Overview of U.S. COVID-19 vaccine safety surveillance systems
This report describes the U.S. government's COVID-19 vaccine safety monitoring systems and programs used by the Centers for Disease Control and Prevention, the U.S. Food and Drug Administration, the Department of Defense, the Department of Veterans Affairs, and the Indian Health Service. Using the adverse event of myocarditis following mRNA COVID-19 vaccination as a model, we demonstrate how the multiple, complementary monitoring systems worked to rapidly detect, assess, and verify a vaccine safety signal. In addition, longer-term follow-up was conducted to evaluate the recovery status of myocarditis cases following vaccin...
Source: Vaccine - April 17, 2024 Category: Allergy & Immunology Authors: Julianne Gee Tom T Shimabukuro John R Su David Shay Margaret Ryan Sridhar V Basavaraju Karen R Broder Matthew Clark C Buddy Creech Francesca Cunningham Kristin Goddard Harrison Guy Kathryn M Edwards Richard Forshee Tanya Hamburger Anne M Hause Nicola P Kl Source Type: research
Understanding the views of adult migrants around catch-up vaccination for missed routine immunisations to define strategies to improve coverage: A UK in-depth interview study
CONCLUSIONS: The major barrier to adult catch-up vaccination for missed routine immunisations and doses in migrant communities in the UK is the limited opportunities, recommendations or tailored vaccination information presented to migrants by health services. This could be improved with financial incentives for provision of catch-up vaccination in UK primary care, alongside training of healthcare professionals to support catch-up immunisation and raise awareness of existing guidelines. It will also be essential to address root causes of mistrust around vaccination, where it exists among migrants, by working closely with c...
Source: Vaccine - April 17, 2024 Category: Allergy & Immunology Authors: Anna Deal Alison F Crawshaw Maha Salloum Sally E Hayward Jessica Carter Felicity Knights Farah Seedat Oumnia Bouaddi Nuria Sanchez-Clemente Laura Muzinga Lutumba Lusau Mimi Kitoko Sarah Nkembi Caroline Hickey Sandra Mounier-Jack Azeem Majeed Sally Hargrea Source Type: research
TLR8-activating miR-146a-3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS
In this study, the pro-inflammatory roles of TLR7/TLR8-activating miRs were examined as mediators of FM inflammation in response to bacterial lipopolysaccharide (LPS) using an in vitro human FM explant system, an in vivo mouse model of pregnancy, and human clinical samples. Following LPS exposure, miR-146a-3p was significantly increased in both human FM explants and wild-type mouse FMs. Expression of miR-146a-3p was also significantly elevated in FMs from women with preterm birth and chorioamnionitis. FM IL-8 and inflammasome-mediated IL-1β production in response to LPS was dependent on miR-146a-3p and TLR8 downstream of ...
Source: Immunology - April 17, 2024 Category: Allergy & Immunology Authors: Hanah M Georges Caterina Cassin Mancy Tong Vikki M Abrahams Source Type: research
Effect of homemade peanut oil consumption during pregnancy on low birth weight and preterm birth outcomes: a cohort study in Southwestern China
CONCLUSIONS: Homemade peanut oil consumption was a potential risk factor for both LBW and PB, of which health authorities who are responsible for food safety of the country should pay more attention to providing recommendation for oil consumption during pregnancy.PMID:38629142 | DOI:10.1080/16549716.2024.2336312 (Source: Global Health Action)
Source: Global Health Action - April 17, 2024 Category: International Medicine & Public Health Authors: Yanxu Zhong Huan Lu Yuyan Jiang Minyan Rong Xiangming Zhang Tippawan Liabsuetrakul Source Type: research
Time to pregnancy recognition among users of an FDA-cleared fertility application
Conclusion: Generalisability is limited, as all participants were using a fertility app and had relatively homogenous sociodemographic characteristics.PMID:38630958 | DOI:10.1080/01443615.2024.2337687 (Source: Journal of Obstetrics and Gynaecology)
Source: Journal of Obstetrics and Gynaecology - April 17, 2024 Category: OBGYN Authors: Agathe van Lamsweerde Jack T Pearson Rachel Urrutia Kristina Gemzell-Danielsson Helena Kopp Kallner Anita Nelson Eleonora Benhar Carlotta Favaro Elina Berglund Scherwitzl Raoul Scherwitzl Source Type: research
Safety evaluation of single-sperm cryopreservation technique applied in intracytoplasmic sperm injection
Zygote. 2024 Apr 17:1-8. doi: 10.1017/S0967199424000078. Online ahead of print.ABSTRACTIntracytoplasmic sperm injection (ICSI) is a technique that directly injects a single sperm into the cytoplasm of mature oocytes. Here, we explored the safety of single-sperm cryopreservation applied in ICSI. This retrospective study enrolled 186 couples undergoing ICSI-assisted pregnancy. Subjects were allocated to the fresh sperm (group A)/single-sperm cryopreservation (group B) groups based on sperm type, with their clinical baseline/pathological data documented. We used ICSI-compliant sperm for subsequent in vitro fertilization and f...
Source: Zygote - April 17, 2024 Category: Reproduction Medicine Authors: Duanjun Zhang Wenliang Yao Mingliang Zhang Lijuan Yang Lin Li Shujuan Liu Xianglong Jiang Yingli Sun Shuonan Hu Yufang Huang Jie Xue Xiaoting Zheng Qi Xiong Shenghui Chen Haiqin Zhu Source Type: research
“I wouldn't have felt so alone”: The sexual health education experiences of transgender and gender diverse youth living in the southeastern United States
ConclusionThere is much work needed to improve the breadth, quality, and relevance of school-based sexual health education. Sexual health education can improve by strengthening critical media literacy skills of youth; raising staff cultural competency on gender, race, and sexual identity through training and supports; using culturally relevant and inclusive curricula; and partnering with community-based organizations. Transgender and gender diverse youth would benefit from sexual health education from multiple sources which is queer-friendly, affirms their existence, and provides information on gender, race, and sexuality ...
Source: Perspectives on Sexual and Reproductive Health - April 17, 2024 Category: Sexual Medicine Authors: Paula E. Jayne,
Leigh E. Szucs,
Catherine A. Lesesne,
Rose Grace Grose,
Michelle M. Johns Tags: ARTICLE Source Type: research
Serum Folate and Vitamin B12 Modify the Associations of N6AMT1 Genetic Variants with Gestational Diabetes Mellitus: A Cross-Sectional Study in Chinese Pregnant Women
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - April 17, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
Adverse birth outcome among women who gave birth at the University of Gondar comprehensive specialized hospital, Northwest Ethiopia
In Ethiopia, various maternal and child health interventions, including comprehensive and basic obstetric cares were conducted to curb high neonatal and infant morbidity and mortality. As such, adverse birth o... (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - April 17, 2024 Category: OBGYN Authors: Melak Jejaw, Getachew Teshale, Lake Yazachew, Endalkachew Dellie and Ayal Debie Tags: Research Source Type: research
Decision-making for congenital anomalies diagnosed during pregnancy: a narrative review
ConclusionMany factors contribute to an individual ’s decision-making after a diagnosis of a fetal anomalies diagnosed in the second trimester of pregnancy, ranging from personal beliefs and goals to shared experiences of others and access to care. Understanding how sources of information may be deemed both as facilitators and barriers to differen t individuals during the decision-making process is important for healthcare providers in order to understand how to most effectively support patients. There is a dearth of information on training healthcare professionals to provide support to patients facing these decisions. (...
Source: Journal of Assisted Reproduction and Genetics - April 17, 2024 Category: Reproduction Medicine Source Type: research
Klotho-mediated activation of the anti-oxidant Nrf2/ARE signal pathway affects cell apoptosis, senescence and mobility in hypoxic human trophoblasts: involvement of Klotho in the pathogenesis of preeclampsia
The anti-aging gene Klotho is implicated in the pathogenesis of preeclampsia (PE), which is a pregnancy disease characterized by hypertension and proteinuria. Oxidative stress is closely associated with the wo... (Source: Cell Division)
Source: Cell Division - April 17, 2024 Category: Cytology Authors: Baomei Xu, Fang Cheng and Xiaolei Xue Tags: Research Source Type: research
Effect of implementation of the WHO intrapartum care model on maternal and neonatal outcomes: a randomized control trial
This study aimed to determine the effects... (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - April 17, 2024 Category: OBGYN Authors: Somayeh Abdolalipour, Shamsi Abbasalizadeh, Sakineh Mohammad-Alizadeh-Charandabi, Fatemeh Abbasalizadeh, Shayesteh Jahanfar, Fatemeh Raphi and Mojgan Mirghafourvand Tags: Research Source Type: research
Risk factors for relaparotomy after a cesarean delivery: a case-control study
Relaparotomy following a cesarean delivery (CD) is an infrequent complication, with inconsistency regarding risk factors and indications for its occurrence. We therefore aimed to determine risk factors and ind... (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - April 17, 2024 Category: OBGYN Authors: Uri Amikam, Yael Botkovsky, Alyssa Hochberg, Aviad Cohen, Ishai Levin, Yariv Yogev, Liran Hiersch and Anat Lavie Tags: Research Source Type: research
Landscapes of gut bacterial and fecal metabolic signatures and their relationship in severe preeclampsia
Preeclampsia is a pregnancy-specific disease leading to maternal and perinatal morbidity. Hypertension and inflammation are the main characteristics of preeclampsia. Many factors can lead to hypertension and i... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 17, 2024 Category: Research Authors: Xianxian Liu, Xiaoming Zeng, Xing Li, Siming Xin, Feng Zhang, Faying Liu, Yang Zeng, Jilin Wu, Yang Zou and Xinwei Xiong Tags: Research Source Type: research
Seromolecular study on the prevalence and risk factors of Toxoplasma gondii infection in pregnant women referred to a gynecology hospital in Urmia, northwest part of Iran in 2022
Toxoplasmosis is a frequent infection among the human population. The infection can cause devastating complications for the fetus during pregnancy. The present study aimed to determine the serological and mole... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - April 17, 2024 Category: Infectious Diseases Authors: Nasim Bashour, Arash Aminpour, Shabnam Vazifehkhah and Rasool Jafari Tags: Research Source Type: research
