Rapid screening of infertility-associated gynecological conditions via ambient glow discharge mass spectrometry utilizing urine metabolic fingerprints
Talanta. 2024 Apr 8;274:125969. doi: 10.1016/j.talanta.2024.125969. Online ahead of print.ABSTRACTInfertility presents a widespread challenge for many families worldwide, often arising from various gynecological diseases (GDs) that hinder successful pregnancies. Current diagnostic methods for GDs have disadvantages such as low efficiency, high cost, misdiagnose, invasive injury and etc. This paper introduces a rapid, non-invasive, efficient, and straightforward analytical method that utilizes desorption, separation, and ionization mass spectrometry (DSI-MS) platform in conjunction with machine learning (ML) to detect urine...
Source: Talanta - April 12, 2024 Category: Chemistry Authors: Yijiao Qu Ming Chen Yiran Wang Liangliang Qu Ruiyue Wang Huihui Liu Liping Wang Zongxiu Nie Source Type: research
Case report: The role of hypertension retinopathy graduation in the management of systemic cardiovascular disease
J Family Med Prim Care. 2024 Feb;13(2):787-791. doi: 10.4103/jfmpc.jfmpc_1772_22. Epub 2024 Mar 6.ABSTRACTModerate to severe hypertensive retinopathies are more likely to correlate with uncontrolled blood pressure in all ages. Mild microvascular changes are expected with natural aging and are therefore more concerning in patients younger than 40. Risk assessment is subsequently determined based on blood pressure measurements and patient symptoms. The goal of this paper is to discuss current opinions regarding the role of grading hypertensive retinopathy in the risk assessment of systemic cardiovascular disease in the conte...
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Kathryn Kosteva Evan J Kaufman Alicia Kinch Source Type: research
Pre-term labour: A study on evaluation of causes and outcome
CONCLUSION: Pre-maturity is a huge health and financial burden in rural and semi-urban central Gujarat. Pre-mature rupture of membranes, previous MTP, extreme physical activity, and maternal anaemia were the major risk factors linked with pre-term labour. Poor neonatal outcomes like LBW, IUGR, and a low Apgar score were significantly associated with the babies delivered pre-mature in our study.PMID:38605778 | PMC:PMC11006067 | DOI:10.4103/jfmpc.jfmpc_2411_22 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Rumi S Bhattacharjee Riya J Shah Nitin S Raithatha Mamta R Patel Source Type: research
The impact of weekly semaglutide, a glucagon-like peptide-1 agonist, on kidney outcomes in adults with type 2 diabetes mellitus
CONCLUSION: Our study on the impact of weekly semaglutide in adults with T2DM reveals positive effects on kidney outcomes, including weight loss, glycemic control and improved urine albumin creatine ratio, and a reduced risk of nephropathy. These findings highlight the potential of semaglutide as a safe and effective treatment option for improving renal health in individuals with T2DM.PMID:38605766 | PMC:PMC11006082 | DOI:10.4103/jfmpc.jfmpc_1031_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Ahmad A Algarni Fahad S Alqarni Hanin A Shalaby Source Type: research
Clomiphene citrate administered in peri-conception phase causes fetal loss and developmental impairment in mice
Endocrinology. 2024 Apr 12:bqae047. doi: 10.1210/endocr/bqae047. Online ahead of print.ABSTRACTClomiphene citrate is a common treatment for ovulation induction in subfertile women, but its use is associated with elevated risk of adverse perinatal outcomes and birth defects. To investigate the biological plausibility of a causal relationship, this study investigated in mice the consequences for fetal development and pregnancy outcome of peri-conception clomiphene citrate administration at doses approximating human exposures. A dose-dependent adverse effect of clomiphene citrate given twice in the 36 h after mating was seen,...
Source: Endocrinology - April 12, 2024 Category: Endocrinology Authors: Peck Y Chin Tom E C Kieffer Jelmer R Prins Darryl L Russell Michael J Davies Sarah A Robertson Source Type: research
