A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 admitted to the intensive care unit (MelCOVID study): a structured summary of a study protocol for a randomized controlled trial
AbstractObjectives• Primary objective: to evaluate the effect of intravenous melatonin (IVM) on mortality in adult patients admitted to the intensive care unit (ICU) with COVID-19.• Secondary objectives:◦ To evaluate the effect of IVM on ICU length of stay.◦ To evaluate the effect of IVM on the length of mechanical ventilation (MV).◦ To evaluate if the use of IVM is associated with an increase in the number of ventilator-free days.◦ To evaluate if the use of IVM is associated with a reduced number of failing organs as determined by the sequential organ failure assessment (SOFA) scale.◦ To evaluate if th...
Source: Trials - August 5, 2020 Category: Research Source Type: clinical trials

Influence of Diet on Pregnancy With Polyhydramnios
Condition:   Polyhydramnios Intervention:   Other: Diet as recommended for gestational diabetes Sponsor:   Wolfson Medical Center Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 4, 2020 Category: Research Source Type: clinical trials

Musculoskeletal Problems During Pregnancy
Condition:   Most Common Musculoskeletal Problems in Pregnancy Intervention:   Other: No intervention Sponsor:   Eskisehir City Hospital Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 3, 2020 Category: Research Source Type: clinical trials

A Smartphone-Assisted Brief Behavioral Intervention for Pregnant Women With Depression
Condition:   Perinatal Depression Interventions:   Behavioral: Motherly 1.0;   Behavioral: Brief Psychotherapy;   Behavioral: Educational app Sponsors:   University of Sao Paulo;   Grand Challenges Canada;   Fundação Maria Cecilia Souto Vidigal Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 31, 2020 Category: Research Source Type: clinical trials

Evaluation of the Impact of the IN •Clued Curriculum: An LGBTQ Sex ed Program
Conditions:   Teen Pregnancy;   STD Prevention Intervention:   Behavioral: The IN•clued program Sponsors:   Philliber Research & Evaluation;   Planned Parenthood of the Great Northwest and the Hawaiian Islands;   The Office of Adolescent Health, HHS Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 31, 2020 Category: Research Source Type: clinical trials

A Smartphone-Assisted Brief Behavioral Intervention for Pregnant Women With Depression
Condition:   Perinatal Depression Interventions:   Behavioral: Motherly 1.0;   Behavioral: Brief Psychotherapy;   Behavioral: Educational app Sponsors:   University of Sao Paulo;   Grand Challenges Canada;   Fundação Maria Cecilia Souto Vidigal Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 31, 2020 Category: Research Source Type: clinical trials

Evaluation of the Impact of the IN •Clued Curriculum: An LGBTQ Sex ed Program
Conditions:   Teen Pregnancy;   STD Prevention Intervention:   Behavioral: The IN•clued program Sponsors:   Philliber Research & Evaluation;   Planned Parenthood of the Great Northwest and the Hawaiian Islands;   The Office of Adolescent Health, HHS Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 31, 2020 Category: Research Source Type: clinical trials

A Smartphone-Assisted Brief Behavioral Intervention for Pregnant Women With Depression
Condition:   Perinatal Depression Interventions:   Behavioral: Motherly 1.0;   Behavioral: Brief Psychotherapy;   Behavioral: Educational app Sponsors:   University of Sao Paulo;   Grand Challenges Canada;   Fundação Maria Cecilia Souto Vidigal Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 31, 2020 Category: Research Source Type: clinical trials

Evaluation of the Impact of the IN •Clued Curriculum: An LGBTQ Sex ed Program
Conditions:   Teen Pregnancy;   STD Prevention Intervention:   Behavioral: The IN•clued program Sponsors:   Philliber Research & Evaluation;   Planned Parenthood of the Great Northwest and the Hawaiian Islands;   The Office of Adolescent Health, HHS Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 31, 2020 Category: Research Source Type: clinical trials

A Smartphone-Assisted Brief Behavioral Intervention for Pregnant Women With Depression
Condition:   Perinatal Depression Interventions:   Behavioral: Motherly 1.0;   Behavioral: Brief Psychotherapy;   Behavioral: Educational app Sponsors:   University of Sao Paulo;   Grand Challenges Canada;   Fundação Maria Cecilia Souto Vidigal Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 31, 2020 Category: Research Source Type: clinical trials

Evaluation of the Impact of the IN •Clued Curriculum: An LGBTQ Sex ed Program
Conditions:   Teen Pregnancy;   STD Prevention Intervention:   Behavioral: The IN•clued program Sponsors:   Philliber Research & Evaluation;   Planned Parenthood of the Great Northwest and the Hawaiian Islands;   The Office of Adolescent Health, HHS Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 31, 2020 Category: Research Source Type: clinical trials

A Smartphone-Assisted Brief Behavioral Intervention for Pregnant Women With Depression
Condition:   Perinatal Depression Interventions:   Behavioral: Motherly 1.0;   Behavioral: Brief Psychotherapy;   Behavioral: Educational app Sponsors:   University of Sao Paulo;   Grand Challenges Canada;   Fundação Maria Cecilia Souto Vidigal Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 31, 2020 Category: Research Source Type: clinical trials

Evaluation of the Impact of the IN •Clued Curriculum: An LGBTQ Sex ed Program
Conditions:   Teen Pregnancy;   STD Prevention Intervention:   Behavioral: The IN•clued program Sponsors:   Philliber Research & Evaluation;   Planned Parenthood of the Great Northwest and the Hawaiian Islands;   The Office of Adolescent Health, HHS Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 31, 2020 Category: Research Source Type: clinical trials

A Smartphone-Assisted Brief Behavioral Intervention for Pregnant Women With Depression
Condition:   Perinatal Depression Interventions:   Behavioral: Motherly 1.0;   Behavioral: Brief Psychotherapy;   Behavioral: Educational app Sponsors:   University of Sao Paulo;   Grand Challenges Canada;   Fundação Maria Cecilia Souto Vidigal Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 31, 2020 Category: Research Source Type: clinical trials

Evaluation of the Impact of the IN •Clued Curriculum: An LGBTQ Sex ed Program
Conditions:   Teen Pregnancy;   STD Prevention Intervention:   Behavioral: The IN•clued program Sponsors:   Philliber Research & Evaluation;   Planned Parenthood of the Great Northwest and the Hawaiian Islands;   The Office of Adolescent Health, HHS Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 31, 2020 Category: Research Source Type: clinical trials

Misoprostol With Mechanical Dilation Versus Oxytocin With Mechanical Dilation for High-risk Pregnancy Inductions
Conditions:   Cesarean Section;   Misoprostol;   Oxytocin;   High Risk Pregnancy Interventions:   Drug: Oxytocin;   Drug: Misoprostol Sponsor:   Thomas Jefferson University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Evaluation of Systemic and Oral Conditions of Pregnant Women and Their Babies, With Exposure to COVID-19 Infection
Conditions:   Exposure During Pregnancy;   Corona Virus Infection Intervention:   Other: congenital malformation Sponsors:   University of Sao Paulo;   Maria Aparecida de Andrade Moreira Machado;   Thais Marchini de Oliveira Valarelli Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Supervised Safety and Feasibility Evaluation of Automated Insulin Delivery in Pregnant Patients With Type 1 Diabetes
Conditions:   Type 1 Diabetes;   Pregnancy Intervention:   Device: Automated Insulin Delivery Sponsors:   Sansum Diabetes Research Institute;   Mayo Clinic;   Harvard University;   Icahn School of Medicine at Mount Sinai Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Hair Care Product Use Among Women Of Color
Conditions:   Breast Cancer;   Pregnancy Related;   Exposure During Pregnancy Intervention:   Behavioral: Educational Intervention Sponsor:   Columbia University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Supervised Safety and Feasibility Evaluation of Automated Insulin Delivery in Pregnant Patients With Type 1 Diabetes
Conditions:   Type 1 Diabetes;   Pregnancy Intervention:   Device: Automated Insulin Delivery Sponsors:   Sansum Diabetes Research Institute;   Mayo Clinic;   Harvard University;   Icahn School of Medicine at Mount Sinai Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Evaluation of Systemic and Oral Conditions of Pregnant Women and Their Babies, With Exposure to COVID-19 Infection
Conditions:   Exposure During Pregnancy;   Corona Virus Infection Intervention:   Other: congenital malformation Sponsors:   University of Sao Paulo;   Maria Aparecida de Andrade Moreira Machado;   Thais Marchini de Oliveira Valarelli Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Misoprostol With Mechanical Dilation Versus Oxytocin With Mechanical Dilation for High-risk Pregnancy Inductions
Conditions:   Cesarean Section;   Misoprostol;   Oxytocin;   High Risk Pregnancy Interventions:   Drug: Oxytocin;   Drug: Misoprostol Sponsor:   Thomas Jefferson University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Hair Care Product Use Among Women Of Color
Conditions:   Breast Cancer;   Pregnancy Related;   Exposure During Pregnancy Intervention:   Behavioral: Educational Intervention Sponsor:   Columbia University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Supervised Safety and Feasibility Evaluation of Automated Insulin Delivery in Pregnant Patients With Type 1 Diabetes
Conditions:   Type 1 Diabetes;   Pregnancy Intervention:   Device: Automated Insulin Delivery Sponsors:   Sansum Diabetes Research Institute;   Mayo Clinic;   Harvard University;   Icahn School of Medicine at Mount Sinai Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Evaluation of Systemic and Oral Conditions of Pregnant Women and Their Babies, With Exposure to COVID-19 Infection
Conditions:   Exposure During Pregnancy;   Corona Virus Infection Intervention:   Other: congenital malformation Sponsors:   University of Sao Paulo;   Maria Aparecida de Andrade Moreira Machado;   Thais Marchini de Oliveira Valarelli Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Misoprostol With Mechanical Dilation Versus Oxytocin With Mechanical Dilation for High-risk Pregnancy Inductions
Conditions:   Cesarean Section;   Misoprostol;   Oxytocin;   High Risk Pregnancy Interventions:   Drug: Oxytocin;   Drug: Misoprostol Sponsor:   Thomas Jefferson University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Hair Care Product Use Among Women Of Color
Conditions:   Breast Cancer;   Pregnancy Related;   Exposure During Pregnancy Intervention:   Behavioral: Educational Intervention Sponsor:   Columbia University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Supervised Safety and Feasibility Evaluation of Automated Insulin Delivery in Pregnant Patients With Type 1 Diabetes
Conditions:   Type 1 Diabetes;   Pregnancy Intervention:   Device: Automated Insulin Delivery Sponsors:   Sansum Diabetes Research Institute;   Mayo Clinic;   Harvard University;   Icahn School of Medicine at Mount Sinai Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Evaluation of Systemic and Oral Conditions of Pregnant Women and Their Babies, With Exposure to COVID-19 Infection
Conditions:   Exposure During Pregnancy;   Corona Virus Infection Intervention:   Other: congenital malformation Sponsors:   University of Sao Paulo;   Maria Aparecida de Andrade Moreira Machado;   Thais Marchini de Oliveira Valarelli Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Misoprostol With Mechanical Dilation Versus Oxytocin With Mechanical Dilation for High-risk Pregnancy Inductions
Conditions:   Cesarean Section;   Misoprostol;   Oxytocin;   High Risk Pregnancy Interventions:   Drug: Oxytocin;   Drug: Misoprostol Sponsor:   Thomas Jefferson University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Hair Care Product Use Among Women Of Color
Conditions:   Breast Cancer;   Pregnancy Related;   Exposure During Pregnancy Intervention:   Behavioral: Educational Intervention Sponsor:   Columbia University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Supervised Safety and Feasibility Evaluation of Automated Insulin Delivery in Pregnant Patients With Type 1 Diabetes
Conditions:   Type 1 Diabetes;   Pregnancy Intervention:   Device: Automated Insulin Delivery Sponsors:   Sansum Diabetes Research Institute;   Mayo Clinic;   Harvard University;   Icahn School of Medicine at Mount Sinai Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Evaluation of Systemic and Oral Conditions of Pregnant Women and Their Babies, With Exposure to COVID-19 Infection
Conditions:   Exposure During Pregnancy;   Corona Virus Infection Intervention:   Other: congenital malformation Sponsors:   University of Sao Paulo;   Maria Aparecida de Andrade Moreira Machado;   Thais Marchini de Oliveira Valarelli Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Misoprostol With Mechanical Dilation Versus Oxytocin With Mechanical Dilation for High-risk Pregnancy Inductions
Conditions:   Cesarean Section;   Misoprostol;   Oxytocin;   High Risk Pregnancy Interventions:   Drug: Oxytocin;   Drug: Misoprostol Sponsor:   Thomas Jefferson University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Hair Care Product Use Among Women Of Color
Conditions:   Breast Cancer;   Pregnancy Related;   Exposure During Pregnancy Intervention:   Behavioral: Educational Intervention Sponsor:   Columbia University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Supervised Safety and Feasibility Evaluation of Automated Insulin Delivery in Pregnant Patients With Type 1 Diabetes
Conditions:   Type 1 Diabetes;   Pregnancy Intervention:   Device: Automated Insulin Delivery Sponsors:   Sansum Diabetes Research Institute;   Mayo Clinic;   Harvard University;   Icahn School of Medicine at Mount Sinai Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Evaluation of Systemic and Oral Conditions of Pregnant Women and Their Babies, With Exposure to COVID-19 Infection
Conditions:   Exposure During Pregnancy;   Corona Virus Infection Intervention:   Other: congenital malformation Sponsors:   University of Sao Paulo;   Maria Aparecida de Andrade Moreira Machado;   Thais Marchini de Oliveira Valarelli Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Misoprostol With Mechanical Dilation Versus Oxytocin With Mechanical Dilation for High-risk Pregnancy Inductions
Conditions:   Cesarean Section;   Misoprostol;   Oxytocin;   High Risk Pregnancy Interventions:   Drug: Oxytocin;   Drug: Misoprostol Sponsor:   Thomas Jefferson University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Hair Care Product Use Among Women Of Color
Conditions:   Breast Cancer;   Pregnancy Related;   Exposure During Pregnancy Intervention:   Behavioral: Educational Intervention Sponsor:   Columbia University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Supervised Safety and Feasibility Evaluation of Automated Insulin Delivery in Pregnant Patients With Type 1 Diabetes
Conditions:   Type 1 Diabetes;   Pregnancy Intervention:   Device: Automated Insulin Delivery Sponsors:   Sansum Diabetes Research Institute;   Mayo Clinic;   Harvard University;   Icahn School of Medicine at Mount Sinai Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Evaluation of Systemic and Oral Conditions of Pregnant Women and Their Babies, With Exposure to COVID-19 Infection
Conditions:   Exposure During Pregnancy;   Corona Virus Infection Intervention:   Other: congenital malformation Sponsors:   University of Sao Paulo;   Maria Aparecida de Andrade Moreira Machado;   Thais Marchini de Oliveira Valarelli Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

Misoprostol With Mechanical Dilation Versus Oxytocin With Mechanical Dilation for High-risk Pregnancy Inductions
Conditions:   Cesarean Section;   Misoprostol;   Oxytocin;   High Risk Pregnancy Interventions:   Drug: Oxytocin;   Drug: Misoprostol Sponsor:   Thomas Jefferson University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 30, 2020 Category: Research Source Type: clinical trials

RECOVERY- Respiratory Support: Respiratory Strategies for patients with suspected or proven COVID-19 respiratory failure; Continuous Positive Airway Pressure, High-flow Nasal Oxygen, and standard care: A structured summary of a study protocol for a randomised controlled trial
AbstractObjectiveThe trial objective is to determine if Continuous Positive Airway Pressure (CPAP) or High-Flow Nasal Oxygen (HFNO) is clinically effective compared to standard oxygen therapy in patients with confirmed or suspected COVID-19.Trial designAdaptive (group-sequential), parallel group, pragmatic, superiority randomised controlled, open-label, multi-centre, effectiveness trial.ParticipantsThe trial is being conducted across approximately 60 hospitals across England, Wales, Scotland, and Northern Ireland. Inpatients at participating hospitals are eligible to participate if they have respiratory failure with suspec...
Source: Trials - July 29, 2020 Category: Research Source Type: clinical trials

Pre-exposure prophylaxis with hydroxychloroquine for high-risk healthcare workers during the COVID-19 pandemic: A structured summary of a study protocol for a multicentre, double-blind randomized controlled trial
AbstractObjectivesThe aim of this study is to assess the efficacy of the use of pre-exposure prophylaxis (PrEP) with hydroxychloroquine against placebo in healthcare workers with high risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in reducing their risk of coronavirus disease 2019 (COVID-19) disease during an epidemic period.As secondary objectives, we would like to: i) assess the efficacy of the use of PrEP with hydroxychloroquine against placebo in healthcare workers with high risk of SARS-CoV-2 infection in reducing their risk of exposure to SARS-CoV-2 (defined by seroconversion) during a...
Source: Trials - July 29, 2020 Category: Research Source Type: clinical trials

Stria Gravidarum and Olive Oil for Pregnancy Women
Conditions:   Striae Gravidarum;   Pregnancy Related Intervention:   Other: Olive oil Sponsor:   Ayca Solt Kirca Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 28, 2020 Category: Research Source Type: clinical trials