Cover
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 21, 2021 Category: Gastroenterology Source Type: research

Editorial Board
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 21, 2021 Category: Gastroenterology Source Type: research

Contents
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 21, 2021 Category: Gastroenterology Source Type: research

Elsewhere in the AGA Journals
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 21, 2021 Category: Gastroenterology Source Type: research

Information for Authors and Readers
Clinical Gastroenterology and Hepatology is the go-to resource on a broad spectrum of themes in clinical gastroenterology and hepatology. The official clinical practice journal of the AGA Institute brings you the best original research in the field with a unique combination of reviews, editorials, podcasts, video abstracts, and outcomes research —all supporting clinical practice. Articles on education, policy, and practice management highlight issues pertinent to clinicians. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 21, 2021 Category: Gastroenterology Source Type: research

Factors Associated With Chronic De Novo Post-Coronavirus Disease Gastrointestinal Disorders in a Metropolitan US County
The first coronavirus disease 2019 (COVID-19) pandemic surge harshly impacted the medically underserved populations of the urbanized northeastern United States. SARS-CoV-2 virions infect the gastrointestinal (GI) tract, and GI symptoms are common during acute infection.1 Post-COVID syndromes increasingly are recognized as important public health considerations.2 Postinfectious disorders of gut –brain interaction (DGBIs; formerly known as functional gastrointestinal disorders) can occur after enteric illness; the COVID-19 pandemic is anticipated to provoke DGBI development3 within a rapidly evolving post-COVID framework o...
Source: Clinical Gastroenterology and Hepatology - October 20, 2021 Category: Gastroenterology Authors: Christopher V élez, Mary Paz, Casey Silvernale, Lawrence W. Stratton, Braden Kuo, Kyle Staller, Suffolk County COVID-19 Gastrointestinal Symptom Assessment Tags: Research Letters Source Type: research

Decompensation in Advanced Nonalcoholic Fatty Liver Disease May Occur at Lower Hepatic Venous Pressure Gradient Levels Than in Patients With Viral Disease
Portal hypertension is the strongest predictor of hepatic decompensation and death in patients with cirrhosis. However, its discriminatory accuracy in patients with nonalcoholic fatty liver disease (NAFLD) has been challenged because hepatic vein catheterization may not reflect the real portal vein pressure as accurately as in patients with other etiologies. We aimed to evaluate the relationship between hepatic venous pressure gradient (HVPG) and presence of portal hypertension –related decompensation in patients with advanced NAFLD (aNAFLD). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 20, 2021 Category: Gastroenterology Authors: Octavi Bassegoda, Pol Olivas, Laura Turco, Mattias Mandorfer, Miquel Serra-Burriel, Luis Tellez, Wilhelmus Kwanten, Alexia Laroyenne, Oana Farcau, Edilmar Alvarado, Lucile Moga, Elise Vuille-Lessard, Jose Ignacio Fortea, Luis Iba ñez, Giulia Tosetti, Tho Source Type: research

High-Volume Split-Dose Versus Low-Volume Split-Dose Polyethylene Glycol Preparations: Which Is a Better Choice?
We read with great interest the article written by Barkun et  al.1 This large national randomized clinical trial emphasized high-volume split-dose polyethylene glycol (PEG) (2 L + 2 L) provides statistically greater yet clinically comparable results for adequate bowel preparation compared with low-volume split-dose PEG (1 L + 1 L). This result, which is co nsistent with our conventional notion, will help us better explain the choice of colonoscopy preparation to our patients, individualizing them to patients’ preferences. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 20, 2021 Category: Gastroenterology Authors: Hongyu Huang, Xian Zhang, Kai Deng Tags: Letter to the Editor Source Type: research

Decompensation in advanced non-alcoholic fatty liver disease may occur at lower hepatic venous pressure gradient levels that in patients with viral disease
Portal hypertension (PH) is the strongest predictor of hepatic decompensation and death in patients with cirrhosis. However, its discriminatory accuracy in patients with non-alcoholic fatty liver disease (NAFLD) has been challenged as hepatic vein catheterization may not reflect the real portal vein pressure as accurately as in patients with other etiologies. We aimed to evaluate the relationship between hepatic venous pressure gradient (HVPG) and presence of portal hypertension related decompensation in patients with advanced NAFLD (aNAFLD). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 20, 2021 Category: Gastroenterology Authors: Octavi Bassegoda, Pol Olivas, Laura Turco, Mattias Mandorfer, Miquel Serra-Burriel, Luis Tellez, Wilhelmus Kwanten, Alexia Laroyenne, Oana Farcau, Edilmar Alvarado, Lucile Moga, Elise Vuille-Lessard, Jose Ignacio Fortea, Luis Iba ñez, Giulia Tosetti, Tho Source Type: research

Lymphangioma in a child managed with debulking surgery
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 20, 2021 Category: Gastroenterology Authors: Takeshi Onda, Kamichika Hayashi, Masayuki Takano Tags: Image of the Month Source Type: research

Factors associated with chronic de novo post-COVID gastrointestinal disorders in a metropolitan United States county
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 20, 2021 Category: Gastroenterology Authors: Christopher V élez, Mary Paz, Casey Silvernale, Lawrence W. Stratton, Braden Kuo, Kyle Staller, Suffolk County COVID-19 Gastrointestinal Symptom Assessment Source Type: research

High-Volume Split-Dose versus Low-Volume Split-Dose Polyethylene Glycol (PEG) Preparations: which is a better choice?
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 20, 2021 Category: Gastroenterology Authors: Hongyu Huang, Xian Zhang, Kai Deng Source Type: research

Risk Prediction and Comparative Efficacy of Anti-TNF vs Thiopurines, for Preventing Postoperative Recurrence in Crohn's Disease: A Pooled Analysis of 6 Trials
The superiority of anti-TNF- α agents to thiopurines for the prevention of postoperative recurrence of Crohn’s disease (CD) after ileocolonic resection remains controversial. In this meta-analysis of individual participant data (IPD), the effect of both strategies was compared and assessed after risk stratification. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 19, 2021 Category: Gastroenterology Authors: Evelien M.J. Beelen, Daan Nieboer, Jeanine H.C. Arkenbosch, Miguel D. Regueiro, Jack Satsangi, Sandro Ardizzone, Antonio L ópez-Sanromán, Edoardo Savarino, Alessandro Armuzzi, C. Janneke van der Woude, Annemarie C. de Vries Source Type: research

Risk Prediction, and Comparative Efficacy of Anti-TNF vs Thiopurines, for Preventing Postoperative Recurrence in Crohn's Disease: A Pooled Analysis of 6 Trials
The superiority of anti-TNF- α agents to thiopurines for the prevention of postoperative recurrence of Crohn’s disease (CD) after ileocolonic resection remains controversial. In this meta-analysis of individual participant data (IPD), the effect of both strategies was compared and assessed after risk stratification. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 19, 2021 Category: Gastroenterology Authors: Evelien M.J. Beelen, Daan Nieboer, Jeanine H.C. Arkenbosch, Miguel D. Regueiro, Jack Satsangi, Sandro Ardizzone, Antonio L ópez-Sanromán, Edoardo Savarino, Alessandro Armuzzi, C. Janneke van der Woude, Annemarie C. de Vries Source Type: research

Reply
We thank Liu et  al1 for their comments on our study, pointing out the potential nonadherence to practice guidelines and lack of rigorous follow-up evaluation as potential causes of the serious adverse events reported in our study. We totally agreed with them on these points, which also were precisely the goals of our study, aiming to report what really happened in routine practice and not what would be expected in the ideal world where all care providers and patients follow exactly what is written in practice guidelines and/or when patients are rigorously observed under a research protocol as performed in t heir publishe...
Source: Clinical Gastroenterology and Hepatology - October 19, 2021 Category: Gastroenterology Authors: Yao-Chun Hsu, Cheng-Hao Tseng, Mindie H. Nguyen Tags: Letter to the Editor Source Type: research