Adrenocortical suppression in children with nephrotic syndrome treated with corticosteroids
ConclusionsA significant proportion of children with nephrotic syndrome were detected with adrenal insufficiency on ACTH stimulation test. A cumulative steroid intake of > 0.22 mg/kg/day on an alternate day basis emerged as a risk factor for predicting adrenocortical suppression.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Levamisole in childhood idiopathic nephrotic syndrome: new promises, and advocacy for global access
This study suggests that both of these st rategies are efficacious and safe. Results of this study should redefine the role of levamisole in future guidelines, and a call for global availability of levamisole should be advocated. (Source: Kidney International)
Source: Kidney International - April 18, 2024 Category: Urology & Nephrology Authors: Eugene Yu-hin Chan, Olivia Boyer Tags: Commentary Source Type: research
A Case of Adult-onset Still's Disease (AOSD) with Gastrointestinal Lesions
Intern Med. 2024 Apr 16. doi: 10.2169/internalmedicine.3412-23. Online ahead of print.ABSTRACTA 51-year-old woman with fever was admitted to our hospital. A computed tomography (CT) scan showed thickened colonic walls. Colonoscopy revealed erosion in the ileum and colon. Adult-onset Still's disease (AOSD) was diagnosed due to a subsequent sore throat and skin rash. Following AOSD treatment, methylprednisolone pulse therapy, followed by prednisolone and cyclosporine, was initiated. Despite achieving a temporary improvement, relapse occurred with fever, abdominal pain, with worsening CT and endoscopic findings. The reappeara...
Source: Internal Medicine - April 17, 2024 Category: Internal Medicine Authors: Takahito Harada Yoshikazu Hirata Hayato Kawamura Yuki Yamamoto Yuka Kobayashi Daisuke Kumai Akihisa Adachi Yoshihito Nagura Hirokazu Ikeuchi Noriyuki Hayashi Hiroki Takada Satoshi Sobue Megumi Yoshida Source Type: research
Diagnosis, Treatment, and Follow-Up of Giant-Cell Arteritis: A Retrospective Multicenter Study
CONCLUSIONS: This study observed high dropout rates and short follow-ups. Adverse effects of prednisolone were common, and relapses occurred in approximately one-tenth of Korean patients with GCA. Thus, optimizing GCA treatment necessitates regular monitoring and long-term follow-up.PMID:38627226 | DOI:10.3988/jcn.2023.0169 (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - April 16, 2024 Category: Neurology Authors: Mi-Kyoung Kang Yooha Hong Yoo Hwan Kim Hong-Kyun Park Soo-Kyoung Kim Jong-Hee Sohn Jiyoung Kim Ki-Han Kwon Soo-Jin Cho Source Type: research
Effective treatment of steroid ‐resistant immune checkpoint inhibitor pneumonitis with mycophenolate mofetil
We report two cases of steroid-resistant CIP treated with MMF. Both patients responded to initial treatment with prednisolone (PSL), but the CIP flared up repeatedly as the steroids were gradually tapered off. Upon receiving MMF in addition to PSL, their subjective symptoms improved, and the shadows gradually disappeared, allowing for a reduction in the steroid dose. Ultimately, no CIP recurrence was observed despite discontinuing PSL and MMF. Both cases were completely resolved by treatment with MMF. This indicates that MMF may be effective in treating steroid-resistant CIP. In the future, the effects and safety of MMF sh...
Source: Respirology Case Reports - April 16, 2024 Category: Respiratory Medicine Authors: Nao Shioiri,
Ryota Kikuchi,
Itsuka Matsumoto,
Kanako Furukawa,
Kenichi Kobayashi,
Shinji Abe Tags: CASE REPORT Source Type: research
Repeated Pulses of Methyl-Prednisolone in Adults Hospitalized With COVID-19 Pneumonia and Acute Respiratory Distress Syndrome: A Preliminary Before-After Study (CortiCOVID Study)
CONCLUSIONS: In patients with severe pneumonia due to COVID-19, the administration of methylprednisolone pulses was associated with a lower rate of OTI and/or death and a shorter hospitalization episode.PMID:38620829 | PMC:PMC7977067 | DOI:10.1016/j.opresp.2021.100086 (Source: Respiratory Care)
Source: Respiratory Care - April 15, 2024 Category: Respiratory Medicine Authors: Michelle Espinosa-Solano Demetrio Gonzalez-Vergara Marta Ferrer-Galvan Maria Isabel Asensio-Cruz Jose M Lomas Cristina Roca-Oporto Maria Dolores Navarro-Amuedo Maria Paniagua-Garcia Cesar Sotomayor Nuria Espinosa Manuel Garcia-Gutierrez Jose Molina Gil-Be Source Type: research
Recurrence of sarcoidosis accompanied by lung cancer after drug ‐induced pulmonary sarcoidosis with lung injury
We present the case of sarcoidosis recurrence associated with lung cancer after drug-induced pulmonary sarcoidosis with lung injury. To our knowledge, this is the first report of sarcoidosis triggered by drug administration and lung cancer. Histological diagnosis of mediastinal lymphadenopathy with lung cancer is essential for differentiating metastasis from sarcoidosis. AbstractSarcoidosis is a multisystemic granulomatous disease that is frequently localized in the lungs and lymph nodes. We herein report a case of pulmonary sarcoidosis secondary to shin'iseihaito administration. During remission with 5 mg prednisolone/...
Source: Respirology Case Reports - April 12, 2024 Category: Respiratory Medicine Authors: Kentaro Suzuki,
Yoshiro Kai,
Ryosuke Kataoka,
Maiko Takeda,
Shigeo Muro Tags: CASE REPORT Source Type: research
Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force
CONCLUSIONS: cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research.PMID:38604255 | DOI:10.1016/j.clim.2024.110214 (Source: Clinical Immunology)
Source: Clinical Immunology - April 11, 2024 Category: Allergy & Immunology Authors: E M D Smith A Aggarwal J Ainsworth E Al-Abadi T Avcin L Bortey J Burnham C Ciurtin C M Hedrich S Kamphuis L Lambert D M Levy L Lewandowski N Maxwell E Morand S Özen C E Pain A Ravelli C Saad Magalhaes C Pilkington D Schonenberg-Meinema C Scott K Tullus M Source Type: research
Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force
CONCLUSIONS: cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research.PMID:38604255 | DOI:10.1016/j.clim.2024.110214 (Source: Clinical Immunology)
Source: Clinical Immunology - April 11, 2024 Category: Allergy & Immunology Authors: E M D Smith A Aggarwal J Ainsworth E Al-Abadi T Avcin L Bortey J Burnham C Ciurtin C M Hedrich S Kamphuis L Lambert D M Levy L Lewandowski N Maxwell E Morand S Özen C E Pain A Ravelli C Saad Magalhaes C Pilkington D Schonenberg-Meinema C Scott K Tullus M Source Type: research
Oral low dose prednisolone treatment for frozen shoulder: A randomized prospective study
This study aimed to estimate the outcomes of a comparison of low-dose prednisolone (PSL) oral treatment and non-steroidal anti-inflammatory drugs (NSAIDs) treatment for frozen shoulder with randomized prospective methods. (Source: Journal of Shoulder and Elbow Surgery)
Source: Journal of Shoulder and Elbow Surgery - April 11, 2024 Category: Orthopaedics Authors: Yuichi Nagase, Masashi Naito, Masahiko Morishige, Hideaki Asai, Sakae Tanaka, Kazuya Tamai Source Type: research
Control of pleural effusion with prednisolone in a patient with yellow nail syndrome: A case report
Exp Ther Med. 2024 Mar 22;27(5):224. doi: 10.3892/etm.2024.12512. eCollection 2024 May.ABSTRACTYellow nail syndrome (YNS) can induce bilateral exudative pleural effusion; however, to the best of our knowledge, no standard treatment for YNS has been established. The present study describes a patient with YNS for whom the pleural effusion was controlled by prednisolone. A 73-year-old man was referred to the University of Tsukuba Hospital (Ibaraki, Japan) complaining of shortness of breath, which was diagnosed as being due to bilateral pleural effusion. Based on the presence of yellowing and growth retardation of the toenails...
Source: Experimental and Therapeutic Medicine - April 10, 2024 Category: General Medicine Authors: Manato Taguchi Hironori Masuko Kai Kawashima Tetsuya Yamagishi Yuka Kitaoka Rie Shigemasa Kazufumi Yoshida Chikako Tsurushige Hiroaki Satoh Nobuyuki Hizawa Source Type: research
