Fight Aging! Newsletter, January 3rd 2022
In this study, we showed that the iPaD (inducing Plagl2 and anti-Dyrk1a) lentivirus substantially rejuvenated the proliferative and neurogenic potential of NSCs in the aged brain. Clonal analysis by a sparse labeling approach as well as transcriptome analysis indicated that iPaD can rejuvenate aged NSCs (19-21 mo of age) to a level comparable with those at 1 or 2 months of age and successfully improved cognition of aged mice.
Once rejuvenated and activated by iPaD, aged dormant NSCs can generate, on average, 4.9 neurons but very few astrocytes in 3-week tracing. Furthermore, these activated NSCs were maintained for ...
Source: Fight Aging! - January 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2021: Progress Towards the Treatment of Aging as a Medical Condition
Well, here we are again, at the end of another pandemic year, a year older and - hopefully - a year wiser and more knowledgeable. I said all that really needs to be said on the topic of COVID-19 as an age-related condition at the end of last year. We might hope that, given widespread vaccination, the pandemic will become a topic of diminishing importance as the year ahead progresses, even given the present round of variants, fears, and reintroduction of restrictions.
Advocacy for Aging Research
Have we finally made significant progress in convincing the world that aging is the cause of age-related disease, th...
Source: Fight Aging! - December 31, 2021 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Ancient Love
The post Ancient Love appeared first on Dr. William Davis. (Source: Wheat Belly Blog)
Source: Wheat Belly Blog - December 28, 2021 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle oxytocin probiotic Source Type: blogs
Fight Aging! Newsletter, December 27th 2021
We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases....
Source: Fight Aging! - December 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Saccharomyces boulardii Cranberry Cocktail
The post Saccharomyces boulardii Cranberry Cocktail appeared first on Dr. William Davis. (Source: Wheat Belly Blog)
Source: Wheat Belly Blog - December 26, 2021 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle boulardii probiotic saccharomyces super gut supergut Source Type: blogs
Nicotinamide Mononucleotide Supplement Adjusts the Gut Microbiome
In today's open access paper, the authors report on their investigation of the effects of nicotinamide mononucleotide (NMN) supplementation on the gut microbiome in mice. The gut microbiome changes with age, exhibiting a loss of helpful populations that produce metabolites necessary to health, and the growth in harmful populations that provoke chronic inflammation. Rejuvenating the aged gut microbiome via fecal microbiota transplantation from a young individual has been shown to improve health and extend life in short-lived species. Thus there is some interest in evaluating the effects on the gut microbiome produced by int...
Source: Fight Aging! - December 24, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 29th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - November 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Modulation of the Aged Gut Microbiome to Benefit Health is a Field in its Infancy
Research of the past decade makes it clear that it is plausible and possible to alter the aged gut microbiome in ways that will reduce chronic inflammation and improve long-term health. This goal has been achieved in animal models via a range of different means, including flagellin immunization and fecal microbiota transplantation. In short-lived species, healthy life spans can be extended by restoring a more youthful gut microbiome, and in our own species, the detrimental changes that take place in gut microbiome populations are increasingly well catalogued. The next step has yet to be taken in earnest, however: to roll o...
Source: Fight Aging! - November 25, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Truth About Food Intolerances
Ever since the 1990s, food intolerances are proving to be a rapidly growing problem: intolerances to nightshades, so-called FODMAPs, fructose, histamine-containing foods and others. But why? And does just eliminating the food solve the problem?
We need to view food intolerances as a warning sign of the process that causes food intolerances in the first place: disruptions of bowel flora and especially small intestinal bacterial overgrowth, SIBO. Unrecognized or ignored and SIBO can lead over time to weight gain, type 2 diabetes, autoimmune conditions, neurodegenerative diseases, even gastrointestinal cancers. Recogni...
Source: Wheat Belly Blog - November 5, 2021 Category: Cardiology Authors: Dr. Davis Tags: Open defiant health food intolerances podcast super gut Source Type: blogs
Food Intolerances: A Warning of Bad Things Ahead
I’ve recently discussed how the majority of food intolerances, whether to FODMAPs, histamine, nightshades, fructose, etc., are really manifestations of dysbiosis and SIBO. Here is another way to view these phenomena: Food intolerances are your body’s signal to you that serious deterioration in your health is coming.
In other words, if all you do is choose to reduce or eliminate the offending food, you are still left with the massive disruption of your intestinal microbiome that caused the food intolerance in the first place, along with increased intestinal permeability and endotoxemia. So say you eliminate ferm...
Source: Wheat Belly Blog - November 1, 2021 Category: Cardiology Authors: Dr. Davis Tags: Open microbiota prebiotic probiotic sibo small intestinal bacterial super gut undoctored wheat belly Source Type: blogs
Defiant Health Podcast: Appetite Control Freak
Many people struggle with controlling their appetite, inevitably giving into temptation and impulse and thereby struggling with weight and multiple measures of health: higher blood sugars, higher blood pressure, higher triglycerides, fatty liver and others.
You have the potential for spectacular control over appetite by adopting several natural, healthy, safe practices that allow you to make smart choices in diet, not be plagued by incessant hunger, be satisfied with less food than other people—no drugs, no procedures, just 3 natural and powerful strategies.
Find this episode here or in your favorite podcast director...
Source: Wheat Belly Blog - October 28, 2021 Category: Cardiology Authors: Dr. Davis Tags: Open appetite defiant health podcast reuteri undoctored Weight Loss wheat belly Source Type: blogs
Latest Defiant Health podcast: The Magic of Oxytocin
While many call the hormone oxytocin “the love hormone” due to its effects on enhancing feelings of affection and closeness to other people, we could also call it “the hormone of youthfulness.” Boosting oxytocin blood levels yield effects such as smoother skin with reduced wrinkles, accelerated healing, restoration of youthful muscle and strength, deeper sleep with vivid dreams, and preservation of bone density—all markers of youthfulness.
Increasing oxytocin has, until recently, been problematic, as injectable forms last only 3 minutes, while intranasal delivery lasts only around 90 minutes.
...
Source: Wheat Belly Blog - October 22, 2021 Category: Cardiology Authors: Dr. Davis Tags: Open anti-aging microbiota oxytocin probiotic Source Type: blogs
You need more kimchi in your life
The post You need more kimchi in your life appeared first on Dr. William Davis. (Source: Wheat Belly Blog)
Source: Wheat Belly Blog - October 18, 2021 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle bowel flora microbiota prebiotic probiotic undoctored Source Type: blogs
The Happiness Microbe?
The post The Happiness Microbe? appeared first on Dr. William Davis. (Source: Wheat Belly Blog)
Source: Wheat Belly Blog - October 3, 2021 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle anxiety bowel flora happiness microbiota mood probiotic super gut undoctored Source Type: blogs
Fight Aging! Newsletter, September 27th 2021
This study provides causal evidence of a lipoprotein-Aß /capillary axis for onset and progression of a neurodegenerative process.
The Staggering Ongoing Cost of Failing to Aggressively Pursue the Development of Rejuvenation Therapies
https://www.fightaging.org/archives/2021/09/the-staggering-ongoing-cost-of-failing-to-aggressively-pursue-the-development-of-rejuvenation-therapies/
No feasible amount of funding that could be devoted to the research and development of rejuvenation therapies would be too much. If near all other projects were dropped, and institutions radically retooled on a short term basi...
Source: Fight Aging! - September 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
