Predictors of medications-free and long-term remission in anti-neutrophil cytoplasmic antibody-associated vasculitis: Real-world evidence
CONCLUSIONS: Induction therapy leads to long-term and medications-free remission in 72% and 38% of patients with AAV, respectively.PMID:38567565 | PMC:PMC11008330 | DOI:10.36141/svdld.v41i1.14367 (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 3, 2024 Category: Respiratory Medicine Authors: Parvin Babapoor Mehrzad Hajialilo Mehran Rahimi Kamal Esalatmanesh Dara Rahmanpour Ali Barahimi Alireza Khabbazi Source Type: research
Sarcoidosis as a cause of chronic back pain: a case report
In this report, we present a case involving a previously healthy 55-year-old woman who sought medical attention due to chronic back pain. She was subsequently diagnosed with spinal sarcoidosis, based on MRI, PET scan, and biopsy results. Furthermore, treatment with prednisolone monotherapy demonstrated substantial improvement in her symptoms.PMID:38567561 | PMC:PMC11008322 | DOI:10.36141/svdld.v41i1.14813 (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 3, 2024 Category: Respiratory Medicine Authors: Georges El Hasbani Jessica Nicolas Vicky Najjar Ali Jawad Imad Uthman Source Type: research
Prednisolone Versus Colchicine for Acute Gout in Primary Care: statistical analysis plan for the pragmatic, multicenter, randomized, and double-blinded COPAGO non-inferiority trial
To date, colchicine and prednisolone are two effective therapies for the treatment of acute gout but have never been compared directly in a randomized clinical trial. In addition, in previous trials of treatin... (Source: Trials)
Source: Trials - April 3, 2024 Category: General Medicine Authors: Adrian Richter, Julia Truthmann, Eva Hummers, Julia Freyer Martins Pereira, Ildik ó Gágyor, Franziska Schuster, Amelie Witte, Susanne Böhm, Alexandra Greser, Petra Kamin, Sylvia Stracke, Marcus Dörr, Robin Bülow, Stefan Engeli, Jean François Chenot Tags: Update Source Type: research
The effect of prednisolone and a short-term prednisolone discontinuation for the diagnostic accuracy of FDG-PET/CT in polymyalgia rheumatica-a prospective study of 101 patients
CONCLUSION: FDG-PET/CT has limited diagnostic accuracy for differentiating PMR from other inflammatory diseases. If FDG-PET/CT is intended for diagnostic purposes, prednisolone should be discontinued to enhance diagnostic accuracy.TRIAL REGISTRATION: ClinicalTrials.gov (NCT04519580). Registered 17th of August 2020.PMID:38563881 | DOI:10.1007/s00259-024-06697-8 (Source: Molecular Medicine)
Source: Molecular Medicine - April 2, 2024 Category: Molecular Biology Authors: Andreas Wiggers Nielsen Ib T ønder Hansen Berit Dalsgaard Nielsen S øren Geill Kjær Jesper Blegvad-Nissen Kate Rewers Christian M øller Sørensen Ellen-Margrethe Hauge Lars Christian Gormsen Kresten Krarup Keller Source Type: research
The effect of prednisolone and a short-term prednisolone discontinuation for the diagnostic accuracy of FDG-PET/CT in polymyalgia rheumatica-a prospective study of 101 patients
CONCLUSION: FDG-PET/CT has limited diagnostic accuracy for differentiating PMR from other inflammatory diseases. If FDG-PET/CT is intended for diagnostic purposes, prednisolone should be discontinued to enhance diagnostic accuracy.TRIAL REGISTRATION: ClinicalTrials.gov (NCT04519580). Registered 17th of August 2020.PMID:38563881 | DOI:10.1007/s00259-024-06697-8 (Source: Molecular Medicine)
Source: Molecular Medicine - April 2, 2024 Category: Molecular Biology Authors: Andreas Wiggers Nielsen Ib T ønder Hansen Berit Dalsgaard Nielsen S øren Geill Kjær Jesper Blegvad-Nissen Kate Rewers Christian M øller Sørensen Ellen-Margrethe Hauge Lars Christian Gormsen Kresten Krarup Keller Source Type: research
The effect of prednisolone and a short-term prednisolone discontinuation for the diagnostic accuracy of FDG-PET/CT in polymyalgia rheumatica —a prospective study of 101 patients
ConclusionFDG-PET/CT has limited diagnostic accuracy for differentiating PMR from other inflammatory diseases. If FDG-PET/CT is intended for diagnostic purposes, prednisolone should be discontinued to enhance diagnostic accuracy.Trial registrationClinicalTrials.gov (NCT04519580). Registered 17th of August 2020. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 2, 2024 Category: Nuclear Medicine Source Type: research
Successful treatment with tofacitinib for anti-melanoma differentiation-associated gene 5 antibody-positive juvenile dermatomyositis: case reports and review of the literature
We describe two female Japanese patients with anti-MDA5 Ab + JDM and rapidly progressive interstitial lung disease who achieved remission by adding tofacitinib to existing immunosuppressive drugs and present a literature review. While both patients received various immunosuppressive or anti-inflammatory treatments for induction therapy, remission could not be achieved. Subsequently, tofacitinib was administered to reduce the Krebs von den Lungen-6 level 5 months after diagnosis in one patient; the other patient received tofacitinib 4 months after diagnosis to reduce ferritin levels and skin manifestations. Subsequently, bo...
Source: Herpes - April 1, 2024 Category: Infectious Diseases Authors: Susumu Yamazaki Masaki Shimizu Ayane Yakabe Eisuke Inage Keisuke Jimbo Mitsuyoshi Suzuki Futaba Miyaoka Shuya Kaneko Hitoshi Irabu Asami Shimbo Yoshiyuki Ohtomo Masaaki Mori Tomohiro Morio Toshiaki Shimizu Source Type: research
Bone quality in zebrafish vertebrae improves after alendronate administration in a glucocorticoid-induced osteoporosis model
J Mech Behav Biomed Mater. 2024 Mar 24;154:106521. doi: 10.1016/j.jmbbm.2024.106521. Online ahead of print.ABSTRACTGlucocorticoid-induced osteoporosis (GIOP) changes the microarchitecture of bones and often leads to the reduction of bone-mineral density (BMD) and increased fracture rates. Zebrafish has been used as an alternative model for GIOP, however, the interaction of GIOP, and its treatment, with zebrafish bone morphometrics and mechanical properties, remains a challenge. Thus, this study aimed to evaluate the effects of prednisolone and alendronate on the properties of zebrafish vertebrae. Adult 7-month-old zebrafis...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 31, 2024 Category: Materials Science Authors: Fabio Rocha Bohns Riaz Akhtar Yung-Jen Chuang Po-Yu Chen Source Type: research
Bone quality in zebrafish vertebrae improves after alendronate administration in a glucocorticoid-induced osteoporosis model
J Mech Behav Biomed Mater. 2024 Mar 24;154:106521. doi: 10.1016/j.jmbbm.2024.106521. Online ahead of print.ABSTRACTGlucocorticoid-induced osteoporosis (GIOP) changes the microarchitecture of bones and often leads to the reduction of bone-mineral density (BMD) and increased fracture rates. Zebrafish has been used as an alternative model for GIOP, however, the interaction of GIOP, and its treatment, with zebrafish bone morphometrics and mechanical properties, remains a challenge. Thus, this study aimed to evaluate the effects of prednisolone and alendronate on the properties of zebrafish vertebrae. Adult 7-month-old zebrafis...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 31, 2024 Category: Materials Science Authors: Fabio Rocha Bohns Riaz Akhtar Yung-Jen Chuang Po-Yu Chen Source Type: research
Bone quality in zebrafish vertebrae improves after alendronate administration in a glucocorticoid-induced osteoporosis model
J Mech Behav Biomed Mater. 2024 Mar 24;154:106521. doi: 10.1016/j.jmbbm.2024.106521. Online ahead of print.ABSTRACTGlucocorticoid-induced osteoporosis (GIOP) changes the microarchitecture of bones and often leads to the reduction of bone-mineral density (BMD) and increased fracture rates. Zebrafish has been used as an alternative model for GIOP, however, the interaction of GIOP, and its treatment, with zebrafish bone morphometrics and mechanical properties, remains a challenge. Thus, this study aimed to evaluate the effects of prednisolone and alendronate on the properties of zebrafish vertebrae. Adult 7-month-old zebrafis...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 31, 2024 Category: Materials Science Authors: Fabio Rocha Bohns Riaz Akhtar Yung-Jen Chuang Po-Yu Chen Source Type: research
Prednisolone with azathioprine or mycophenolate mofetil as first-line therapy in autoimmune hepatitis: insights from a randomized controlled trial
We express our appreciation to our colleagues for their invaluable feedback1-5 on our recent publication,6, which has garnered considerable interest. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 28, 2024 Category: Gastroenterology Authors: Rom ée J.A.L.M. Snijders, Anna E.C. Stoelinga, Bart van Hoek, Joost P.H. Drenth Tags: Letter to the Editor Source Type: research
Prednisolone in COPD: the overlooked harm
Br J Gen Pract. 2024 Mar 27;74(741):155. doi: 10.3399/bjgp24X736809. Print 2024 Apr.NO ABSTRACTPMID:38538126 | DOI:10.3399/bjgp24X736809 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - March 27, 2024 Category: Primary Care Authors: Sophie Elizabeth Yale Source Type: research
Prednisolone in COPD: the overlooked harm
Br J Gen Pract. 2024 Mar 27;74(741):155. doi: 10.3399/bjgp24X736809. Print 2024 Apr.NO ABSTRACTPMID:38538126 | DOI:10.3399/bjgp24X736809 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - March 27, 2024 Category: Primary Care Authors: Sophie Elizabeth Yale Source Type: research
Prednisolone in COPD: the overlooked harm
Br J Gen Pract. 2024 Mar 27;74(741):155. doi: 10.3399/bjgp24X736809. Print 2024 Apr.NO ABSTRACTPMID:38538126 | PMC:PMC10962531 | DOI:10.3399/bjgp24X736809 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - March 27, 2024 Category: Primary Care Authors: Sophie Elizabeth Yale Source Type: research
