Flow controlled ventilation in Acute Respiratory Distress Syndrome associated with COVID-19: A structured summary of a study protocol for a randomised controlled trial
This study aims to demonstrate the positive effects on oxygenation of flow-controlled ventilation compared to conventionally ventilated patients in patients suffering from Acute respiratory distress syndrome (ARDS) associated with COVID-19.We define ARDS according to the “Berlin” definition integrating the oxygenation index (P/F ratio), the level of Positive End Expiratory Pressure (PEEP), radiological and clinical findings.Trial designThis is a prospective, randomized (1:1 ratio), parallel group feasibility study in adult patients with proven COVID-19 associated ARDS.ParticipantsAll adult patients admitted to the ICU ...
Source: Trials - September 10, 2020 Category: Research Source Type: clinical trials

Anticoagulation in critically ill patients on mechanical ventilation suffering from COVID-19 disease, The ANTI-CO trial: A structured summary of a study protocol for a randomised controlled trial
AbstractObjectivesTo assess the effect of anticoagulation with bivalirudin administered intravenously on gas-exchange in patients with COVID-19 and respiratory failure using invasive mechanical ventilation.Trial designThis is a single centre parallel group, superiority, randomized (1:1 allocation ratio) controlled trial.ParticipantsAll patients admitted to the Hamad Medical Corporation -ICU in Qatar for COVID-19 associated respiratory distress and in need of mechanical ventilation are screened for eligibility.Inclusion criteria: all adult patients admitted to the ICU who test positive for COVID-19 by PCR-test and in need f...
Source: Trials - September 6, 2020 Category: Research Source Type: clinical trials

Immune Profiling of COVID19-patients Admitted to ICU
Condition:   COVID-19 Intervention:   Other: No intervention Sponsors:   Hamad Medical Corporation;   Qatar University;   Weill Cornell Medical College in Qatar Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 16, 2020 Category: Research Source Type: clinical trials