Resistance training-induced changes in muscle proteolysis and extracellular matrix remodeling biomarkers in the untrained and trained states
ConclusionOur results are the first to show that RT does not attenuate the acute-induced response of proteolysis and ECM remodeling-related biomarkers. (Source: European Journal of Applied Physiology)
Source: European Journal of Applied Physiology - April 23, 2024 Category: Physiology Source Type: research
Platelet Physiology
Semin Thromb Hemost DOI: 10.1055/s-0044-1786387Platelets are the smallest blood cells, numbering 150 to 350 × 109/L in healthy individuals. The ability of activated platelets to adhere to an injured vessel wall and form aggregates was first described in the 19th century. Besides their long-established roles in thrombosis and hemostasis, platelets are increasingly recognized as pivotal players in numerous other pathophysiological processes including inflammation and atherogenesis, antimicrobial host defense, and tumor growth and metastasis. Consequently, profound knowledge of platelet structure and function is becoming...
Source: Seminars in Thrombosis and Hemostasis - April 23, 2024 Category: Hematology Authors: Gremmel, Thomas Frelinger, Andrew L. Michelson, Alan D. Tags: Historical Paper Source Type: research
Optogenetic manipulation of lysosomal physiology and autophagy-dependent clearance of amyloid beta
by Wenping Zeng, Canjun Li, Ruikun Wu, Xingguo Yang, Qingyan Wang, Bingqian Lin, Yanan Wei, Hao Li, Ge Shan, Lili Qu, Chunlei Cang
Lysosomes are degradation centers of cells and intracellular hubs of signal transduction, nutrient sensing, and autophagy regulation. Dysfunction of lysosomes contributes to a variety of diseases, such as lysosomal storage diseases (LSDs) and neurodegeneration, but the mechanisms are not well understood. Altering lysosomal activity and examining its impact on the occurrence and development of disease is an important strategy for studying lysosome-related diseases. However, methods to dynamical...
Source: PLoS Biology: Archived Table of Contents - April 23, 2024 Category: Biology Authors: Wenping Zeng Source Type: research
Considerations of sex as a binary variable in clinical algorithms
Nature Reviews Nephrology, Published online: 23 April 2024; doi:10.1038/s41581-024-00840-2Clinical algorithms that are used to guide medical decision-making often include sex as a variable. However, binary considerations of sex and/or gender might introduce bias due to potentially inaccurate assumptions about sex and gender-specific physiology, hormones and exposures. An equity-focused approach to sex and gender is essential when using clinical algorithms to ensure health equity across populations. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 23, 2024 Category: Urology & Nephrology Authors: Dinushika Mohottige Samira Farouk Tonia Poteat Asa Radix Selma Feldman Witchel Source Type: research
Intracoronary physiology: Easier to measure, but still complex. The art of interpreting intracoronary pressure wire data.
Since the introduction of fractional flow reserve (FFR) [1], coronary physiology has progressively gained prominence in coronary diagnosis and intervention. Its implementation has led to improved outcomes, safely avoiding unnecessary revascularisations without increasing or even decreasing the number of adverse events. Recently, FFR has facilitated a new approach to understanding ischemic heart disease, explaining its symptoms and consequences beyond coronary stenoses [2]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 23, 2024 Category: Cardiology Authors: Ram ón López-Palop, Pilar Carrillo, Alfonso Freites Source Type: research
Enhancing pig growth and gut health with fermented Jatropha curcas cake: Impacts on microbiota, metabolites, and neurotransmitters
AbstractGiven the escalating global crisis in feed protein availability,Jatropha curcas L. cake has attracted significant interest as a viable alternative protein source in animal feed. This experiment was conducted to investigate the effects of fermentedJatropha curcas L. cake (FJCC) as a protein feed in the diet of pigs. A total of 96 growing pigs with an average weight of 27.60 ± 1.59 kg were divided into three dietary groups with varying FJCC inclusion levels (0, 2.5, and 5%) for a 28 d trial. Results showed that the diet with 5% FJCC (FJCC5) demonstrated significant improvements in average daily gain (p = ...
Source: Journal of Animal Physiology and Animal Nutrition - April 22, 2024 Category: Zoology Authors: Zhenyu Zhang,
Hua Zhao,
Xiaoling Chen,
Gang Tian,
Guangmang Liu,
Jingyi Cai,
Gang Jia Tags: ORIGINAL ARTICLE Source Type: research
Gastric GDF15 levels are regulated by age, sex, and nutritional status in rodents and humans
ConclusionsOur results provide clear evidence that gastric GDF15 is a critical contributor of circulating GDF15 levels and can explain some of the metabolic effects induced by GDF15. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 22, 2024 Category: Endocrinology Source Type: research
Farnesol and Selected Nanoparticles (Silver, Gold, Copper, and Zinc Oxide) as Effective Agents Against Biofilms Formed by Pathogenic Microorganisms
CONCLUSION: The in vitro studies demonstrated antibiofilm properties of composites based on farnesol and nanoparticles. The greatest changes in biofilm structure were triggered by AgF, causing an alteration in the biofilm formation process as well as in the biofilm structure.PMID:38645468 | PMC:PMC11032122 | DOI:10.2147/NSA.S457124 (Source: Appl Human Sci)
Source: Appl Human Sci - April 22, 2024 Category: Physiology Authors: Agata Lange Arkadiusz Matuszewski Marta Kutwin Agnieszka Ostrowska S ławomir Jaworski Source Type: research
Interactive effects of exercise intensity and recovery posture on post-exercise hypotension
Am J Physiol Regul Integr Comp Physiol. 2024 Apr 22. doi: 10.1152/ajpregu.00036.2024. Online ahead of print.ABSTRACTPost-exercise reduction in blood pressure, termed post-exercise hypotension (PEH), is relevant for both acute and chronic health reasons and potentially for peripheral cardiovascular adaptations. We investigated the interactive effects of exercise intensity and recovery postures (seated, supine, and standing) on PEH. Thirteen normotensive men underwent a VO2max test on a cycle ergometer and 5 exhaustive constant load trials to determine critical power (CP) and the gas exchange threshold (GET). Subsequently, w...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - April 22, 2024 Category: Physiology Authors: Xueer Lu Richie Philip Goulding Toby Mundel Zachary J Schlader James D Cotter Shunsaku Koga Naoto Fujii I-Lin Wang Ziyang Liu Hao-Yu Li Hui Wang Huixin Zheng Narihiko Kondo Chin-Yi Gu Tze-Huan Lei Faming Wang Source Type: research
Mitochondrial Physiology of Cellular Redox Regulations
Physiol Res. 2024 Apr 22. Online ahead of print.ABSTRACTMitochondria (mt) represent the vital hub of the molecular physiology of the cell, being decision-makers in cell life/death and information signaling, including major redox regulations and redox signaling. Now we review recent advances in understanding mitochondrial redox homeostasis, including superoxide sources and H2O2 consumers, i.e., antioxidant mechanisms, as well as exemplar situations of physiological redox signaling, including the intramitochondrial one and mt-to-cytosol redox signals, which may be classified as acute and long-term signals. This review exempl...
Source: Biomed Res - April 22, 2024 Category: Research Authors: P Je žek A Dlaskov á H Engstov á J Špačková J Tauber P Pr ůchová E Kloppel O Mozheitova M Jab ůrek Source Type: research
Mitochondrial Physiology of Cellular Redox Regulations
Physiol Res. 2024 Apr 22. Online ahead of print.ABSTRACTMitochondria (mt) represent the vital hub of the molecular physiology of the cell, being decision-makers in cell life/death and information signaling, including major redox regulations and redox signaling. Now we review recent advances in understanding mitochondrial redox homeostasis, including superoxide sources and H2O2 consumers, i.e., antioxidant mechanisms, as well as exemplar situations of physiological redox signaling, including the intramitochondrial one and mt-to-cytosol redox signals, which may be classified as acute and long-term signals. This review exempl...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: P Je žek A Dlaskov á H Engstov á J Špačková J Tauber P Pr ůchová E Kloppel O Mozheitova M Jab ůrek Source Type: research
Redox Status as a Key Driver of Healthy Pancreatic Beta-Cells
Physiol Res. 2024 Apr 22. Online ahead of print.ABSTRACTRedox status plays a multifaceted role in the intricate physiology and pathology of pancreatic beta-cells, the pivotal regulators of glucose homeostasis through insulin secretion. They are highly responsive to changes in metabolic cues where reactive oxygen species are part of it, all arising from nutritional intake. These molecules not only serve as crucial signaling intermediates for insulin secretion but also participate in the nuanced heterogeneity observed within the beta-cell population. A central aspect of beta-cell redox biology revolves around the localized p...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: B Holendov á Š Benáková M K řivonosková L Plecit á-Hlavatá Source Type: research
Involvement of kinesins in skeletal dysplasia - a review
Am J Physiol Cell Physiol. 2024 Apr 22. doi: 10.1152/ajpcell.00613.2023. Online ahead of print.ABSTRACTSkeletal dysplasias are group of rare genetic diseases resulting from mutations in genes encoding structural proteins of the cartilage extracellular matrix (ECM), signaling molecules, transcription factors, epigenetic modifiers, and several intracellular proteins. Cell division, organelle maintenance, and intracellular transport are all orchestrated by the cytoskeleton associated proteins, and intracellular processes effected through microtubule-associated movement are important for the function of skeletal cells. Amongst...
Source: American Journal of Physiology. Cell Physiology - April 22, 2024 Category: Cytology Authors: Roufaida Bouchenafa Francesca Manuela de Sousa Brito Katarzyna Anna Pirog Source Type: research
Ubiquitin-driven G Protein-Coupled Receptor Inflammatory Signaling at the Endosome
Am J Physiol Cell Physiol. 2024 Apr 22. doi: 10.1152/ajpcell.00161.2024. Online ahead of print.ABSTRACTG protein-coupled receptors (GPCRs) are ubiquitously expressed cell surface receptors that mediate numerous physiological responses and are highly druggable. Upon activation GPCRs rapidly couple to heterotrimeric G proteins and are then phosphorylated and internalized from the cell surface. Recent studies indicate that GPCRs not only localize at the plasma membrane but also exist in intracellular compartments where they are competent to signal. Intracellular signaling by GPCRs is best described to occur at endosomes. Seve...
Source: American Journal of Physiology. Cell Physiology - April 22, 2024 Category: Cytology Authors: Norton Cheng Julio M Pimentel JoAnn Trejo Source Type: research
SEMA3B inhibits TGF β-induced extracellular matrix protein production and its reduced levels are associated with a decline in lung function in IPF
Am J Physiol Cell Physiol. 2024 Apr 22. doi: 10.1152/ajpcell.00681.2023. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is marked by the activation of fibroblasts, leading to excessive production and deposition of extracellular matrix (ECM) within the lung parenchyma. Despite the pivotal role of ECM overexpression in IPF, potential negative regulators of ECM production in fibroblasts have yet to be identified. Semaphorin class 3B (SEMA3B), a secreted protein highly expressed in lung tissues, has established roles in axonal guidance and tumor suppression. However, the role of SEMA3B in ECM production by f...
Source: American Journal of Physiology. Cell Physiology - April 22, 2024 Category: Cytology Authors: Dan Jk Yombo Sudhir Ghandikota Chanukya P Vemulapalli Priyanka Singh Anil G Jegga William D Hardie Sathish K Madala Source Type: research
