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Bone quality in zebrafish vertebrae improves after alendronate administration in a glucocorticoid-induced osteoporosis model
J Mech Behav Biomed Mater. 2024 Mar 24;154:106521. doi: 10.1016/j.jmbbm.2024.106521. Online ahead of print.ABSTRACTGlucocorticoid-induced osteoporosis (GIOP) changes the microarchitecture of bones and often leads to the reduction of bone-mineral density (BMD) and increased fracture rates. Zebrafish has been used as an alternative model for GIOP, however, the interaction of GIOP, and its treatment, with zebrafish bone morphometrics and mechanical properties, remains a challenge. Thus, this study aimed to evaluate the effects of prednisolone and alendronate on the properties of zebrafish vertebrae. Adult 7-month-old zebrafis...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 31, 2024 Category: Materials Science Authors: Fabio Rocha Bohns Riaz Akhtar Yung-Jen Chuang Po-Yu Chen Source Type: research

Prednisolone with azathioprine or mycophenolate mofetil as first-line therapy in autoimmune hepatitis: insights from a randomized controlled trial
We express our appreciation to our colleagues for their invaluable feedback1-5 on our recent publication,6, which has garnered considerable interest. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 28, 2024 Category: Gastroenterology Authors: Rom ée J.A.L.M. Snijders, Anna E.C. Stoelinga, Bart van Hoek, Joost P.H. Drenth Tags: Letter to the Editor Source Type: research

Prednisolone in COPD: the overlooked harm
Br J Gen Pract. 2024 Mar 27;74(741):155. doi: 10.3399/bjgp24X736809. Print 2024 Apr.NO ABSTRACTPMID:38538126 | DOI:10.3399/bjgp24X736809 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - March 27, 2024 Category: Primary Care Authors: Sophie Elizabeth Yale Source Type: research

Prednisolone in COPD: the overlooked harm
Br J Gen Pract. 2024 Mar 27;74(741):155. doi: 10.3399/bjgp24X736809. Print 2024 Apr.NO ABSTRACTPMID:38538126 | PMC:PMC10962531 | DOI:10.3399/bjgp24X736809 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - March 27, 2024 Category: Primary Care Authors: Sophie Elizabeth Yale Source Type: research

Facial cutaneous Rosai-Dorfman disease: a case report
ConclusionAlthough cutaneous Rosai-Dorfman disease is considered benign and well medical responded disease, patients with atypical presentation and rapid growing lesion may necessitate aggressive multimodal treatment. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 27, 2024 Category: General Medicine Source Type: research

Inhibition of IL-25/IL-17RA improves immune-related adverse events of checkpoint inhibitors and reveals antitumor activity
CONCLUSION: These findings suggest that IL-25/IL-17RA may serve as an additional target when treating ICI-responsive tumors, allowing for better tumor control while suppressing immune-related toxicities.PMID:38519059 | DOI:10.1136/jitc-2023-008482 (Source: Cancer Control)
Source: Cancer Control - March 22, 2024 Category: Cancer & Oncology Authors: Xizi Hu Shoiab M Bukhari Carly Tymm Kieran Adam Shalom Lerrer Brian S Henick Robert J Winchester Adam Mor Source Type: research

Evaluation of the effectiveness of using prednisolone, tacrolimus, and intravenous immunoglobulin combination therapy on immune ‐mediated necrotizing myopathy—A non‐randomized, observational research
ConclusionThe combination therapy of prednisolone, tacrolimus, and IVIG has demonstrated favorable efficacy in IMNM and broadened the treatment options for this disease. However, the results still require further validation by large-scale and randomized controlled studies. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 22, 2024 Category: Rheumatology Authors: Mengyang Liu, Jiaqi Liu, Ke Li, Lingya Qiao, Juan Chen, Ying Lin, Qiang Shi Tags: ORIGINAL ARTICLE Source Type: research

Sudden onset of symptoms in concurrent Takayasu arteritis and Ulcerative colitis: A case report with neurological complications
We present a rare case of a 44-year-old female diagnosed with both UC and TAK, characterized by an unusual acute asymptomatic onset accompanied by neurological manifestations. The patient exhibited symptoms of acute ischemic stroke along with vascular abnormalities, as well as colon inflammation associated with UC. The patient's asymptomatic presentation at the onset differs from previously reported cases. The presence of additional complications, such as hepatocellular adenoma and primary sclerosing cholangitis, further complicated the diagnostic challenges. The patient's treatment involved a combination of methylpredniso...
Source: Clinical Case Reports - March 22, 2024 Category: General Medicine Authors: Amirreza Khalaji, Taha Mahdian, Amir Taher Eftekharsadat, Mehdi Jafarpour Tags: CASE REPORT Source Type: research

Initiation of belimumab with higher daily prednisolone is effective for rapid glucocorticoid reduction: A 96-week retrospective study
CONCLUSIONS: Our study showed that a delay in belimumab initiation led to higher SLEDAI-2K score and difficulty in achieving a 50% GC reduction at 96 weeks. Since GC-related adverse events increase with long-term administration of GC though with small daily doses, we proposed here that belimumab should be started in combination with higher daily prednisolone.PMID:38509864 | DOI:10.1177/09612033241240859 (Source: Lupus)
Source: Lupus - March 21, 2024 Category: Rheumatology Authors: Takashi Yamane Akira Hashiramoto Source Type: research