Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons
by Claudia I. Perez, Jorge Luis-Islas, Axel Lopez, Xarenny Diaz, Omar Molina, Benjamin Arroyo, Mario G. Moreno, Elvi Gil Lievana, Esmeralda Fonseca, Gilberto Casta ñeda-Hernández, Ranier Gutierrez
Obesity is a major global health epidemic that has adverse effects on both the people affected as well as the cost to society. Several anti-obesity drugs that target GLP-1 receptors have recently come to the market. Here, we describe the effects of tesofensine, a novel anti-obesity drug that acts as a triple monoamine neurotransmitter reuptake inhibitor. Using various techniques, we investigated its effects on weight loss and ...
Source: PLoS One - April 24, 2024 Category: Biomedical Science Authors: Claudia I. Perez Source Type: research
Exploring the association between weight loss-inducing medications and multiple sclerosis: insights from the FDA adverse event reporting system database
CONCLUSION: Our findings suggest a potential consideration for repurposing anti-diabetic weight loss-inducing drugs including semaglutide, dulaglutide, and liraglutide (glucagon-like peptide-1 receptor agonists), empagliflozin (sodium-glucose cotransporter-2 inhibitor), and metformin (biguanide), for MS. This warrants validation through rigorous methodologies and prospective studies.PMID:38566910 | PMC:PMC10986166 | DOI:10.1177/17562864241241383 (Source: Adv Data)
Source: Adv Data - April 3, 2024 Category: Epidemiology Authors: Afsaneh Shirani Anne H Cross Olaf Stuve Source Type: research
Current State of Pharmacotherapy in Obesity
Korean J Gastroenterol. 2024 Mar 25;83(3):94-101. doi: 10.4166/kjg.2024.016.ABSTRACTThe prevalence of obesity with various complications is increasing rapidly in Korea. Although lifestyle modification is fundamental in obesity treatment, more effective treatment tools are required. Many advances in obesity treatment have been reported recently, including lifestyle modifications and pharmacological, endoscopic, and surgical treatments. Drugs with proven long-term efficacy and safety are preferred because management for obesity treatment is a long-term process. Currently, four medications are available for long-term use in K...
Source: Korean J Gastroenter... - March 24, 2024 Category: Gastroenterology Authors: Won Jun Kim Source Type: research
Current State of Pharmacotherapy in Obesity
Korean J Gastroenterol. 2024 Mar 25;83(3):94-101. doi: 10.4166/kjg.2024.016.ABSTRACTThe prevalence of obesity with various complications is increasing rapidly in Korea. Although lifestyle modification is fundamental in obesity treatment, more effective treatment tools are required. Many advances in obesity treatment have been reported recently, including lifestyle modifications and pharmacological, endoscopic, and surgical treatments. Drugs with proven long-term efficacy and safety are preferred because management for obesity treatment is a long-term process. Currently, four medications are available for long-term use in K...
Source: Korean J Gastroenter... - March 24, 2024 Category: Gastroenterology Authors: Won Jun Kim Source Type: research
Current State of Pharmacotherapy in Obesity
Korean J Gastroenterol. 2024 Mar 25;83(3):94-101. doi: 10.4166/kjg.2024.016.ABSTRACTThe prevalence of obesity with various complications is increasing rapidly in Korea. Although lifestyle modification is fundamental in obesity treatment, more effective treatment tools are required. Many advances in obesity treatment have been reported recently, including lifestyle modifications and pharmacological, endoscopic, and surgical treatments. Drugs with proven long-term efficacy and safety are preferred because management for obesity treatment is a long-term process. Currently, four medications are available for long-term use in K...
Source: Korean J Gastroenter... - March 24, 2024 Category: Gastroenterology Authors: Won Jun Kim Source Type: research
Current State of Pharmacotherapy in Obesity
Korean J Gastroenterol. 2024 Mar 25;83(3):94-101. doi: 10.4166/kjg.2024.016.ABSTRACTThe prevalence of obesity with various complications is increasing rapidly in Korea. Although lifestyle modification is fundamental in obesity treatment, more effective treatment tools are required. Many advances in obesity treatment have been reported recently, including lifestyle modifications and pharmacological, endoscopic, and surgical treatments. Drugs with proven long-term efficacy and safety are preferred because management for obesity treatment is a long-term process. Currently, four medications are available for long-term use in K...
Source: Korean J Gastroenter... - March 24, 2024 Category: Gastroenterology Authors: Won Jun Kim Source Type: research
Current State of Pharmacotherapy in Obesity
Korean J Gastroenterol. 2024 Mar 25;83(3):94-101. doi: 10.4166/kjg.2024.016.ABSTRACTThe prevalence of obesity with various complications is increasing rapidly in Korea. Although lifestyle modification is fundamental in obesity treatment, more effective treatment tools are required. Many advances in obesity treatment have been reported recently, including lifestyle modifications and pharmacological, endoscopic, and surgical treatments. Drugs with proven long-term efficacy and safety are preferred because management for obesity treatment is a long-term process. Currently, four medications are available for long-term use in K...
Source: Korean J Gastroenter... - March 24, 2024 Category: Gastroenterology Authors: Won Jun Kim Source Type: research
Current State of Pharmacotherapy in Obesity
Korean J Gastroenterol. 2024 Mar 25;83(3):94-101. doi: 10.4166/kjg.2024.016.ABSTRACTThe prevalence of obesity with various complications is increasing rapidly in Korea. Although lifestyle modification is fundamental in obesity treatment, more effective treatment tools are required. Many advances in obesity treatment have been reported recently, including lifestyle modifications and pharmacological, endoscopic, and surgical treatments. Drugs with proven long-term efficacy and safety are preferred because management for obesity treatment is a long-term process. Currently, four medications are available for long-term use in K...
Source: Korean J Gastroenter... - March 24, 2024 Category: Gastroenterology Authors: Won Jun Kim Source Type: research
Current State of Pharmacotherapy in Obesity
Korean J Gastroenterol. 2024 Mar 25;83(3):94-101. doi: 10.4166/kjg.2024.016.ABSTRACTThe prevalence of obesity with various complications is increasing rapidly in Korea. Although lifestyle modification is fundamental in obesity treatment, more effective treatment tools are required. Many advances in obesity treatment have been reported recently, including lifestyle modifications and pharmacological, endoscopic, and surgical treatments. Drugs with proven long-term efficacy and safety are preferred because management for obesity treatment is a long-term process. Currently, four medications are available for long-term use in K...
Source: Korean J Gastroenter... - March 24, 2024 Category: Gastroenterology Authors: Won Jun Kim Source Type: research
Current State of Pharmacotherapy in Obesity
Korean J Gastroenterol. 2024 Mar 25;83(3):94-101. doi: 10.4166/kjg.2024.016.ABSTRACTThe prevalence of obesity with various complications is increasing rapidly in Korea. Although lifestyle modification is fundamental in obesity treatment, more effective treatment tools are required. Many advances in obesity treatment have been reported recently, including lifestyle modifications and pharmacological, endoscopic, and surgical treatments. Drugs with proven long-term efficacy and safety are preferred because management for obesity treatment is a long-term process. Currently, four medications are available for long-term use in K...
Source: Korean J Gastroenter... - March 24, 2024 Category: Gastroenterology Authors: Won Jun Kim Source Type: research
Current State of Pharmacotherapy in Obesity
Korean J Gastroenterol. 2024 Mar 25;83(3):94-101. doi: 10.4166/kjg.2024.016.ABSTRACTThe prevalence of obesity with various complications is increasing rapidly in Korea. Although lifestyle modification is fundamental in obesity treatment, more effective treatment tools are required. Many advances in obesity treatment have been reported recently, including lifestyle modifications and pharmacological, endoscopic, and surgical treatments. Drugs with proven long-term efficacy and safety are preferred because management for obesity treatment is a long-term process. Currently, four medications are available for long-term use in K...
Source: Korean J Gastroenter... - March 24, 2024 Category: Gastroenterology Authors: Won Jun Kim Source Type: research
Current State of Pharmacotherapy in Obesity
Korean J Gastroenterol. 2024 Mar 25;83(3):94-101. doi: 10.4166/kjg.2024.016.ABSTRACTThe prevalence of obesity with various complications is increasing rapidly in Korea. Although lifestyle modification is fundamental in obesity treatment, more effective treatment tools are required. Many advances in obesity treatment have been reported recently, including lifestyle modifications and pharmacological, endoscopic, and surgical treatments. Drugs with proven long-term efficacy and safety are preferred because management for obesity treatment is a long-term process. Currently, four medications are available for long-term use in K...
Source: Korean J Gastroenter... - March 24, 2024 Category: Gastroenterology Authors: Won Jun Kim Source Type: research
Current State of Pharmacotherapy in Obesity
Korean J Gastroenterol. 2024 Mar 25;83(3):94-101. doi: 10.4166/kjg.2024.016.ABSTRACTThe prevalence of obesity with various complications is increasing rapidly in Korea. Although lifestyle modification is fundamental in obesity treatment, more effective treatment tools are required. Many advances in obesity treatment have been reported recently, including lifestyle modifications and pharmacological, endoscopic, and surgical treatments. Drugs with proven long-term efficacy and safety are preferred because management for obesity treatment is a long-term process. Currently, four medications are available for long-term use in K...
Source: Korean J Gastroenter... - March 24, 2024 Category: Gastroenterology Authors: Won Jun Kim Source Type: research
Current State of Pharmacotherapy in Obesity
Korean J Gastroenterol. 2024 Mar 25;83(3):94-101. doi: 10.4166/kjg.2024.016.ABSTRACTThe prevalence of obesity with various complications is increasing rapidly in Korea. Although lifestyle modification is fundamental in obesity treatment, more effective treatment tools are required. Many advances in obesity treatment have been reported recently, including lifestyle modifications and pharmacological, endoscopic, and surgical treatments. Drugs with proven long-term efficacy and safety are preferred because management for obesity treatment is a long-term process. Currently, four medications are available for long-term use in K...
Source: Korean J Gastroenter... - March 24, 2024 Category: Gastroenterology Authors: Won Jun Kim Source Type: research
Current State of Pharmacotherapy in Obesity
Korean J Gastroenterol. 2024 Mar 25;83(3):94-101. doi: 10.4166/kjg.2024.016.ABSTRACTThe prevalence of obesity with various complications is increasing rapidly in Korea. Although lifestyle modification is fundamental in obesity treatment, more effective treatment tools are required. Many advances in obesity treatment have been reported recently, including lifestyle modifications and pharmacological, endoscopic, and surgical treatments. Drugs with proven long-term efficacy and safety are preferred because management for obesity treatment is a long-term process. Currently, four medications are available for long-term use in K...
Source: Korean J Gastroenter... - March 24, 2024 Category: Gastroenterology Authors: Won Jun Kim Source Type: research
