Temporal tracking of cysteine 34 oxidation of plasma albumin as a biomarker of muscle damage following a bout of eccentric exercise
ConclusionThe levels of thiol-oxidised albumin increase in response to EIMD and remain elevated for several days post-exercise. The temporal pattern of change in the level of thiol-oxidised albumin suggests that this may be a useful biomarker of muscle repair post-EIMD. (Source: European Journal of Applied Physiology)
Source: European Journal of Applied Physiology - April 16, 2024 Category: Physiology Source Type: research
Network-neuron interactions underlying sensory responses of layer 5 pyramidal tract neurons in barrel cortex
by Arco Bast, Rieke Fruengel, Christiaan P. J. de Kock, Marcel Oberlaender
Neurons in the cerebral cortex receive thousands of synaptic inputs per second from thousands of presynaptic neurons. How the dendritic location of inputs, their timing, strength, and presynaptic origin, in conjunction with complex dendritic physiology, impact the transformation of synaptic input into action potential (AP) output remains generally unknown forin vivo conditions. Here, we introduce a computational approach to reveal which properties of the input causally underlie AP output, and how this neuronal input-output computation is influenced...
Source: PLoS Computational Biology - April 16, 2024 Category: Biology Authors: Arco Bast Source Type: research
Gulf toadfish (Opsanus beta) gill neuroepithelial cells in response to hypoxia exposure
AbstractNeuroepithelial cells (NECs) within the fish gill contain the monoamine neurochemical serotonin (5-HT), sense changes in the partial pressure of oxygen (PO2) in the surrounding water and blood, and initiate the cardiovascular and ventilatory responses to hypoxia. The distribution of neuroepithelial cells (NECs) within the gill is known for some fish species but not for the Gulf toadfish,Opsanus beta, a fish that has always been considered hypoxia tolerant. Furthermore, whether NEC size, number, or distribution changes after chronic exposure to hypoxia, has never been tested. We hypothesize that toadfish NECs will r...
Source: Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology - April 16, 2024 Category: Physiology Source Type: research
Knowledge, Attitude and Practice of Use of Sanitary Napkin Among Menstruating Females in Rural West Bengal, India
ConclusionRight knowledge will help develop hygienic menstrual practice and overcome misconceptions and taboos. Proper policies need to be framed and implemented to cover this public health need for overall health and community development. (Source: The Journal of Obstetrics and Gynecology of India)
Source: The Journal of Obstetrics and Gynecology of India - April 16, 2024 Category: OBGYN Source Type: research
Metformin ameliorates endometrial thickness in a rat model of thin endometrium
In conclusion, the study demonstrated that metformin ameliorates endometrial thickness in a rat model of thin endometrium by increasing endometrial proliferation and angiogenesis, without restoration of embryo implantation.PMID:38621769 | DOI:10.1111/1440-1681.13862 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 15, 2024 Category: Drugs & Pharmacology Authors: M Imran Aditya Khandvilkar Siddhanath Metkari Geetanjali Sachdeva Uddhav Chaudhari Source Type: research
Colorectal cancer cells with stably expressed SIRT3 demonstrate proliferating retardation by Wnt/ β-catenin cascade inactivation
In conclusion, our findings suggest that the inhibition of CRC cell proliferation by SIRT3 is closely associated with the inactivation of the Wnt/β-catenin signalling pathway.PMID:38621772 | DOI:10.1111/1440-1681.13856 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 15, 2024 Category: Drugs & Pharmacology Authors: Tianyu Li Leqi Fan Yijiang Jia Chen Xu Wei Guo Yuji Wang Ye Li Source Type: research
Decoding the Neurotoxic Effects of Propofol: Insights into the RAR α-Snhg1-Bdnf Regulatory Cascade
Am J Physiol Cell Physiol. 2024 Apr 15. doi: 10.1152/ajpcell.00547.2023. Online ahead of print.ABSTRACTThe potential neurotoxic effects of propofol, an extensively utilized anesthetic, underline the urgency to comprehend its influence on neuronal health. Insights into the role of the RARα-Snhg1-Bdnf network can offer significant advancements in minimizing these effects. The study targets the exploration of the RARα and Snhg1 regulatory network's influence on Bdnf expression in the realm of propofol-induced neurotoxicity. Harnessing the GEO database and utilizing JASPAR and RPISeq for projections, the study embarks on an ...
Source: American Journal of Physiology. Cell Physiology - April 15, 2024 Category: Cytology Authors: Yuhai Xu Xin Xin Tianzhu Tao Source Type: research
Macrophages in necrotic liver lesion repair: opportunities for therapeutical applications
Am J Physiol Cell Physiol. 2024 Apr 15. doi: 10.1152/ajpcell.00053.2024. Online ahead of print.ABSTRACTHealthy livers contain 80% of body resident macrophages known as Kupffer cells. In diseased livers, the number of Kupffer cells usually drops, but is compensated by infiltration of monocyte-derived macrophages, which can differentiate into Kupffer-like cells. Early studies suggest that Kupffer cells play important roles in both promoting liver injury as well as liver regeneration. Yet, the distinction of the functionalities from resident and infiltrating macrophages is not always made. By using more specific macrophage ma...
Source: American Journal of Physiology. Cell Physiology - April 15, 2024 Category: Cytology Authors: Yang Wang Robim M Rodrigues Cheng Chen Dechun Feng Luca Maccioni Bin Gao Source Type: research
Extracellular vesicles and their therapeutic applications: a review article (part1)
Int J Physiol Pathophysiol Pharmacol. 2024 Feb 25;16(1):1-9. eCollection 2024.ABSTRACTExtracellular vesicles (EVs) have emerged as a captivating field of study in molecular biology with diverse applications in therapeutics. These small membrane-bound structures, released by cells into the extracellular space, play a vital role in intercellular communication and hold immense potential for advancing medical treatments. EVs, including exosomes, microvesicles, and apoptotic bodies, are classified based on size and biogenesis pathways, with exosomes being the most extensively studied. The aim of this study was to examine the mo...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - April 15, 2024 Category: Physiology Authors: Diana Rafieezadeh Aryan Rafieezadeh Source Type: research
Macrophages in necrotic liver lesion repair: opportunities for therapeutical applications
Am J Physiol Cell Physiol. 2024 Apr 15. doi: 10.1152/ajpcell.00053.2024. Online ahead of print.ABSTRACTHealthy livers contain 80% of body resident macrophages known as Kupffer cells. In diseased livers, the number of Kupffer cells usually drops, but is compensated by infiltration of monocyte-derived macrophages, which can differentiate into Kupffer-like cells. Early studies suggest that Kupffer cells play important roles in both promoting liver injury as well as liver regeneration. Yet, the distinction of the functionalities from resident and infiltrating macrophages is not always made. By using more specific macrophage ma...
Source: American Journal of Physiology. Cell Physiology - April 15, 2024 Category: Cytology Authors: Yang Wang Robim M Rodrigues Cheng Chen Dechun Feng Luca Maccioni Bin Gao Source Type: research
Decoding the Neurotoxic Effects of Propofol: Insights into the RAR α-Snhg1-Bdnf Regulatory Cascade
Am J Physiol Cell Physiol. 2024 Apr 15. doi: 10.1152/ajpcell.00547.2023. Online ahead of print.ABSTRACTThe potential neurotoxic effects of propofol, an extensively utilized anesthetic, underline the urgency to comprehend its influence on neuronal health. Insights into the role of the RARα-Snhg1-Bdnf network can offer significant advancements in minimizing these effects. The study targets the exploration of the RARα and Snhg1 regulatory network's influence on Bdnf expression in the realm of propofol-induced neurotoxicity. Harnessing the GEO database and utilizing JASPAR and RPISeq for projections, the study embarks on an ...
Source: American Journal of Physiology. Cell Physiology - April 15, 2024 Category: Cytology Authors: Yuhai Xu Xin Xin Tianzhu Tao Source Type: research
First Author Highlights
Am J Physiol Renal Physiol. 2024 Apr 1;326(4):i. doi: 10.1152/ajprenal.2024.326.4.AU.NO ABSTRACTPMID:38619298 | DOI:10.1152/ajprenal.2024.326.4.AU (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - April 15, 2024 Category: Physiology Source Type: research
Establishment and characterization of a kidney cell line from hybrid snakehead (male Channa argus × female Channa maculata) and its susceptibility to hybrid snakehead rhabdovirus (HSHRV)
In this study, a fish cell line called CAMK, derived from the kidneys of hybrid snakehead, was established and characterized. CAMK cells exhibited the maximum growth rate at 28 °C in Leibovitz's-15 medium supplemented with 10% fetal bovine serum(FBS). Karyotyping revealed diploid chromosomes in 54% of the cells at the 50th passage (2n = 66), and 16S rRNA sequencing validated that CAMK cells originated fromhybrid snakehead, and the detection of kidney-specific antibodies suggested that it originated from kidney. .The culture was free from mycoplasma contamination, and the green fluorescent protein gene was effectively tran...
Source: Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology. - April 15, 2024 Category: Biochemistry Authors: Huiling Deng Shucheng Zheng Yingying Li Xubing Mo Jian Zhao Jiyuan Yin Cunbin Shi Qing Wang Yingying Wang Source Type: research
Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types
We report the synthesis of a novel, Zn2+-chelating derivative of the pan-BETi (+)-JQ1, (+)-JQ1-DPA, in which (+)-JQ1 was conjugated to dipicolyl amine (DPA). As controls, we synthesized (+)-JQ1-DBA, a non-Zn2+-chelating derivative, and (-)-JQ1-DPA, an inactive enantiomer that chelates Zn2+. Molecular modeling and biophysical assays showed that (+)-JQ1-DPA and (+)-JQ1-DBA retain potent binding to BET bromodomains in vitro. Cellular assays demonstrated (+)-JQ1-DPA attenuated NF-ĸB target gene expression in β-cells stimulated with the pro-inflammatory cytokine interleukin 1β. To assess β-cell selectivity, we isolated isle...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - April 15, 2024 Category: Physiology Authors: Rachel A Jones Lipinski Jennifer S Stancill Raymundo Nu ñez Sarah L Wynia-Smith Daniel J Sprague Joshua A Nord Amir Bird John A Corbett Brian C Smith Source Type: research
Colorectal cancer cells with stably expressed SIRT3 demonstrate proliferating retardation by Wnt/ β-catenin cascade inactivation
In conclusion, our findings suggest that the inhibition of CRC cell proliferation by SIRT3 is closely associated with the inactivation of the Wnt/β-catenin signalling pathway.PMID:38621772 | DOI:10.1111/1440-1681.13856 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 15, 2024 Category: Drugs & Pharmacology Authors: Tianyu Li Leqi Fan Yijiang Jia Chen Xu Wei Guo Yuji Wang Ye Li Source Type: research
