Foxglove poisoning: diagnostic and therapeutic differences with medicinal digitalis glycosides overdose - Maes KR, Depuydt P, Vermassen J, De Paepe P, Buylaert W, Lyphout C.
We report a case of a 19-year-old woman who ingested Digitalis purpurea leaves as a suicide attempt. She developed gastro-intestinal symptoms, loss of colour vision, cardiac conduction disturbances as well as an elevated serum potassium. Treatment was init... (Source: SafetyLit)
Source: SafetyLit - June 9, 2020 Category: International Medicine & Public Health Tags: Home and Consumer Product Safety Source Type: news
Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice
We present a cofactor-free bioelectronic interface that directly links wireless-powered electrical stimulation of human cells to either synthetic promoter–driven transgene expression or rapid secretion of constitutively expressed protein therapeutics from vesicular stores. Electrogenetic control was achieved by coupling ectopic expression of the L-type voltage-gated channel CaV1.2 and the inwardly rectifying potassium channel Kir2.1 to the desired output through endogenous calcium signaling. Focusing on type 1 diabetes, we engineered electrosensitive human β cells (Electroβ cells). Wireless electrical stimu...
Source: ScienceNOW - May 27, 2020 Category: Science Authors: Krawczyk, K., Xue, S., Buchmann, P., Charpin-El-Hamri, G., Saxena, P., Hussherr, M.-D., Shao, J., Ye, H., Xie, M., Fussenegger, M. Tags: Medicine, Diseases r-articles Source Type: news
U.S. FDA Approves New Pediatric Formulation of SIRTURO ® (bedaquiline) as Part of Combination Therapy to Treat Children with Pulmonary Multidrug-Resistant Tuberculosis
NEW BRUNSWICK, NJ, May 27, 2020 — The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) has granted approval for a new pediatric formulation of SIRTURO®
(bedaquiline). SIRTURO® is now indicated for use as part of combination therapy in the treatment of adult and pediatric patients (5 years and older and weighing at least 15 kg) with pulmonary multidrug-resistant tuberculosis (MDR‑TB). In the U.S., the medicine should be reserved for use when an effective treatment regimen cannot otherwise be provided. This indication received accelerated appro...
Source: Johnson and Johnson - May 27, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news
Phexxi (Lactic Acid, Ctric Acid, and Potassium Bitartrate Vaginal Gel) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 27, 2020 Category: Drugs & Pharmacology Source Type: news
FDA Approves Phexxi for Use as On-Demand Contraceptive FDA Approves Phexxi for Use as On-Demand Contraceptive
Phexxi (lactic acid, citric acid and potassium bitartrate) has been approved for the prevention of pregnancy in women of reproductive potential.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 26, 2020 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Alert Source Type: news
FDA Approves Phexxi (lactic acid, citric acid and potassium bitartrate) Non-Hormonal Prescription Gel for the Prevention of Pregnancy
SAN DIEGO, May 22, 2020 /PRNewswire/ -- Evofem Biosciences, Inc. (NASDAQ: EVFM) today announced that the U.S. Food and Drug Administration (FDA) has approved Phexxi™ (lactic acid, citric acid and potassium bitartrate)... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - May 22, 2020 Category: Drugs & Pharmacology Source Type: news
PharMEDium Services Issues Voluntary Nationwide Recall of Specific Lots of Potassium Phosphate and Succinylcholine Chloride Due to a Lack of Sterility Assurance
PharMEDium Services is conducting a limited, voluntary recall due to Hospira Inc. ’s (“Hospira”) June 15, 2017 recall announcement that microbial growth was detected during a routine simulation of the manufacturing process and therefore there was a lack of sterility assurance. The products being recalled by PharMEDium Services were compounded using certain Hospira products. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - May 22, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news
Roche launches new blood gas digital solution designed to improve patient care
Basel, 15 May 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced the CE mark availability of Roche v-TAC, a new digital diagnostic solution that allows clinicians to obtain results for arterial blood gas values from patients with respiratory or metabolic abnormalities via a simpler, less invasive venous puncture through the use of a digital algorithm. Blood gas analysis is typically used in hospital point of care (POC) settings, where quick and accurate results are needed. This includes emergency rooms, intensive care units and operating rooms. The analysis provides clinicians with information about a patient ’s p...
Source: Roche Investor Update - May 15, 2020 Category: Pharmaceuticals Source Type: news
Roche launches new blood gas digital solution designed to improve patient care
Basel, 15 May 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced the CE mark availability of Roche v-TAC, a new digital diagnostic solution that allows clinicians to obtain results for arterial blood gas values from patients with respiratory or metabolic abnormalities via a simpler, less invasive venous puncture through the use of a digital algorithm. Blood gas analysis is typically used in hospital point of care (POC) settings, where quick and accurate results are needed. This includes emergency rooms, intensive care units and operating rooms. The analysis provides clinicians with information about a patient ’s p...
Source: Roche Media News - May 15, 2020 Category: Pharmaceuticals Source Type: news
Suicide attempt using potassium tablets for congenital chloride diarrhea: a case report - Iijima S.
BACKGROUND: Congenital chloride diarrhea (CCD) is a rare inherited disorder of intestinal electrolyte transport that results in a large wastage of electrolytes and water. Advances in substitution therapy using sodium chloride (NaCl) and potassium chloride ... (Source: SafetyLit)
Source: SafetyLit - May 11, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Best supplements for high blood pressure - how to protect against hypertension
SUPPLEMENTS could be used to lower your risk, or even prevent, some high blood pressure symptoms. Adding potassium to your diet every day could help you to avoid the signs of hypertension. Should you be adding more potassium-rich foods to your daily routine? (Source: Daily Express - Health)
Source: Daily Express - Health - April 29, 2020 Category: Consumer Health News Source Type: news
The Night I Broke: A Doctor on the Conversations That Never Get Easier
I watched the cardiac monitor of a patient who had a “Do Not Resuscitate” order transform from a sinusoidal rhythm – seen when patients have very high levels of potassium that the kidneys are not working well enough to clear – to asystole, better known as a flat line. The patient was COVID-19 positive, like most, of the patients in the hospital in New York City at the end of March. He presented to the emergency department days earlier with respiratory distress and had required a breathing tube and ventilator support. At that time, he did not have a “Do Not Resuscitate” order, but was rat...
Source: TIME: Health - April 29, 2020 Category: Consumer Health News Authors: Kristen Kelly Tags: Uncategorized COVID-19 Source Type: news
New route of assembly and ionic channel traffic in cardiac cells
(University of Barcelona) Ionic channels -integral proteins in the cell membrane- are essential in several processes such as cardiac activity, nervous transmission, cell proliferation and the regulation of blood pressure. A study which has now been published in Science Advances describes for the first time the membrane traffic and association mechanisms of the Iks cardiac currents, a flow of potassium ions through ionic channels in the cell membrane which is decisive for the right cardiovascular function. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 17, 2020 Category: International Medicine & Public Health Source Type: news
Experimental study on using water mist containing potassium compounds to suppress methane/air explosions - Liu Z, Zhong X, Zhang Q, Lu C.
To understand the suppression effects of different potassium compounds on methane/air explosions, a 20-L spherical explosion system and a high-speed camera were used to obtain the explosion overpressure and the flame morphology for explosions at different ... (Source: SafetyLit)
Source: SafetyLit - April 9, 2020 Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
Potassium Iodide as a Thyroid Blocking Agent in Radiation Emergencies
Procedural (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - April 8, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news
