Metabolic outcomes in obese mice undergoing one-anastomosis gastric bypass (OAGB) with a long or a short biliopancreatic limb
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00327.2023. Online ahead of print.ABSTRACTOne-anastomosis gastric bypass (OAGB) has gained importance as a safe and effective operation to treat morbid obesity. It is not known whether a long biliopancreatic limb (BPL) in OAGB surgery compared to a short BPL results in beneficial metabolic outcomes. 5-week-old male C57BL/6J mice fed a high-fat diet for 8 weeks underwent OAGB surgery with defined short and long BPL lengths, or sham surgery combined with caloric restriction. Weight loss, glucose tolerance, obesity-related comorbidities, endocrine effects, gut m...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 17, 2024 Category: Physiology Authors: Ioannis I Lazaridis Angela J T Bosch Lena Keller Andy J Y Low Jeanne Tamarelle Seraina O Moser Denise V Winter Cristina G ómez Caspar J Peterson Romano Schneider Marko Kraljevic Alex Odermatt Pascale Vonaesch Ralph Peterli Tarik Delko Claudia Cavelti-Wed Source Type: research
Mechanisms of spinophilin-dependent pancreas dysregulation in obesity
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00099.2023. Online ahead of print.ABSTRACTSpinophilin is an F-actin binding and protein phosphatase 1 (PP1) targeting protein that acts as a scaffold of PP1 to its substrates. Spinophilin knockout (Spino-/-) mice have decreased fat mass, increased lean mass, and improved glucose tolerance, with no difference in feeding behaviors. While spinophilin is enriched in neurons, its roles in non-neuronal tissues, such as beta cells of the pancreatic islets, are unclear. We have corroborated and expanded upon previous studies to determine that Spino-/- mice have decre...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 17, 2024 Category: Physiology Authors: Kaitlyn C Stickel Nikhil R Shah Emily T Claeboe Kara S Orr Amber L Mosley Emma H Doud Teri L Belecky-Adams Anthony J Baucum Source Type: research
Advancements in Diabetic Kidney Disease Management: Integrating Innovative Therapies and Targeted Drug Development
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00026.2024. Online ahead of print.ABSTRACTDiabetic kidney disease (DKD) is a leading cause of chronic kidney disease and affects approximately 40% of diabetic individuals. Cases of DKD continue to rise globally as the prevalence of diabetes mellitus increases, with an estimated 415 million people living with diabetes in 2015 and a projected 642 million by 2040. DKD is associated with significant morbidity and mortality, representing 34% and 36% of all chronic kidney disease deaths in men and women, respectively. Common co-morbidities including hypertension an...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 17, 2024 Category: Physiology Authors: Shaarav Ghose Matthew Satariano Saichidroopi Korada Thomas Cahill Raghav Shah Rupesh Raina Source Type: research
A randomised multicentre study of angiography- versus physiologyguided percutaneous coronary intervention in patients with coronary artery disease undergoing TAVI: design and rationale of the FAITAVI trial
EuroIntervention. 2024 Apr 15;20(8):e504-e510. doi: 10.4244/EIJ-D-23-00679.ABSTRACTThe treatment of coronary artery disease (CAD) in patients with severe aortic valve stenosis (AVS) eligible for transcatheter aortic valve implantation (TAVI) is not supported by clinical evidence, and the role of physiology over anatomy as well as the timing of coronary intervention are not defined. FAITAVI (ClinicalTrials.gov: NCT03360591) is a nationwide prospective, open-label, multicentre, randomised controlled study comparing the angiography-guided versus the physiology-guided coronary revascularisation strategy in patients with combin...
Source: EuroIntervention - April 17, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Flavio Ribichini Gabriele Pesarini Tommaso Fabris Mattia Lunardi Marco Barbierato Gianpiero D'Amico Chiara Zanchettin Dario Gregori Tommaso Piva Elisa Nicolini Caterina Gandolfo Massimo Fineschi Anna Sonia Petronio Sergio Berti Francesco Caprioglio France Source Type: research
Reply to “letter to the editor: Measuring renal hemodynamics during exercise using Doppler ultrasound”
(Source: Physiological Reports)
Source: Physiological Reports - April 17, 2024 Category: Physiology Authors: Shotaro Kawakami,
Tetsuhiko Yasuno,
Saki Kawakami,
Ai Ito,
Kanta Fujimi,
Takuro Matsuda,
Shihoko Nakashima,
Kosuke Masutani,
Yoshinari Uehara,
Yasuki Higaki,
Ryoma Michishita Tags: LETTER TO THE EDITOR Source Type: research
Effect of different levels of single cell protein and probiotic microorganisms on performance, immunological responses, and intestinal histology in laying hens
AbstractAn experiment was conducted to evaluate the effects of single-cell protein (SCP), as a valuable by-product and substitute for soybean meal, and multistrain probiotics on the performance, blood biochemistry, intestinal histomorphology, ileal microbiota, and immune responses in laying hens. Leghorn laying hens were randomly assigned to nine experimental treatments with eight replicates of five birds each. Dietary treatments consisted of three levels of replacement of soybean meal with SCP (0.0%, 30%, and 60%) and three levels of probiotics (0.0, 50, 100 mg/kg) offered through 70 days of main recording. The result ...
Source: Journal of Animal Physiology and Animal Nutrition - April 17, 2024 Category: Zoology Authors: Rasoul Rashedi Dehsahraee,
Amir Hossein Mahdavi,
Mohammad Sedghi,
Hassan Saleh Tags: ORIGINAL ARTICLE Source Type: research
Protective effect of chlorogenic acid on liver injury in heat ‐stressed meat rabbits
This study investigated the protective effects of chlorogenic acid (CGA) on production performance and liver function of rabbits under heat stress (HS) condition. A total of 120 healthy New Zealand weaned rabbits with similar initial body weight, were randomly divided into 3 treatments with 20 replicates per treatment and 2 weaned rabbits per replicate: control (CON) group (rabbits were housed at 25 ± 1°C and fed a basal diet), HS group (rabbits were housed at 35 ± 1°C and fed a basal diet), and HS + CGA group (rabbits were housed at 35 ± 1°C and fed a basal diet supplemented with 800 mg/kg CGA). T...
Source: Journal of Animal Physiology and Animal Nutrition - April 17, 2024 Category: Zoology Authors: Rongmei Ji,
Jiali Chen,
Jian Xu,
Lirui Zhang,
Lei Liu,
Fuchang Li Tags: ORIGINAL ARTICLE Source Type: research
Spirulina (Arthrospira platensis) supplementation: Impact on growth, metabolism, and antioxidant status in zebrafish
In conclusion, this study indicates that SP supplementation has substantial potential as a growth promoter, positively influencing lipid metabolism and antioxidant enzyme activity without affecting zebrafish survival. (Source: Journal of Animal Physiology and Animal Nutrition)
Source: Journal of Animal Physiology and Animal Nutrition - April 17, 2024 Category: Zoology Authors: Aline Pereira Coli,
William Franco Carneiro,
Kiara C ândido Duarte da Silva,
Tássia Flávia Dias Castro,
João Paulo Lima de Oliveira,
Moisés Silvestre Azevedo de Martins,
Luis David Solis Murgas Tags: ORIGINAL ARTICLE Source Type: research
Measuring renal hemodynamics during exercise using doppler ultrasound
(Source: Physiological Reports)
Source: Physiological Reports - April 17, 2024 Category: Physiology Authors: Christopher L. Chapman,
Rachel C. Drew,
John R. Halliwill,
Christopher T. Minson,
Zachary J. Schlader Tags: LETTER TO THE EDITOR Source Type: research
Niacin supplementation attenuates the regression of three ‐dimensional capillary architecture in unloaded female rat skeletal muscle
In this study involving adult female Sprague –Dawley rats, the animals were randomly assigned to one of four groups: control (CON), hindlimb unloading (HU), NA, and HU with NA supplementation (HU + NA). For a period of 2 weeks, the rats in the HU and HU + NA groups underwent HU, while those in the NA and HU + NA groups received NA (750 mg/kg) twice daily through oral administration. The results demonstrated that HU lowered capillary number, luminal diameter, and capillary volume, as well as decreased succinate dehydrogenase activity, slow fiber composition, and PGC-1α expression within the soleus muscle....
Source: Physiological Reports - April 17, 2024 Category: Physiology Authors: Hao Lin,
Jihao Xing,
Han Pan,
Takumi Hirabayashi,
Noriaki Maeshige,
Ryosuke Nakanishi,
Hiroyo Kondo,
Hidemi Fujino Tags: ORIGINAL ARTICLE Source Type: research
Differential effects of cholecalciferol and calcitriol on muscle proteolysis and oxidative stress in angiotensin II ‐induced C2C12 myotube atrophy
Cholecalciferol exhibited beneficial roles, whereas calcitriol possessed the negative impact on skeletal muscle proteostasis in angiotensin II-induced muscle atrophy. AbstractRenin –angiotensin system activation contributes to skeletal muscle atrophy in aging individuals with chronic diseases. We aimed to explore the effects of cholecalciferol (VD3) and calcitriol (1,25VD3) on signaling of muscle proteolysis and oxidative stress in myotubes challenged with angiotensin II (AII). The mouse C2C12 myotubes were assigned to vehicle, AII, AII + VD3, AII + 1,25VD3, and AII + losartan groups. The expression levels...
Source: Physiological Reports - April 17, 2024 Category: Physiology Authors: Muthita Hirunsai,
Ratchakrit Srikuea Tags: ORIGINAL ARTICLE Source Type: research
Voluntary exercise fails to prevent metabolic dysfunction ‐associated steatotic liver disease progression in male rats fed a high‐fat high‐cholesterol diet
AbstractMetabolic dysfunction-associated steatotic liver disease (MASLD) is a major public health issue with a worldwide prevalence of 30% –32%. In animal models, voluntary exercise may be an alternative to forced physical activity, avoiding stress, potential injuries, and being logistically simpler. Here, we assessed voluntary exercise (Vex) in Sprague–Dawley rats fed a high-fat, high-cholesterol diet for 18 weeks to induce MASL D. We quantified workload (speed and distance) using exercise wheels and evaluated energy expenditure using calorimetric cages. MASLD progression was assessed using circulating and hepatic b...
Source: Physiological Reports - April 17, 2024 Category: Physiology Authors: Cl ément Besqueut‐Rougerie,
Vivien Chavanelle,
Arnaud Michaux,
Yolanda F. Otero,
Pascal Sirvent,
James A. King,
Gaël Ennequin Tags: ORIGINAL ARTICLE Source Type: research
TSS-ConvNet for electrical impedance tomography image reconstruction
The objective of this study was to propose a novel data-driven method for solving ill-posed inverse problems, particularly in certain conditions such as time-difference electrical impedance tomography for detecting the location and size of bubbles inside a pipe. Approach. We introduced a new layer architecture composed of three paths: spatial, spectral, and truncated spectral paths. The spatial path processes information locally, whereas the spectral and truncated spectral paths provide the network with a global receptive field. This unique architecture helps eliminate the ill-posedness and nonlinearity inherent in the inv...
Source: Physiological Measurement - April 17, 2024 Category: Physiology Authors: Ayman A Ameen, Achim Sack and Thorsten P öschel Source Type: research
Toxicokinetics of aluminium —novel insights in an old adjuvant
ConclusionThe Hethey model is an important step towards prediction of Al exposure in man from various sources. For use in risk assessment of Al exposure from SCIT products further extension of the model is warranted. (Source: Allergo Journal International)
Source: Allergo Journal International - April 17, 2024 Category: Allergy & Immunology Source Type: research
Focusing on mitochondria in the brain: from biology to therapeutics
AbstractMitochondria have multiple functions such as supplying energy, regulating the redox status, and producing proteins encoded by an independent genome. They are closely related to the physiology and pathology of many organs and tissues, among which the brain is particularly prominent. The brain demands 20% of the resting metabolic rate and holds highly active mitochondrial activities. Considerable research shows that mitochondria are closely related to brain function, while mitochondrial defects induce or exacerbate pathology in the brain. In this review, we provide comprehensive research advances of mitochondrial bio...
Source: Translational Neurodegeneration - April 17, 2024 Category: Neurology Source Type: research
