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Deep remission in Crohn ’s disease – optional or quintessential.
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 26, 2021 Category: Gastroenterology Authors: Suprabhat Giri, Sumaswi A, Vaneet Jearth Source Type: research

Impact of SARS-CoV-2 pandemic on vascular liver diseases
Vascular liver diseases (VLD) are represented mainly by portosinusoidal vascular disease (PSVD), non-cirrhotic splanchnic vein thrombosis (SVT) and Budd Chiari syndrome (BCS). It is unknown whether patients with VLD constitute a high-risk population for complications and greater COVID-19-related mortality from SARS-CoV-2 infection. Our objective was to assess the prevalence and severity of SARS-CoV-2 infection among patients with VLD, as well as to assess its impact on hepatic decompensation and survival. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 26, 2021 Category: Gastroenterology Authors: A. Baiges, E. Cerda, C. Amicone, L. T éllez, E. Alvarado-Tapias, A. Puente, J.I. Fortea, E. Llop, F. Rocha, L. Orts, O. Ros-Fargas, P. Vizcarra, K. Zekrini, Y. Ould Amara, G. Touati, N. Jimenez, M.J. Serrano, A. Falgà, M. Magaz, P. Olivas, F. Betancourt Source Type: research

Test characteristics of cross-sectional imaging and concordance with endoscopy in postoperative Crohn ’s disease
Postoperative Crohn ’s disease (CD) surveillance relies on endoscopic monitoring. The role of cross-sectional imaging is less clear. We evaluated the concordance of cross-sectional enterography with endoscopic recurrence and the predictive ability of radiography for future CD postoperative recurrence. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 26, 2021 Category: Gastroenterology Authors: Salam P. Bachour, Ravi Shah, Ruishen Lyu, Takahiro Nakamura, Michael Shen, Terry Li, Bari Dane, Edward L. Barnes, Florian Rieder, Benjamin Cohen, Taha Qazi, Bret Lashner, Jean Paul Achkar, Jessica Philpott, Stefan D. Holubar, Amy L. Lightner, Miguel Regue Source Type: research

Racial and Ethnic Disparities in Barriers to Care in Patients with Hepatocellular Carcinoma
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 25, 2021 Category: Gastroenterology Authors: Haley Schoenberger, Nicole E. Rich, Patricia Jones, Sruthi Yekkaluri, Adam Yopp, Amit G. Singal, Multi-Ethnic HCC Cohort Investigators Source Type: research

Prevalence of High-risk Nonalcoholic Steatohepatitis (NASH) in the United States: Results From NHANES 2017 –2018
The population prevalence of high-risk non-alcoholic steatohepatitis (NASH), defined as nonalcoholic fatty liver disease activity score ≥4 and fibrosis stage ≥2, is unknown. The FibroScan-AST (FAST) score, calculated using liver stiffness measurement and controlled attenuation parameter values from FibroScan and aspartate aminotransferase levels, is a validated algorithm to identify individuals with high-risk NASH. We estimated the prevalence of high-risk NASH using the FAST score in the United States population. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 24, 2021 Category: Gastroenterology Authors: Eduardo Vilar-Gomez, Raj Vuppalanchi, Andrea Mladenovic, Niharika Samala, Samer Gawrieh, Phil N. Newsome, Naga Chalasani Source Type: research

Comment on “An Observational Data Meta-Analysis on the Differences in Prevalence and Risk Factors Between MAFLD vs NAFLD”
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 24, 2021 Category: Gastroenterology Authors: Stefano Ciardullo, Gianluca Perseghin Source Type: research

Prevalence of High-risk Non-alcoholic Steatohepatitis (NASH) in the United States: Results from NHANES 2017-2018
The population prevalence of high-risk non-alcoholic steatohepatitis (NASH), defined as NAFLD activity score ≥4 and fibrosis stage ≥2, is unknown. FAST score, calculated using LSM and CAP values from FibroScan® and AST levels, is a validated algorithm to identify individuals with high-risk NASH. We estimated the prevalence of high-risk NASH using the FAST score in the U.S. population. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 24, 2021 Category: Gastroenterology Authors: Eduardo Vilar-Gomez, Raj Vuppalanchi, Andrea Mladenovic, Niharika Samala, Samer Gawrieh, Phil N. Newsome, Naga Chalasani Source Type: research

Pregnancy outcomes in women with autoimmune hepatitis – A nationwide population-based cohort study with histopathology
Autoimmune hepatitis (AIH) is a chronic inflammatory liver condition that predominantly affects women. However, pregnancy risks remain unclear. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 23, 2021 Category: Gastroenterology Authors: Rajani Sharma, Tracey G. Simon, Olof Stephansson, Elizabeth C. Verna, Jean Emond, Jonas S öderling, Bjorn Roelstraete, Hannes Hagström, Jonas F. Ludvigsson Source Type: research

Empirical second-line therapy in 5,000 patients of the European Registry on Helicobacter pylori Management (Hp-EuReg)
After a first Helicobacter pylori eradication attempt, approximately 20% of patients will remain infected. The aim of current study was to assess the effectiveness and safety of second-line empirical treatment in Europe. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 23, 2021 Category: Gastroenterology Authors: Olga P. Nyssen, Dino Vaira, Ángeles Pérez Aísa, Luis Rodrigo, Manuel Castro-Fernandez, Laimas Jonaitis, Bojan Tepes, Liudmila Vologzhanina, María Caldas, Angel Lanas, Alfredo J. Lucendo, Luis Bujanda, Juan Ortuño, Jesús Barrio, Jose M. Huguet, Irina Source Type: research

COVID-19 vaccine is effective in inflammatory bowel disease patients and is not associated with disease exacerbation
Studies have shown decreased response to COVID-19 vaccinations in some populations. In addition, it is possible that vaccine-triggered immune activation could trigger immune-dysregulation and thus exacerbate inflammatory bowel diseases (IBD). In this population-based study we used the epi-Israeli IBD Research Nucleus (IIRN) validated cohort to explore the effectiveness of COVID-19 vaccination in IBD and to assess its effect on disease outcomes. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 23, 2021 Category: Gastroenterology Authors: Raffi Lev-Tzion, Gili Focht, Rona Lujan, Adi Mendelovici, Chagit Friss, Shira Greenfeld, Revital Kariv, Amir Ben-Tov, Eran Matz, Daniel Nevo, Yuval Barak-Corren, Iris Dotan, Dan Turner Source Type: research

Defining the Patchy Landscape of Esophageal Eosinophilia in Children with Eosinophilic Esophagitis
Eosinophilic Esophagitis (EoE) is a patchy disease of the esophagus with significant variability in intra-epithelial eosinophilia. Three biopsies each from distal and proximal esophagus are recommended for identification of active EoE. Recent work suggests 3 biopsy sites is more optimal. We sought to evaluate 2-site vs. 3-site esophageal biopsy combinations for utility to identify active EoE. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 22, 2021 Category: Gastroenterology Authors: Joshua B. Wechsler, Scott M. Bolton, Elizabeth Gray, Kwang-Youn Kim, Amir F. Kagalwalla Source Type: research

Associations of Food Intolerance with Irritable Bowel Syndrome, Psychological Symptoms, and Quality of Life
The impact of different types of food intolerance on gastrointestinal symptoms and quality of life (QOL) is poorly understood. We aimed to investigate associations of food intolerance and type of intolerance with irritable bowel syndrome (IBS), health-related QOL, and psychological symptoms. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 21, 2021 Category: Gastroenterology Authors: Claire L. Jansson-Knodell, Mattie White, Carolyn Lockett, Huiping Xu, Andrea Shin Source Type: research

Higher drug exposure during the first 24 weeks of ustekinumab treatment is associated with endoscopic remission in Crohn ’s disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 20, 2021 Category: Gastroenterology Authors: Nathalie Van den Berghe, Bram Verstockt, S éverine Vermeire, Debby Thomas, Paul Declerck Source Type: research

Safety and immunogenicity of SARS-CoV-2 vaccines in patients with chronic liver diseases (CHESS-NMCID 2101): A multicenter study
We aim to assess the safety and immunogenicity of inactivated whole-virion SARS-CoV-2 vaccines in patients with chronic liver diseases (CLD) in this study. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 20, 2021 Category: Gastroenterology Authors: Jingwen Ai, Jitao Wang, Dengxiang Liu, Huiling Xiang, Ying Guo, Jiaojian Lv, Qiran Zhang, Jinlong Li, Xiaochong Zhang, Qianqian Li, Jing Liang, Xiaoqing Guo, Yinong Feng, Luxiang Liu, Xuying Zhang, Wei Qin, Xiaodong Wang, Wei Rao, Qun Zhang, Qiuju Tian, Y Source Type: research

Supplementing Dietary Fibers With a Low-FODMAP Diet in Irritable Bowel Syndrome: A Randomized Controlled Crossover Trial
Institution of a diet low in fermented oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) in patients with irritable bowel syndrome (IBS) may lead to inadequate fiber intake. This trial aimed to investigate the effects of supplementing specific fibers concomitantly with low-FODMAP diet on relevant clinical and physiological indices in symptomatic patients with IBS. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 17, 2021 Category: Gastroenterology Authors: Daniel So, Chu K. Yao, Zaid S. Ardalan, Phoebe A. Thwaites, Kourosh Kalantar-Zadeh, Peter R. Gibson, Jane G. Muir Source Type: research