LPA < sub > 5 < /sub > -Dependent Signaling Regulates Regeneration of the Intestinal Epithelium Following Irradiation
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 9. doi: 10.1152/ajpgi.00269.2023. Online ahead of print.ABSTRACTLysophosphatidic acid (LPA) is a bioactive lipid molecule that regulates a wide array of cellular functions, including proliferation, differentiation, and survival, via activation of cognate receptors. The LPA5 receptor is highly expressed in the intestinal epithelium, but its function in restoring intestinal epithelial integrity following injury has not been examined. Here, we use a radiation-induced injury model to study the role of LPA5 in regulating intestinal epithelial regeneration. Control mice (Lpar5f/f...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - April 9, 2024 Category: Physiology Authors: Beth B McConnell Zhongxing Liang Chad Xu Yiran Han C Chris Yun Source Type: research
Tribute to Andrea Huwiler (1966-2023)
Pflugers Arch. 2024 Apr 9. doi: 10.1007/s00424-024-02958-5. Online ahead of print.NO ABSTRACTPMID:38592461 | DOI:10.1007/s00424-024-02958-5 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - April 9, 2024 Category: Physiology Authors: Josef Pfeilschifter Erich Gulbins Source Type: research
StarD5 levels of expression correlate with onset and progression of steatosis and liver fibrosis
CONCLUSIONS: StarD5's downregulation with hepatic lipid excess is a previously unappreciated physiologic function appearing to promote lipid storage for future needs. Conversely, StarD5's lingering downregulation with prolonged lipid/cholesterol excess accelerates fatty liver's transition to fibrosis; mediated via dysregulation in the oxysterol signaling pathway.PMID:38591148 | DOI:10.1152/ajpgi.00024.2024 (Source: American Journal of Physiology. Gastrointestinal and Liver Physiology)
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - April 9, 2024 Category: Physiology Authors: Genta Kakiyama Kei Minowa Nanah Bai-Kamara Taishi Hashiguchi William M Pandak Daniel Rodriguez-Agudo Source Type: research
Oral tryptophan activates duodenal aryl hydrocarbon receptor in healthy subjects: a crossover randomized controlled trial
Conclusions: At the doses used in this study, oral tryptophan supplementation in humans induces microbial indole and host kynurenine metabolic pathways in the small intestine, known to be immunomodulatory. The results should prompt tryptophan intervention strategies in inflammatory conditions of the small intestine where the AhR pathway is impaired.PMID:38591144 | DOI:10.1152/ajpgi.00306.2023 (Source: American Journal of Physiology. Gastrointestinal and Liver Physiology)
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - April 9, 2024 Category: Physiology Authors: Gaston H Rueda Natalia Causada-Calo Rajka Borojevic Andrea Nardelli Maria Ines Pinto-Sanchez Marco Constante Josie Libertucci Vidhyalakshmi Mohan Philippe Langella Linda M P Loonen Jerry M Wells Harry Sokol Elena F Verdu Premysl Bercik Source Type: research
Milk and < em > Lacticaseibacillus casei < /em > BL23 effects on intestinal responses in a murine model of colitis
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 9. doi: 10.1152/ajpgi.00259.2023. Online ahead of print.ABSTRACTProbiotic-containing fermented dairy foods have the potential to benefit human health, but the importance of the dairy matrix for efficacy remains unclear. We investigated the capacity of Lacticaseibacillus casei BL23 in phosphate-buffered saline (BL23-PBS), BL23-fermented milk (BL23-milk), and milk to modify intestinal and behavioral responses in a Dextran Sodium Sulfate (DSS, 3% w/v) mouse model of colitis. Significant sex-dependent differences were found such that female mice exhibited more severe colitis, g...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - April 9, 2024 Category: Physiology Authors: Glory Bui Cristina Torres-Fuentes Matteo M Pusceddu Melanie G Gareau Maria L Marco Source Type: research
High-Energy Pacing Inhibits Slow Wave Dysrhythmias in the Small Intestine
This study assessed the use of pacing to suppress glucagon-induced slow wave dysrhythmias in the small intestine. Slow waves in the jejunum were mapped in vivo using a high-resolution surface-contact electrode array in pigs (n=7). Glucagon was intravenously administered to induce hyperglycemia. Slow wave propagation patterns were categorized into antegrade, retrograde, collision, pacemaker and uncoupled activity. Slow wave characteristics such as period, amplitude and speed were also quantified. Post-glucagon infusion, pacing was applied at 4 mA and 8 mA and the resulting slow waves were quantified spatiotemporally. Antegr...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - April 9, 2024 Category: Physiology Authors: Nipuni D Nagahawatte Recep Avci Niranchan Paskaranandavadivel Leo K Cheng Source Type: research
N-glycosylation of SCAP exacerbates hepatocellular inflammation and lipid accumulation via ACSS2-mediated histone H3K27 acetylation
In conclusion, SCAP N-glycosylation aggravates inflammation and lipid accumulation through enhancing ACSS2-mediated H3K27ac in hepatocytes.PMID:38591127 | DOI:10.1152/ajpgi.00273.2023 (Source: American Journal of Physiology. Gastrointestinal and Liver Physiology)
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - April 9, 2024 Category: Physiology Authors: Xuemei Li Xiaoqin Tang Yue Xiang Zhibo Zhao Yanping Li Qiuying Ding Linkun Zhang Jingyuan Xu Lei Zhao Yao Chen Source Type: research
LPA < sub > 5 < /sub > -Dependent Signaling Regulates Regeneration of the Intestinal Epithelium Following Irradiation
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 9. doi: 10.1152/ajpgi.00269.2023. Online ahead of print.ABSTRACTLysophosphatidic acid (LPA) is a bioactive lipid molecule that regulates a wide array of cellular functions, including proliferation, differentiation, and survival, via activation of cognate receptors. The LPA5 receptor is highly expressed in the intestinal epithelium, but its function in restoring intestinal epithelial integrity following injury has not been examined. Here, we use a radiation-induced injury model to study the role of LPA5 in regulating intestinal epithelial regeneration. Control mice (Lpar5f/f...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - April 9, 2024 Category: Physiology Authors: Beth B McConnell Zhongxing Liang Chad Xu Yiran Han C Chris Yun Source Type: research
Tribute to Andrea Huwiler (1966-2023)
Pflugers Arch. 2024 Apr 9. doi: 10.1007/s00424-024-02958-5. Online ahead of print.NO ABSTRACTPMID:38592461 | DOI:10.1007/s00424-024-02958-5 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - April 9, 2024 Category: Physiology Authors: Josef Pfeilschifter Erich Gulbins Source Type: research
The Relationship of Open- and Closed-Kinetic-Chain Rate of Force Development With Jump Performance Following Anterior Cruciate Ligament Reconstruction
CONCLUSIONS: While both OKC and CKC RFD were strongly related to jump performance and knee-joint power, OKC RFD was able to detect between-limbs RFD asymmetries and was strongly related to knee-joint kinematics. These findings indicate that isometric knee extension may be optimal for assessing RFD after ACL reconstruction.PMID:38594016 | DOI:10.1123/ijspp.2023-0361 (Source: International Journal of Sports Physiology and Performance)
Source: International Journal of Sports Physiology and Performance - April 9, 2024 Category: Sports Medicine Authors: Megan C Graham Kelsey A Reeves Tereza Janatova Brian Noehren Source Type: research
Chronic intermittent hypoxia elicits distinct transcriptomic responses among neurons and oligodendrocytes within the brainstem of mice
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 9. doi: 10.1152/ajplung.00320.2023. Online ahead of print.ABSTRACTChronic intermittent hypoxia (CIH) is a prevalent condition characterized by recurrent episodes of oxygen deprivation, linked to respiratory and neurological disorders. Prolonged CIH is known to have adverse effects, including endothelial dysfunction, chronic inflammation, oxidative stress, and impaired neuronal function. These factors can contribute to serious comorbidities, including metabolic disorders and cardiovascular diseases. To investigate the molecular impact of CIH, we examined male C57BL/6J mice expose...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 9, 2024 Category: Cytology Authors: Hemalatha Bhagavan Aguan D Wei Luiz M Oliveira Kimberly A Aldinger Jan-Marino Ramirez Source Type: research
Natural antibodies targeting LPS in pleural effusions of various etiologies
CONCLUSIONS: Our results highlight a potential role of anti-LPS NAbs in the pleural cavity that should be further explored.PMID:38591123 | DOI:10.1152/ajplung.00377.2023 (Source: American Journal of Physiology. Lung Cellular and Molecular Physiology)
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 9, 2024 Category: Cytology Authors: Ioannis Sarrigeorgiou Erasmia Rouka Ourania S Kotsiou Garyfallia Perlepe Efrosini S Gerovasileiou Konstantinos I Gourgoulianis Peggy Lymberi Sotirios G Zarogiannis Source Type: research
Evaluation of different media compositions promoting hepatocyte differentiation in the canine liver organoid model
Heliyon. 2024 Mar 25;10(7):e28420. doi: 10.1016/j.heliyon.2024.e28420. eCollection 2024 Apr 15.ABSTRACTOrganoids are 3-dimensional (3D) self-assembled structures capable of replicating the microanatomy and physiology of the epithelial components of their organ of origin. Adult stem cell (ASC) derived organoids from the liver have previously been shown to differentiate into primarily mature cholangiocytes, and their partial differentiation into functional hepatocytes can be promoted using specific media compositions. While full morphological differentiation of mature hepatocytes from ASCs has not yet been reported for any s...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Vojtech Gabriel Addison Lincoln Christopher Zdyrski Abigail Ralston Hannah Wickham Sydney Honold Basant H Ahmed Karel Paukner Ryan Feauto Maria M Merodio Pablo Pi ñeyro David Meyerholz Karin Allenspach Jonathan P Mochel Source Type: research
Tribute to Andrea Huwiler (1966-2023)
Pflugers Arch. 2024 Apr 9. doi: 10.1007/s00424-024-02958-5. Online ahead of print.NO ABSTRACTPMID:38592461 | DOI:10.1007/s00424-024-02958-5 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - April 9, 2024 Category: Physiology Authors: Josef Pfeilschifter Erich Gulbins Source Type: research
LPA < sub > 5 < /sub > -Dependent Signaling Regulates Regeneration of the Intestinal Epithelium Following Irradiation
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 9. doi: 10.1152/ajpgi.00269.2023. Online ahead of print.ABSTRACTLysophosphatidic acid (LPA) is a bioactive lipid molecule that regulates a wide array of cellular functions, including proliferation, differentiation, and survival, via activation of cognate receptors. The LPA5 receptor is highly expressed in the intestinal epithelium, but its function in restoring intestinal epithelial integrity following injury has not been examined. Here, we use a radiation-induced injury model to study the role of LPA5 in regulating intestinal epithelial regeneration. Control mice (Lpar5f/f...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - April 9, 2024 Category: Physiology Authors: Beth B McConnell Zhongxing Liang Chad Xu Yiran Han C Chris Yun Source Type: research
