A Study of Ocular Toxicity Evaluation and Mitigation During Treatment With Mirvetuximab Soravtansine in Participants With Recurrent Ovarian Cancer With High Folate Receptor-Alpha Expression
Conditions: Recurrent Ovarian Cancer; Folate Receptor-Alpha Positive Interventions: Drug: Mirvetuximab Soravtansine; Drug: Lubricating Eye Drops; Drug: Prednisolone acetate ophthalmic suspension 1% eye drops; Drug: Brimonidine tartrate ophthalmic solution eye drops Sponsors: ImmunoGen, Inc. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
Prednisolone Versus Colchicine for Acute Gout in Primary Care: statistical analysis plan for the pragmatic, multicenter, randomized, and double-blinded COPAGO non-inferiority trial
DiscussionThe trial will provide evidence from a direct comparison of colchicine and prednisolone regarding their efficacy of pain reduction in acute gout patients of primary care and to indicate possible safety signals.Trial registrationClinicalTrials.gov Identifier: NCT05698680 first posted on January 26, 2023 (retrospectively registered). (Source: Trials)
Source: Trials - April 3, 2024 Category: Research Source Type: clinical trials
Ma-Spore ALL 2020 Study
Conditions: B Lymphoblastic Leukemia Interventions: Drug: Prednisolone; Drug: Dexamethasone; Drug: Vincristine; Drug: Methotrexate; Drug: L-Asparaginase; Drug: Pegylated asparaginase; Drug: Erwinase; Drug: Dasatinib; Drug: Imatinib; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Mercaptopurine; Drug: Thioguanine; Drug: Rituximab; Drug: Doxorubicin; Drug: Fludarabine Sponsors: National University Hospital, Singapore Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 28, 2024 Category: Research Source Type: clinical trials
A Randomised Controlled Platform Trial Testing Treatments in Metastatic Hormone Sensitive Prostate Cancer
Conditions: Prostate Cancer Metastatic Interventions: Radiation: Stereotactic Ablative Body Radiotherapy (SABR); Other: 177Lu-PSMA-617; Drug: Niraparib and Abiraterone Acetate Dual Action Tablet DAT; Drug: Abiraterone Acetate; Drug: Apalutamide; Drug: Androgen Deprivation Therapy (ADT); Drug: Androgen Receptor Signalling Inhibitor (ARSI); Radiation: Local Radiotherapy; Drug: Prednisolone; Drug: Docetaxel Sponsors: University College, London; Cancer Research UK; Novartis; Janssen Pharmaceutica NV Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 20, 2024 Category: Research Source Type: clinical trials
Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia
Conditions: Acute Leukemia of Ambiguous Lineage; B Acute Lymphoblastic Leukemia Interventions: Drug: Asparaginase Erwinia chrysanthemi; Procedure: Biospecimen Collection; Biological: Blinatumomab; Procedure: Bone Marrow Aspiration; Drug: Calaspargase Pegol; Procedure: Computed Tomography; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Daunorubicin; Drug: Dexamethasone; Drug: Doxorubicin; Procedure: Echocardiography; Procedure: FDG-Positron Emission Tomography; Drug: Leucovorin; Procedure: Lumbar Puncture; Procedure: Magnetic Resonance Imaging; Drug: Mercaptopurine; Drug: Methotrexate; Procedure: Multigated Acquisition Sca...
Source: ClinicalTrials.gov - March 19, 2024 Category: Research Source Type: clinical trials
The Effect of Three Different Medications on Anesthetic Success and Postoperative Pain
Conditions: Symptomatic Irreversible Pulpitis Interventions: Drug: Trypsin, Bromelain and Rutoside; Drug: Diclofenac Potassium; Drug: Prednisolone Oral Tablet; Other: Placebo Sponsors: Cairo University; Egyptian Russian University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 7, 2024 Category: Research Source Type: clinical trials
A Trial of Prednisolone in Combination With SPI-62 in Participants With Polymyalgia Rheumatica (PMR)
Conditions: Polymyalgia Rheumatica Interventions: Drug: Prednisolone; Drug: SPI-62 Sponsors: Sparrow Pharmaceuticals Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 28, 2024 Category: Research Source Type: clinical trials
Efficacy and Safety of add-on Apremilast Versus add-on Methotrexate in Patients With Oral Lichen Planus
Conditions: Oral Lichen Planus Interventions: Drug: Prednisolone; Drug: Apremilast; Drug: Methotrexate Sponsors: All India Institute of Medical Sciences, Bhubaneswar Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 15, 2024 Category: Research Source Type: clinical trials
Prevention of Anthracycline-Induced Cardiac Dysfunction With Dexrazoxane in Patients With Diffuse Large-B Cell Lymphoma
Conditions: DLBCL - Diffuse Large B Cell Lymphoma Interventions: Drug: Dexrazoxane; Drug: Rituximab; Drug: Cyclophosphamide; Drug: Doxorubicin; Drug: Vincristine; Drug: Prednisolone; Drug: Lenalidomide Sponsors: Stichting Hemato-Oncologie voor Volwassenen Nederland; UMC Utrecht; Amsterdam University Medical Centers; The Dutch Network for Cardiovascular Research (WCN) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 23, 2024 Category: Research Source Type: clinical trials
Tacrolimus versus mycophenolate for AutoImmune hepatitis patients with incompLete response On first-line therapy (TAILOR study): a study protocol for a phase III, open-label, multicentre, randomised controlled trial
DiscussionThis is the first randomised controlled trial comparing two second-line therapies for AIH. Currently, second-line treatment is based on retrospective cohort studies. The rarity of AIH is the main issue in clinical research for alternative treatment options. The results of this trial can be implemented in existing international clinical guidelines.Trial registrationClinicalTrials.govNCT05221411. Retrospectively registered on 3 February 2022; EudraCT number 2021 –003420-33. Prospectively registered on 16 June 2021. (Source: Trials)
Source: Trials - January 17, 2024 Category: Research Source Type: clinical trials
Multicenter Study of Safety and Efficacy Nivolumab at the Fixed Dose 40 mg (Nivo40) in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed PMBL
Conditions: Primary Mediastinal Lymphoma Interventions: Drug: Cyclophosphamide; Drug: Doxorubicin Hydrochloride; Drug: Etoposide Phosphate; Drug: Prednisolone; Drug: Rituximab; Drug: Vincristine Sulfate; Drug: Filgrastim; Drug: Pegfilgrastim; Drug: Nivolumab 40 mg in 4 ml Injection Sponsors: National Research Center for Hematology, Russia Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 3, 2024 Category: Research Source Type: clinical trials
A Randomized Trial of Prednisolone, Itraconazole, or Their Combination in Allergic Bronchopulmonary Aspergillosis
Conditions: Allergic Bronchopulmonary Aspergillosis Interventions: Drug: Prednisolone; Drug: Itraconazole Sponsors: Postgraduate Institute of Medical Education and Research Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 18, 2023 Category: Research Source Type: clinical trials
Comparison Of Efficacy Of Hydrocortisone And Methyl Prednisolone In Acute Severe Asthma
Conditions: Asthma Acute Interventions: Drug: Methylprednisolone, Sponsors: University of Karachi Enrolling by invitation (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 15, 2023 Category: Research Source Type: clinical trials
Role of Extended Low Dose Prednisolone in Achieving Clinical and Biochemical Remission in Steroid Responsive Severe Alcoholic Hepatitis
Conditions: Severe Alcoholic Hepatitis Interventions: Drug: Prednisolone; Other: Standard Medical therapy; Drug: Placebo Sponsors: Institute of Liver and Biliary Sciences, India Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 4, 2023 Category: Research Source Type: clinical trials
Effects of Glucocortioids in Human Skeletal Muscle, Adipose Tissue and Skin
Conditions: Glucocorticoids Toxicity; Iatrogenic Effect Interventions: Other: Prednisolone; Other: Placebo Sponsors: University of Aarhus Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 22, 2023 Category: Research Source Type: clinical trials
