Double positivity for anti ‐N‐methyl‐d‐aspartate receptor and anti‐aquaporin‐4 antibodies in a patient presenting with hypersomnolence, personality change, and reduced spontaneity
ConclusionsAlthough her main symptoms were compatible with NMDARE, MRI findings were more compatible with NMOSD. Therefore, we interpreted her clinical and imaging features as a mixed phenotype of NMOSD and NMDARE. This case report provides additional evidence that double positivity for AQP4 ‐ab and NMDAR‐ab is associated with a mixed phenotype of NMOSD and NMDARE. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - March 31, 2020 Category: Neurology Authors: Motoi Yoshimura, Taira Uehara, Eizo Tanaka, Toshiki Okadome, Takahiro Yamaguchi, Yasuhiro Maeda, Noriko Isobe, Takuya Matsushita, Ryo Yamasaki, Jun ‐ichi Kira Tags: CASE REPORT Source Type: research

A Multicentre Comparative Analysis of Use of Steroids and Prophylactic Antibiotics with First-line Docetaxel in Hormone Sensitive Metastatic Prostate Cancer
Purpose: To assess the benefits and risks of co-administering maintenance prednisolone with docetaxel and androgen-deprivation therapy (ADT) in hormone sensitive metastatic prostate cancer (HSMPC). (Source: Clinical Oncology)
Source: Clinical Oncology - March 31, 2020 Category: Radiology Authors: K. Ng, L. Pemberton, H. Barot, C. Alifrangis, U. McGovern, J. Shamash Source Type: research

Glucocorticoids Disrupt Skeletal Angiogenesis Through Transrepression of NF ‐κB–Mediated Preosteoclast Pdgfb Transcription in Young Mice
ABSTRACTIn the growing skeleton, angiogenesis is intimately coupled with osteogenesis. Chronic, high doses of glucocorticoids (GCs) are associated with decreased bone vasculature and induce osteoporosis and growth failure. The mechanism of GC ‐suppression of angiogenesis and relationship to osteoporosis and growth retardation remains largely unknown. Type H vessels, which are regulated by preosteoclast (POC) platelet‐derived growth factor–BB (PDGF‐BB), are specifically coupled with bone formation and development. We determined th e effect of GCs on POC synthesis of PDGF‐BB in relation to type H vessel formati...
Source: Journal of Bone and Mineral Research - March 30, 2020 Category: Orthopaedics Authors: Yi Peng, Shan Lv, Yusheng Li, Jianxi Zhu, Shijie Chen, Gehua Zhen, Xu Cao, Song Wu, Janet L. Crane Tags: Original Article Source Type: research

Reduction in the Number of Varicella-Zoster Virus-Specific T-Cells in Immunocompromised Children with Varicella.
In conclusion, the decreased numbers of VZV-specific CD8+T-cells during the acute phase and VZV-specific CD4+T-cells during the convalescent phase of disease may account for severe varicella in immunocompromised children. PMID: 32213753 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - March 28, 2020 Category: Research Authors: Murata K, Hoshina T, Onoyama S, Tanaka T, Kanno S, Ishimura M, Koga Y, Nakayama H, Ohga S Tags: Tohoku J Exp Med Source Type: research

A case of eosinophilic fasciitis and generalized morphea overlap
A 60-year old man developed skin hardening and edema on his extremities. Although he had been treated with oral prednisolone at another hospital, skin stiffness relapsed during tapering of prednisolone. At the initial visit to our department, physical examination showed skin hardening of the extremities and also symmetric erythematous macules on the back. Histological examination revealed fasciitis on the forearm and morphea on the back. Eosinophilic fasciitis is occasionally associated with morphea. However, cases of concurrent eosinophilic fasciitis and generalized morphea are rare. In the present case, CD34 was differen...
Source: Dermatology Online Journal - March 27, 2020 Category: Dermatology Source Type: research

Prednisolone Prophase for a Week Versus Upfront Multiagent Chemotherapy in Childhood Acute Lymphoblastic Leukemia: An Analysis With Reference to Induction Mortality in a Developing Country
In childhood acute lymphoblastic leukemia, high treatment-related mortality, especially in the induction phase of treatment, is a major challenge for developing countries. The reasons are multifactorial, including a late presentation with higher disease burden, malnourishment, and limited support services. These factors may aggravate the toxic effects of upfront multiagent chemotherapy in terms of severe neutropenic sepsis and tumor lysis. Therefore, instead of upfront chemotherapy, we offered prednisolone prophase for 1 week with the objective of balancing the antileukemic versus the toxic effect of treatment. The data of...
Source: Journal of Pediatric Hematology Oncology - March 25, 2020 Category: Hematology Tags: Original Articles Source Type: research

Anti-arthritic activity of ferulic acid in complete Freund ’s adjuvant (CFA)-induced arthritis in rats: JAK2 inhibition
This study aimed to investigate the anti-arthritic activity and possible mechanism(s) of action of FA in complete Freund ’s adjuvant (CFA)-induced arthritis. The progression of rheumatoid arthritis (RA) involves the activation of the Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway by proinflammatory cytokines. Molecular docking of FA showed promising Janus kinase 2 (JAK2) inhibition with a docking score of − 6.7, which is comparable with that of ruxolitinib, a standard inhibitor. However, in vitro JAK2 inhibition assay showed a half maximal inhibitory concentration (IC50) of 6.6...
Source: Inflammopharmacology - March 24, 2020 Category: Drugs & Pharmacology Source Type: research

Efficacy of body weight vs body surface area-based prednisolone regimen in nephrotic syndrome
ConclusionsIn treating children with uncomplicated NS, both BSA and BW regimens were equally effective in achieving initial remission and maintaining disease remission. Due to fewer adverse events and lesser cumulative steroid exposure with BW based regimen, it may be considered as better option over BSA regimen.Clinical trial registry nameClinical Trial Registry of India (CTRI/2015/03/005655) (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 22, 2020 Category: Urology & Nephrology Source Type: research

Prednisolone suppresses the immunostimulatory effects of 27-hydroxycholesterol.
Authors: Kim BY, Son Y, Kim MS, Kim K Abstract In cholesterol-fed rabbits, site-specific targeting of prednisolone nanoparticles results in significantly reduced neo-intimal inflammation with a decreased infiltration of monocytes/macrophages. To understand the molecular mechanisms underlying this, the current study investigated whether prednisolone affects the immune attributes of 27-hydroxycholesterol (27OHChol), the major oxidized cholesterol molecule in circulation and tissue, in human (THP-1) monocyte/macrophage cells. THP-1 cells were exposed to 27OHChol in the presence of prednisolone followed by evaluation o...
Source: Experimental and Therapeutic Medicine - March 21, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Efficacy and safety of the modified EPOCH regimen (etoposide, vincristine, doxorubicin, carboplatin, and prednisolone) for adult T-cell leukemia/lymphoma: a multicenter retrospective study
Publication date: Available online 20 March 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Yasuhiro Tsukamoto, Junichi Kiyasu, Ilseung Choi, Mitsuo Kozuru, Naokuni Uike, Hayato Utsunomiya, Akie Hirata, Eriko Fujioka, Hirofumi Ohno, Eriko Nakashima, Yasuhiro Nakashima, Kaname Miyashita, Yoshimichi Tachikawa, Taisuke Narazaki, Mariko Tsuda, Shojiro Haji, Akiko Takamatsu, Emi Tanaka, Tatsuro Goto, Hiroshi Takatsuki (Source: Clinical Lymphoma Myeloma and Leukemia)
Source: Clinical Lymphoma Myeloma and Leukemia - March 21, 2020 Category: Cancer & Oncology Source Type: research

Myasthenia gravis with myositis induced by pembrolizumab therapy in a patient with metastatic urothelial carcinoma
We report a case of pembrolizumab-induced myasthenia gravis that occurred in an 84-year-old Japanese female with metastatic urothelial carcinoma in multiple organs. She developed right ptosis 3  days after the second pembrolizumab treatment. Although prednisolone was administered, her symptoms did not change and dysphagia appeared. She needed the steroid pulse therapy for treatment eventually. On the other hand, 9 weeks after the first pembrolizumab treatment, reductions in the sizes of liver and adrenal metastases was observed. However, unfortunately, the severe immune-related adverse events did not allow her to...
Source: International Cancer Conference Journal - March 21, 2020 Category: Cancer & Oncology Source Type: research

Independent risk factors for death in patients admitted for asthma exacerbation in Taiwan.
This study aimed to investigate these independent risk factors and the relationship between mortality and the prescription patterns of anti-asthmatic medications in patients admitted for asthma exacerbation. Using a nested case-control design, we identified 267 cases (death after asthma admission) and 1035 controls (survival after asthma admission) from the Taiwan National Health Insurance Research Database (NHIRD) from 2001 to 2010. Conditional logistic regressions were used to estimate the odds ratios (ORs) with 95% confidence intervals (CIs). We identified the independent risk factors for death as the comorbidities of p...
Source: Primary Care - March 19, 2020 Category: Primary Care Authors: Chang YL, Ko HK, Lu MS, Chou CL, Su KC, Hsu CC, Chou KT, Chen TJ, Perng DW, Chou YC Tags: NPJ Prim Care Respir Med Source Type: research

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia.
CONCLUSIONS: There are currently limited trials comparing the efficacy and safety of different glucocorticoid replacement regimens for treating 21-hydroxylase deficiency CAH in children and adults and we were unable to draw any firm conclusions based on the evidence that was presented in the included trials. No trials included long-term outcomes such as quality of life, prevention of adrenal crisis, presence of osteopenia, presence of testicular or ovarian adrenal rest tumours, subfertility and final adult height. There were no trials examining a modified-release formulation of HC or use of 24-hour circadian continuous sub...
Source: Cochrane Database of Systematic Reviews - March 19, 2020 Category: General Medicine Authors: Ng SM, Stepien KM, Krishan A Tags: Cochrane Database Syst Rev Source Type: research

Efficacy and safety of the modified EPOCH regimen (etoposide, vincristine, doxorubicin, carboplatin, and prednisolone) for adult T-cell leukemia/lymphoma: a multicenter retrospective study
We retrospectively analyzed 103 patients with untreated aggressive adult T-cell leukemia/lymphoma who received the modified EPOCH (mEPOCH) regimen, comprising etoposide, doxorubicin, vincristine, prednisolone, and carboplatin. We observed a response rate of 58% (complete response rate of 25%) and median survival time of 9.8 months, comparable with previous studies. mEPOCH is an effective and well-tolerated alternative regimen for adult T-cell leukemia/lymphoma. (Source: Clinical Lymphoma, Myeloma and Leukemia)
Source: Clinical Lymphoma, Myeloma and Leukemia - March 19, 2020 Category: Hematology Authors: Yasuhiro Tsukamoto, Junichi Kiyasu, Ilseung Choi, Mitsuo Kozuru, Naokuni Uike, Hayato Utsunomiya, Akie Hirata, Eriko Fujioka, Hirofumi Ohno, Eriko Nakashima, Yasuhiro Nakashima, Kaname Miyashita, Yoshimichi Tachikawa, Taisuke Narazaki, Mariko Tsuda, Shoji Tags: Original Study Source Type: research

Integration of Zebrafish Model and Network Pharmacology to Explore Possible Action Mechanisms of Morinda Officinalis HOW. for Treating Osteoporosis.
In this study, we used prednisolone (PNSL)-induced zebrafish OP model to screen the antiosteoporosis components in MOH. A network pharmacology approach was further proposed to explore the underlying mechanism of MOH on OP. The PNSL-induced zebrafish model validated that two anthraquinones, one iridoid glycoside, and two saccharides exerted antiosteoporotic effect. We constructed the components-targets network, and obtained the enriched Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. A total of 26 candidate compounds of MOH and 257 related targets could probably treat OP through regulat...
Source: Chemistry and Biodiversity - March 19, 2020 Category: Biochemistry Authors: Fu SQ, Wang ZY, Jiang ZM, Liu EH, Bi ZM Tags: Chem Biodivers Source Type: research

Do dried blood spots (DBS) have the potential to support result management processes in routine sports drug testing?
AbstractDried blood spots (DBS) have been considered as complementary matrix in sports drug testing for many years. Especially concerning substances prohibited in ‐competition only, the added value of DBS collected concomitantly with routine doping control urine samples has been debated, and an increasing potential of DBS has been discussed in the scientific literature. To which extent and under which prerequisites DBS can contribute to enhanced anti‐dopi ng efforts is currently evaluated. As a proof‐of‐principle, two analytical applications, one targeting cocaine/benzoyl ecgonine and the other prednisone/prednisol...
Source: Drug Testing and Analysis - March 18, 2020 Category: Drugs & Pharmacology Authors: Mario Thevis, Tiia Kuuranne, Josef Dib, Andreas Thomas, Hans Geyer Tags: PERSPECTIVE Source Type: research

IgA Vasculitis Triggered by Infective Endocarditis of Pulmonary Artery with Congenitally Corrected Transposition of the Great Arteries.
Authors: Akagi M, Iwanaga N, Torisu Y, Fujita H, Kawahara C, Horai Y, Izumi Y, Kawakami A Abstract A man in his 40s with a history of congenitally corrected transposition of the great arteries (CCTGA) and closure of ventricular septal defect was referred to our hospital with purpura and hematuria. Presence of purpura, renal damage, and pathological findings on skin biopsy led to the diagnosis of IgA vasculitis (IgAV). Oral prednisolone (PSL) was initiated. However, Streptococcus pseudoporcinus was isolated from blood cultures, and transthoracic echocardiogram revealed vegetation on the pulmonary valve. From these f...
Source: International Heart Journal - March 18, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Diffuse large B-cell lymphoma involving the left sternoclavicular joint mimicking rheumatoid arthritis flare: a case-based review
We report the case of a 65-year-old man with RA suffering from pain and swelling of left sternoclavicular (SC) joint, which was not relieved by adding low-dose glucocorticoid. Magnetic resonance imaging (MRI) showed a para-osseous soft tissue swelling around the SC joint and a fracture of proximal clavicle. Histology of the soft tissue demonstrated diffuse large B-cell lymphoma and the patient subsequently underwent R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) chemotherapy. He was successfully treated with six cycles of R-CHOP chemotherapy, with discontinuation of MTX, resulting in a com...
Source: Rheumatology International - March 14, 2020 Category: Rheumatology Source Type: research

Prophylactic steroid administration against strictures is not enough for mucosal defects involving the entire circumference of the esophageal lumen after esophageal endoscopic submucosal dissection (ESD)
ConclusionAlthough additional study is required in a larger number of patients, careful consideration needs to be given to ESD as an indication for large spreading ESCC involving the entire circumference of esophagus given its high stricture risk. (Source: Esophagus)
Source: Esophagus - March 14, 2020 Category: Gastroenterology Source Type: research

Pembrolizumab-associated nephrotic syndrome recovered from transient hemodialysis in a patient with lung cancer
AbstractA 70-year-old man diagnosed with lung adenocarcinoma was referred to our department for an evaluation of acute onset of nephrotic syndrome with acute kidney injury (AKI) after the 7th course of pembrolizumab treatment. Renal biopsy could not be performed, because he needed anticoagulation therapy for venous thrombosis. Pembrolizumab was discontinued, and prednisolone was started. Hemodialysis was also started, because oliguria was not resolved, and dyspnea due to pulmonary congestion appeared even with the high dose of diuretics. Hemodialysis was successfully withdrawn within 5-week duration because of renal functi...
Source: CEN Case Reports - March 13, 2020 Category: Urology & Nephrology Source Type: research

Glucocorticoids Disrupt Skeletal Angiogenesis Through Transrepression of NF ‐κB–Mediated Preosteoclast Pdgfb Transcription in Young Mice
ABSTRACTIn the growing skeleton, angiogenesis is intimately coupled with osteogenesis. Chronic, high doses of glucocorticoids (GCs) are associated with decreased bone vasculature and induce osteoporosis and growth failure. The mechanism of GC ‐suppression of angiogenesis and relationship to osteoporosis and growth retardation remains largely unknown. Type H vessels, which are regulated by preosteoclast (POC) platelet‐derived growth factor–BB (PDGF‐BB), are specifically coupled with bone formation and development. We determined th e effect of GCs on POC synthesis of PDGF‐BB in relation to type H vessel formati...
Source: Journal of Bone and Mineral Research - March 12, 2020 Category: Orthopaedics Authors: Yi Peng, Shan Lv, Yusheng Li, Jianxi Zhu, Shijie Chen, Gehua Zhen, Xu Cao, Song Wu, Janet L. Crane Tags: Original Article Source Type: research

Alginate-based hydrogels modified with olive pomace and lignin to removal organic pollutants from aqueous solutions.
In this study, new hybrid biopolymers based on alginate and low cost materials belong lignocellulose group such as lignin and olive pomace were used to removal organic pollutants. The organic carbon content, granule size, average mass, zero charge point, water uptake and swelling of the resulting alginate-based modified adsorbents were measured. The homogeneity, complexity and encapsulation viability of the novel biopolymers were studied by FT-IR, TGA and SEM. As model of emerging contaminants belong to glucocorticoids group prednisolone drug was selected. 3,4-dichloroaniline (3,4-DCA) was chosen as aniline derivate pollut...
Source: International Journal of Biological Macromolecules - March 11, 2020 Category: Biochemistry Authors: Flores-Céspedes F, Villafranca-Sánchez M, Fernández-Pérez M Tags: Int J Biol Macromol Source Type: research

Drug retention of secondary biologics or JAK inhibitors after tocilizumab or abatacept failure as first biologics in patients with rheumatoid arthritis -the ANSWER cohort study-
ConclusionsSwitching to ABT in TCZ-treated patients led to higher retention as compared with TNFi. Switching to TCZ in ABT-treated patients tended to lead to higher retention due to effectiveness, although total retention was similar as compared with TNFi.Key Point• This is the first retrospective, multi-center study aimed to clarify the retention rates of secondary bDMARDs or JAKi in patients with RA who were primarily being treated by TCZ or ABT as the first bDMARDs. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 11, 2020 Category: Rheumatology Source Type: research

Atypical type A thymoma variant manifesting polymyalgia rheumatic.
We report a case of atypical type A thymoma variant manifesting polymyalgia rheumatica. A 68-year-old man underwent extended thymectomy with concomitant resection of the pericardium and right lung for an anterior mediastinal tumor. He was diagnosed with atypical type A thymoma variant with pericardial invasion. He developed pain in his extremities one year and 2 months after surgery. Detailed examinations resulted in a diagnosis of polymyalgia rheumatica and bone metastasis of thymoma. He was treated with oral prednisolone for polymyalgia rheumatica. His symptoms and bone lesion have been stable up to the present time of 3...
Source: The Annals of Thoracic Surgery - March 7, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Yanagiya M, Hamaya H, Matsuzaki H, Ikemura M, Nakajima J Tags: Ann Thorac Surg Source Type: research

Comparative Efficacy of Bortezomib, Melphalan, and Prednisone (VMP) With or Without Daratumumab versus VMP Alone in the Treatment of Newly Diagnosed Multiple Myeloma: Propensity Score Matching of ALCYONE and VISTA Phase 3 Studies
A propensity score-matched analysis compared bortezomib, melphalan and prednisolone (VMP) in the ALCYONE study ( ± daratumumab [D]) with VMP in the VISTA study as no direct comparisons are available. Results indicated a lower intensity VMP regimen such as in ALCYONE has a favorable benefit/risk profile compared with the VISTA VMP schedule and D-VMP significantly improves efficacy versus VISTA VMP. (Source: Clinical Lymphoma, Myeloma and Leukemia)
Source: Clinical Lymphoma, Myeloma and Leukemia - March 6, 2020 Category: Hematology Authors: Michele Cavo, Meletios A. Dimopoulos, Jesus San-Miguel, Maria-Victoria Mateos, Andrzej Jakubowiak, William Deraedt, Annette Lam, Tobias Kampfenkel, Ming Qi, Jianming He Tags: Original Study Source Type: research

Unilateral Presentation of Vogt-Koyanagi-Harada Syndrome.
Conclusion: Ophthalmologists should recognize unilateral and asymmetrical VKH disease with subtle systemic involvement. PMID: 32128086 [PubMed] (Source: Journal of Ophthalmic and Vision Research)
Source: Journal of Ophthalmic and Vision Research - March 5, 2020 Category: Opthalmology Tags: J Ophthalmic Vis Res Source Type: research

Molecules, Vol. 25, Pages 1140: Zinc and Calcium Cations Combination in the Production of Floating Alginate Beads as Prednisolone Delivery Systems
a P. Aquino The aim of this research was to verify the application of alginate in combination with Ca2+ and Zn2+ ions to produce a floating and prolonged release system for the oral administration of prednisolone. Hollow and floating gel-beads were designed using prilling/ionotropic gelation as the microencapsulation technique, zinc acetate in the gelling solution as the alginate external crosslinker, and calcium carbonate in the feed as the internal crosslinking agent able to generate gas when in contact with the acidic zinc acetate solution. To achieve this goal, drug/alginate solutions were opportunely combined with...
Source: Molecules - March 4, 2020 Category: Chemistry Authors: Paola Russo Silvana Morello Aldo Pinto Pasquale Del Gaudio Giulia Auriemma Rita P. Aquino Tags: Article Source Type: research

Therapeutic efficacy of combined glucocorticoid, intravenous cyclophosphamide, and double-filtration plasmapheresis for skin sclerosis in diffuse systemic sclerosis
The objective of this study was to analyze its effectiveness in a case series of patients who received triple therapy. We enrolled 8 patients with diffuse cutaneous systemic sclerosis (dcSSc) who received triple therapy at our hospital from 2008 to 2016. We analyzed the mean change in the modified Rodnan skin score (mRSS), percentage of the predicted forced vital capacity (%FVC), percentage of the predicted carbon monoxide diffusing capacity (%DLCO), and serum KL-6 levels from baseline to follow-up. All patients were treated with an intermediate dose of oral prednisolone (30.6 ± 2.1 mg/day) initially. The me...
Source: Medicine - March 1, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Prednisolone as Adjunctive Treatment to Risperidone in Children With Regressive Type of Autism Spectrum Disorder: A Randomized, Placebo-Controlled Trial
This study aimed to evaluate efficacy and safety of prednisolone as an adjunctive treatment to risperidone, in children with regressive autism spectrum disorder (ASD). Methods The current 12-week, randomized, single-blinded, placebo-controlled trial recruited 37 patients with regressive ASD. The participants were allocated to receive either 1 mg/kg per day prednisolone or matched placebo in addition to risperidone. The Aberrant Behavior Checklist-Community Edition (ABC-C) scale and Childhood Autism Rating Scale (CARS) were used to measure behavioral outcomes at weeks 0, 4, 8, and 12 of the study course. The primary outc...
Source: Clinical Neuropharmacology - March 1, 2020 Category: Neurology Tags: Original Articles Source Type: research

Focal Eosinophilic Myositis Affecting the Orbicularis Muscle: Clinical and Image Aspects
Focal eosinophilic myositis (FEM) is a rare disease that is even more uncommon in affecting the periocular area. The authors are reporting the first case of FEM occurring in the lower eyelid of a 45-year-old Caucasian female who presented with localized painful area of glossy induration and peau d’orange skin lesion. Magnetic resonance image shows significant hyperintense thickening of the pre-septal orbicularis muscle region on T2-weighted images. Incisional biopsy of the induration revealed marked fibrinoid degeneration of the orbicularis muscle and adjacent fascia, mixed cellular infiltration of lymphocytes and eo...
Source: Ophthalmic Plastic and Reconstructive Surgery - March 1, 2020 Category: Opthalmology Tags: Case Reports Source Type: research

Carboplatin/paclitaxel/prednisolone
(Source: Reactions Weekly)
Source: Reactions Weekly - March 1, 2020 Category: Drugs & Pharmacology Source Type: research

Methylprednisolone/prednisolone
(Source: Reactions Weekly)
Source: Reactions Weekly - March 1, 2020 Category: Drugs & Pharmacology Source Type: research

Apoptosis Induced by Prednisolone Occurs without Altering the Promoter Methylation of BAX and BCL-2 Genes in Acute Lymphoblastic Leukemia Cells CCRF-CEM.
CONCLUSION: Lack of alteration through prednisolone treatment in DNA methylation template of BAX and BCL2 genes make this possible that Prednisolone affects apoptotic gene expression via different pathways, which need more research to be done about it.. PMID: 32102534 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Comparison of topically administered 0.05% difluprednate and 1% prednisolone acetate for inhibition of aqueocentesis-induced breakdown of the blood-aqueous barrier in healthy dogs.
CONCLUSIONS AND CLINICAL RELEVANCE: All 4 treatments were effective for reducing aqueocentesis-induced anterior uveitis in healthy dogs regardless of the drug or frequency of administration. Topical ophthalmic administration of 0.05% difluprednate may be a viable treatment option for dogs with anterior uveitis and warrants further study. PMID: 32101036 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - February 28, 2020 Category: Veterinary Research Authors: Allbaugh RA, Wehrman RF, Sebbag L Tags: Am J Vet Res Source Type: research

Modulation of Th17 Proliferation and IL-17A Gene Expression by Acetylated Form of Apigenin in Patients with Multiple Sclerosis.
This study aimed to investigate the in vitro effects of the Apigenin 3-Acetate on Th17 cells of MS patients and compare its efficacy with Apigenin and Methyl Prednisolone Acetate.IC50 for Apigenin 3-Acetate, and Methyl Prednisolone Acetate were determined using three healthy volunteers. The peripheral blood mononuclear cells (PBMCs) of five MS patients were isolated and co-cultured with a selected dose of Apigenin, Apigenin 3-Acetate, and Methyl Prednisolone Acetate for 48 hr, and then theproliferation of Th17 cells in isolated PBMCs was assessed by flow cytometry. The levels of RAR-related orphan receptor (RORC) and IL-17...
Source: Immunological Investigations - February 28, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Glucocorticoids disrupt skeletal angiogenesis through transrepression of NF ‐κB‐mediated preosteoclast Pdgfb transcription in young mice
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - February 27, 2020 Category: Orthopaedics Authors: Yi Peng, Shan Lv, Yusheng Li, Jianxi Zhu, Shijie Chen, Gehua Zhen, Xu Cao, Song Wu, Janet L. Crane Tags: Original Article Source Type: research

Incidence of cystoid macular edema following routine cataract surgery using NSAIDs alone or with corticosteroids
ABSTRACT Purpose: To evaluate the rate of cystoid macular edema development among cataract surgery patients on four different therapeutic regimens. Methods: The present study is a retrospective analysis of 5,380 eyes following uncomplicated phacoemulsification at Wake Forest University. The study period went from July 2007 to December 2012. Patients received one of four regimens, as follows: postoperative generic ketorolac 0.4% and prednisolone 1%, postoperative name-brand ketorolac 0.45% and prednisolone 1%, postoperative bromfenac 0.09% and prednisolone 1%, preoperative and postoperative bromfenac 0.09% alone. A statisti...
Source: Arquivos Brasileiros de Oftalmologia - February 27, 2020 Category: Opthalmology Source Type: research

Breast implant-associated anaplastic large-cell lymphoma: first case detected in a Japanese breast cancer patient.
Abstract This paper details the first breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) case detected in Japan. The patient, a 67-year-old Japanese woman, was diagnosed with left unilateral breast cancer 17 years ago. Induration and redness presented in the left breast, which had undergone immediate breast reconstructive surgery using a tissue expander, later replaced by a silicone breast implant (SBI). Breast ultrasound showed fluid collection around the SBI. Surgery was performed to remove the left breast implant and the fragmented capsule surrounding the implant. Postoperative pathologica...
Source: Breast Cancer - February 24, 2020 Category: Cancer & Oncology Authors: Ohishi Y, Mitsuda A, Ejima K, Morizono H, Yano T, Yokoyama M, Takeuchi K, Fujiwara M, Nemoto T, Minabe T Tags: Breast Cancer Source Type: research

Omalizumab in patients with NSAIDs-exacerbated respiratory disease.
CONCLUSIONS: Omalizumab is an effective therapy option in N-ERD patients in a 9 month study period. PMID: 32077449 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - February 22, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Glucocorticoids disrupt skeletal angiogenesis through transrepression of NF ‐κB‐mediated preosteoclast Pdgfb transcription in young mice
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - February 21, 2020 Category: Orthopaedics Authors: Yi Peng, Shan Lv, Yusheng Li, Jianxi Zhu, Shijie Chen, Gehua Zhen, Xu Cao, Song Wu, Janet L. Crane Tags: Original Article Source Type: research

Strongyloides stercoralis hyperinfection syndrome presenting as mechanical ileus after short-course oral steroids for chronic obstructive pulmonary disease (COPD) exacerbation
We report a case of a fatal Strongyloides stercoralis hyperinfection syndrome (SHS) in a migrant from Kenya, who had been living in Germany for three decades. A short-course oral steroid treatment for Chronic Obstructive Lung Disease (COPD) exacerbation had been administered four weeks prior to the presentation. The initial clinical and radiological findings suggested a mechanical small bowel obstruction as a cause of ileus. Our case highlights the importance of maintaining a high index of suspicion for strongyloidiasis in patients from endemic areas even years after they left the country of origin. It demonstrates that ev...
Source: Parasitology International - February 20, 2020 Category: Parasitology Source Type: research

Outcome of Children Treated for Infantile Hepatic Hemangioendothelioma
Conclusions: Overall, patients with IHHE do well, a significant percentage of whom do not require drug therapy, particularly for those with small focal lesions. In patients with multifocal/diffuse disease, there is a high incidence of low T3 and T4 and while some of these patients did well without additional therapy, those with rapidly progressive lesions during treatment may do poorly. (Source: Journal of Pediatric Hematology Oncology)
Source: Journal of Pediatric Hematology Oncology - February 20, 2020 Category: Hematology Tags: Original Articles Source Type: research

Corticosteroid Tapering Regimens in Rheumatic Disease: A Systematic Review
Conclusions There is no high-level evidence to guide tapering until discontinuation after extended courses of medium- to high-dose treatment regimens, as current guidelines rely heavily on expert opinion and small case series with a trial-and-error approach. This review supports the need for additional research to shift tapering recommendations to a more evidence-based practice. (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - February 20, 2020 Category: Rheumatology Tags: Original Articles Source Type: research

No Major Effect of Innate Immune Genetics on Acute Kidney Rejection in the First 2 Weeks Post-Transplantation
ConclusionsThis study did not detect any statistically significant effects of recipient or donor innate immune genetics on acute rejection incidence in the first 2 weeks post-transplantation. However, the sample size was small, and future larger studies or meta-analyses are required to demonstrate conclusively if innate immune genetics such as IL6 influence the risk of acute rejection after kidney transplantation. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 20, 2020 Category: Drugs & Pharmacology Source Type: research

[Treatment of giant cell arteritis and polymyalgia rheumatica].
Abstract Patients with untreated active giant cell arteritis (GCA) are at high risk of permanent vision loss. Therefore, treatment with glucocorticoids should be immediately initiated at an initial dose of 40-60 mg prednisolone equivalent dose per day. Once remission is achieved, the prednisolone dose should be reduced to 15-20 mg within 2-3 months and then to ≤5 mg per day within 1 year. Glucocorticoid-sparing treatment with tocilizumab or alternatively methotrexate should be initiated in patients with an increased risk or pre-existing complications of glucocorticoid treatment and patients with...
Source: Zeitschrift fur Rheumatologie - February 20, 2020 Category: Rheumatology Authors: Horvath L, Hellmich B Tags: Z Rheumatol Source Type: research

[an adult case of periodic fever, aphthous stomatitis, pharyngitis, and adenitis (pfapa) syndrome developed in childhood and diagnosed after progress more than 30 years].
We report an adult case of periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome, who had a tonsillectomy at 10 years old and relapsed later. An early 40's-year-old man had been suffering from recurrent fever attack once in 1-2 months during childhood. He was accompanied by fever which was persist for several days, aphthous stomatitis, tongued tonsillitis with moss, pharyngitis, and submandibular lymphadenitis with tenderness. He was not doing well during fare-up. At the time of admission, CRP level was 12.5mg/dl and the remarkably increased expression of CD64 on neutrophils was found. Bacterial i...
Source: Arerugi - February 15, 2020 Category: Allergy & Immunology Authors: Tsukadaira A, Takeuchi Y, Watanabe K, Tsukamoto K, Okubo Y, Agematsu K Tags: Arerugi Source Type: research

Salmonella enterica Subspecies arizonae Detected from Bilateral Pleural Fluid in a Patient with Systemic Lupus Erythematosus and Malignant Lymphoma.
Authors: Shima N, Nakamura J, Saito K, Kamata Y, Nagatani K, Nagashima T, Iwamoto M, Akine D, Saito T, Sato K, Minota S Abstract A 72-year-old woman was admitted to our hospital with bilateral pleural effusions. She had a 31-year history of systemic lupus erythematosus and had been treated with prednisolone and azathioprine. Pleural fluid culture revealed Salmonella enterica subsp. arizonae infection. This pathogen rarely infects humans but is commonly found in the gut flora of reptiles, especially snakes. Our patient had not come in contact with reptiles. Despite antibiotic therapies and negative pleural cultures,...
Source: Internal Medicine - February 15, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

Comparative study on the efficacy of non-steroidal, steroid and non-use of anti-inflammatory in the treatment of acute epidemic conjunctivitis.
CONCLUSION: The prednisolone acetate was not superior to the use of sodium diclofenac or artificial tears in relieving the signs and symptoms of viral conjunctivitis. PMID: 32049186 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - February 13, 2020 Category: Surgery Authors: Santiago LA, Silva JMRD, Azevedo OGR, Vasconcelos PRL Tags: Acta Cir Bras Source Type: research

An Embolic Stroke in a Patient With PROC p.Lys193del
We report a 58-year-old woman who suddenly developed brain infarction with weakness of the left lower extremity and left perioral dysesthesia during postoperative tamoxifen therapy for breast cancer and prednisolone therapy for rheumatoid arthritis. Diffusion-weighted images detected multiple areas of hyperintensity in the posterior circulation system of the brain. Despite extensive examinations, we could not identify any embolic sources except hypoplasia of the right vertebral artery. We found decreased activity of protein C against its antigen level (activity: 59% versus antigen: 122%) with enhanced activity of coagulati...
Source: Journal of Stroke and Cerebrovascular Diseases - February 11, 2020 Category: Neurology Authors: Kana Ueki, Kuniyuki Nakamura, Yoshinobu Wakisaka, Shinichi Wada, Yoji Yoshikawa, Shinya Matsumoto, Taeko Hotta, Dongchong Kang, Takanari Kitazono, Tetsuro Ago Tags: Case Report Source Type: research

A 13-year-old systemic lupus erythematosus girl initially presenting with Raccoon eyes and neuropsychiatric manifestations
ConclusionSLE may present with Raccoon eyes. Rapid detection and treatment of the disease based on clinical symptoms is critical for these patients. Prednisolone and cyclophosphamide are the best choice for treatment of the disease in children. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - February 8, 2020 Category: Rheumatology Source Type: research