Early heart and skeletal muscle mitochondrial response to a moderate hypobaric hypoxia environment
In conclusion, mitochondria from the muscle and heart respond differently to MHH: mitochondrial supercomplexes increase in the heart, whereas, in skeletal muscle, the mitochondrial pro-fission response is trigged. Considering that skeletal muscle was not actively involved in the ascent when the heart was beating faster to compensate for the hypobaric, hypoxic conditions, we speculate that the different responses to MHH are a result of the different energetic requirements of the tissues upon MHH. KEY POINTS: The heart and the skeletal muscle showed different mitochondrial responses to moderate hypobaric hypoxia. Moderate hy...
Source: The Journal of Physiology - April 17, 2024 Category: Physiology Authors: Jer ónimo Aragón-Vela Rafael A Casuso Ana Sagrera Aparisi Julio Plaza-D íaz Ascensi ón Rueda-Robles Agust ín Hidalgo-Gutiérrez Luis Carlos L ópez Andrea Rodr íguez-Carrillo Jos é Antonio Enriquez Sara Cogliati Jes ús R Huertas Source Type: research
Dynamic cerebral autoregulation is governed by two time constants: Arterial transit time and feedback time constant
In this study, the processes that govern dCA are examined and it is proposed that the application of biophysical models remains limited due to a lack of understanding about the physical processes that are being modelled, partly due to the specific model formulation that has been most widely used (the equivalent electrical circuit). Based on the analysis presented here, it is proposed that the two most important time constants are arterial transit time and feedback time constant. It is therefore time to revisit equivalent electrical circuit models of dCA and to develop a more physiologically realistic alternative, one that ...
Source: The Journal of Physiology - April 17, 2024 Category: Physiology Authors: Stephen J Payne Source Type: research
Calcineurin regulates synaptic Ca < sup > 2+ < /sup > -permeable AMPA receptors in hypothalamic presympathetic neurons via α2δ-1-mediated GluA1/GluA2 assembly
J Physiol. 2024 Apr 17. doi: 10.1113/JP286081. Online ahead of print.ABSTRACTHypertension is a major adverse effect of calcineurin inhibitors, such as tacrolimus (FK506) and cyclosporine, used clinically as immunosuppressants. Calcineurin inhibitor-induced hypertension (CIH) is linked to augmented sympathetic output from the hypothalamic paraventricular nucleus (PVN). GluA2-lacking, Ca2+-permeable AMPA receptors (CP-AMPARs) are a key feature of glutamatergic synaptic plasticity, yet their role in CIH remains elusive. Here, we found that systemic administration of FK506 in rats significantly increased serine phosphorylation...
Source: The Journal of Physiology - April 17, 2024 Category: Physiology Authors: Jing-Jing Zhou Jian-Ying Shao Shao-Rui Chen Hong Chen Hui-Lin Pan Source Type: research
Metabolic and ultrastructural renal changes in adult Wistar rats fed by a cafeteria diet
CONCLUSIONS: The intake of lipids and simple carbohydrates were found to be associated with alteration in the glomerular ultrastructure. However, more studies are needed to evaluate not only the effects of high-protein and high-fat diets on components of the glomerular filtration barrier, but also renal physiology.PMID:38629653 | PMC:PMC11020636 | DOI:10.1590/acb392224 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - April 17, 2024 Category: Surgery Authors: Priscila Fernandes Dos Santos Diogo Benchimol de Souza Eduardo Jos é Lopes Torres Waldemar Silva Costa Francisco Jos é Barcellos Sampaio Bianca Martins Gregorio Source Type: research
Safety and feasibility pilot study of continuous low-dose maternal supplemental oxygen in fetal single ventricle heart disease
CONCLUSIONS: This pilot phase 1 clinical trial indicates low-dose maternal supplemental oxygen therapy is safe and well tolerated in pregnancies diagnosed with fetal SVP. However, our protocol was not associated with any significant changes in fetal circulatory physiology or improvements in early neurologic or neurodevelopmental outcomes. This article is protected by copyright. All rights reserved.PMID:38629477 | DOI:10.1002/uog.27657 (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - April 17, 2024 Category: Radiology Authors: F-T Lee L Sun A Szabo N Milligan A Saini D Chetan J-L Hunt C K Macgowan L Freud E Jaeggi T Van Mieghem J Kingdom S P Miller M Seed Source Type: research
Physick to Physiology: Tales from an Oxford Life in Medicine
Anesth Analg. 2024 Apr 11. doi: 10.1213/ANE.0000000000006981. Online ahead of print.NO ABSTRACTPMID:38630032 | DOI:10.1213/ANE.0000000000006981 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 17, 2024 Category: Anesthesiology Authors: Alistair G McKenzie Source Type: research
Cross Talk opposing view: Marr's three levels of analysis are not useful as a framework for neuroscience
J Physiol. 2024 Apr 16. doi: 10.1113/JP279550. Online ahead of print.NO ABSTRACTPMID:38628062 | DOI:10.1113/JP279550 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 17, 2024 Category: Physiology Authors: Jonathan W Pillow Source Type: research
Crosstalk rebuttal: Marr's three levels of analysis are not useful as a framework for neuroscience
J Physiol. 2024 Apr 16. doi: 10.1113/JP286426. Online ahead of print.NO ABSTRACTPMID:38628068 | DOI:10.1113/JP286426 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 17, 2024 Category: Physiology Authors: M áté Lengyel Source Type: research
CrossTalk rebuttal
J Physiol. 2024 Apr 16. doi: 10.1113/JP286427. Online ahead of print.NO ABSTRACTPMID:38628075 | DOI:10.1113/JP286427 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 17, 2024 Category: Physiology Authors: Jonathan W Pillow Source Type: research
Marr's three levels of analysis are useful as a framework for neuroscience
J Physiol. 2024 Apr 16. doi: 10.1113/JP279549. Online ahead of print.NO ABSTRACTPMID:38628044 | DOI:10.1113/JP279549 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 17, 2024 Category: Physiology Authors: M áté Lengyel Source Type: research
Metabolic outcomes in obese mice undergoing one-anastomosis gastric bypass (OAGB) with a long or a short biliopancreatic limb
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00327.2023. Online ahead of print.ABSTRACTOne-anastomosis gastric bypass (OAGB) has gained importance as a safe and effective operation to treat morbid obesity. It is not known whether a long biliopancreatic limb (BPL) in OAGB surgery compared to a short BPL results in beneficial metabolic outcomes. 5-week-old male C57BL/6J mice fed a high-fat diet for 8 weeks underwent OAGB surgery with defined short and long BPL lengths, or sham surgery combined with caloric restriction. Weight loss, glucose tolerance, obesity-related comorbidities, endocrine effects, gut m...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 17, 2024 Category: Physiology Authors: Ioannis I Lazaridis Angela J T Bosch Lena Keller Andy J Y Low Jeanne Tamarelle Seraina O Moser Denise V Winter Cristina G ómez Caspar J Peterson Romano Schneider Marko Kraljevic Alex Odermatt Pascale Vonaesch Ralph Peterli Tarik Delko Claudia Cavelti-Wed Source Type: research
Mechanisms of spinophilin-dependent pancreas dysregulation in obesity
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00099.2023. Online ahead of print.ABSTRACTSpinophilin is an F-actin binding and protein phosphatase 1 (PP1) targeting protein that acts as a scaffold of PP1 to its substrates. Spinophilin knockout (Spino-/-) mice have decreased fat mass, increased lean mass, and improved glucose tolerance, with no difference in feeding behaviors. While spinophilin is enriched in neurons, its roles in non-neuronal tissues, such as beta cells of the pancreatic islets, are unclear. We have corroborated and expanded upon previous studies to determine that Spino-/- mice have decre...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 17, 2024 Category: Physiology Authors: Kaitlyn C Stickel Nikhil R Shah Emily T Claeboe Kara S Orr Amber L Mosley Emma H Doud Teri L Belecky-Adams Anthony J Baucum Source Type: research
Advancements in Diabetic Kidney Disease Management: Integrating Innovative Therapies and Targeted Drug Development
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00026.2024. Online ahead of print.ABSTRACTDiabetic kidney disease (DKD) is a leading cause of chronic kidney disease and affects approximately 40% of diabetic individuals. Cases of DKD continue to rise globally as the prevalence of diabetes mellitus increases, with an estimated 415 million people living with diabetes in 2015 and a projected 642 million by 2040. DKD is associated with significant morbidity and mortality, representing 34% and 36% of all chronic kidney disease deaths in men and women, respectively. Common co-morbidities including hypertension an...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 17, 2024 Category: Physiology Authors: Shaarav Ghose Matthew Satariano Saichidroopi Korada Thomas Cahill Raghav Shah Rupesh Raina Source Type: research
A randomised multicentre study of angiography- versus physiologyguided percutaneous coronary intervention in patients with coronary artery disease undergoing TAVI: design and rationale of the FAITAVI trial
EuroIntervention. 2024 Apr 15;20(8):e504-e510. doi: 10.4244/EIJ-D-23-00679.ABSTRACTThe treatment of coronary artery disease (CAD) in patients with severe aortic valve stenosis (AVS) eligible for transcatheter aortic valve implantation (TAVI) is not supported by clinical evidence, and the role of physiology over anatomy as well as the timing of coronary intervention are not defined. FAITAVI (ClinicalTrials.gov: NCT03360591) is a nationwide prospective, open-label, multicentre, randomised controlled study comparing the angiography-guided versus the physiology-guided coronary revascularisation strategy in patients with combin...
Source: EuroIntervention - April 17, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Flavio Ribichini Gabriele Pesarini Tommaso Fabris Mattia Lunardi Marco Barbierato Gianpiero D'Amico Chiara Zanchettin Dario Gregori Tommaso Piva Elisa Nicolini Caterina Gandolfo Massimo Fineschi Anna Sonia Petronio Sergio Berti Francesco Caprioglio France Source Type: research
Reply to “letter to the editor: Measuring renal hemodynamics during exercise using Doppler ultrasound”
(Source: Physiological Reports)
Source: Physiological Reports - April 17, 2024 Category: Physiology Authors: Shotaro Kawakami,
Tetsuhiko Yasuno,
Saki Kawakami,
Ai Ito,
Kanta Fujimi,
Takuro Matsuda,
Shihoko Nakashima,
Kosuke Masutani,
Yoshinari Uehara,
Yasuki Higaki,
Ryoma Michishita Tags: LETTER TO THE EDITOR Source Type: research
