Increase in antibiotic-resistant bacteria hinders treatment of kidney infections
The increase in illnesses and deaths linked to medication-resistant bacteria has been well-documented by researchers and received extensive public attention in recent years. Now, UCLA-led research shows how these bacteria are making it more difficult to treat a common but severe kidney infection.Pyelonephritis — infection of the kidney usually caused by E. coli bacteria and which can start as a urinary tract infection — causes fever, back pain and vomiting. About half of people infected require hospitalization. If not treated with effective antibiotics, it can cause sepsis and death.In a UCLA-led study based on data f...
Source: UCLA Newsroom: Health Sciences - September 16, 2016 Category: Universities & Medical Training Source Type: news

Zavante recruits first patient in Zeus study of ZTI-01 to treat cUTI
US-based biopharmaceutical firm Zavante Therapeutics has randomised the first patient in the Zeus pivotal clinical study of ZTI-01 (fosfomycin for injection) to treat complicated urinary tract infections (cUTI), including acute pyelonephritis. (Source: Drug Development Technology)
Source: Drug Development Technology - July 11, 2016 Category: Pharmaceuticals Source Type: news

Complicated urinary tract infections: ceftolozane/tazobactam
This advice outlines how in a randomised controlled trial in adults with complicated urinary tract infections or acute pyelonephritis, an intravenous infusion of ceftolozane/tazobactam was found to be non‑inferior to IV levofloxacin for the composite outcome of microbiological eradication of all baseline uropathogens and clinical cure. In 2 RCTs in people receiving ceftolozane/tazobactam for complicated urinary tract or intra-abdominal infections. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 9, 2016 Category: Consumer Health News Source Type: news

At What Age Does the Risk of Infant Listeria Infection Decrease?
Discussion Neonatal bacterial infections are commonly caused by Group B Streptococcus, enteric gram-negative organisms such as Escherichia coli, coagulase negative Staphylococcus, Listeria monocytogenes and Haemophilus influenza. Infections are usually because of transplacental infection or ascending infection from the mother’s genitourinary tract. Empiric treatment for suspected sepsis for neonates is usually combined IV aminoglycoside and expanded-spectrum penicillin antibiotic therapy in the US and Canada and this combination specifically covers for Listeria. Listeria monocytogenes was first discovered in 1927 ...
Source: - January 25, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

SGLT2 Inhibitors: Drug Safety Communication - Labels to Include Warnings About Too Much Acid in the Blood and Serious Urinary Tract Infections
Labeling changes describe risks of ketoacidosis, urosepsis and pyelonephritis. (Source: FDA MedWatch)
Source: FDA MedWatch - December 4, 2015 Category: American Health Source Type: news

A Murine Model for Escherichia coli Urinary Tract Infection
Urinary tract infections (UTI) are among the most common bacterial infections of humans. The mouse provides an excellent and tractable model system for cystitis and pyelonephritis caused by Escherichia coli and other uropathogens. Using a well-established model of experimental cystitis in which the bladders of female mice are infected via transurethral catheterization, the molecular details of the pathogenesis of bacterial cystitis have been substantially illuminated in the last decade. Uropathogenic E. coli attach to bladder epithelium (both in human and mouse) via adhesive type 1 pili, establish a replicative niche withi...
Source: Springer protocols feed by Immunology - October 16, 2015 Category: Allergy & Immunology Source Type: news

FDA Approves Antibacterial Combination Drug
The Food and Drug Administration has approved the antibacterial drug ceftazidime-avibactam (Avycaz) for complicated intra-abdominal infections in combination with metronidazole, and for complicated urinary tract infections including pyelonephritis in adults. (Source: Caring for the Ages)
Source: Caring for the Ages - August 1, 2015 Category: Health Management Authors: Patricia Wendling Source Type: news

Merck Receives Positive CHMP Opinion for Investigational Antibiotic ZERBAXA™ (Ceftolozane and Tazobactam)
Dateline City: KENILWORTH, N.J. KENILWORTH, N.J.--(BUSINESS WIRE)--Merck (NYSE:MRK), known as MSD outside the United States and Canada, today announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion recommending approval of the investigational antibiotic ZERBAXA™ (ceftolozane and tazobactam) for the treatment of the following infections in adults: complicated intra-abdominal infections, acute pyelonephritis, and complicated urinary tract i...
Source: - Corporate News - July 27, 2015 Category: Pharmaceuticals Tags: Prescription Medicine News Corporate News Latest News Source Type: news

CHMP Says Yes to Combination Antibacterial ZerbaxaCHMP Says Yes to Combination Antibacterial Zerbaxa
Zerbaxa combines ceftolozane and tazobactam and is indicated for adults with complicated intra-abdominal infections, acute pyelonephritis, and complicated urinary tract infections. International Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 24, 2015 Category: Consumer Health News Tags: Infectious Diseases News Alert Source Type: news

Radiological Case: Emphysematous PyelonephritisRadiological Case: Emphysematous Pyelonephritis
This patient presented with severe abdominal pain, fever, hypotension, tachycardia and leukocytosis. What did CT scan reveal? Applied Radiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 29, 2015 Category: Consumer Health News Tags: Radiology Journal Article Source Type: news

FDA approves new antibacterial drug Avycaz
The U.S. Food and Drug Administration today approved Avycaz (ceftazidime-avibactam), a new antibacterial drug product, to treat adults with complicated intra-abdominal infections (cIAI), in combination with metronidazole, and complicated urinary tract infections (cUTI), including kidney infections (pyelonephritis), who have limited or no alternative treatment options. (Source: Food and Drug Administration)
Source: Food and Drug Administration - February 25, 2015 Category: American Health Source Type: news

Pyelonephritis Therapeutic Pipeline Review H1 2015 Market Research... adds “Pyelonephritis – Pipeline Review, H1 2015” to its store. The report provides an overview of the Pyelonephritis’s therapeutic pipeline.(PRWeb January 27, 2015)Read the full story at (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - January 27, 2015 Category: Pharmaceuticals Source Type: news

Urinary Tract Infections: Signs, Symptoms, Causes, and Treatment Options
A urinary tract infection, also known as a bladder infection or acute cystitis, is an infection of a part or parts of the female or male urinary tract. The urinary tract is made up of the ureters, kidneys, urethra and bladder. A urinary tract infection (UTI) is not technically a sexually transmitted one; however, sexual activity is a common cause of UTI’s for adults who are sexually active. When the infection affects the lower urinary tract the condition is known as a, 'simple cystitis,' or bladder infection. When it affects the upper urinary tract it is known as, 'pyelonephritis,' or a kidney infection. The most common ...
Source: Disabled World - October 26, 2014 Category: Disability Tags: Health and Disability Source Type: news

Episodic Flank Pain With Urinary Frequency in an HIV-Positive Man
The 46-year-old man had presented 3 times with similar symptoms in the past year, was given a diagnosis of pyelonephritis and treated with antibiotics each time. He improved each time, but the symptoms returned. What else is going on? (Source: Consultant Live)
Source: Consultant Live - November 6, 2013 Category: Primary Care Source Type: news

Emphysematous PyelonephritisEmphysematous Pyelonephritis
Nephrectomy can be avoided with early diagnosis of this serious complication of diabetes. The British Journal of Diabetes and Vascular Disease (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 8, 2013 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news