViewRay to highlight MRIdian Linac research at AAPM 1st patients treated with ViewRay's MRIdian system ViewRay sees drop in Q1 revenue ViewRay boosts borrowing capacity ViewRay lands FDA clearance for MRI linac (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - August 8, 2017 Category: Radiology Source Type: news

Promising Drug Reduces Growth of Aggressive Mesothelioma
Scientists in Italy have found a platinum-based drug that successfully lessens growth of the most aggressive type of mesothelioma cancer cells. Researchers at the University of Salento discovered the experimental drug Ptac2S was more effective in reducing the spread of sarcomatoid malignant pleural mesothelioma cells in mice compared to cisplatin — the most widely used chemotherapy drug for treating mesothelioma. Sarcomatoid is the least common of the three mesothelioma cell types but is considered more aggressive and harder to treat. A diagnosis with the sarcomatoid cell type is typically associated with a poor pro...
Source: Asbestos and Mesothelioma News - August 7, 2017 Category: Environmental Health Authors: Matt Mauney Tags: Alimta alternatives to cisplatin Antonella Muscella Biphasic mesothelioma chemotherapy for mesothelioma chemotherapy resistance DNA adducts epithelioid mesothelioma genomic activities mesothelioma clinical trials mesothelioma survival Source Type: news

Faced with many options, men with prostate cancer get help choosing the right treatments
Like many men diagnosed with prostate cancer, Bill Pickett faced a tough question when he came to UCLA for treatment: how to fight it?Prostate cancer is one of the more curable cancers — it has a 96 percent survival rate 15 years after diagnosis, according to the American Cancer Society. The options men have after a diagnosis have different side effects and trade-offs. So choosing, for example, between radiation therapy or surgery, can be complicated for a person.“When you’re diagnosed with prostate cancer, you realize that each treatment can have very different side effects,” said Pickett, who...
Source: UCLA Newsroom: Health Sciences - August 4, 2017 Category: Universities & Medical Training Source Type: news

Elekta MR-linac Consortium Brings Founding Members Together With Clinicians From Five New Centers to Highlight Progress
International experts collaborate to advance magnetic resonance radiation therapy (MR/RT) as a transformative approach to cancer care STOCKHOLM, August 3, 2017 -- (Healthcare Sales & Marketing Network) -- Elekta (EKTA-B.ST) announced today that five le... Devices, Oncology Elekta, Elekta MR-linac Consortium, radiotherapy (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - August 3, 2017 Category: Pharmaceuticals Source Type: news

Accuray wins FDA nod for iDMS data management system
Accuray (NSDQ:ARAY)  said today it won FDA 510(k) clearance for its iDMS data management system designed for sharing data between the company’s treatment delivery platforms. The Sunnyvale, Calif.-based company said the iDMS system is designed to integrate data from its technology platforms, including the Radixact, TomoTherapy and CyberKnife systems, as well as the company’s Accuray Precision treatment planning and oncology information systems. The iDMS allows users to store and manage all patient and treatment data across multiple devices to allow for more informed, efficient radiation treatments, Acc...
Source: Mass Device - July 31, 2017 Category: Medical Devices Authors: Fink Densford Tags: 510(k) Food & Drug Administration (FDA) Regulatory/Compliance Software / IT Accuray Inc. Source Type: news

Elekta touts 21 studies at AAPM 2017
Radiation oncology vendor Elekta said its investigational Unity MR radiation...Read more on AuntMinnie.comRelated Reading: Elekta to install Bhutan's 1st linear accelerator Elekta begins installation of MR-linac system Elekta receives order from Ala. provider Elekta points to study of older lung cancer patients Elekta debuts MR-linac radiation therapy system at ESTRO (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - July 31, 2017 Category: Radiology Source Type: news

Founder of brain tumor program named Health Care Heroes Lifetime Achievement honoree
This year's Memphis Business Journal Health Care Heroes Lifetime Achievement winner spent 32 years at St. Jude Children's Research Hospital. Dr. Larry Kun joined St. Jude in 1984 to establish a department to treat cancer with radiation therapy and to initiate the hospital's multidisciplinary brain tumor program. The initiative eventually grew to become the largest pediatric brain tumor research program in the country. Before retiring last year, Kun served as St. Jude's clinical director and executive… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - July 31, 2017 Category: American Health Authors: Elle Perry Source Type: news

Boston Scientific warns on fluke S-ICD death
Boston Scientific (NYSE:BSX) last month alerted physicians after learning of a fluke incident involving its S-ICD pacemaker, in which a patient died when the device’s memory was corrupted by radiation. In a June letter to physicians, Marlborough, Mass.-based Boston Scientific wrote of “a single, isolated S-ICD event that resulted in a device-related patient death in May of this year.” “Boston Scientific engineers have determined that this patient’s S-ICD repeatedly delivered an atypical amount of energy (similar to the arrhythmia induction function) because a specific memory location was ...
Source: Mass Device - July 28, 2017 Category: Medical Devices Authors: Brad Perriello Tags: Cardiovascular Wall Street Beat Boston Scientific Cardiac Rhythm Management Source Type: news

Antiperspirant OK During Radiation Therapy Antiperspirant OK During Radiation Therapy
Most clinicians advise breast cancer patients who are undergoing radiation therapy to not use an antiperspirant, but a new study finds no scientific evidence to support this advice.Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 27, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Results of NRG-RTOG 0436 highlight need for biomarkers in treatment of esophageal cancer
(NRG Oncology) NRG-RTOG 0436 has determined that adding an epidermal growth factor receptor (EGFR) inhibitor to a chemo-radiation regimen does not improve overall survival for patients with locally advanced esophageal cancer treated in a non-operative manner. These results are reported in 'Effect of the Addition of Cetuximab to Paclitaxel, Cisplatin, and Radiation Therapy for Patients with Esophageal Cancer -- The NRG Oncology RTOG 0436 Phase 3 Randomized Clinical Trial,' which was recently published in the Journal of the American Medical Association Oncology. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 25, 2017 Category: International Medicine & Public Health Source Type: news

Elekta Introduces Advanced Cancer Treatment to Kingdom of Bhutan
THIMPHU, Bhutan, July 24, 2017 -- (Healthcare Sales & Marketing Network) -- Elekta (EKTA-B.ST) announced today that it has been chosen to deliver the first ever radiation therapy system to the Kingdom of Bhutan. The National Referral Hospital, the largest... Devices, Oncology Elekta, Elekta Compact, linear accelerator, radiotherapy (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - July 24, 2017 Category: Pharmaceuticals Source Type: news

Breast cancer patients can use antiperspirants during radiotherapy
(University of Pennsylvania School of Medicine) Women undergoing daily radiation therapy for breast cancer are commonly told they should not use antiperspirant for fear that it could cause greater radiation damage to the skin, but a new study from the Perelman School of Medicine at the University of Pennsylvania showed there was no difference in the radiation skin dose absorbed by these patients with or without these deodorants. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 24, 2017 Category: International Medicine & Public Health Source Type: news

ViewRay to highlight MRIdian Linac research at AAPM
Image-guided radiation therapy developer ViewRay plans to highlight 30 clinical...Read more on AuntMinnie.comRelated Reading: 1st patients treated with ViewRay's MRIdian system ViewRay sees drop in Q1 revenue ViewRay boosts borrowing capacity ViewRay lands FDA clearance for MRI linac ViewRay lands Japanese order (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - July 21, 2017 Category: Radiology Source Type: news

University Of Maryland School Of Medicine Scientist Receives Top Award for His Pioneering Work on Improving Radiation Therapy Outcome
Søren M. Bentzen, PhD, DMSc, a professor in the Department of Epidemiology and Public Health (EPH) at the University of Maryland School of Medicine (UM SOM), has been awarded a gold medal from the American Society for Radiation Oncology (ASTRO). This is the highest honor bestowed upon ASTRO members. It recognizes a distinguished scientist who has made major contributions to the field of radiation oncology. (Source: University of Maryland School of Medicine News Headlines)
Source: University of Maryland School of Medicine News Headlines - July 21, 2017 Category: Universities & Medical Training Source Type: news

Accuray touts study data in head-to-head between TomoTherapy and Varian ’ s RapidArc
Accuray (NSDQ:ARAY) today released data from a prospective study comparing its TomoTherapy intensity-modulated radiation therapy system with Varian Medical‘s (NYSE:VAR), RapidArc radiotherapy system, touting a higher survival rate for patients treated with its TomoTherapy system. Results from the study were published last month in the International Journal of Radiation Oncology – Biology – Physics. Accuray said that the 166-patient, multi-center study was the 1st to prospectively compare clinical outcomes across radiation platforms. In the study, 74 individuals were treated with the TomoTherapy...
Source: Mass Device - July 20, 2017 Category: Medical Devices Authors: Fink Densford Tags: Clinical Trials Oncology Accuray Inc. Varian Medical Systems Source Type: news

CU Boulder discovery could lead to better results for patients undergoing radiation
(University of Colorado at Boulder) A new study involving CU Boulder shows why some cells treated with radiation therapy for cancer leak chemical signals and damage unexposed healthy cells, findings that could lead to new medications that patients could take prior to radiation. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 19, 2017 Category: Cancer & Oncology Source Type: news

Radiation prior to surgery reduces risk of secondary tumors in early-stage breast cancer
(H. Lee Moffitt Cancer Center& Research Institute) Moffitt researchers found that patients who have neoadjuvant radiation therapy have a significantly lower risk of developing a second primary tumor at any site. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 17, 2017 Category: Cancer & Oncology Source Type: news

The Role of Genomic Techniques in Predicting Response to Radiation Therapy
The understanding of the relationship between genetic variation and an individual patient ’s response to radiation therapy has gained significant ground over the past several years. Genetic markers have been identified that could ultimately serve as the foundation for predictive models in clinical practice, and that hold the potential to revolutionize the delivery of precision medicine in oncology. (Source: CancerNetwork)
Source: CancerNetwork - July 15, 2017 Category: Cancer & Oncology Authors: Nicholas G. Zaorsky, MD Noelle L. Williams, MD Robert B. Den, MD Shivank Garg, MD Tu Dan, MD Tags: Oncology Journal Radiation Oncology Review Article Source Type: news

American Society for Radiation Oncology Updates Insurance Coverage Recommendations for Proton Therapy
Proton beam therapy model policy recommends expanded access to advanced radiation therapy treatment for cancer patients ARLINGTON, Va., July 13, 2017 -- (Healthcare Sales & Marketing Network) -- The American Society for Radiation Oncology (ASTRO) has i... Devices, Oncology ASTRO , proton beam, proton therapy, radiotherapy (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - July 13, 2017 Category: Pharmaceuticals Source Type: news

Radiotherapy boost based on PET not always helpful
Selectively increasing radiotherapy dose in tumor areas with significant uptake...Read more on AuntMinnie.comRelated Reading: Brain PET enhances radiation therapy planning Radiotherapy exploits advances in diagnostic imaging (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - July 13, 2017 Category: Radiology Source Type: news

Right-Sided Metastatic CRC Benefits From Adding SIRT to Chemotherapy
Patients with colorectal cancer that has metastasized to the liver derive a significant benefit from selective internal radiation therapy (SIRT) combined with chemotherapy if their primary tumor is a right-sided tumor, but not if it is a left-sided primary tumor. (Source: CancerNetwork)
Source: CancerNetwork - July 10, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Colorectal Cancer Gastrointestinal Cancer News Source Type: news

Medical News Today: Colorectal cancer: Adding SIRT to chemotherapy boosts survival
For patients with advanced colorectal cancer, new research suggests that adding selective internal radiation therapy to chemotherapy may prolong survival. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 7, 2017 Category: Consumer Health News Tags: Colorectal Cancer Source Type: news

SMART Protocol for Mesothelioma Adds Immunotherapy
In conclusion, we demonstrated the importance of the immune system in the benefit of clinical protocols using…radiation followed by surgery.” The post SMART Protocol for Mesothelioma Adds Immunotherapy appeared first on Mesothelioma Center - Vital Services for Cancer Patients & Families. (Source: Asbestos and Mesothelioma News)
Source: Asbestos and Mesothelioma News - July 6, 2017 Category: Environmental Health Authors: Walter Pacheco Tags: emerging treatments for mesothelioma immunotherapy for mesothelioma SMART mesothelioma SMART protocol mesothelioma smart protocol mix with immunotherapy Source Type: news

FDA requests more info on IsoRay ’ s GammaTile
IsoRay (NYSE:ISR) said today that the FDA requested additional data on the company’s pending 510(k) application for its GammaTile radiation therapy system. The Richland, Wash.-based company’s GammaTile is a radiation system using Cesium-131 radiation seeds embedded in a collagen ’tile’ which is designed to be placed in surgical margins at the time of surgery. “This is a good outcome for the novel GammaTile product. With the completion of additional testing anticipated by the end of 2017, we project potential 510(k) clearance of the GammaTile product in the 1st half of 2018 which would all...
Source: Mass Device - July 6, 2017 Category: Medical Devices Authors: Fink Densford Tags: Food & Drug Administration (FDA) Oncology IsoRay Source Type: news

A Rockville biotech could be the latest Md. firm to go public
The company said it needs the funding for clinical trials of two radiation therapy drugs. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - July 5, 2017 Category: Pharmaceuticals Authors: Andrea Cwieka Source Type: news

A Rockville biotech could be the latest D.C.-area firm to go public
The company said it needs the funding for clinical trials of two radiation therapy drugs. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - July 5, 2017 Category: American Health Authors: Andrea Cwieka Source Type: news

New Analysis Reveals First-Line Treatment Data on SIR-Spheres(R) Y-90 Resin Microspheres for Patients with Liver Metastases from Right-Sided Primary Colon Cancer
SIRFLOX and FOXFIRE Global findings suggest that adding liver-directed Selective Internal Radiation Therapy (SIRT) to standard first-line chemotherapy may improve overall survival in metastatic colorectal cancer (mCRC) patients with right-sided primary tum... Devices, Oncology Sirtex Medical, SIR-Spheres, Y-90 resin, microspheres, radiotherapy (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - July 3, 2017 Category: Pharmaceuticals Source Type: news

FDA clears Varian's Halcyon rad therapy system
The U.S. Food and Drug Administration (FDA) has cleared radiation oncology...Read more on AuntMinnie.comRelated Reading: Varian to build radiation oncology centers in Vietnam Varian awarded Thai proton therapy contract Varian installs proton therapy system in Fla. Varian launches Halcyon radiation therapy unit at ESTRO Varian adds to revenues in Q2 (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - June 29, 2017 Category: Radiology Source Type: news

Orlando Health's new $30M cancer center to have the latest technology
The new Orlando Health UF Health Cancer Center – Ocoee in Health Central hospital will use Central Florida's latest cancer-tracking technology called MRIdian. The cutting-edge technology provides a combination of simultaneous radiation therapy and magnetic resonance imaging (MRI) for cancer treatment. The MRIdian System from ViewRay Inc. (Na sdaq: VRAY) enables cancer specialists to directly view and track the tumor during treatment. Because it uses MRI technology instead of computed tomography… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - June 28, 2017 Category: Biotechnology Authors: Veronica Brezina Source Type: news

Orlando Health's new $30M cancer center to have the latest technology
The new Orlando Health UF Health Cancer Center – Ocoee in Health Central hospital will use Central Florida's latest cancer-tracking technology called MRIdian. The cutting-edge technology provides a combination of simultaneous radiation therapy and magnetic resonance imaging (MRI) for cancer treatment. The MRIdian System from ViewRay Inc. (Na sdaq: VRAY) enables cancer specialists to directly view and track the tumor during treatment. Because it uses MRI technology instead of computed tomography… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - June 28, 2017 Category: American Health Authors: Veronica Brezina Source Type: news

Study describes changes to structural brain networks after radiotherapy for brain tumors
(Mary Ann Liebert, Inc./Genetic Engineering News) Researchers compared the thickness of brain cortex in patients with brain tumors before and after radiation therapy was applied and found significant dose-dependent changes in the structural properties of cortical neural networks, at both the local and global level. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 26, 2017 Category: Cancer & Oncology Source Type: news

Elekta Aims for More Accurate Radiation Therapy with Unity
(Source: MDDI)
Source: MDDI - June 20, 2017 Category: Medical Devices Authors: MDDI Staff Tags: Medical Device Business Source Type: news

ASTRO Issued New Guideline on Use of SBRT in Early-Stage Lung Cancer
The American Society for Radiation Oncology issued a new clinical guideline for the use of stereotactic body radiation therapy in patients with early-stage lung cancer. (Source: CancerNetwork)
Source: CancerNetwork - June 16, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Lung Cancer News Source Type: news

Radiation therapy for brain cancer found to cause significant damage to the brain
(Natural News) Radiation therapy (RT) may be seen as an effective method in treating cancer, but it comes at a high cost. New research shows that RT does not just kill brain tumors, but even the healthy tissue surrounding them, causing significant damage in the brains of patients. The study was done by researchers at the... (Source: NaturalNews.com)
Source: NaturalNews.com - June 16, 2017 Category: Consumer Health News Source Type: news

Elekta points to study of older lung cancer patients
Radiation oncology vendor Elekta is highlighting research that found stereotactic...Read more on AuntMinnie.comRelated Reading: Elekta debuts MR-linac radiation therapy system at ESTRO Varian, Elekta settle patent dispute Elekta nabs Canadian Medical Device License Elekta gets FDA clearance for brachytherapy applicator Elekta to support ASTRO safety initiative (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - June 15, 2017 Category: Radiology Source Type: news

Stereotactic Body Radiation Therapy as an Alternative to Surgery in Early-Stage Non –Small-Cell Lung Cancer
Three randomized trials of SBRT vs surgical resection closed due to poor accrual, but an analysis of patients treated in these trials suggested that SBRT might even be superior to surgery. New trials are underway to further assess the question of whether SBRT can be the definitive treatment for early-stage NSCLC instead of surgery. (Source: CancerNetwork)
Source: CancerNetwork - June 15, 2017 Category: Cancer & Oncology Authors: Kenneth Rosenzweig, MD Tags: Lung Cancer Oncology Journal Review Article Source Type: news

AccuBoost names U.S. distributor
Women's health firm AccuBoost said Bionix Radiation Therapy has signed on to...Read more on AuntMinnie.comRelated Reading: AccuBoost wins trade grant AccuBoost signs Baptist Memorial Health Care AccuBoost adds Fla. site AccuBoost lands Minn. customer AccuBoost gets Fla. installation (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - June 14, 2017 Category: Radiology Source Type: news

How Math Is Reshaping Mesothelioma Chemotherapy
This study demonstrates the feasibility of this approach since both preliminary encouraging signs of activity and no unexpected toxicities were observed, in this heavily pre-treated patients’ population.” Study Size and Rarity of Mesothelioma Present Challenges As a phase I clinical trial, it is a novel approach at this point but a promising step for future chemotherapy treatment plan protocols. The limited number of patients in the study — nine NSCLC and three mesothelioma — is also problematic, but the planned second phase of the study will include the new model’s effect on the immune syste...
Source: Asbestos and Mesothelioma News - June 13, 2017 Category: Environmental Health Authors: Matt Mauney Tags: Aix-Marseille University anemia chemotherapy best vinorelbine regimen chemotherapy side effects Fabrice Barlesi low-dose oral chemotherapy drugs math cancer chemotherapy math to fight cancer mathematical modeling cancer mesothelioma chem Source Type: news

ASTRO issues guideline for use of stereotactic radiation in early-stage lung cancer
(American Society for Radiation Oncology) The American Society for Radiation Oncology (ASTRO) issued a new clinical guideline for the use of stereotactic body radiation therapy (SBRT) in early-stage lung cancer today. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 12, 2017 Category: Cancer & Oncology Source Type: news

Combining radionuclide therapy with a PARP inhibitor slows neuroendocrine tumor growth
(Society of Nuclear Medicine) Patients with neuroendocrine tumors (NETs) may experience fewer symptoms and survive longer by undergoing peptide-receptor radionuclide therapy (PRRT) combined with a drug that makes tumor cells more sensitive to radiation therapy, say researchers presenting at the 2017 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 12, 2017 Category: International Medicine & Public Health Source Type: news

Radiation therapy vital to treating brain tumors, but it exacts a toll
(University of California - San Diego) Radiation therapy (RT) using high-energy particles is a common and critical component in successfully treating patients with brain tumors but it is also associated with significant adverse effects. In a new study, researchers at the University of California San Diego School of Medicine report that irradiation can cause broader adverse effects, altering the structural network properties in impacted brains and perhaps contributing to delayed cognitive impairments observed in many patients following brain RT. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 9, 2017 Category: Cancer & Oncology Source Type: news

Radiation inhibits salivary gland function by promoting STIM1 cleavage by caspase-3 and loss of SOCE through a TRPM2-dependent pathway
We report that radiation treatment caused persistent salivary gland dysfunction by activating a TRPM2-dependent mitochondrial pathway, leading to caspase-3–mediated cleavage of stromal interaction molecule 1 (STIM1) and loss of SOCE. After irradiation, acinar cells from the submandibular glands of TRPM2+/+, but not those from TRPM2–/– mice, displayed an increase in the concentrations of mitochondrial Ca2+ and reactive oxygen species, a decrease in mitochondrial membrane potential, and activation of caspase-3, which was associated with a sustained decrease in STIM1 abundance and attenuation of SOCE. In a s...
Source: Signal Transduction Knowledge Environment - June 6, 2017 Category: Science Authors: Liu, X., Gong, B., de Souza, L. B., Ong, H. L., Subedi, K. P., Cheng, K. T., Swaim, W., Zheng, C., Mori, Y., Ambudkar, I. S. Tags: STKE Research Articles Source Type: news

Science Signaling Podcast for 6 June 2017: Calcium signaling and dry mouth
Abstract This Podcast features a conversation with Indu Ambudkar, senior author of a Research Resource that appears in the 6 June 2017 issue of Science Signaling, about how activation of the cation channel TRPM2 is involved in radiation-induced dry mouth. Patients who receive radiation therapy for head and neck cancers often develop dry mouth as a side effect, and this condition is frequently permanent. Radiation does not kill cells in the salivary gland, yet it causes the acinar cells of the gland to reduce the amount of saliva they secrete. Liu et al. found that radiation-induced activation of the cation channel TRPM2 tr...
Source: Signal Transduction Knowledge Environment - June 6, 2017 Category: Science Authors: Ambudkar, I., VanHook, A. M. Tags: STKE Podcasts Source Type: news

Highlight: Understanding radiation sialadenitis
A nonapoptotic function of caspase-3 underlies the salivary gland complications of radiation therapy of head and neck cancers. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - June 6, 2017 Category: Science Authors: Yaffe, M. B. Tags: STKE Editors ' Choice Source Type: news

Varian to build radiation oncology centers in Vietnam
Radiation oncology firm Varian Medical Systems has signed an agreement with...Read more on AuntMinnie.comRelated Reading: Varian awarded Thai proton therapy contract Varian installs proton therapy system in Fla. Varian launches Halcyon radiation therapy unit at ESTRO Varian adds to revenues in Q2 Varian launches direct sales in South Africa (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - June 5, 2017 Category: Radiology Source Type: news

CT detects frailty and predicts survival in elderly
CT scans are going beyond identifying broken bones to detecting skeletal frailty...Read more on AuntMinnie.comRelated Reading: Data from CTC scans improve osteoporosis screening JAMA: Early imaging questionable for older adults with back pain Fracture risk grows after prostate cancer radiation therapy Space radiation study offers bone loss clues (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - June 2, 2017 Category: Radiology Source Type: news

Use of SBRT in Treating Pancreatic Cancer
This video highlights the evolution of stereotactic body radiation therapy in the treatment of pancreatic cancer. (Source: CancerNetwork)
Source: CancerNetwork - June 1, 2017 Category: Cancer & Oncology Authors: Sarah E. Hoffe, MD Tags: Pancreatic Cancer Radiation Oncology Videos Gastrointestinal Cancers Source Type: news