GSE142061 Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and non-antibiotic pharmaceuticals stressed Acinetobacter baylyi ADP1 Transcriptomes
Contributors : Yue Wang ; Jianhua Guo ; Likai MaoSeries Type : Expression profiling by high throughput sequencingOrganism : Acinetobacter baylyiThe goals of this study are to use Next-generation sequencing (NGS) to detect bacterial mRNA profiles of wild-type A.baylyi ADP1, and its mRNA response under the exposure of six non-antibiotic pharmaceuticals, including ibuprofen, naproxen, gemfibrozil, diclofenac, propanolol, and iopromide. The concentrations were 0.5 mg/L for ibuprofen, naproxen, gemfibrozil, diclofenac, propanolol, and 1.0 mg/L for iopromide. The group without dosing pharmaceutical was the control group. Each co...
Source: GEO: Gene Expression Omnibus - July 22, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Acinetobacter baylyi Source Type: research

Single-step pyrolysis for producing magnetic activated carbon from tucumã (Astrocaryum aculeatum) seed and nickel(II) chloride and zinc(II) chloride. Application for removal of nicotinamide and propanolol
Publication date: Available online 22 May 2020Source: Journal of Hazardous MaterialsAuthor(s): Pascal S. Thue, Cibele S. Umpierres, Eder C. Lima, Diana R. Lima, Fernando M. Machado, Glaydson S. dos Reis, Raphaelle S. da Silva, Flavio A. Pavan, Hai Nguyen Tran (Source: Journal of Hazardous Materials)
Source: Journal of Hazardous Materials - May 23, 2020 Category: Environmental Health Source Type: research

Propranolol for Surgeons in the Treatment of Infantile Hemangiomas
Conclusion: Low dose propranolol and topical Timolol is been safe and easy to use for surgeons who may not be regular prescribers or unfamiliar with treating children with IHs with beta-blocker therapy. In patient monitoring is unnecessary and parents can be taught easily to recognise side effects. Treating children from the start builds a trusting relationship with the family before the child requesting cosmetic revision of the fibro-fatty remnant. (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - December 27, 2019 Category: Surgery Tags: Original Articles Source Type: research

Objective evaluation of infantile hemangiomas response to propanolol treatment using a 3D imaging system.
This article is protected by copyright. All rights reserved. PMID: 30919412 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 28, 2019 Category: Dermatology Authors: Moro R, Fabiano A, Mangeri F, Di Buduo A, Manerba A, Rossini M, Calzavara-Pinton PG, Gualdi G Tags: Br J Dermatol Source Type: research

Fetal supraventricular tachycardia at 12 weeks of gestation: diagnosis and follow up. A case report.
This report describes a case of fetal supraventricular tachycardia (SVT) diagnosed at 12 weeks of gestation in a pregnant woman with diabetes mellitus. Transplacental digoxin therapy administered orally to the mother was unsuccessful. Subsequently, sotalol was added to digoxin to achieve fetal heart rate (HR) control and the conversion to sinus rhythm was achieved. The fetal HR remained stable until term, and a healthy male baby was born. The newborn electrocardiogram showed sinus rhythm with normal PR and QTc intervals. When the newborn was stable, he was discharged with propanolol. Sustained SVT is extremely rare during ...
Source: Medical Ultrasonography - February 21, 2019 Category: Radiology Tags: Med Ultrason Source Type: research

Identification of a 2-propanol analogue modulating the non-enzymatic function of indoleamine 2,3-dioxygenase 1.
Abstract Indoleamine 2,3 dioxygenase 1 (IDO1) is a metabolic enzyme that catalyzes the conversion of the essential amino acid tryptophan (Trp) into a series of immunoactive catabolites, collectively known as kynurenines. Through the depletion of Trp and the generation of kynurenines, IDO1 represents a key regulator of the immune responses involved in physiologic homeostasis as well as in neoplastic and autoimmune pathologies. The IDO1 enzyme has been described as an important immune checkpoint to be targeted by catalytic inhibitors in the treatment of cancer. In contrast, a defective expression/activity of the enz...
Source: Biochemical Pharmacology - October 31, 2018 Category: Drugs & Pharmacology Authors: Albini E, Coletti A, Greco F, Pallotta MT, Mondanelli G, Gargaro M, Belladonna ML, Volpi C, Bianchi R, Grohmann U, Macchiarulo A, Orabona C Tags: Biochem Pharmacol Source Type: research

Interdisciplinary Management of Head and Neck Vascular Anomalies: Clinical Presentation, Diagnostic Findings and Minimalinvasive Therapies
ConclusionsThis review provides knowledge on the current ISSVA classification of vascular anomalies, their clinical presentation, diagnostic evaluation and minimally invasive therapy options to encourage the establishment of a comprehensive interdisciplinary management for head and neck vascular anomalies. (Source: European Journal of Radiology Open)
Source: European Journal of Radiology Open - July 11, 2018 Category: Radiology Source Type: research

Effect of propranolol on heart rate variability in hyperthyroidism
We aimed to determine the effect of propanolol on heart rate variability (HRV) in hyperthyroidism before antithyroid treatment. This was a before and after study, on ten patients presenting overt hyperthyroidi... (Source: BMC Research Notes)
Source: BMC Research Notes - February 22, 2018 Category: Research Authors: Aurel T. Tankeu, Marcel Azabji-Kenfack, Chris-Nad ège Nganou, Eliane Ngassam, Liliane Kuate-Mfeukeu, Camille Mba, Mesmin Y. Dehayem, Jean-Claude Mbanya and Eugene Sobngwi Tags: Research note Source Type: research

Propranolol May Help Patients With PTSD
While exposure therapy is recognized as one of the best strategies for treating patients with posttraumatic stress disorder (PTSD), many continue to experience significant problems. Astudy published inAJP in Advance suggests that patients with PTSD who take propranolol (a noradrenergic beta-receptor blocker) prior to recalling their traumatic event may experience greater PTSD symptom reduction than those who do not take the medication.“PTSD participants who actively recalled their traumatic event under the influence of propranolol once a week for up to six weeks showed a substantial decrease in symptom ratings compar...
Source: Psychiatr News - January 16, 2018 Category: Psychiatry Tags: ajp in advance post-traumatic stress disorder propanolol PTSD trauma reactivation therapy Source Type: research

Propranolol May Help PTSD Patients Receiving Exposure Therapy
While exposure therapy is recognized as one of the best strategies for treating patients with posttraumatic stress disorder (PTSD), many continue to experience significant problems. Astudy published inAJP in Advance suggests that patients with PTSD who take propranolol (a noradrenergic beta-receptor blocker) prior to recalling their traumatic event may experience greater PTSD symptom reduction than those who do not take the medication.“PTSD participants who actively recalled their traumatic event under the influence of propranolol once a week for up to six weeks showed a substantial decrease in symptom ratings compar...
Source: Psychiatr News - January 16, 2018 Category: Psychiatry Tags: ajp in advance post-traumatic stress disorder propanolol PTSD trauma reactivation therapy Source Type: research

Resolution of aquagenic pruritus with intermittent UVA/NBUVB combined therapy
This article is protected by copyright. All rights reserved. (Source: Photodermatology, Photoimmunology and Photomedicine)
Source: Photodermatology, Photoimmunology and Photomedicine - June 5, 2017 Category: Radiology Authors: Daniel Morgado ‐Carrasco, José Riera‐Monroig, Xavier Fustà‐Novell, Sebastian Podlipnik, Paula Aguilera Tags: Letter to the Editor Source Type: research

Interdisciplinary Management of Head and Neck Vascular Anomalies: Clinical Presentation, Diagnostic Findings and Minimalinvasive Therapies
Conclusions This review provides knowledge on the current ISSVA classification of vascular anomalies, their clinical presentation, diagnostic evaluation and minimally invasive therapy options to encourage the establishment of a comprehensive interdisciplinary management for head and neck vascular anomalies. (Source: European Journal of Radiology Open)
Source: European Journal of Radiology Open - May 14, 2017 Category: Radiology Source Type: research

One step minilaparotomy-assisted transmesenteric portal vein recanalization combined with transjugular intrahepatic portosystemic shunt placement: A novel surgical proposal in pediatrics.
Abstract Transjugular intrahepatic portosystemic shunt (TIPS) placement is a standard procedure for the treatment of portal hypertension complications. When this conventional approach is not feasible, alternative procedures for systemic diversion of portal blood have been proposed. A one-step interventional approach, combining minilaparotomy-assisted transmesenteric (MAT) antegrade portal recanalization and TIPS, is described in an adolescent with recurrent esophageal varice bleeding and portal cavernoma (PC). A 16-year-old girl was admitted to our Unit because of repeated bleeding episodes over a short period of ...
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Pelizzo G, Quaretti P, Moramarco LP, Corti R, Maestri M, Iacob G, Calcaterra V Tags: World J Gastroenterol Source Type: research

A case of drug-induced metabolic encephalopathy presenting to the stroke unit (P3.282)
Conclusions:This highly unusual case of acute drug-induced encephalopathy with profound thyrotoxicosis presents as a stroke-mimic. Cannabinoids are more typically associated with reversible cerebral vasoconstriction syndrome which was not present here illustrating an important point that there is much less certainty about the actual content of recreational drugs with the advent of ‘legal-highs’. We speculate as to whether his neurological presentation and thyrotoxicosis are related to his drug use or he has in fact two separate insults to his brain.Study Supported by: Not applicableDisclosure: Dr. Maduakor has ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Maduakor, C., Vasan, S., Khan, U. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Antidiarrheal activity of hexane extract of Citrus limon peel in an experimental animal model
Conclusion These results suggest that C. limon peel possesses antidiarrheal effects through antisecretory and antimotility mechanisms that act through the β adrenergic system. (Source: Journal of Integrative Medicine)
Source: Journal of Integrative Medicine - March 21, 2017 Category: Complementary Medicine Source Type: research

Survey on treatments for primary headaches in 13 specialized juvenile Headache Centers: The first multicenter Italian study.
DISCUSSION: Non-steroidal anti-inflammatory drugs, especially ibuprofen, should be preferred to acetaminophen for acute attacks of migraine or tension-type headache, because they were usually more effective and well tolerated. Triptans could be used more frequently as first or almost second choice for treating migraine attack in adolescents. Non-pharmacological preventive treatments are recommended by some pediatric guidelines as first-line interventions for primary headaches and their use should be implemented in clinical practice. Prospective multicenter studies based on larger series are warranted to better understand t...
Source: European Journal of Paediatric Neurology - December 31, 2016 Category: Neurology Authors: Toldo I, Rattin M, Perissinotto E, De Carlo D, Bolzonella B, Nosadini M, Rossi LN, Vecchio A, Simonati A, Carotenuto M, Scalas C, Sciruicchio V, Raieli V, Mazzotta G, Tozzi E, Valeriani M, Cianchetti C, Balottin U, Guidetti V, Sartori S, Battistella PA Tags: Eur J Paediatr Neurol Source Type: research

Choriocarcinoma as a cause of hyperthyroidism
Our patient is a 31-year-old lady who delivered her third child 3 months prior to the current admission. The delivery was uneventful but she continued to have per vaginal spotting occasionally. She presented with cough and breathlessness for 2 months associated with significant weight and appetite loss. On examination she was pale and tachycardic. She had fine tremor but no goiter or Grave’s opthalmopathy. Breath sounds were reduced bilaterally. Endocrine team was consulted as her thyroid function test showed freeT4 of 50 pmol/l with suppressed thyroid stimulating hormone (TSH) of 200 000 mIU/ml...
Source: QJM - November 15, 2016 Category: Internal Medicine Source Type: research

Hepatotoxicity of illegal home-made alcohols
Conclusion Obtained findings suggest that trans-anethole containing alcoholic beverages are more hepatotoxic compared to commercial alcoholic beverages. (Source: Journal of Forensic and Legal Medicine)
Source: Journal of Forensic and Legal Medicine - July 31, 2016 Category: Forensic Medicine Source Type: research

Pharmacological interventions on early functional gastrointestinal disorders
Conclusion There is some evidence that a pharmacological intervention is necessary for rectal disimpaction in childhood constipation and that PEG is the first line therapy. In contrast, for the other early FGIDs there is a lack of well-designed high-quality RCTs and no evidence on the use of pharmacological therapy was found. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - July 16, 2016 Category: Pediatrics Source Type: research

Low Dose Propanolol for Infantile Haemangioma
(Source: Journal of Paediatrics and Child Health)
Source: Journal of Paediatrics and Child Health - June 21, 2016 Category: Pediatrics Authors: Margie Danchin, Suzanne Lesley Boyce, Linny Phuong, Eden Cooper, Suzanna Vidmar Tags: Letter to the Editor Source Type: research

Pharmacogenomics in Headache Practice (I3.010)
Conclusions: NSAIDs with triptan may cause intolerance due to side effects since they were metabolized in same pathway and preventive medication has more than 35[percnt] risk of side effect and discontinuation in population . Pharmcogenomics is another tool that can be used by a headaches specialty practice to control and treat headaches.Disclosure: Dr. Bringham has nothing to disclose. Dr. Kumar has nothing to disclose. Dr. Kumar has nothing to disclose. (Source: Neurology)
Source: Neurology - April 4, 2016 Category: Neurology Authors: Bringham, M., Kumar, M., Kumar, S. Tags: New and Emerging Therapeutic Options in Migraine and Other Headache Disorders Poster Presentations Source Type: research

Pharmacogenomics in Headache Practice (P1.161)
Conclusions: NSAIDs with triptan may cause intolerance due to side effects since they were metabolized in same pathway and preventive medication has more than 35[percnt] risk of side effect and discontinuation in population . Pharmcogenomics is another tool that can be used by a headaches specialty practice to control and treat headaches.Disclosure: Dr. Bringham has nothing to disclose. Dr. Kumar has nothing to disclose. Dr. Kumar has nothing to disclose. (Source: Neurology)
Source: Neurology - April 4, 2016 Category: Neurology Authors: Bringham, M., Kumar, M., Kumar, S. Tags: Headache: Health Services/Outcomes Research, Genetics, and Therapeutics Source Type: research

The effects of nebivolol on weight in individuals with hypertension
Traditional non-vasodilatory β-blockers (eg, atenolol, metoprolol, propanolol)–a commonly utilized class of medications for cardiovascular diseases including hypertension–are associated with a high incidence of adverse events, including significant weight gain (ranging up to 3.5 kg) which occurs within the first few months of treatment. Treatment with the third generation vasodilatory β1-selective antagonist/β3 agonist, nebivolol, does not appear to affect body weight or other metabolic parameters. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - April 1, 2016 Category: Cardiology Authors: John Flack, Madhuja Mallick, Mehul Patel Tags: Obesity and Hypertension Source Type: research

Visual acuity and astigmatism in periocular infantile hemangiomas treated with oral beta-blocker versus intralesional corticosteroid injection
Conclusions In this patient cohort oral beta-blocker was well-tolerated. Treatment was therefore often initiated prior to the induction of significant astigmatism, with treatment effects comparable to steroid treatment. Visual outcomes were good. Early treatment may minimize the potential effect of astigmatism on postnatal visual development. (Source: Journal of American Association for Pediatric Ophthalmology and Strabismus)
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - February 23, 2016 Category: Opthalmology Source Type: research

Cardiotoxic and Arrhythmogenic Effects of Hemiscorpius lepturus Scorpion Venom in Rats.
CONCLUSION: Our study paves the way for further in vivo investigation of cardiovascular effects of this venom for finding suitable treatments instead of its ordinary antivenom medication in cardiogenic shock induced by the venom. PMID: 26623433 [PubMed] (Source: Iranian Journal of Arthropod-Borne Diseases)
Source: Iranian Journal of Arthropod-Borne Diseases - December 20, 2015 Category: Infectious Diseases Tags: J Arthropod Borne Dis Source Type: research

One Dose of Propanolol Decreases Pre-Existing Phobia
Researchers from the Netherlands have used a familiar drug to counteract a pre-existing phobia, with effects lasting up to one year.For the last 15 years, neuroscientists have been interested in the reconsolidation period, when memories are recalled and can be modified, wrote Marieke Soeter, Ph.D., and Merel Kindt, Ph.D., of the Department of Psychology at the University of Amsterdam, in the December 15 issue of Biological Psychiatry.Thirty participants who were afraid of spiders were exposed to a caged tarantula for two minutes to reactivate their fears, and then asked to report their level of fear or anxiety. Afterwards,...
Source: Psychiatr News - December 11, 2015 Category: Psychiatry Tags: APA arachnophobia beta-blocker CBT cognitive behavioral therapy Marieke Soeter Merel Kindt propanolol psychiatry spiders University of Amsterdam Source Type: research

Review of topical beta blockers as treatment for infantile hemangiomas
The treatment of infantile hemangiomas changed from the use of oral corticosteroids to oral propranolol on the serendipitous discovery of propanolol's clinical effectiveness in 2008. Since then, clinicians have begun to use topical beta blockers—in particular, timolol maleate 0.5% gel forming solution—with good effect. Topical beta blockers are now used for lesions with both deep and superficial components and those that are amblyogenic. When initiated in the proliferative phase of the lesion, the effectiveness of the treatment can be seen within days. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - September 22, 2015 Category: Opthalmology Authors: Sally L. Painter, Göran Darius Hildebrand Tags: Therapeutic review Source Type: research

Evaluation of the Effect of 1,3-Bis(4-Phenyl)-1H-1,2,3-Triazolyl-2-Propanolol on Gene Expression Levels of JAK2-STAT3, NF-κB, and SOCS3 in Cells Cultured from Biopsies of Mammary Lesions.
In conclusion, this molecule in development has an effect on the gene expression of JAK3 and STAT3; nevertheless, the lack of change in NF-κB indicates that it is not a regulator of inflammation, and therefore, more studies should be performed. PMID: 26315497 [PubMed - as supplied by publisher] (Source: Biochemical Genetics)
Source: Biochemical Genetics - August 28, 2015 Category: Genetics & Stem Cells Authors: Becerril JL, Benítez JG, Juárez JJ, Bañales JM, Zerón HM, Navarro MD Tags: Biochem Genet Source Type: research

A case of thyroid storm complicated by acute hepatitis due to propylthiouracil treatment.
Abstract UNLABELLED: A 57-year-old female presented 17 days after treatment with radioactive iodine (RAI) for difficult-to-control hyperthyroidism. She was febrile, had a sinus tachycardia, and was clinically thyrotoxic. Her thyroid function tests showed a suppressed TSH 75 pmol/l and total triiodothyronine (TT3) 6.0 nmol/l. She was diagnosed with thyroid storm and was managed with i.v. fluids, propylthiouracil (PTU) 200 mg four times a day, prednisolone 30 mg once daily and propanolol 10 mg three times a day. She gradually improved over 2 weeks and was discharged home on PTU with β blockade. On cli...
Source: Diabetes Metab - August 20, 2015 Category: Endocrinology Authors: Tufton N, Hashim N, Sze C, Waterhouse M Tags: Endocrinol Diabetes Metab Case Rep Source Type: research

Congenital Ulcerated Lip Hemangioma Treated With a Cleft Lip Technique.
Abstract Aneonate presented to our clinic for evaluation of unusual congenital cleft lip. The clinical follow-up showed at first an ulceration of the lesion and then a stable result after propanolol systemic therapy. After 18 months of clinical follow-up, surgical treatment was performed, which consisted of double unilimb Z-plasty according to Mulliken's microform cleft lip repair. Knowing the existence of these strange vascular anomalies of the lip will allow us to improve the differential diagnosis and treatment plan. PMID: 26120886 [PubMed - as supplied by publisher] (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - June 29, 2015 Category: ENT & OMF Authors: Bianchi A, Amadori S, Bassi M, Neri I, Campobassi A, Marchetti C Tags: Cleft Palate Craniofac J Source Type: research

Propanolol effectively treats significant infantile hemangiomas
Leaute-Labreze C, Hoeger P, Mazereeuw-Hautier J, Guibaud L, Baselga E, Posiunas G, et al. A randomized, controlled trial of oral propranolol in infantile hemangioma. N Engl J Med. 2015;372:735-46. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 26, 2015 Category: Pediatrics Authors: Nancy M. Bauman Tags: Current Best Evidence Source Type: research

The stress hormone norepinephrine increases migration of prostate cancer cells in vitro and in vivo.
rra C Abstract The metastatic process is the most serious cause of cancer death. Norepinephrine, secreted in chronic stress conditions, stimulates the motility of breast and colon cells through β-adrenergic receptor. On these bases, we examined its possible role in metastasis formation and development in vitro and in vivo. Treatments with norepinephrine (β2-adrenoreceptor agonist) in mice xenografted with human DU145 prostate cancer cells increased the metastatic potential of these cells. Specifically, we showed that treatment of mice with norepinephrine induced a significant increase of the migrato...
Source: International Journal of Oncology - June 8, 2015 Category: Cancer & Oncology Authors: Barbieri A, Bimonte S, Palma G, Luciano A, Rea D, Giudice A, Scognamiglio G, La Mantia E, Franco R, Perdonà S, De Cobelli O, Ferro M, Zappavigna S, Stiuso P, Caraglia M, Arra C Tags: Int J Oncol Source Type: research

Systematic review of the effect of propanolol on hypermetabolism in burn injuries
Conclusions Propranolol reduces the hypermetabolic response in pediatric burn patients. More studies on its effects in adult burn patients are needed. (Source: Medicina Intensiva)
Source: Medicina Intensiva - February 26, 2015 Category: Intensive Care Source Type: research

Investigation of Cardiomyopathy in Children With Cirrhotic and Noncirrhotic Portal Hypertension
Conclusions: Approximately 20% of children with PHT have CCMP. A detailed cardiac examination should be carried out periodically in children with cirrhotic PHT, especially in the presence of ascites and high Child-Pugh score. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - February 1, 2015 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Idiopathic aquagenic pruritus: pathogenesis and effective treatment with atenolol
Abstract Aquagenic pruritus (AP) is a rare condition with unknown pathogenesis. We explored its pathogenesis through investigations of a patient and report the first case to be effectively treated with atenolol. A 36‐year‐old Indian female presented with idiopathic AP. Small‐fiber neuropathy involving itch/pain‐transmitting C‐fibers appears to be pathogenetically important: compared with matched controls, our patient had increased intra‐epidermal nerve fibers, raised warmth detection threshold, and marked hyperknesis to electrical stimulation. Autonomic nerve function tests and fingertips vasoconstriction respo...
Source: Dermatologic Therapy - January 30, 2015 Category: Dermatology Authors: Taige Cao, Angeline Anning Yong, Kong Bing Tan, Hong Liang Tey Tags: Therapeutic Hotline Source Type: research

Muscle metaboreflex activation during dynamic exercise evokes epinephrine release resulting in β2-mediated vasodilation.
Muscle metaboreflex activation during dynamic exercise evokes epinephrine release resulting in β2-mediated vasodilation. Am J Physiol Heart Circ Physiol. 2014 Dec 24;:ajpheart.00648.2014 Authors: Kaur J, Spranger MD, Hammond RL, Krishnan AC, Alvarez A, Augustyniak RA, O'Leary DS Abstract Muscle metaboreflex-induced increases in mean arterial pressure (MAP) during submaximal dynamic exercise are mediated principally by increases in cardiac output. To what extent, if any, the peripheral vasculature contributes to this rise in MAP is debatable. In several studies, we observed that in response to mus...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 24, 2014 Category: Physiology Authors: Kaur J, Spranger MD, Hammond RL, Krishnan AC, Alvarez A, Augustyniak RA, O'Leary DS Tags: Am J Physiol Heart Circ Physiol Source Type: research

The Effect of Fat Emulsion on Hemodynamics Following Treatment With Propranolol and Clonidine in Anesthetized Rats / El Efecto de la Emulsión Lipídica en los Parámetros Hemodinámicos tras el Tratamiento con Propranolol y Clonidina en Ratas Anestesiadas.
Abstract ObjectivesThere is evidence indicating that intravenous fatty emulsion (IFE) is beneficial in restoring circulatory function in certain types of drug overdose. The authors investigated the hemodynamic effects of IFE compared to epinephrine in rats treated with propranolol and clonidine. MethodsAnesthetized male Sprague‐Dawley rats were instrumented for measurement of hemodynamics. Rats were randomly assigned to one of six groups (n = 6–8), and each received a clonidine infusion (150 μg/kg) or an equivalent volume of normal saline (0.9% NaCl) over 1 hour. Each rat then received normal...
Source: Academic Emergency Medicine - November 6, 2014 Category: Emergency Medicine Authors: Kimberly Macala, Reza Tabrizchi Tags: Original Contribution Source Type: research

Minor Enantiomer Recycling: Application to Enantioselective Syntheses of Beta Blockers.
Abstract Continuous recycling of the minor product enantiomer obtained from the acetylcyanation of prochiral aldehydes provided access to highly enantiomerically enriched products. Cyanohydrin derivatives, which under normal conditions are obtained with modest or poor enantiomeric ratios, were formed with high enantiomeric purity by using a reinforcing combination of a chiral Lewis acid catalyst and a biocatalyst. The primarily obtained products were transformed into β-adrenergic antagonists (S)-propanolol, (R)-dichloroisoproterenol, and (R)-pronethalol by means of a two-step procedure. PMID: 24574310 [P...
Source: Chemistry - February 26, 2014 Category: Chemistry Authors: Wen YQ, Hertzberg R, Gonzalez I, Moberg C Tags: Chemistry Source Type: research

A further experience of propranolol for severe infantile hemangiomas of the face: an observational study
Abstract Infantile hemangiomas (IHs) are the most common proliferating embrional tumors of infancy, which are constituted by endothelial cell hyperproliferation. The authors want to report their observations of further 14 patients suffering from complicated IHs involving the facial district who were treated with propranolol. 14 patients, with ages between 3 and 12 months, completed a cycle of treatment with propanolol. The observational study aimed at focusing IHs involving the facial district. The treatment with propranolol showed good to very good results in the major part of the treated young patients. The authors want ...
Source: Dermatologic Therapy - February 18, 2014 Category: Dermatology Authors: Antonella Greco, Angelo Massimiliano D'Erme, Barbara Zamma Gallarati, Roberto Caputo, Maurizio Martino Tags: Therapeutic Hotline Source Type: research

Treatment of infantile haemangioma with propranolol is both safe and effective
Aim: Infantile haemangioma is the most common benign tumour affecting young children. Although not present at birth, it can very rapidly proliferate, causing problems with the child's development. During treatment of Hypertrophic Obstructive Cardiomyopathy with Propanolol, an incidental reduction in haemangioma size has been described. Our aim was to demonstrate the effect of propranolol treatment alone on haemangioma size whilst monitoring for any potential side effects. (Source: International Journal of Surgery)
Source: International Journal of Surgery - November 6, 2013 Category: Surgery Authors: Harry Sargeant, Stephen Goldie, William Anderson Tags: Abstracts from the Association of Surgeons in Training Conference Source Type: research

Noradrenaline acting on astrocytic β2-adrenoceptors induces neurite outgrowth in primary cortical neurons.
In conclusion, this study indicates a novel role for NA acting at glial β2-adrenoceptors to induce neuritic growth through the expression of soluble factors that elicit a neurotrophic action and increase neuronal complexity. PMID: 24126345 [PubMed - as supplied by publisher] (Source: Neuropharmacology)
Source: Neuropharmacology - October 11, 2013 Category: Drugs & Pharmacology Authors: Day JS, 'neill EO, Cawley C, Aretz NK, Kilroy D, Gibney SM, Harkin A, Connor TJ Tags: Neuropharmacology Source Type: research

Potassium channel openers and prostacyclin play a crucial role in mediating the vasorelaxant activity of Gynura procumbens
The objectives of this study were therefore to further purify the active compounds that exhibited selective effects on blood vessels, determine the mechanism of actions, and to qualitatively analyse the putative compounds present. Methods: The butanolic fraction (BU) of the crude ethanolic extract was purified using column chromatography to obtain several sub-fractions of different polarities. The in vitro effects of BU and the sub-fractions on vascular tension were subsequently determined using isolated rat thoracic aortic rings. The most potent sub-fraction (F1) alone was then investigated for its mechanisms of the vasor...
Source: BMC Complementary and Alternative Medicine - July 23, 2013 Category: Complementary Medicine Authors: Hien-Kun NgTing-Fung PohSau-Kuen LamSee-Ziau Hoe Source Type: research

Postcricoid infantile hemangioma: Management of a case in the propranolol era
We describe a rare case of a postcricoid infantile hemangioma (IH) and treatment with propranolol. A newborn female was found to have a large, postcricoid submucosal mass. The patient was brought to the operating theater for endoscopy and biopsy. The histopathology and GLUT-1 immunoreactivity confirmed the diagnosis of IH. The lesion was treated with direct injection of triamcinolone (40mg/ml) and systemic propranolol therapy. The patient responded well, and her symptoms resolved quickly. Propanolol provides a promising therapy as a first line treatment to avoid surgery, tracheostomy, and prolonged use of steroids. (Source...
Source: International Journal of Pediatric Otorhinolaryngology Extra - July 22, 2013 Category: ENT & OMF Authors: Jeffrey Cheng, Kyle Hatten, Ian Jacobs Tags: Case reports Source Type: research

WITHDRAWN: Pharmacological interventions for benzodiazepine mono-dependence management in outpatient settings.
CONCLUSIONS: All included studies showed that gradual taper was preferable to abrupt discontinuation. The results of this systematic review point to the potential value of carbamazepine as an effective intervention for benzodiazepine gradual taper discontinuation. But, larger controlled studies are needed to confirm carbamazepine's potential benefit, to assess adverse effects and to identify when its clinical use might be most indicated. Other treatment approaches to benzodiazepine discontinuation management should be explored (antidepressants, benzodiazepine receptors modulator). PMID: 23780681 [PubMed - as supplied ...
Source: Cochrane Database of Systematic Reviews - June 18, 2013 Category: Journals (General) Authors: Denis C, Fatseas M, Lavie E, Auriacombe M Tags: Cochrane Database Syst Rev Source Type: research

A Quantitative Analysis of the Spontaneous Reporting of Congestive Heart Failure-Related Adverse Events With Systemic Anti-Fungal Drugs.
Abstract To investigate spontaneous reporting relationships between representative antifungal agents and congestive heart failure (CHF)-related adverse events (AE) we performed multiple disproportionality analyses of the US FDA AERS database. Specifically we performed analysis of drug-AE associations (2D) plus drug-drug-AE and drug-AE-AE-associations (3D), the latter two to explore the potential contribution of reported pharmacodynamic interactions, overexposure from pharmacokinetic interactions, and drug overdose. Itraconazole displayed a pattern of statistical reporting dependencies across multiple analyses (2D ...
Source: The Journal of Clinical Pharmacology - May 16, 2013 Category: Drugs & Pharmacology Authors: Hauben M, Hung EY Tags: J Clin Pharmacol Source Type: research

Role of Bisoprolol in Patients with Long QT Syndrome
ConclusionsBeta‐blocking therapy is the cornerstone of LQTS therapy but actually there is no clear indication about which beta‐blocker should be used. In our experience bisoprolol proved to be less harmful and easier to manage than propranolol and nadolol in patients with LQTS, with the same effectiveness in preventing major cardiovascular events. (Source: Annals of Noninvasive Electrocardiology)
Source: Annals of Noninvasive Electrocardiology - May 3, 2013 Category: Cardiology Authors: Giovanni Fazio, Federica Vernuccio, Giuseppe Lo Re, Giuseppe Grutta, Maurizio Mongiovì Tags: ORIGINAL ARTICLE Source Type: research

Use of propanolol for treatment of large infantile haemangiomas-a report of two cases and review of the literature.
PMID: 23771115 [PubMed - in process] (Source: Annals of the Academy of Medicine, Singapore)
Source: Annals of the Academy of Medicine, Singapore - May 1, 2013 Category: Journals (General) Authors: Chandran S, Ari D, Jose J Tags: Ann Acad Med Singapore Source Type: research

Non-Antidepressant Long-Term Treatment in Post-Traumatic Stress Disorder (PTSD).
Discussion: Antipsychotics can be considered a reasonable alternative option to PTSD, with the largest body of evidence for risperidone, even though larger RCTs are warranted. Prazosin is also a promising agent, especially for sleep-related disturbances, while anticonvulsants and benzodiazepines lack empirical support. However, the most promising area for pharmacotherapy in PTSD is the modulation of the fear conditioning process, through agents used in adjunct to exposure therapy. PMID: 23438728 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 4, 2013 Category: Drugs & Pharmacology Authors: Kerbage H, Richa S Tags: Curr Clin Pharmacol Source Type: research