An overview of current advances in perinatal alcohol exposure and pathogenesis of fetal alcohol spectrum disorders
AbstractThe adverse use of alcohol is a serious global public health problem. Maternal alcohol consumption during pregnancy usually causes prenatal alcohol exposure (PAE) in the developing fetus, leading to a spectrum of disorders known as fetal alcohol spectrum disorders (FASD) and even fetal alcohol syndrome (FAS) throughout the lifelong sufferers. The prevalence of FASD is approximately 7.7 per 1,000 worldwide, and is even higher in developed regions. Generally, Ethanol in alcoholic beverages can impair embryonic neurological development through multiple pathways leading to FASD. Among them, the leading mechanism of FAS...
Source: Journal of Neurodevelopmental Disorders - April 20, 2024 Category: Neurology Source Type: research
CD20 + T lymphocytes in isolated Hashimoto’s thyroiditis and type 3 autoimmune polyendocrine syndrome: a pilot study
ConclusionsThese preliminary findings indicate that CD8+CD20+ T cells are activated in patients with autoimmune thyroiditis and may behave differently according to the presence of poly-autoimmunity and hypothyroidism. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 20, 2024 Category: Endocrinology Source Type: research
Embryos Don ’t Care if the Sperm is There - Intravaginal Semen Deposition Does Not Increase Pregnancy Rates in IVF
(Source: Fertility and Sterility)
Source: Fertility and Sterility - April 20, 2024 Category: Reproduction Medicine Authors: Sara C. Pierpoint, Linnea R. Goodman Tags: Reflections Source Type: research
Estimating the cost of Rh testing and prophylaxis in early pregnancy: A time-driven activity-based costing study
To estimate the cost of Rh testing and prophylaxis for first-trimester vaginal bleeding in the ambulatory setting. (Source: Contraception)
Source: Contraception - April 20, 2024 Category: OBGYN Authors: Emma V. Gilmore, Louise B. Russell, Heidi S. Harvie, Courtney A. Schreiber Tags: Original Research Article Source Type: research
Factors affecting weight management in pregnant women with overweight or obesity - A meta ‐synthesis of qualitative studies
Overweight and obesity have multiple negative consequences for the health of both the mother and the child. Interventions to prevent excessive weight gain during pregnancy have had varying success, and the proportion of pregnant women who exceed national guidelines for weight gain continues to increase. (Source: Journal of the American Dietetic Association)
Source: Journal of the American Dietetic Association - April 20, 2024 Category: Nutrition Authors: Elahe Banafshe, Nahid Javadifar, Zahra Abbaspoor, Majid Karandish, Saeed Ghanbari Tags: Systematic Review Source Type: research
Fructooligosaccharides Intake during Pregnancy Improves Metabolic Phenotype of Offspring in High Fat Diet ‐Induced Obese Mice
ConclusionThe findings highlight the link between the maternal gut environment and the developmental origin of metabolic syndrome in offspring. These results open novel research avenues into preemptive therapies for metabolic disorders by targeting the maternal gut microbiota. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 19, 2024 Category: Food Science Authors: Junki Miyamoto,
Yuna Ando,
Akari Nishida,
Mayu Yamano,
Shunsuke Suzuki,
Hiromi Takada,
Ikuo Kimura Tags: Research Article Source Type: research
Improvement of Pre-check and Triage Efficiency and Guarantee of Maternal and Infant Safety in Pandemic Situation
CONCLUSION: This study demonstrates the significance of improving pre-check and triage efficiency, strengthening the management of medical staff, and implementing specialized measures for pregnant women, parturients, and neonates to ensure their safety during the COVID-19 pandemic. The established protocols and procedures can serve as a valuable reference for other healthcare facilities seeking to enhance their pandemic prevention and control strategies in gynecology and obstetrics settings.PMID:38639611 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Zhibin Lin Yanhua Ding Xiaohui Gan Juling Wang Haidong Zheng Wenjun Li Zhichuan Chen Source Type: research
Evaluation of histological and ultrastructural changes provoked by prenatal tramadol on postnatal cortical cerebellar neuronal development in rats: possible implication of Ki67, GFAP and MicroRNA-7/P53 signalling trajectories
J Mol Histol. 2024 Apr 19. doi: 10.1007/s10735-024-10189-2. Online ahead of print.ABSTRACTTramadol is a novel centrally acting analgesic. Despite, its implementation during pregnancy may impair neuronal survival and synaptic development in neonatal cerebella. The current investigation assessed the histological and ultrastructural alterations in postnatal cortical cerebellar neuronal development induced by prenatal tramadol. 30 offsprings were divided to control group I: fifteen pups born to mothers given saline from D10 till D21 of gestation. Tramadol-treated group II: fifteen pups born to mothers received tramadol HCL (50...
Source: Molecular Medicine - April 19, 2024 Category: Molecular Biology Authors: Walaa Adel Abdelmoez Source Type: research
Uterine fluid microRNAs in repeated implantation failure
Clin Chim Acta. 2024 Apr 17:119678. doi: 10.1016/j.cca.2024.119678. Online ahead of print.ABSTRACTRecurrent implantation failure (RIF) is a significant obstacle in assisted reproductive procedures, primarily because of compromised receptivity. As such, there is a need for a dependable and accurate clinical test to evaluate endometrial receptiveness, particularly during embryo transfer. MicroRNAs (miRNAs) have diverse functions in the processes of implantation and pregnancy. Dysregulation of miRNAs results in reproductive diseases such as recurrent implantation failure (RIF). The endometrium secretes several microRNAs (miRN...
Source: International Journal of Clinical Chemistry - April 19, 2024 Category: Chemistry Authors: Pourya Rokhsartalab Azar Mahdi Maleki Aghdam Sarmad Karimi Arian Haghtalab Sonia Sadeghpour Hassan Mellatyar Mortaza Taheri-Anganeh Hojat Ghasemnejad-Berenji Source Type: research
Exposure to organophosphate esters and maternal-child health
Environ Res. 2024 Apr 17:118955. doi: 10.1016/j.envres.2024.118955. Online ahead of print.ABSTRACTOrganophosphate esters (OPEs) are a class of chemicals now widely used as flame retardants and plasticizers after the phase-out of polybrominated diphenyl ethers (PBDEs). However, OPEs carry their own risk of developmental toxicity, which poses concern for recent birth cohorts as they have become ubiquitous in the environment. In this review, we summarize the literature evaluating the association between OPE exposure and maternal, perinatal, and child health outcomes. We included original articles investigating associations of...
Source: Environmental Research - April 19, 2024 Category: Environmental Health Authors: Sarvenaz Shahin Eleanor A Medley Mrudula Naidu Leonardo Trasande Akhgar Ghassabian Source Type: research
Can the endometrioma be an obstacle to complete oocyte retrieval in IVF cycles? A retrospective study
CONCLUSIONS: In conclusion, patients with endometrioma can undergo high-performance oocyte recovery procedures thanks to safe accessory maneuvers during the ovum pick-up.PMID:38639522 | DOI:10.26355/eurrev_202404_35911 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 19, 2024 Category: Drugs & Pharmacology Authors: G M Baldini A S Lagan à A Mastrorocco A Malvasi D Baldini D Ferri R Sciorio G Trojano Source Type: research
Effect of Nutrition and Behavior Modification Program (NBMP) on maternal and neonatal outcomes among hyperglycemic mothers
CONCLUSIONS: The study's conclusions draw attention to the possible roles that maternal wellness, physical activity, and diet may have in reducing risks for both hyperglycemic mothers and their newborns. The NBMP resulted in higher adherence to lifestyle changes. Further research on a larger sample of hyperglycemic mothers is recommended to expand the generalizability of the findings.PMID:38639514 | DOI:10.26355/eurrev_202404_35903 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 19, 2024 Category: Drugs & Pharmacology Authors: P Premalatha H M A Maha H A Shadia V Krishnaraju K Prabahar N T Mathar Mohideen V Vinoth Prabhu B Prema R M Mashat E L Sampayan A E Hala A A Z Marwa G Kandasamy R Ahmed M A Mervat Source Type: research
Can the endometrioma be an obstacle to complete oocyte retrieval in IVF cycles? A retrospective study
CONCLUSIONS: In conclusion, patients with endometrioma can undergo high-performance oocyte recovery procedures thanks to safe accessory maneuvers during the ovum pick-up.PMID:38639522 | DOI:10.26355/eurrev_202404_35911 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - April 19, 2024 Category: Drugs & Pharmacology Authors: G M Baldini A S Lagan à A Mastrorocco A Malvasi D Baldini D Ferri R Sciorio G Trojano Source Type: research
Effect of Nutrition and Behavior Modification Program (NBMP) on maternal and neonatal outcomes among hyperglycemic mothers
CONCLUSIONS: The study's conclusions draw attention to the possible roles that maternal wellness, physical activity, and diet may have in reducing risks for both hyperglycemic mothers and their newborns. The NBMP resulted in higher adherence to lifestyle changes. Further research on a larger sample of hyperglycemic mothers is recommended to expand the generalizability of the findings.PMID:38639514 | DOI:10.26355/eurrev_202404_35903 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - April 19, 2024 Category: Drugs & Pharmacology Authors: P Premalatha H M A Maha H A Shadia V Krishnaraju K Prabahar N T Mathar Mohideen V Vinoth Prabhu B Prema R M Mashat E L Sampayan A E Hala A A Z Marwa G Kandasamy R Ahmed M A Mervat Source Type: research
Safety of Monoclonal Antibodies Inhibiting PCSK9 in Pregnancy: Disproportionality Analysis in VigiBase ®
In conclusion, this study showed that, currently, there are no signals of increased reporting of spontaneous abortion with alirocumab and evolocumab compared with the full database and statins in VigiBase®. Notwithstanding, lack of disproportionality is not synonymous with safety and, as disproportionality analyses depend on the number of safety reports that progressively accumulate in VigiBase®, they should be repeated at regular intervals to confirm the results of the present study.PMID:38637956 | DOI:10.1002/cpt.3269 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - April 19, 2024 Category: Drugs & Pharmacology Authors: Roberta Noseda Francesca Bedussi Alice Panchaud Alessandro Ceschi Source Type: research
