Experience with lower dose flumazenil at an academic medical center
Benzodiazepines (BZDs) are frequently used in self-poisonings [1]. Flumazenil effects for BZD reversal are dose-dependent and higher doses are often used to achieve desired outcomes. However, higher doses are associated with increased risk of seizures, cardiac dysrhythmias, and other adverse drug effects (ADEs) [2,3]. Multidrug intoxications involving tricyclic antidepressants (TCAs), stimulants, ethanol, anticonvulsants, propoxyphene, barbiturates, and other anxiolytics increase the frequency of significant ADEs from flumazenil [1-6]. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - February 4, 2021 Category: Emergency Medicine Authors: Rachel F. Schult, Deena Omar, Timothy J. Wiegand, Rachel M. Gordetsky, Nicole M. Acquisto Source Type: research
Propoxyphene Mediates Oxyhemoglobin-Induced Injury in Rat Cortical Neurons Through Up-Regulation of Active- β-Catenin
Wnt/β-catenin signaling is involved in various biological processes, including the development of the central nervous system. The dysfunction of mitochondria has been shown to participate in the progress of subarachnoid hemorrhage (SAH). Traumatic subarachnoid hemorrhage (tSAH) is a serious complication in acute craniocerebral trauma. Opioids can activate the canonical Wnt/β-catenin signaling pathway. c-Myc, a downstream protein of Wnt/β-catenin signaling, contributes to the fusion of mitochondria. Here, we investigated the protective roles of Propoxyphene (Pro) against Oxyhemoglobin (OxyHb)-induced primary cultured neu...
Source: Frontiers in Pharmacology - January 29, 2020 Category: Drugs & Pharmacology Source Type: research
Response to Propoxyphene Market Withdrawal: Analgesic Substitutes, Doses, and Adverse Events
Conclusions:
After propoxyphene market withdrawal, many individuals experienced abrupt discontinuation of opioids. Policymakers might consider supporting appropriate treatment transitions and monitoring responses following drug withdrawals. (Source: Medical Care)
Source: Medical Care - December 12, 2019 Category: Health Management Tags: Original Article Source Type: research
Salt stress alleviation in Pennisetum glaucum through secondary metabolites modulation by Aspergillus terreus L
Publication date: Available online 23 September 2019Source: Plant Physiology and BiochemistryAuthor(s): Faiza Khushdil, Farzana Gul Jan, Gul Jan, Muhammad Hamayun, Amjad Iqbal, Anwar Hussain, Nusrat BibiAbstractThe growth promoting activities of the isolated endophyte Aspergillus terreus from Aloe barbendsis was studied in the salt stressed Pennisetum glaucum (pearl millet). A significant (P = 0.05) increase in the root-shoot lengths, fresh and dry weights and chlorophyll content of pearl millet seedlings was noticed after colonization by A. terreus under normal conditions. At 100 mM NaCl stress and A. terreus inocul...
Source: Plant Physiology and Biochemistry - September 24, 2019 Category: Biochemistry Source Type: research
Interpretation and Utility of Drug of Abuse Screening Immunoassays: Insights From Laboratory Drug Testing Proficiency Surveys.
CONCLUSIONS.—: Survey results indicate strong clinical interest in urine drug testing and some adoption of new assays. However, urine drug testing availability does not parallel prevailing patterns of drug prescribing and abuse patterns. In particular, specific immunoassays for synthetic opioids and a lower positive cutoff for opiate immunoassays may be underused, whereas immunoassays for barbiturates, methadone, propoxyphene, and phencyclidine may be overused. Laboratories are encouraged to review their test menu, cutoffs, and assay performance and adjust their test offerings based on clinical needs and technical capabi...
Source: Archives of Pathology and Laboratory Medicine - July 16, 2019 Category: Laboratory Medicine Authors: Krasowski MD, McMillin GA, Melanson SEF, Dizon A, Magnani B, Snozek CLH Tags: Arch Pathol Lab Med Source Type: research
Interrupted Time Series Needed to Analyze Effects of Propoxyphene Withdrawal From Market and Health Outcome Trend Estimates: Comment on the Article by Curtis et al
Arthritis&Rheumatology,Volume 70, Issue 5, Page 794-795, May 2018. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - March 25, 2018 Category: Rheumatology Authors: Ahl Jeffrey Caseja MD
,
Johnson Ukken MS
,
Mary Froehlich MA
,
Hamayon Babary MD
,
Yong ‐Jae Lee MD
,
Ji Won Yoo MD Source Type: research
Reply to “Necessity for interrupted time series to analyze the effects of propoxyphene withdrawal from the market and further health outcome trend estimates”
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 13, 2018 Category: Rheumatology Authors: Fenglong Xie, Lang Chen, Huifeng Yun, Jeffrey R Curtis Tags: Reply to Letter to the Editor Source Type: research
Necessity for interrupted time series to analyze the effects of propoxyphene withdrawal from the market and health outcome trend estimates
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 13, 2018 Category: Rheumatology Authors: Ahl Jeffrey Caseja, Johnson Ukken, Mary Froehlich, Hamayon Babary, Yong ‐Jae Lee, Ji Won Yoo Tags: Letter to the Editor Source Type: research
Simultaneous quantitation of meperidine, normeperidine, tramadol, propoxyphene and norpropoxyphene in human plasma using solid-phase extraction and gas chromatography/mass spectrometry: Method validation and application to cardiovascular safety of therapeutic doses.
PMID: 29108129 [PubMed - in process] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 7, 2017 Category: Chemistry Authors: Fernández N, Olivera NM, Keller GA, Diez RA, Di Girolamo G, Quiroga PN Tags: Rapid Commun Mass Spectrom Source Type: research
Changing Trends in Opioid Use Among Patients With Rheumatoid Arthritis in the United States
ConclusionIn the US, opioid use in older patients with RA peaked in 2010 and is now declining slightly. Withdrawal of propoxyphene from the US market in 2010 had minimal effect on overall opioid use, because use of propoxyphene was replaced by increased use of other opioids. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - August 13, 2017 Category: Rheumatology Authors: Jeffrey R. Curtis, Fenglong Xie, Christian Smith, Kenneth G. Saag, Lang Chen, Timothy Beukelman, Melissa Mannion, Huifeng Yun, Stefan Kertesz Tags: Full Length Source Type: research
Simultaneous quantitation of meperidine, nor-meperidine, tramadol, propoxyphene and nor-propoxyphene, in human plasma using solid-phase extraction and gas chromatography-mass spectrometry: Method validation and application to cardiovascular safety of therapeutic doses.
CONCLUSIONS: A GC/MS method for the rapid and simultaneous determination of meperidine, normeperidine, tramadol, propoxyphene and norpropoxyphene in human plasma was developed, optimized and validated. This procedure was shown to be sensitive and specific using small specimen amounts, suitable for application in routine analysis for forensic purposes and therapeutic monitoring. To our knowledge, this is the first full validation of the simultaneous determination of these opioids and their metabolites in plasma samples.
PMID: 28686794 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - July 7, 2017 Category: Chemistry Authors: Fernández N, Olivera NM, Keller GA, Diez RA, Di Girolamo G, Quiroga PN Tags: Rapid Commun Mass Spectrom Source Type: research
Changing Trends in Opioid Use among U.S. Rheumatoid Arthritis Patients
Conclusion
In the US, opioid use peaked in older RA patients in 2010 and is now declining slightly. Withdrawal of propoxyphene from the U.S. market in 2010 had minimal effect on overall use, as it was replaced with greater use of other opioids. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - June 1, 2017 Category: Rheumatology Authors: Jeffrey R Curtis, Fenglong Xie, Christian Smith, Kenneth G. Saag, Lang Chen, Timothy Beukelman, Melissa Mannion, Huifeng Yun, Stefan Kertesz Tags: Full Length Source Type: research
Assessing the impact of prescribing directives on opioid prescribing practices among Veterans Health Administration providers
ConclusionsWhile prescribing compliance increased throughout the period, release of FDA and VHA alerts and guidelines did not appear to contribute to this change. Given the fivefold increase in the rate of drug‐related overdose deaths since 1990, identifying effective methods to communicate safety messages and change prescriber behavior remains a priority for future work. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - July 31, 2016 Category: Drugs & Pharmacology Authors: Catherine Barber, David Gagnon, Jennifer Fonda, Kelly Cho, John Hermos, Matthew Miller Tags: Original Report Source Type: research
Key opioid prescription concerns in cancer patients: A nationwide study.
CONCLUSION: The use of short-acting strong opioids increased during the study period. Instead of oral opioids, transdermal fentanyl was the most commonly used opioid among Taiwan cancer patients. The use of weak opioids, particularly tramadol, was high. These concerns should be the focus of pain management education.
PMID: 27317483 [PubMed - as supplied by publisher] (Source: Acta Anaesthesiologica Taiwanica)
Source: Acta Anaesthesiologica Taiwanica - June 13, 2016 Category: Anesthesiology Authors: Lin CP, Hsu CH, Fu WM, Chen HM, Lee YH, Lai MS, Shao YY Tags: Acta Anaesthesiol Taiwan Source Type: research
Rates of Opioid Dispensing and Overdose after Introduction of Abuse-deterrent Extended-release Oxycodone and Withdrawal of Propoxyphene
Prescription opiate and heroin overdose has been a growing public health problem over the last 20 years. Between 1999 and 2010, prescription opioid overdose deaths quadrupled in parallel with increases in prescription opioid sales. Strong associations between prescription opioid supply and prescription opioid overdose have been demonstrated. One might hypothesize that supply-based interventions would curb opioid overdose overall, but some have hypothesized that a reduction in the prescription opioid supply may lead opioid-dependent patients to substitute alternative opioids such as heroin. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - October 1, 2015 Category: Emergency Medicine Authors: Kathryn Eastley Tags: Abstract Source Type: research
