Eight weeks of treatment with mineralocorticoid receptor blockade does not alter vascular function in individuals with and without type 2 diabetes
In conclusion, we found no effect of MR blockade endothelial function in individuals with and without type 2 diabetes. As the individuals with type 2 diabetes did not have vascular dysfunction, these results might not apply to individuals with vascular dysfunction. (Source: Physiological Reports)
Source: Physiological Reports - April 13, 2024 Category: Physiology Authors: Stine H. Finsen,
Mie R. Hansen,
Pernille B. L. Hansen,
Stefan P. Mortensen Tags: ORIGINAL ARTICLE Source Type: research
GSE246304 A brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli
This study provides compelling evidence that circRNAs can regulate biologically relevant functions in neurons, with modulatory effects at multiple levels of the phenotype, establishing a proof-of-principle for the regulatory role of circRNAs in neural processes. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 13, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Non ‐canonical IKB kinases regulate YAP/TAZ and pathological vascular remodeling behaviors in pulmonary artery smooth muscle cells
AbstractPulmonary arterial hypertension (PAH) causes pulmonary vascular remodeling, increasing pulmonary vascular resistance (PVR) and leading to right heart failure and death. Matrix stiffening early in the disease promotes remodeling in pulmonary artery smooth muscle cells (PASMCs), contributing to PAH pathogenesis. Our research identified YAP and TAZ as key drivers of the mechanobiological feedback loop in PASMCs, suggesting targeting them could mitigate remodeling. However, YAP/TAZ are ubiquitously expressed and carry out diverse functions, necessitating a cell-specific approach. Our previous work demonstrated that tar...
Source: Physiological Reports - April 13, 2024 Category: Physiology Authors: Aja Aravamudhan,
Paul B. Dieffenbach,
Kyoung Moo Choi,
Patrick A. Link,
Jeffrey A. Meridew,
Andrew J. Haak,
Laura E. Fredenburgh,
Daniel J. Tschumperlin Tags: ORIGINAL ARTICLE Source Type: research
Surgical outcomes of the systemic-to-pulmonary artery shunt: risk factors of post-operative acute events and effectiveness of regulation of pulmonary blood flow with metal clips
ConclusionSurgical outcomes after SPS were acceptable and metal clip regulation of pulmonary blood flow appears to be safe and effective. PA/IVS was still a significant risk factor for acute events. (Source: General Thoracic and Cardiovascular Surgery)
Source: General Thoracic and Cardiovascular Surgery - April 13, 2024 Category: Cardiovascular & Thoracic Surgery Source Type: research
Exploration of postural effects on the external jugular and diploic venous system using upright computed tomography scanning
ConclusionCompared to the supine position, the contribution of external jugular tributaries to head venous drainage decreased in the sitting position, whilst most diploic veins maintained their contribution. These results could enhance our understanding of the physiology and pathophysiology of the head region in upright and sitting positions. (Source: Neuroradiology)
Source: Neuroradiology - April 13, 2024 Category: Radiology Source Type: research
Effect of repeated post-resistance exercise cold or hot water immersion on in-season inflammatory responses in academy rugby players: a randomised controlled cross-over design
ConclusionPost-resistance exercise CWI or HWI resulted in trivial and moderate reductions in CK, respectively, which may be partly due to hydrostatic effects of water immersion. Post-resistance exercise HWI moderately decreased IL-1ra, which may be associated with post-resistance exercise skeletal muscle inflammation influencing chronic resistance exercise adaptive responses. Following post-resistance exercise water immersion, CWI increased HSP-72 suggesting a thermoregulatory response indicating improved adaptive inflammatory responses to temperature changes, while HWI increased growth factors (PDGF-BB, IGF-1) indicating ...
Source: European Journal of Applied Physiology - April 13, 2024 Category: Physiology Source Type: research
Active intervals between sets and exercise of resistance exercises potentiate the magnitude of post-exercise hypotension in middle-aged hypertensive women
ConclusionsPassive or active intervals in resistance exercise promote PEH in hypertensive women. Active intervals shorten the PEH onset time as additional benefit. (Source: European Journal of Applied Physiology)
Source: European Journal of Applied Physiology - April 13, 2024 Category: Physiology Source Type: research
The Physiologically Difficult Airway and Management Considerations
AbstractPurpose of ReviewThis paper evaluates the recent literature regarding the physiologically difficult airway.Recent FindingsAdverse events mainly desaturation, cardiovascular collapse, and cardiac arrest remain common complications. This risk is greatly increased in patients with altered physiology prior to intubation. Studies published over the last 5 years have explored many aspects surrounding the epidemiology, risks, and approach to managing the physiologically difficult airway.SummaryImportant work has been done to identify directly modifiable risks of complications related to the physiologically difficult air...
Source: Current Anesthesiology Reports - April 13, 2024 Category: Anesthesiology Source Type: research
Intermittent fasting promotes rejuvenation of immunosenescent phenotypes in aged adipose tissue
AbstractThe aging of white adipose tissue (WAT) involves senescence of adipose stem and progenitor cells (ASPCs) and dysregulation of immune cell populations, serving as a major driver of age-associated adipose dysfunction and metabolic diseases. Conversely, the elimination of senescent ASPCs is associated with improvements in overall health. Intermittent fasting (IF), a dietary intervention that incorporates periodic cycles of fasting and refeeding, has been reported to promote weight loss and fat mass reduction and improve glucose and insulin homeostasis in both murine and human studies. While previous studies have asses...
Source: European Journal of Applied Physiology - April 12, 2024 Category: Physiology Source Type: research
Sleep and Overactive Bladder in Parkinson's Disease
Urol Clin North Am. 2024 May;51(2):197-207. doi: 10.1016/j.ucl.2024.02.005. Epub 2024 Mar 10.ABSTRACTPatients with Parkinson's disease (PD) have disturbances in their bladder and sleep physiology that lead to nocturia and overactive bladder (OAB). These symptoms can be extremely bothersome and impact not only their quality of life (QoL) but also the QoL of their caretakers. We aim to highlight the changes in bladder and sleep physiology in PD and explore OAB/nocturia treatment strategies in this population.PMID:38609192 | DOI:10.1016/j.ucl.2024.02.005 (Source: The Urologic Clinics of North America)
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Yu Zheng Anne P Cameron Source Type: research
Tailoring Transfection for Cardiomyocyte Cell Lines: Balancing Efficiency and Toxicity in Lipid versus Polymer-Based Transfection Methods in H9c2 and HL-1 Cells
In this study, we introduce meticulously crafted protocols to enhance the culture and transfection of HL-1 and H9c2 cells, emphasizing the reduction of cytotoxic effects while improving transfection efficiency. Through the examination of polymer-based and lipid-based transfection methods, we offer a comparative analysis that underscores the heightened efficiency and reduced toxicity of these approaches. Our research provides an extensive array of step-by-step procedures designed to foster robust cell cultures and outlines troubleshooting practices to rectify issues of low transfection rates. We discuss the merits and drawb...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 12, 2024 Category: Physiology Authors: Flobater I Gawargi Hamid R Shahshahan Paras K Mishra Source Type: research
The Association of Self-Reported Sleep and Circadian Measures with Glycemic Control and Diabetes Complications among Young Adults with Type 2 Diabetes
In conclusion, late bedtime on work/school days, rather than short sleep duration, daytime sleepiness, or poor sleep quality, was independently associated with loss of glycemic control in this longitudinal cohort of young adults with youth-onset type 2 diabetes.PMID:38607342 | DOI:10.1152/ajpheart.00550.2023 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 12, 2024 Category: Physiology Authors: Dorit Koren Kristen L Knutson Brian K Burke Kimberly L Drews Fida Bacha Lorraine Katz Marsha D Marcus Siripoom McKay Kristen Nadeau Babak Mokhlesi Source Type: research
Loss of ADAM15 in female mice does not worsen pressure overload cardiomyopathy, independent of ovarian hormones
Am J Physiol Heart Circ Physiol. 2024 Apr 12. doi: 10.1152/ajpheart.00116.2024. Online ahead of print.ABSTRACTCardiac hypertrophy is a common feature in several cardiomyopathies. We previously reported that loss of ADAM15 (disintegrin and metalloproteinase 15) worsened cardiac hypertrophy and dilated cardiomyopathy following cardiac pressure overload. Here, we investigated the impact of ADAM15 loss in female mice following cardiac pressure overload induced by transverse aortic constriction (TAC). Female Adam15-/-mice developed the same degree of cardiac hypertrophy, dilation and dysfunction as the parallel female wildtype ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 12, 2024 Category: Physiology Authors: Vidhya Krishnan Nikki Atanasova Preetinder K Aujla Devon Hupka Caroline A Owen Zamaneh Kassiri Source Type: research
Sleep and Overactive Bladder in Parkinson's Disease
Urol Clin North Am. 2024 May;51(2):197-207. doi: 10.1016/j.ucl.2024.02.005. Epub 2024 Mar 10.ABSTRACTPatients with Parkinson's disease (PD) have disturbances in their bladder and sleep physiology that lead to nocturia and overactive bladder (OAB). These symptoms can be extremely bothersome and impact not only their quality of life (QoL) but also the QoL of their caretakers. We aim to highlight the changes in bladder and sleep physiology in PD and explore OAB/nocturia treatment strategies in this population.PMID:38609192 | DOI:10.1016/j.ucl.2024.02.005 (Source: The Medical Clinics of North America)
Source: The Medical Clinics of North America - April 12, 2024 Category: General Medicine Authors: Yu Zheng Anne P Cameron Source Type: research
Clinical course of mild-to-moderate idiopathic pulmonary fibrosis during therapy with pirfenidone: Results of the non-interventional study AERplus
CONCLUSIONS: The results of this study are in line with the established benefit-risk profile of pirfenidone. Therefore, pirfenidone can be considered a valuable treatment option to slow disease progression in mild-to-moderate idiopathic pulmonary fibrosis. NCT02622477.PMID:38608658 | PMC:PMC11014748 | DOI:10.1055/a-2267-2074 (Source: Pneumologie)
Source: Pneumologie - April 12, 2024 Category: Respiratory Medicine Authors: Jens Schreiber Wolfgang Sch ütte Wolfgang Koerber Bernd Seese Dirk Koschel Kathrin Neuland Christian Groh é Source Type: research
