RELEASE (REdressing Long-tErm Antidepressant uSE): protocol for a 3-arm pragmatic cluster randomised controlled trial effectiveness-implementation hybrid type-1 in general practice
This study aims to det ermine the effectiveness of two multi-strategy interventions (RELEASE and RELEASE+) in supporting the safe cessation of long-term antidepressants, estimate cost-effectiveness, and evaluate implementation strategies.MethodsDesign3-arm pragmatic cluster randomised controlled trial effectiveness-implementation hybrid type-1. Setting: primary care general practices in southeast Queensland, Australia. Population: adults 18  years or older taking antidepressants for longer than 1 year. Practices will be randomised on a 1.5:1:1 ratio of Usual care:RELEASE:RELEASE+. Intervention: RELEASE for patients inclu...
Source: Trials - September 28, 2023 Category: Research Source Type: clinical trials

Maximising recruitment of research participants into a general practice based randomised controlled trial concerning lung diagnosis —staff insights from an embedded qualitative study
ConclusionsThe integration of a qualitative component focused on staff experiences participating in a lung diagnostic trial has demonstrated the feasibility to recruit for similar future studies within general practice. Although recruitment into trials can be difficult, results from our study offer suggestions on maximising patient recruitment not just to trials in general but also specifically for a lung diagnosis study.Trial registrationClinicalTrials.gov, NCT01344005. Registered on 27 April 2011 (Source: Trials)
Source: Trials - March 21, 2022 Category: Research Source Type: clinical trials

The SMARTscreen Trial: a randomised controlled trial investigating the efficacy of a GP-endorsed narrative SMS to increase participation in the Australian National Bowel Cancer Screening Program
DiscussionThis efficacy trial will provide initial trial evidence of the utility of an SMS narrative intervention to increase participation in the NBCSP. The results will inform decisions about the need for and design of a larger, multi-state trial of this SMS intervention to determine its cost-effectiveness and future implementation.Trial registrationAustralian New Zealand Clinical Trials RegistryACTRN12620001020976. Registered on 17 October 2020. (Source: Trials)
Source: Trials - January 12, 2022 Category: Research Source Type: clinical trials

Optimizing blood pressure control by an Information Communication Technology-supported case management (PIA study): study protocol for a cluster-randomized controlled trial of a delegation model for general practices
DiscussionIt is hypothesized that the PIA-Intervention will improve the quality of BP care. Perspectively, it may constitute an important health service model for primary care in Germany.Trial registrationGerman Clinical Trials Register DRKS00012680. Registered on May 10, 2019 (Source: Trials)
Source: Trials - October 25, 2021 Category: Research Source Type: clinical trials

Patient and healthcare professional experiences of the Salford Lung Studies: qualitative insights for future effectiveness trials
ConclusionsPatients and HCPs had positive experiences of the SLS. The study design, closely aligned with routine care, was considered important to their high likelihood of participating in future trials. The experiences of patients and HCPs in the SLS provide valuable insights that will help inform future best practice in the design and conduct of future real-world effectiveness RCTs in primary care. The detailed first-hand experiences of HCPs will be of significant value to others considering engaging in clinical research and participating in effectiveness RCTs. (Source: Trials)
Source: Trials - September 16, 2020 Category: Research Source Type: clinical trials

Remote Ischemic Conditioning as a Treatment for Traumatic Brain Injury
Conditions:   Traumatic Brain Injury;   Trauma, Nervous System;   Reperfusion Injury;   Ischemia, Brain Interventions:   Device: CellAegis Technologies autoRIC device;   Other: Best Practice Management of Traumatic Brain Injury Sponsors:   St. Michael's Hospital, Toronto;   Dr. Markus Ziesmann;   Dr. Shawn Rhind;   Dr. Sandro Rizoli;   Canadian Institute for Military and Veteran Health Research Not yet recruiting - verified June 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - May 15, 2017 Category: Research Source Type: clinical trials