Pleomorphic xanthoastrocytoma (PXA) : MRI
History– A 14 yr female c/o headache since 2 months. 2 episodes of seizures in last one weekFindings- An ill-defined soild-cystic mass is seen in the left parietal lobe with surrounding mild to moderate edema. The cystic component shows restriction of diffusion and rim enhancement. The solid component shows avid postcontrast enhancementFinal Diagnosis- Pleomorphic xanthoastrocytoma (PXA)Golden PointDDs of cyst with mural nodule-Pilocytic astrocytoma, PXA, ganglioglioma, hemangioblastoma, craniopharyngioma Famous Radiology Blog by Dr Sumer Sethi www.sumersethi.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - February 9, 2022 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Pilomyxoid xanthoastrocytoma (PXA) : MRI
History– A 14 yr female c/o headache since 2 months. 2 episodes of seizures in last one weekFindings- An ill-defined soild-cystic mass is seen in the left parietal lobe with surrounding mild to moderate edema. The cystic component shows restriction of diffusion and rim enhancement. The solid component shows avid postcontrast enhancementFinal Diagnosis- Pilomyxoid xanthoastrocytoma (PXA)Golden PointDDs of cyst with mural nodule-Pilocytic astrocytoma, PXA, ganglioglioma, hemangioblastoma, craniopharyngioma Famous Radiology Blog by Dr Sumer Sethi www.sumersethi.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - February 9, 2022 Category: Radiology Authors: Sumer Sethi Source Type: blogs
cIMPACT-NOW Update 4: diffuse gliomas characterized by MYB, MYBL1, or FGFR1 alterations or BRAFV600E mutation
This cIMPACT-NOW update was published this month:Summary:cIMPACT (Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) has reviewed the status of WHO grade II IDH-wt/H3-wt diffuse gliomas, focusing on those with a BRAFV600E mutation, FGFR1 alteration, or a MYB or MYBL1 rearrangement, and recommends the use of an integrated diagnosis to combine their histologic and genetic features. The consortium ecommends the use of an integrated diagnosis to combine their histologic and genetic features, as suggested in the following:Diffuse glioma, MYB...
Source: neuropathology blog - April 16, 2019 Category: Radiology Tags: molecular studies neoplasms Source Type: blogs
Best Post of June 2018: Who was Rosenthal?
Of the ten posts from June 2018, my favorite was " Who was Rosenthal? " from June 22. So, here ' s the next in our " Best of the Month " series:A Rosenthal fiber in pilocytic astrocytoma" In 1898, the German pathologist Werner Rosenthal noted elongated inclusions within the gliotic edge of a syringeal cavity of an ependymoma. Assigned to write the case report by a senior mentor while serving as a “first assistant” at the University of Erlangen, Rosenthal colorfully described these inclusions as a “glossy formation of little bulbs or wavy sausages with one thick and one pointed end.”…. His supp...
Source: neuropathology blog - August 10, 2018 Category: Radiology Tags: Best of the Month series history Source Type: blogs
Who was Rosenthal?
A Rosenthal fiber in pilocytic astrocytoma" In 1898, the German pathologist Werner Rosenthal noted elongated inclusions within the gliotic edge of a syringeal cavity of an ependymoma. Assigned to write the case report by a senior mentor while serving as a “first assistant” at theUniversity of Erlangen, Rosenthal colorfully described these inclusions as a “glossy formation of little bulbs or wavy sausages with one thick and one pointed end.”…. His supposition that they were related to glial fibers would prove surprisingly insightful. Not until some 20 years later did Bielschowsky and Unger use the t...
Source: neuropathology blog - June 22, 2018 Category: Radiology Tags: neoplasms Source Type: blogs
Pennies-on-a-plate cell in a pilocytic astrocytoma
Multinucleated astrocytes with peripherally situated nuclei like this one in a pilocytic astrocytomaare referred to as having a " pennies-on-a-plate " configurationThis is a common " degenerative " change seen in long-standing pilocytic astrocytomas. I ' m not sure from where this " pennies-on-a-plate " designation derives, but please leave a comment if you know. (Source: neuropathology blog)
Source: neuropathology blog - June 21, 2018 Category: Radiology Tags: neoplasms Source Type: blogs
Pilomyxoid astrocytoma
Angiocentricity, a hallmark of pilomyxoid astroctyoma, is demonstrated hereAlthough thought to be related to pilocytic astrocytoma, full characterization of pilomyxoid astrocytoma has yet to yield a definitive WHO grade for these tumors (although the prior edition of the WHO book pegged this tumor as grade II). Pilomyxoid astrocytomas differ from pilocytic astrocytomas in that they tend not to be biphasic or harbor Rosenthal fibers. (Source: neuropathology blog)
Source: neuropathology blog - May 2, 2018 Category: Radiology Tags: neoplasms Source Type: blogs
University of Colorado residents show up in force for CAP16
Left to right: Drs. Robinson, Greer, Roberts, Klein, and Graham (with me kneeling)Five PGY2 pathology residents, the most from a single class in the history of the institution, are presenting posters today and tomorrow at the annual meeting of the College of American Pathologists. Most are neuropathology related. Here are the titles:Caleb Graham,et al. Pilocytic Astrocytoma: A Diagnostic Consideration in Lateral Ventricular TumorsAshley Greer,et al. BRAF Mutational Status in Desmoplastic Infantile Astrocytoma/GangliogliomaColleen Klein,et al. Hemophagocytic Lymphohistiocytosis Discovered Clinically and at Autopsy: A Dual-I...
Source: neuropathology blog - September 26, 2016 Category: Radiology Tags: CAP16 abstracts meetings Source Type: blogs
CAP16 Abstract Highlights -- Pilocytic Astrocytoma: A Diagnostic Consideration in Lateral Ventricular Tumors
Conclusions: Lateral ventricle PAs are uncommon but should be considered when encountering lateral ventricular tumors. (Source: neuropathology blog)
Source: neuropathology blog - September 13, 2016 Category: Radiology Tags: CAP16 abstracts neoplasms Source Type: blogs
