Unlocking P(V): Reagents for chiral phosphorothioate synthesis
Phosphorothioate nucleotides have emerged as powerful pharmacological substitutes of their native phosphodiester analogs with important translational applications in antisense oligonucleotide (ASO) therapeutics and cyclic dinucleotide (CDN) synthesis. Stereocontrolled installation of this chiral motif has long been hampered by the systemic use of phosphorus(III) [P(III)]–based reagent systems as the sole practical means of oligonucleotide assembly. A fundamentally different approach is described herein: the invention of a P(V)-based reagent platform for programmable, traceless, diastereoselective phosphorus-sulfur in...
Source: ScienceNOW - September 20, 2018 Category: Science Authors: Knouse, K. W., deGruyter, J. N., Schmidt, M. A., Zheng, B., Vantourout, J. C., Kingston, C., Mercer, S. E., Mcdonald, I. M., Olson, R. E., Zhu, Y., Hang, C., Zhu, J., Yuan, C., Wang, Q., Park, P., Eastgate, M. D., Baran, P. S. Tags: Chemistry reports Source Type: news

Flame-retardant and smoke-suppressant flexible polyurethane foams based on reactive phosphorus-containing polyol and expandable graphite - Rao WH, Liao W, Wang H, Zhao HB, Wang YZ.
In this manuscript, flame-retardant and smoke-suppressant flexible polyurethane foams (FPUFs) were designed and synthesized based on novel liquid phosphorus-containing polyol named as PDEO and expandable graphite (EG). The reactive PDEO can be chemically a... (Source: SafetyLit)
Source: SafetyLit - August 30, 2018 Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news

Soil phosphorus availability and lime: More than just pH?
(American Society of Agronomy) Plants can't do without phosphorus. But there is often a 'withdrawal limit' on how much phosphorus they can get from the soil. A new study looks at how liming, soil management history and enzymes relate to plants' access to phosphorus. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - August 1, 2018 Category: Biology Source Type: news

Early Use of Burosumab Eases XLH Symptoms in Kids
(MedPage Today) -- Treatment improved rickets severity, serum phosphorus, and calcitriol levels (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - May 20, 2018 Category: Endocrinology Source Type: news

Research brief: Freshwater ecosystems filter pollutants before they reach oceans
(University of Minnesota) By adding excess nutrients to crops, some are very likely to end up in rivers, lakes and streams. But not all of the carbon, nitrogen and phosphorus that enter waterways end up downstream. Freshwater ecosystems filter some of the excess pollutants out of the water before it reaches the ocean, according to a new study. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 30, 2018 Category: Biology Source Type: news

FDA approves first therapy for rare inherited form of rickets, x-linked hypophosphatemia
The U.S. Food and Drug Administration has approved Crysvita (burosumab-twza), the first drug approved to treat adults and children ages 1 year and older with x-linked hypophosphatemia (XLH), a rare, inherited form of rickets. XLH causes low levels of phosphorus in the blood. It leads to impaired bone growth and development in children and adolescents and problems with bone mineralization throughout a patient's life. (Source: World Pharma News)
Source: World Pharma News - April 19, 2018 Category: Pharmaceuticals Tags: Featured FDA Regulatory Affairs Source Type: news

New Penn State-USDA patented technology removes phosphorus from manure
(Penn State) An innovation that could have a huge impact on water quality problems in the United States, a system capable of removing almost all phosphorus from stored livestock manure, was developed by a team of researchers from Penn State and the US Department of Agriculture's Agricultural Research Service. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 9, 2018 Category: Biology Source Type: news

Pee and pesticides: Thoreau's Walden Pond in trouble, warn scientists
Immortalised for its beauty by Henry David Thoreau, the Massachusetts pond is under threat from increased human activity and climate change according to a new studyThe water of Walden Pond, which Henry David Thoreau described in 1854 as “so transparent that the bottom can easily be discerned at the depth of 25 or 30 feet”, is no longer quite so clear according to a new study.The Massachusetts pond was made famous in Walden, the transcendentalist writer ’s account of the years he spent next to it in order to “live so sturdily and Spartan-like as to put to rout all that was not life”. The pond has been greatly affe...
Source: Guardian Unlimited Science - April 6, 2018 Category: Science Authors: Alison Flood Tags: Henry David Thoreau Books Culture Environment Climate change Science Massachusetts US news Science and nature Water Source Type: news

Phosphoric acid as a precursor to chemicals traditionally synthesized from white phosphorus
White phosphorus, generated in the legacy thermal process for phosphate rock upgrading, has long been the key industrial intermediate for the synthesis of phosphorus-containing chemicals, including herbicides, flame-retardants, catalyst ligands, battery electrolytes, pharmaceuticals, and detergents. In contrast, phosphate fertilizers are made on a much larger scale from phosphoric acid, obtained by treating phosphate rock with sulfuric acid. Dehydration of phosphoric acid using sodium chloride gives trimetaphosphate, and here we report that trichlorosilane, primarily used for the production of high-purity silicon, reduces ...
Source: ScienceNOW - March 22, 2018 Category: Science Authors: Geeson, M. B., Cummins, C. C. Tags: Chemistry reports Source Type: news

From rock-stable to reactive phosphorus
(Source: ScienceNOW)
Source: ScienceNOW - March 22, 2018 Category: Science Authors: Protasiewicz, J. D. Tags: Chemistry perspective Source Type: news

Ingestion of fireworks: rare cause of poisoning in children - Yuksekkaya H, Gumus M, Yucel A, Energin M, Demirci S.
BACKGROUND: Mistaken ingestion of all manner of toxic matter is common in childhood, but poisoning with fireworks and matchsticks is rare. Fireworks usually contain 10% yellow phosphorus and 50% potassium chlorate. Potassium chlorate is an extremely reacti... (Source: SafetyLit)
Source: SafetyLit - March 19, 2018 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

Australian scientists move closer to world-beating quantum computer
Led by Australian of the year Michelle Simmons, team has built qubits from single phosphorus atoms in siliconAustralian scientists, led byAustralian of the year Michelle Simmons, have made a significant step in creating a world-beating, single-atom quantum computer.Simmons and her Australian teamannounced on Wednesday they had built quantum bits, known as qubits, from single phosphorus atoms in silicon, that could communicate and correlate with each other.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - March 8, 2018 Category: Science Authors: Naaman Zhou Tags: Computing Science Technology Google Source Type: news

Diverse tropical forests grow fast despite widespread phosphorus limitation
(Smithsonian Tropical Research Institute) Ecological theory says that poor soils limit the productivity of tropical forests, but adding nutrients as fertilizer rarely increases tree growth, suggesting that productivity is not limited by nutrients after all. Researchers at the Smithsonian Tropical Research Institute (STRI) resolved this apparent contradiction, showing that phosphorus limits the growth of individual tree species but not entire forest communities. Their results, published online in Nature, March 8, have sweeping implications for understanding forest growth and change. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 7, 2018 Category: International Medicine & Public Health Source Type: news

The 6 Best Snacks for Anyone Cutting Out Sugar, According to a Nutritionist
This article originally appeared on Health.com (Source: TIME: Health)
Source: TIME: Health - February 28, 2018 Category: Consumer Health News Authors: Cynthia Sass, MPH, RD Tags: Uncategorized Food Healthy Eating onetime Source Type: news

Phosphorus pollution reaching dangerous levels worldwide, new study finds
(American Geophysical Union) Man-made phosphorus pollution is reaching dangerously high levels in freshwater basins around the world, according to new research. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 25, 2018 Category: International Medicine & Public Health Source Type: news