Advances in Molecular Pathophysiology and Targeted Therapy for Cushing's Disease
Cancers (Basel). 2023 Jan 13;15(2):496. doi: 10.3390/cancers15020496.ABSTRACTCushing's disease is caused by autonomous secretion of adrenocorticotropic hormone (ACTH) from corticotroph pituitary neuroendocrine tumors. As a result, excess cortisol production leads to the overt manifestation of the clinical features of Cushing's syndrome. Severe complications have been reported in patients with Cushing's disease, including hypertension, menstrual disorders, hyperglycemia, osteoporosis, atherosclerosis, infections, and mental disorders. Cushing's disease presents with a variety of clinical features, ranging from overt to subt...
Source: Atherosclerosis - January 21, 2023 Category: Cardiology Authors: Shinobu Takayasu Kazunori Kageyama Makoto Daimon Source Type: research

The immune microenviroment in somatotropinomas: from biology to personalized and target therapy
AbstractPituitary tumors are rare neoplasms, with a heterogeneous biological and clinical behavior, due to their clinical course, local invasive growth, resistance to conventional therapies and the risk of disease progression. Recent studies on tumor microenvironment (TME) provided new knowledge on the biology of these neoplasia, that may explain the different phenotypes of these tumors and suggest new biomarkers able to predict the prognosis and the treatment outcome. The identification of molecular markers that act as targets for biological therapies may open new perspectives in the medical treatments of aggressive pitui...
Source: Reviews in Endocrine and Metabolic Disorders - January 20, 2023 Category: Endocrinology Source Type: research

The immune microenviroment in somatotropinomas: from biology to personalized and target therapy
Rev Endocr Metab Disord. 2023 Jan 20. doi: 10.1007/s11154-022-09782-1. Online ahead of print.ABSTRACTPituitary tumors are rare neoplasms, with a heterogeneous biological and clinical behavior, due to their clinical course, local invasive growth, resistance to conventional therapies and the risk of disease progression. Recent studies on tumor microenvironment (TME) provided new knowledge on the biology of these neoplasia, that may explain the different phenotypes of these tumors and suggest new biomarkers able to predict the prognosis and the treatment outcome. The identification of molecular markers that act as targets for...
Source: ENDOCR REV - January 19, 2023 Category: Endocrinology Authors: Sabrina Chiloiro Laura De Marinis Source Type: research

The immune microenviroment in somatotropinomas: from biology to personalized and target therapy
Rev Endocr Metab Disord. 2023 Jan 20. doi: 10.1007/s11154-022-09782-1. Online ahead of print.ABSTRACTPituitary tumors are rare neoplasms, with a heterogeneous biological and clinical behavior, due to their clinical course, local invasive growth, resistance to conventional therapies and the risk of disease progression. Recent studies on tumor microenvironment (TME) provided new knowledge on the biology of these neoplasia, that may explain the different phenotypes of these tumors and suggest new biomarkers able to predict the prognosis and the treatment outcome. The identification of molecular markers that act as targets for...
Source: ENDOCR REV - January 19, 2023 Category: Endocrinology Authors: Sabrina Chiloiro Laura De Marinis Source Type: research

The immune microenviroment in somatotropinomas: from biology to personalized and target therapy
Rev Endocr Metab Disord. 2023 Jan 20. doi: 10.1007/s11154-022-09782-1. Online ahead of print.ABSTRACTPituitary tumors are rare neoplasms, with a heterogeneous biological and clinical behavior, due to their clinical course, local invasive growth, resistance to conventional therapies and the risk of disease progression. Recent studies on tumor microenvironment (TME) provided new knowledge on the biology of these neoplasia, that may explain the different phenotypes of these tumors and suggest new biomarkers able to predict the prognosis and the treatment outcome. The identification of molecular markers that act as targets for...
Source: ENDOCR REV - January 19, 2023 Category: Endocrinology Authors: Sabrina Chiloiro Laura De Marinis Source Type: research

The immune microenviroment in somatotropinomas: from biology to personalized and target therapy
Rev Endocr Metab Disord. 2023 Jan 20. doi: 10.1007/s11154-022-09782-1. Online ahead of print.ABSTRACTPituitary tumors are rare neoplasms, with a heterogeneous biological and clinical behavior, due to their clinical course, local invasive growth, resistance to conventional therapies and the risk of disease progression. Recent studies on tumor microenvironment (TME) provided new knowledge on the biology of these neoplasia, that may explain the different phenotypes of these tumors and suggest new biomarkers able to predict the prognosis and the treatment outcome. The identification of molecular markers that act as targets for...
Source: ENDOCR REV - January 19, 2023 Category: Endocrinology Authors: Sabrina Chiloiro Laura De Marinis Source Type: research

Risk Factors Associated with Postoperative CSF Leak in Extrasellar Tumors
Conclusion Extrasellar tumors, particularly clival tumors, have a higher rate of postoperative CSF leak than pituitary tumors. Prophylactic lumbar drains can be considered for patients at high risk for developing postoperative CSF leak. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - January 16, 2023 Category: Neurosurgery Authors: Zhang, Huan Peeters, Sophie Vengorivich, Gennadiy Antoury, Layal Park, Ki Wan Wells, Christine Suh, Jeffrey D. Lee, Jivianne T. Heaney, Anthony Bergsneider, Marvin Kim, Won Wang, Marilene B. Tags: Original Article Source Type: research

Cancers, Vol. 15, Pages 496: Advances in Molecular Pathophysiology and Targeted Therapy for Cushing & rsquo;s Disease
Cancers, Vol. 15, Pages 496: Advances in Molecular Pathophysiology and Targeted Therapy for Cushing’s Disease Cancers doi: 10.3390/cancers15020496 Authors: Shinobu Takayasu Kazunori Kageyama Makoto Daimon Cushing’s disease is caused by autonomous secretion of adrenocorticotropic hormone (ACTH) from corticotroph pituitary neuroendocrine tumors. As a result, excess cortisol production leads to the overt manifestation of the clinical features of Cushing’s syndrome. Severe complications have been reported in patients with Cushing’s disease, including hypertension,...
Source: Cancers - January 13, 2023 Category: Cancer & Oncology Authors: Shinobu Takayasu Kazunori Kageyama Makoto Daimon Tags: Review Source Type: research

Challenges in the management of a 7 years old child with thyrotropin-secreting pituitary adenoma and the review of the literature
Conclusion: The diagnos is, treatment, and follow-up of TSHomas are challenging and short stature due to accelerated bone maturation is a complication of paediatric TSHomas. (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - January 11, 2023 Category: Endocrinology Source Type: research

Differences in Clinical Characteristics and Surgical Outcomes of Patients with Ischemic and Hemorrhagic Pituitary Adenomas
CONCLUSION: Patients with ischemic PA presented different clinical characteristics to the hemorrhagic ones. Transsphenoidal surgery should be considered for the patients with neuro-ophthalmic deficits and might benefit for pituitary function recovery of the apoplectic adenoma patients, especially pituitary thyroid axis in ischemic PA patients.PMID:36625014 | DOI:10.3340/jkns.2022.0071 (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - January 10, 2023 Category: Neurosurgery Authors: Jingpeng Liu Peng Huang Xiaoqing Zhang Yong Chen Xin Zheng Rufei Shen Xuefeng Tang Hui Yang Song Li Source Type: research

Sub-macroscopic skin presentation of acromegaly and effect of pituitary tumor surgery: A study using dermatoscopy and ultra-high-frequency ultrasound
ConclusionsDermatoscopy and ultra-high-frequency ultrasound provided augmented visual examination of the cutaneous changes in acromegaly. Some of the skin lesions could improve or reverse after pituitary surgery. Baseline GH levels, age, and endocrine remission were correlated with skin improvement at 3-month follow-up. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - January 10, 2023 Category: Endocrinology Source Type: research