Longitudinal Changes in MR Elastography –based Biomarkers in Obese Patients Treated with Bariatric Surgery
Obesity-related chronic inflammation contributes to nonalcoholic fatty liver disease (NAFLD) progression in obese patients (body mass index [BMI]>30 kg/m2).1 The early detection of inflammation with noninvasive imaging technology may help identify individuals with a high risk of developing NAFLD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 29, 2021 Category: Gastroenterology Authors: Jiahui Li, Alina M. Allen, Vijay H. Shah, Armando Manduca, Richard L. Ehman, Meng Yin Tags: Research Letter Source Type: research

Longitudinal Changes in MR Elastography-based Biomarkers in Obese Patients Treated with Bariatric Surgery
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 29, 2021 Category: Gastroenterology Authors: Jiahui Li, Alina M. Allen, Vijay H. Shah, Armando Manduca, Richard L. Ehman, Meng Yin, Corporate Authorship: The Mayo ’s NAFLD MR imaging research group Source Type: research

AGA Clinical Practice Update on Management of Medically Refractory Gastroparesis: Expert Review
Delayed gastric emptying on objective testing defines gastroparesis, but symptoms overlap with functional dyspepsia, and do not correlate well with gastric emptying delay. This review outlines a strategy for defining, diagnosing and managing refractory gastroparesis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 29, 2021 Category: Gastroenterology Authors: Brian E. Lacy, Jan Tack, C. Prakash Gyawali Source Type: research

Limitations of Heartburn and other Societies ’ Criteria in Barrett’s Screening for Detecting De-novo Esophageal Adenocarcinoma
Despite extensive Barrett ’s esophagus (BE) screening efforts, most patients with esophageal adenocarcinoma (EAC) present de novo. It is unclear how much of this problem is due to insensitivity or poor applications of current screening guidelines. We aimed to evaluate the sensitivity of guidelines by determining the propor tion of prevalent EAC cases that meet the American College of Gastroenterology (ACG) or the British Society of Gastroenterology (BSG) guidelines for BE screening and determine whether changes to criteria would enhance detection . (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 29, 2021 Category: Gastroenterology Authors: Tarek Sawas, Shawn A. Zamani, Sarah Killcoyne, Andrew Dullea, Kenneth K. Wang, Prasad G. Iyer, Rebecca C. Fitzgerald, David A. Katzka Source Type: research

Disease progression modelling for economic evaluation in non-alcoholic fatty liver disease – a systematic review
Globally, 25% of people have Non-Alcoholic Fatty Liver Disease (NAFLD) and currently there are no approved pharmacological treatments for NAFLD. With a slow disease progression, long-term impact of pharmacological treatments can only be assessed by complementing emerging clinical trial evidence by data from other sources in disease progression modelling. Although this modelling is crucial for economic evaluation studies assessing the clinical and economic consequences of new treatments the approach to modelling the natural history of NAFLD differs in contemporary research. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 29, 2021 Category: Gastroenterology Authors: Lina Gruneau, Mattias Ekstedt, Stergios Kechagias, Martin Henriksson Source Type: research

Pump Up the Volume? The Complex Relationship of Specialty and Colonoscopy Competency
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 28, 2021 Category: Gastroenterology Authors: Rajesh N. Keswani Source Type: research

Skills or Pills: Randomized Trial Comparing Hypnotherapy to Medical Treatment in Children With Functional Nausea
The potential effectiveness of gut-directed hypnotherapy (HT) is unknown for pediatric chronic nausea. This randomized controlled trial compared HT with standard medical treatment (SMT). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 27, 2021 Category: Gastroenterology Authors: Pamela D. Browne, Clara M.A. de Bruijn, Esther M. Speksnijder, Bibiche den Hollander, Herbert M. van Wering, Margreet M.S. Wessels, Michael Groeneweg, Joery Goede, Carla Frankenhuis, Ellen Tromp, Marc A. Benninga, Arine M. Vlieger Source Type: research

Long-term outcome of gastric mild-moderate dysplasia: A real-world clinical experience
The natural course of gastric mild-moderate dysplasia in a country with high incidence of gastric cancer (GC) is relatively unknown. We aimed to determine the long-term cumulative incidence of and risk factors for advanced neoplasia in patients with gastric dysplasia. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 27, 2021 Category: Gastroenterology Authors: Shiyu Xiao, Haoping Lu, Yan Xue, Rongli Cui, Lingmei Meng, Zhu Jin, Zhihao Yin, Liya Zhou Source Type: research

Pilot Randomized Controlled Trial of an Advance Care Planning Video Decision Tool for Patients with Advanced Liver Disease
Transplant-ineligible patients with advanced liver disease rarely receive timely advance care planning (ACP). Tools are needed to educate these patients about medical interventions available at the end of life to promote ACP. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 27, 2021 Category: Gastroenterology Authors: Nneka N. Ufere, Blair Robinson, John Donlan, Teresa Indriolo, Judith Bloom, Abigail Scherrer, Nancy M. Mason, Arpan Patel, Jennifer C. Lai, Raymond T. Chung, Angelo Volandes, Areej El-Jawahri Source Type: research

Skills or Pills − Randomized trial comparing Hypnotherapy to Medical Treatment in children with Functional Nausea
The potential effectiveness of gut-directed hypnotherapy (HT) is unknown for pediatric chronic nausea. This randomized controlled trial compared HT with standard medical treatment (SMT). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 27, 2021 Category: Gastroenterology Authors: Pamela D. Browne, Clara M.A. de Bruijn, Esther M. Speksnijder, Bibiche den Hollander, Herbert M. van Wering, Margreet M.S. Wessels, Michael Groeneweg, Joery Goede, Carla Frankenhuis, Ellen Tromp, Marc A. Benninga, Arine M. Vlieger Source Type: research

Reply
We thank Liu and Li for their interest in our study, “Risk for post-colonoscopy irritable bowel syndrome in patients with and without antibiotic exposure.”1,2 In their letter, they suggest 2 considerations about the study design and describe their potential implications for the main study conclusion that antibiotic use around the time of colonosco py is not associated with subsequent diagnoses of irritable bowel syndrome. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 26, 2021 Category: Gastroenterology Authors: Ravy K. Vajravelu, Jordan M. Shapiro, Hashem B. El-Serag Tags: Letter to the Editor Source Type: research

A gap in care leads to progression of fibrosis in eosinophilic esophagitis patients
There are few data assessing disease progression in eosinophilic esophagitis (EoE) after diagnosis. We aimed to determine outcomes and assess for progression of fibrosis in EoE patients with a gap in their regular care. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 26, 2021 Category: Gastroenterology Authors: Nicole C. Chang, Kisan P. Thakkar, Corey J. Ketchem, Swathi Eluri, Craig C. Reed, Evan S. Dellon Source Type: research

Impact of the COVID-19 Pandemic on Hospitalizations for Alcoholic Hepatitis or Cirrhosis in Alberta, Canada
COVID-19 pandemic lockdown and restrictions had significant disruption to patient care. We aimed to evaluate the impact of COVID-19 restrictions on hospitalizations of patients with alcoholic and non-alcoholic cirrhosis as well as alcoholic hepatitis (AH) in Alberta, Canada. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 26, 2021 Category: Gastroenterology Authors: Abdel Aziz Shaheen, Kristine Kong, Christopher Ma, Chelsea Doktorchik, Carla S. Coffin, Mark G. Swain, Kelly W. Burak, Stephen E. Congly, Samuel S. Lee, Matthew Sadler, Meredith Borman, Juan G. Abraldes Source Type: research

Authors ’ response to Letter to the Editor from Liu and Li regarding Risk for post-colonoscopy irritable bowel syndrome in patients with and without antibiotic exposure.
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 26, 2021 Category: Gastroenterology Authors: Ravy K. Vajravelu, Jordan M. Shapiro, Hashem B. El-Serag Source Type: research

Issue Highlights
Testing for celiac disease is an appropriate diagnostic step in patients presenting with chronic diarrhea and or abdominal pain.1 Patients with irritable bowel syndrome (IBS) and negative celiac tests frequently will attempt a gluten free diet (GFD) nonetheless with varying success. In this issue of Clinical Gastroenterology& Hepatology, Pinto-Sanchez and colleagues provide data to guide recommendations regarding a GFD in patients with IBS.2 They tested for anti-gliadin antibodies in 50 patients with IBS diagnosed base on ROME III criteria. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 21, 2021 Category: Gastroenterology Authors: Ziad F. Gellad Tags: Issue Highlights Source Type: research