Multi-country self-controlled study of exacerbation rates in severe asthma patients treated with mepolizumab: NEST interim analysis
Conclusion: This interim analysis demonstrates the effectiveness of mepolizumab in patients with SA with eosinophilic phenotype in different countries.Funding: GSK (Study ID: 213475) (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Bavbek, S., Fernandez, P., Mahboub, B., Al-Lehebi, R. O., Maturu, V. N., Cano Rosales, D. J., Soares, C., Dos Santos, D., Abreu, G., Menezes, P., Valladares, R., Queiroz, J., Raimondi, A., Aziz, F., Laucho-Contreras, M., Pizzichini, E., Noibi, S. Tags: Airway pharmacology and treatment Source Type: research

Global, regional, and national trends in incidence of asthma: findings from the Global Burden of Disease Study 2019
Conclusions: Despite a decreasing trend of ASR on a global scale, we observed a remarkable increase in new asthma cases in countries and regions with low SDI. Our findings emphazise the need for geographically specific allocation of healthcare resources to forestall the increasing burden of asthma. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Xing, Y., Jin, Y., Guo, C., Tam, L. S., Wu, D. Tags: Epidemiology Source Type: research

Altered sphingolipid metabolism in childhood asthma and obesity
Conclusion: The decreased levels of sphingolipids in obese-asthmatics and elevated levels of sphingolipids in lean-asthmatics shows that altered metabolism is dependent not only on the presence of asthma but also on overweight and obesity. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Belavendra, A., Shailesh, H., Hani, Y., Noor, S., Hasabelgavi, L., Alfaki, M., Jacob, S. S., Balayya, S. K., Worgall, S., Janahi, I. A. Tags: Paediatric asthma and allergy Source Type: research

Developing a Feasible Integrated Framework for Occupational Heat Stress Protection: A Step Towards Safer Working Environments
CONCLUSIONS: As the climate crisis exacerbates, worker productivity and well-being will decline, underscoring the urgent need for an integrated protection framework. Such a framework is proposed here.PMID:37878259 (Source: Medicina del Lavoro)
Source: Medicina del Lavoro - October 25, 2023 Category: Occupational Health Authors: Georgios Gourzoulidis Flora Gofa Leonidas G Ioannou Ioannis Konstantakopoulos Andreas D Flouris Source Type: research

Developing a Feasible Integrated Framework for Occupational Heat Stress Protection: A Step Towards Safer Working Environments
CONCLUSIONS: As the climate crisis exacerbates, worker productivity and well-being will decline, underscoring the urgent need for an integrated protection framework. Such a framework is proposed here.PMID:37878259 | PMC:PMC10627097 | DOI:10.23749/mdl.v114i5.14504 (Source: Medicina del Lavoro)
Source: Medicina del Lavoro - October 25, 2023 Category: Occupational Health Authors: Georgios Gourzoulidis Flora Gofa Leonidas G Ioannou Ioannis Konstantakopoulos Andreas D Flouris Source Type: research