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Advanced Imaging Within the Bile Duct During Endoscopic Retrograde Cholangiopancreatography
Despite innovation in bile duct imaging over the past 2 decades, indeterminate biliary strictures remain a diagnostic challenge. The prototypical case is a patient who presents with a bile duct stricture, usually symptomatic, but no discrete mass is identified on cross-sectional imaging. The differential diagnosis includes cholangiocarcinoma; other malignancies; and fibroinflammatory causes, such as primary sclerosing cholangitis and autoimmune cholangiopathy. How has recent innovation changed the approach to these patients? (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 4, 2022 Category: Gastroenterology Authors: Kaveh Sharzehi, Gregory A. Cote Tags: Here and Now: Clinical Practice Source Type: research

High-Definition Colonoscopy Compared With Cuff- and Cap-Assisted Colonoscopy: Results From a Multicenter, Prospective, Randomized Controlled Trial
Mucosal exposure devices including distal attachments such as the cuff and cap have shown variable results in improving adenoma detection rates (ADRs) compared with high-definition white light colonoscopy (HDWLE). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 31, 2021 Category: Gastroenterology Authors: Madhav Desai, Douglas K. Rex, Matthew E. Bohm, Perica Davitkov, John M. DeWitt, Monika Fischer, Gregory Faulx, Ryan Heath, Timothy D. Imler, Toyia N. James-Stevenson, Charles J. Kahi, William R. Kessler, Divyanshoo R. Kohli, Lee McHenry, Tarun Rai, Nichol Source Type: research

High-definition colonoscopy compared to cuff- and cap-assisted colonoscopy: Results from a multi-center, prospective, randomized controlled trial
Mucosal exposure devices including distal attachments such as the cuff and cap have shown variable results in improving adenoma detection rates (ADR) compared to high-definition white light colonoscopy (HDWLE). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 31, 2021 Category: Gastroenterology Authors: Madhav Desai, Douglas K. Rex, Matthew E. Bohm, Perica Davitkov, John M. DeWitt, Monika Fischer, Gregory Faulx, Ryan Heath, Timothy D. Imler, Toyia N. James-Stevenson, Charles J. Kahi, William R. Kessler, Divyanshoo R. Kohli, Lee McHenry, Tarun Rai, Nichol Source Type: research

A prospective cohort study of novel markers of hepatitis B virus replication in human immunodeficiency virus coinfection
The contribution of the novel biomarkers, HBV RNA and HBcrAg, to characterization of HBV-HIV coinfection is unclear. We evaluated the longitudinal dynamics of HBV RNA and HBcrAg and their association with classical HBV serum biomarkers and liver histology and viral staining. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 28, 2021 Category: Gastroenterology Authors: Raymond T. Chung, Wendy C. King, Marc G. Ghany, Mauricio Lisker-Melman, Amanda S. Hinerman, Mandana Khalili, Mark Sulkowski, Mamta K. Jain, Eun-Young K. Choi, Michael A. Nalesnik, Atul K. Bhan, Gavin Cloherty, David K. Wong, Richard K. Sterling, HBV-HIV C Source Type: research

Low accuracy of FIB-4 and NAFLD fibrosis scores for screening for liver fibrosis in the population
Fibrosis-4 (FIB-4) and the NAFLD fibrosis score (NFS) are the two most popular non-invasive blood-based serum tests proposed for widespread fibrosis screening. We therefore aimed to describe the accuracy of FIB-4 and NFS to detect elevated liver stiffness as an indicator of hepatic fibrosis in low-prevalence populations. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 28, 2021 Category: Gastroenterology Authors: Isabel Graupera, Maja Thiele, Miquel Serra-Burriel, Lloren ç Caballeria, Dominique Roulot, Grace Lai-Hung Wong, Núria Fabrellas, Indra Neil Guha, Anita Arslanow, Carmen Expósito, Rosario Hernández, Guruprasad Padur Aithal, Peter R. Galle, Guillem Pera Source Type: research

Reply
I would like to reply to the letter to the editor sent by Phan and colleagues regarding our article in Clinical Gastroenterology and Hepatology.1 First, I thank Dr Phan and colleagues for their interest in our research field. The authors raise some concerns on the article addressed in the following. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 27, 2021 Category: Gastroenterology Authors: Benjamin Walter Tags: Letter to the Editor Source Type: research

Reply
We would like to thank Dr Mohta and colleagues for their interest in our study and for their comments. As we showed in our work, our cohort of patients with advanced nonalcoholic fatty liver disease (NAFLD) developed clinical decompensation at lower hepatic venous pressure gradient (HVPG) values as compared with a cohort of patients with hepatitis C virus –related chronic liver disease. We hypothesized that this may be a consequence of an underestimation of the actual portal pressure as assessed by the HVPG measurement,1 although we agree with the authors that the causes underlying this observation may be multifactorial....
Source: Clinical Gastroenterology and Hepatology - December 27, 2021 Category: Gastroenterology Authors: Octavi Bassegoda, Pol Olivas, Isabel Graupera, Virginia Hern ández-Gea Tags: Letter to the Editor Source Type: research

Novel diagnostic autoantibodies against Endothelial Protein C Receptor in patients with ulcerative colitis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 27, 2021 Category: Gastroenterology Authors: Yoichi Kakuta, Tsuyoshi Shirai, Dermot P.B. McGovern, Jonathan Braun, Hiroshi Fujii, Atsushi Masamune Source Type: research

Clip closure does not reduce risk of bleeding after resection of large serrated polyps: results from a randomized trial
Serrated polyps are important colorectal cancer precursors and are most commonly located in the proximal colon where post-polypectomy bleeding rates are higher. There is limited clinical trial evidence to guide best practices for resection of large serrated polyps (LSPs). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 27, 2021 Category: Gastroenterology Authors: Seth D. Crockett, Mouen Khashab, Douglas K. Rex, Ian S. Grimm, Matthew T. Moyer, Amit Rastogi, Todd A. Mackenzie, Heiko Pohl, Large Polyp Study Group Consortium Source Type: research

Reply on Letter to the editor Digital health interventions for colorectal polyp detection: are we ready for prime time?
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 27, 2021 Category: Gastroenterology Authors: Benjamin Walter Source Type: research

Reply to “Decompensation in patients with non-alcoholic steatohepatitis: A multi-hit hypothesis”
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 27, 2021 Category: Gastroenterology Authors: Octavi Bassegoda, Pol Olivas, Isabel Graupera, Virginia Hern ández-Gea Source Type: research

Look for a physical health status surrogate in hepatocellular carcinoma: Have we found the Holy Grail?
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 27, 2021 Category: Gastroenterology Authors: Teh-Ia Huo, Shu-Yein Ho, Chia-Yang Hsu Source Type: research

Upadacitinib Was Efficacious and Well-tolerated Over 30 Months in Patients With Crohn ’s Disease in the CELEST Extension Study
The long-term efficacy and safety of upadacitinib was evaluated in an open-label extension (OLE) of a phase II, double-blind, randomized trial of patients with Crohn ’s disease. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 26, 2021 Category: Gastroenterology Authors: Geert D ’Haens, Julian Panés, Edouard Louis, Ana Lacerda, Qian Zhou, John Liu, Edward V. Loftus Source Type: research

Deep Remission in Crohn ’s Disease: Optional or Quintessential
We read with great interest the recently published article by Laharie et  al,1 reporting the long-term follow-up data of patients with Crohn’s disease (CD) from the TAILORIX trial, having sustained corticosteroid-free remission on infliximab. The authors reported that around 47% of the patients had sustained corticosteroid-free clinical remission at the time of inclus ion. There was no difference concerning anal surgery, major abdominal surgery, CD-related hospitalization, or the need for a new systemic CD treatment between patients who achieved remission and those who did not. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 26, 2021 Category: Gastroenterology Authors: Suprabhat Giri, Sumaswi A, Vaneet Jearth Tags: Letters to the Editor Source Type: research

Upadacitinib Was Efficacious and Well Tolerated Over 30 Months in Patients with Crohn ’s Disease in the CELEST Extension Study
The long-term efficacy and safety of upadacitinib was evaluated in an open-label extension (OLE) of a phase 2, double-blind, randomized trial of patients with Crohn ’s disease (CD). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 26, 2021 Category: Gastroenterology Authors: Geert D ’Haens, Julian Panés, Edouard Louis, Ana Lacerda, Qian Zhou, John Liu, Edward V. Loftus Source Type: research