Safety and efficacy assessment of allogeneic human dental pulp stem cells to treat patients with severe COVID-19: structured summary of a study protocol for a randomized controlled trial (Phase I / II)
AbstractObjectivesTo assess the safety and therapeutic effects of allogeneic human dental pulp stem cells (DPSCs) in treating severe pneumonia caused by COVID-19.Trial designThis is a single centre, two arm ratio 1:1, triple blinded, randomized, placebo-controlled, parallel group, clinical trial.ParticipantsTwenty serious COVID-19 cases will be enrolled in the trial from April 6th to December 31st 2020. Inclusion Criteria: hospitalised patients at Renmin Hospital of Wuhan University satisfy all criteria as below:Adults aged 18-65 years;Voluntarily participate in this clinical trial and sign the “informed consent form” ...
Source: Trials - June 11, 2020 Category: Research Source Type: clinical trials

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
Conditions:   Fibrinolysis; Hemorrhage;   Pulmonary Arterial Hypertension;   Urinary Tract Infections in Children;   Hypertension;   Pain;   Control of Serum Phosphorus;   Primary Hyperaldosteronism;   Edematous Conditions;   Hypokalemia;   Heart Failure;   Hemophilia Prior to Tooth  Extraction;   Menorrhagia;   Insomnia;   Pneumonia;   Skin Infection;   Arrythmia;   Asthma in Children;   Bronchopulmonary Dysplasia;   Adrenal Insufficiency;   Hypertension, Resistant to Conventional Therapy Intervention:   Drug: The POPS02 study is collecting bodily fluid samples (i.e., whole b...
Source: ClinicalTrials.gov - February 20, 2020 Category: Research Source Type: clinical trials