Extramammary Paget ’s Disease of the Penis and Scrotum
AbstractExtramammary Paget ’s disease (EMPD) is an adenocarcinoma arising from the skin or skin appendages which is sometimes associated with an underlying malignancy. EMPD is most commonly seen in the vulva, followed by perianal region, and the male genitalia. In most cases, patient presents with eczematous lesion persisti ng for long duration. A 77-year-old gentleman had a history of chronic eczematous lesion over penis and scrotum for the last 10 years. Examination revealed an erythematous plaque like eczematous lesion over the penis and scrotum. Biopsy with IHC of lesion is suggestive of EMPD. Wide local excision of...
Source: Indian Journal of Surgical Oncology - January 23, 2024 Category: Cancer & Oncology Source Type: research

New EAU/ASCO guideline recommendations on sentinel node biopsy for penile cancer and remaining challenges from a nuclear medicine perspective
ConclusionOver the years, DSNB has evolved significantly, related to the dedicated efforts and innovations in nuclear medicine and subsequent clinical studies validating its efficacy. It is now strongly recommended for surgical staging among selected penile cancer patients. To optimise DSNB further, multidisciplinary collaborative research is required to improve SN identification for better diagnostic accuracy and fewer complications. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 13, 2024 Category: Nuclear Medicine Source Type: research

Pathologically Confirmed Subcutaneous Fat and Lymphovascular Invasion of a Hypopigmented Area in Extramammary Paget Disease
We report a case of a 62-year-old male with EMPD that invaded the subcutaneous fat layer. He presented with a several-year history of a slowly expanding erythematous plaque with the hypopigmented area on the left penoscrotum. One month before presentation, the patient had undergone punch biopsy at another hospital and diagnosed with EMPD. He had no personal history of urogenital cancers. The patient was treated with Mohs micrographic surgery, and negative margins were achieved after four stages. The histopathologic findings revealed Paget cells scattered throughout the epidermis. At the hypopigmented area, Paget cells exte...
Source: Annals of Dermatology - December 7, 2023 Category: Dermatology Authors: Gyoo Huh Ga-Young Lee Yumin Chung Seung-Wan Chae Young-Jun Choi Source Type: research

Chronic myeloid leukemia with sleep-related painful erections as a first symptom: a case report
ConclusionWe considered that the occurrence of sleep-related painful erections was related to chronic myeloid leukemia and the case might be secondary sleep-related painful erections. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - November 30, 2023 Category: General Medicine Source Type: research

Mondor Disease of the Penis After Sentinel Lymph Node Biopsy in a Patient With Melanoma
Actas Dermosifiliogr. 2023 Oct 15:S0001-7310(23)00811-6. doi: 10.1016/j.ad.2022.11.023. Online ahead of print.NO ABSTRACTPMID:37848130 | DOI:10.1016/j.ad.2022.11.023 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - October 17, 2023 Category: Dermatology Authors: D Mar ín Piñero G Mel é Ninot M Quintana Codina Source Type: research

Mondor Disease of the Penis After Sentinel Lymph Node Biopsy in a Patient With Melanoma
Actas Dermosifiliogr. 2023 Oct 15:S0001-7310(23)00811-6. doi: 10.1016/j.ad.2022.11.023. Online ahead of print.NO ABSTRACTPMID:37848130 | DOI:10.1016/j.ad.2022.11.023 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - October 17, 2023 Category: Dermatology Authors: D Mar ín Piñero G Mel é Ninot M Quintana Codina Source Type: research

superinfected penile cancer complicated by genital gangrene: management and role of gangrene biopsy
A 70-year-old man was referred to the urology clinic because of Fournier's genital gangrene, the main reason for consultation in this elderly multitarre patient is the unpleasant odor felt by him (Figure 1). The patient was being followed for unbalanced diabetes and morbid obesity associated with these complications of maceration and prolonged bed rest. Initial urological evaluation revealed necrosis lesions at the base of the penis with pus discharge through, with a fixed right inguinal adenopathy, confirmed by CT scan (Figure 2). (Source: Urology)
Source: Urology - October 10, 2023 Category: Urology & Nephrology Authors: Hammou el farhaoui, Anouar Elmoudane, Debe Sallem, Mohammed Irzi, Ali Barki. Source Type: research

Sentinel node biopsy in male genitourinary cancers: state of the art and future developments
ConclusionThe SLN procedures in penile, prostate and testicular cancers are reviewed. Current trends toward in development of hybrid technique and robot-assisted sentinel lymph node are also discussed. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - September 19, 2023 Category: Radiology Source Type: research

Anogenital distance, a biomarker of fetal androgen exposure and the risk of prostate cancer: A case-control study
CONCLUSIONS: This research suggests that the same gestational environmental exposures, could represent a weak androgen signaling and may also have an increased risk of prostate cancer.PMID:37606191 | DOI:10.1177/03915603231192736 (Source: Cancer Control)
Source: Cancer Control - August 22, 2023 Category: Cancer & Oncology Authors: Florencio Manuel Mar ín-Martínez Julian J Arense-Gonzalo Miriam Artes Artes Emny Rochell Bobadilla Romero V íctor Javier García Porcel Pablo Alcon Cerro Mabel Coromoto Su árez-Pineda Pablo Luis Guzm án Martínez-Valls Jaime Mendiola Source Type: research

Evaluation of androgen receptor markers in erectile dysfunction
ConclusionThese data showed a significant decrease in the expression of proteins downstream of the androgen receptor at lower serumT levels. This suggests a potential correlation between serum T concentration and androgen receptor signaling and supports a potential saturation value between 200 and 300 ng/dL. (Source: Andrology)
Source: Andrology - August 8, 2023 Category: Urology & Nephrology Authors: Kajal Khodamoradi, Katherine Campbell, Himanshu Arora, Ranjith Ramasamy Tags: SHORT COMMUNICATION Source Type: research

Case Report: Optimum excision with split skin graft closure in the management of penile sebaceous carcinoma
We report a case of penile sebaceous carcinoma, an extremely rare anatomical site for SC. A 68-year-old man presented with a 4-month history of painless, non-healing ulcerated nodules over the left side of the penile shaft. Wedge biopsy showed adenocarcinoma with signet ring differentiation. We proceeded with wide local excision (WLE) of the lesion with the inclusion of the indurated skin and 5 mm of normal margin, followed by primary closure of the scrotal defect and split skin grafting of the penile shaft by using a thigh skin donor. The final histopathological examination revealed sebaceous carcinoma with pagetoid spre...
Source: Frontiers in Oncology - July 26, 2023 Category: Cancer & Oncology Source Type: research