Muscarinic Receptors in Cardioprotection and Vascular Tone Regulation
Physiol Res. 2024 Apr 18. Online ahead of print.ABSTRACTMuscarinic acetylcholine receptors are metabotropic G-protein coupled receptors. Muscarinic receptors in the cardiovascular system play a central role in its regulation. Particularly M2 receptors slow down the heart rate by reducing the impulse conductivity through the atrioventricular node. In general, activation of muscarinic receptors has sedative effects on the cardiovascular system, including vasodilation, negative chronotropic and inotropic effects on the heart, and cardioprotective effects, including antifibrillatory effects. First, we review the signaling of i...
Source: Physiological Research - April 18, 2024 Category: Physiology Authors: E Dolej ší A Janou šková J Jakub ík Source Type: research
Sixty Years of Heart Research in the Institute of Physiology of the Czech Academy of Sciences
The objective of this review is to succinctly illuminate the scientific trajectory of an experimental cardiological department over a 60-year span, from its inaugural publication to the present. The old truth - historia magistra vitae - is still valid. Keywords: Heart, Adaptation, Development, Hypoxia, Protection.PMID:38634652 (Source: Physiological Research)
Source: Physiological Research - April 18, 2024 Category: Physiology Authors: B Ostadal F Kolar Source Type: research
Fever in rheumatological diseases
This article provides an overview of the physiology of the development of fever, describes the relevance of fever in individual rheumatological diseases and proposes a workflow for the clinical clarification of rheumatological patients who present with fever.PMID:38634905 | DOI:10.1007/s00393-024-01505-y (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - April 18, 2024 Category: Rheumatology Authors: Jasper F Nies Martin Krusche Source Type: research
Effect of the DASH diet on the sodium-chloride cotransporter and aquaporin-2 in urinary extracellular vesicles
Am J Physiol Renal Physiol. 2024 Apr 18. doi: 10.1152/ajprenal.00274.2023. Online ahead of print.ABSTRACTThe Dietary Approach to Stop Hypertension (DASH) diet, with its low sodium and high potassium content, acts like a diuretic by reducing sodium reabsorption in the kidney's distal convoluted tubule but without the side effects. Previous studies based on animal models didn't explore changes in human ion channel proteins. Recent insights into urinary extracellular vesicles (uEVs) suggest they reflect kidney tissue and physiological modifications. In our inpatient study, we shifted hypertensive volunteers from an American d...
Source: Am J Physiol Renal P... - April 18, 2024 Category: Urology & Nephrology Authors: Dana Bielopolski Luca Musante Ewout J Hoorn Henrik Molina Douglas Barrows Thomas Carroll Michael A Harding Samantha Upson Adam Qureshi Max M Weder Jonathan N Tobin Rhonda G Kost U Erdbr ügger Source Type: research
Chemical Synthesis of Secretoglobin 3A2 Covalent Homodimer and Photocaged Monomeric Variants
In this report, we document the chemical synthesis of SCGB3A2 in multi-milligram quantities. Key to access both monomeric and homo-dimeric SCGB3A2 analogues was the use of KAHA ligation and enabled masking of the cysteine residue. The synthetic proteins were used to investigate SCGB3A2 self-assembly profile, confirming their high propensity to dimerization even in the absence of the key Cys residue.PMID:38635000 | DOI:10.1002/anie.202404992 (Source: Angewandte Chemie)
Source: Angewandte Chemie - April 18, 2024 Category: Chemistry Authors: Thais Gazzi Maria Heinke Fabienne Landolt Jeffrey W Bode Source Type: research
Sixty Years of Heart Research in the Institute of Physiology of the Czech Academy of Sciences
The objective of this review is to succinctly illuminate the scientific trajectory of an experimental cardiological department over a 60-year span, from its inaugural publication to the present. The old truth - historia magistra vitae - is still valid. Keywords: Heart, Adaptation, Development, Hypoxia, Protection.PMID:38634652 (Source: Biomed Res)
Source: Biomed Res - April 18, 2024 Category: Research Authors: B Ostadal F Kolar Source Type: research
The noncanonical NF κB pathway: Regulatory mechanisms in health and disease
This article is categorized under:
Immune System Diseases> Molecular and Cellular Physiology
Cancer> Molecular and Cellular Physiology
Immune System Diseases> Stem Cells and Development (Source: Wiley Interdisciplinary Reviews: Systems Biology and Medicine)
Source: Wiley Interdisciplinary Reviews: Systems Biology and Medicine - April 18, 2024 Category: Biomedical Science Authors: Benancio N. Rodriguez,
Helen Huang,
Jennifer J. Chia,
Alexander Hoffmann Tags: Advanced Review Source Type: research
Sex differences in cachexia and branched ‐chain amino acid metabolism following chemotherapy in mice
Sex differences in chemotherapy-induced cachexia are linked to altered BCAA handling. AbstractChemotherapy is a major contributor to cachexia, but studies often investigate male animals. Here, we investigated whether sex modifies the effects of chemotherapy on cachexia and BCAA metabolism. Ten-week-old CD2F1 male and female mice were treated with the chemotherapy drug cocktail folfiri (50 mg/kg 5-fluorouracil, 90 mg/kg leucovorin, and 24 mg/kg CPT11) (drug) or vehicle twice a week for 6 weeks. Insulin tolerance tests were conducted and BCAA levels and metabolism were measured in plasma and tissues. Drug treatment ...
Source: Physiological Reports - April 18, 2024 Category: Physiology Authors: Stephen Mora,
Gagandeep Mann,
Olasunkanmi A. J. Adegoke Tags: ORIGINAL ARTICLE Source Type: research
Impact of dietary Moringa oleifera leaf supplementation on gut morphometry, behaviour and physiological parameters in growing male rabbits
AbstractMoringa oleifera (MO), a cultivated species of the Moringa, is known for its high concentration of essential nutrients that promote growth. To assess its impact on rabbits' gut morphometric, behavioural, and physiological parameters, a study was conducted using sixty growing male white New Zealand rabbits at 40 days old. The rabbits were divided into four groups and supplemented with dried MO leaves at varying levels (0%, 0.5%, 1% and 2% of body weight) for four weeks. The results revealed significant increases in organ weights, such as liver and intestinal length, and the height of intestinal villi and crypt depth...
Source: Journal of Animal Physiology and Animal Nutrition - April 18, 2024 Category: Zoology Authors: Seham S. Hadad,
Enas K. Aziz,
Adel Hassan Saad,
Hanem El ‐Gendy,
Nazema Abdel‐Megeid,
Shimaa R. Masoud,
Mustafa Shukry,
Ayman A. Swelum,
Muath Q. Al‐Ghadi,
Ahmad R. Alhimaidi,
Guillermo Tellez‐Isaias,
Mohamed E. Abd El‐Hack,
Mohamed Tags: ORIGINAL ARTICLE Source Type: research
Inconsequential role for chemerin ‐like receptor 1 in the manifestation of ozone‐induced lung pathophysiology in male mice
AbstractWe executed this study to determine if chemerin-like receptor 1 (CMKLR1), aGi/o protein-coupled receptor expressed by leukocytes and non-leukocytes, contributes to the development of phenotypic features of non-atopic asthma, including airway hyperresponsiveness (AHR) to acetyl- β-methylcholine chloride, lung hyperpermeability, airway epithelial cell desquamation, and lung inflammation. Accordingly, we quantified sequelae of non-atopic asthma in wild-type mice and mice incapable of expressing CMKLR1 (CMKLR1-deficient mice) following cessation of acute inhalation exposure t o either filtered room air (air) or ozone ...
Source: Physiological Reports - April 18, 2024 Category: Physiology Authors: Richard A. Johnston,
Albert W. Pilkington IV,
Constance L. Atkins,
Theresa E. Boots,
Philip L. Brown,
William T. Jackson,
Chantal Y. Spencer,
Saad R. Siddiqui,
Ikram U. Haque Tags: ORIGINAL ARTICLE Source Type: research
Canadian Nutrition Society 2024 Scientific Abstracts: Canadian Nutrition Society Annual Conference
Applied Physiology, Nutrition, and Metabolism,Volume 49, Issue 4 (Suppl. 1), Page S1-S79, April 2024. (Source: Applied Physiology, Nutrition, and Metabolism)
Source: Applied Physiology, Nutrition, and Metabolism - April 18, 2024 Category: Physiology Source Type: research
Neuroactive steroids in the neuroendocrine control of food intake, metabolism, and reproduction
AbstractNeuroactive steroids are a type of steroid hormones produced within the nervous system or in peripheral glands and then transported to the brain to exert their neuromodulatory effects. Neuroactive steroids have pleiotropic effects, that include promoting myelination, neuroplasticity, and brain development. They also regulate important physiological functions, such as metabolism, feeding, reproduction, and stress response. The homoeostatic processes of metabolism and reproduction are closely linked and mutually dependent. Reproductive events, such as pregnancy, bring about significant changes in metabolism, and meta...
Source: Endocrine - April 18, 2024 Category: Endocrinology Source Type: research
Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care —clinically relevant 3PM innovation
AbstractDespite their subordination in humans, to a great extent, mitochondria maintain their independent status but tightly cooperate with the “host” on protecting the joint life quality and minimizing health risks. Under oxidative stress conditions, healthy mitochondria promptly increase mitophagy level to remove damaged “fellows” rejuvenating the mitochondrial population and sending fragments of mtDNA as SOS signals to all system s in the human body. As long as metabolic pathways are under systemic control and well-concerted together, adaptive mechanisms become triggered increasing systemic protection, activatin...
Source: EPMA Journal - April 18, 2024 Category: International Medicine & Public Health Source Type: research
Effects of different exercise intensities or durations on salivary IgA secretion
ConclusionOur findings suggest that a reduction in s-IgA secretion is induced by exercise intensity of greater than or equal to 75%\({\dot{\text{V}}}\)O2max for 30 min or exercise duration of greater than or equal to 90 min at 55%\({\dot{\text{V}}}\)O2max in healthy untrained young men. (Source: European Journal of Applied Physiology)
Source: European Journal of Applied Physiology - April 18, 2024 Category: Physiology Source Type: research
Motor unit firing rates increase in prepubescent youth following linear periodization resistance exercise training
ConclusionsMU adaptations contribute to strength increases following RET in prepubescent youth. (Source: European Journal of Applied Physiology)
Source: European Journal of Applied Physiology - April 18, 2024 Category: Physiology Source Type: research
