2018 Demystifying Medicine: New viral diseases, universal vaccines, and removing agents from the blood supply
The Demystifying Medicine Lecture Series is designed to help bridge the gap between advances in biology and their applications to major human diseases. The lectures include presentations of patients, pathology, diagnosis, and therapy in the context of major diseases and current research. All clinicians, trainees including fellows, medical students, Ph.D. students, and other healthcare and research professionals are welcome to attend.For more information go tohttps://demystifyingmedicine.od.nih.gov/Air date: 1/9/2018 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 31, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
2018 Demystifying Medicine: Is leukemia curable?
The Demystifying Medicine Lecture Series is designed to help bridge the gap between advances in biology and their applications to major human diseases. The lectures include presentations of patients, pathology, diagnosis, and therapy in the context of major diseases and current research. All clinicians, trainees including fellows, medical students, Ph.D. students, and other healthcare and research professionals are welcome to attend.For more information go tohttps://demystifyingmedicine.od.nih.gov/Air date: 1/16/2018 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 31, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Cellular Ecology
IIG seminar
All untransformed cells require specific growth factors for survival and proliferation. Local provision of growth factors determines tissue composition and size. However, the rules that govern growth factor production are largely unknown. Consequently, we do not know how these rules are violated to produce specific patterns of tissue pathology. In this lecture I will discuss our recent study addressing these questions. Using simplified two cell circuit system, we find that certain features of cell circuit topologies enable generation of stable cell composition. These findings will be discus sed in a broader ...
Source: Videocast - All Events - October 13, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Systemic immunity protects the mind: Can immune checkpoint blockade combat Alzheimer ’ s disease?
NIH Director's Wednesday Afternoon Lecture
It is now widely accepted that immune surveillance is required for supporting brain functional plasticity and repair. Participating cells include the microglia, the resident myeloid immune cells of the brain, circulating monocytes, and CD4+ T cells. Over the years, we demonstrated that leukocytes supporting the brain can gain access to the brain through a unique compartment within the brain territory, the chroid plexus epithelium (CP) at the blood-cerebrospinal fluid-barrier (B-CSF-B), remote from the brain parenchyma. The CP serves as a selective gateway allowing leukocyte entry ...
Source: Videocast - All Events - October 10, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Innate Immunity in Neurodegeneration
NCI's Center for Cancer Research (CCR) Grand Rounds
Dr. Marco Colonna received his medical degree with honors from the School of Medicine at Parma University in 1983, and completed his specialization in Internal Medicine at Parma University in 1988. He began his postdoctoral training as a Research Fellow at the Istituto Nazionale per la Ricerca sul Cancro in Genova, Italy, followed by work as a Research Affiliate in the Department of Molecular Immunology at Roswell Park Memorial Institute in Buffalo, New York and as a Research Fellow in Pathology at Dana Farber Cancer Institute and Harvard Medical School. He then became a ...
Source: Videocast - All Events - September 25, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Multifaceted Functions of Mitochondria in Neuronal Synapses
Director's Seminar Series
The Section on Synapse Development and Synaptic Plasticity led by Dr. Zheng Li is interested in the molecular and cellular mechanisms underlying synapse development and synaptic plasticity in normal brains and synaptopathology associated with psychiatric disorders. Our research shows that mitochondria, the vital organelles in eukaryotic cells, not only are essential for the general cell physiology, but also play multifaceted roles in synapses. In hippocampal neurons, the quantify of mitochondria in dendrites determines the density of synapses and dendritic spines. Mitochondria are permeabilized up...
Source: Videocast - All Events - April 17, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Group 1 innate lymphoid cells in metabolic disease
Immunology Interest Group Seminar Series
Innate lymphoid cells (ILCs) are the most recently identified arm of the innate immune system that function to protect epithelial barriers against pathogens and maintain tissue homeostasis. Although ILCs can also promote pathology at mucosal sites such as the gut or lung, it remains unknown whether aberrant activation of tissue-resident ILCs can contribute to disease in non-barrier tissues. Here, we identify a subset of long-term adipose-resident ILC1 that are dependent on the transcription factors Nfil3 and T-bet, but phenotypically and functionally distinct from circulating mature...
Source: Videocast - All Events - January 17, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Exploring Molecular Linkages to Modifiable Risk in Breast Cancer
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Gardner received his B.S. from Yale University and earned his M.D. and Ph.D. from the Johns Hopkins University School of Medicine where he studied the regulation of membrane skeletal proteins in the Department of Cellular Biology and Anatomy. He completed residency training in anatomic pathology at the National Cancer Institute and is board certified in Anatomic Pathology. Dr. Gardner has had a long term interest in the cellular and molecular biology of gene regulation and, while at NIH, has been developing strategies to define pathways and mechanisms of transcrip...
Source: Videocast - All Events - January 3, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Cytokine Signaling: Genes, Genomes and Drugs
Eleventh annual Philip S. Chen, Jr., Ph.D. Distinguished Lecture on Innovation and Technology Transfer
John J. O'Shea graduated Phi Beta Kappa from St. Lawrence University
with a Bachelor of Science degree, and then gained a Doctor of
Medicine degree from the University of Cincinnati. He carried out a
residency in Internal Medicine at the State University of New York
Upstate Medical University and did subspecialty training at the National
Institute of Allergy and Infectious Diseases, NIH.
Dr. O ’ Shea has made fundamental discoveries related to the basic
mechanisms underlying cytokine signal transduction, molecule...
Source: Videocast - All Events - October 4, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Polyvalent Vaccines Targeting Oncogenic Driver Pathways
NCI Cancer Prevention Fellowship Program
The Annual Advances in Cancer Prevention Lecture is sponsored by the Cancer Prevention Fellowship Program within the Division of Cancer Prevention at NCI. It is also part the course offerings of the annual NCI Summer Curriculum in Cancer Prevention but is open to the entire NIH community and the general public. This annual lecture addresses current challenges and/or approaches used by investigators to address gaps, advance science, and promote the application of successful strategies in the field of cancer prevention and control. Dr. Disis will be presenting the 2016 annual lect...
Source: Videocast - All Events - July 18, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
The Two Faces of p53: Tumor Suppressor and Oncogene
NCI’s Center for Cancer Research (CCR) Grand Rounds
Dr. Carol Prives is the DaCosta Professor of Biological Sciences at Columbia University. She was educated in Canada, receiving her BSc and PhD from McGill University. After postdoctoral training at Albert Einstein College of Medicine and the Weizmann Institute, she became a faculty member at the Weizmann in Israel after which she joined the Biological Sciences Department at Columbia University where she was appointed to a named professorship in 1995. Dr Prives served as Chair of that department between 2000 and 2004. Since the late 1980’s her work has focused on th...
Source: Videocast - All Events - June 13, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Connecting Tumor Suppression and Fate Determination in Mammary Cancer Stem Cells: From Discovery to Preclinical Intervention
NCI’s Center for Cancer Research (CCR) Grand Rounds
Prof. Pier Paolo Di Fiore is group leader at IFOM, an internationally competitive research institute in Milan, which he founded in 1998, and Director of the Molecular Medicine Program at IEO, a leading cancer care center in Milan. He is also Full Professor of General Pathology at the University of Milan, and co-founder of the post-graduate European School of Molecular Medicine.
Dr. Di Fiore has dedicated his scientific career to deciphering the molecular mechanisms of cellular transformation, with emphasis on growth factor receptor signaling, endocytosis and stem cel...
Source: Videocast - All Events - June 6, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Controlling Global Transcriptome Output with MYC, Supercoils, and Topoisomerase
NCI’s Center for Cancer Research (CCR) Grand Rounds
Dr. Levens received his M.D. and Ph.D. from the University of Chicago. Subsequently, he completed residency training in anatomic pathology at the Laboratory of Pathology, NCI, where he is now the chief of the Gene Regulation Section. Dr. Levens studies fundamental mechanisms of gene regulation, emphasizing the control of MYC function and expression. He and his team showed that MYC amplifies is a universal amplifier of gene expression. This explains much of MYC physiology and pathology, but also defines the need to control MYC levels precisely in real time. The Leven...
Source: Videocast - All Events - April 19, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Long Non-coding RNAs and the Homeostasis of Innate Immune Cells
Presented by: Jorge Henao-Mejia, M.D., Ph.D.; Assistant Professor of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of MedicineCategory: ImmunologyAired date: 04/06/2016 (Source: Videocast - All Events)
Source: Videocast - All Events - April 7, 2016 Category: Journals (General) Tags: Past Events Source Type: video
Role and Regulation of the NLRP3 Inflammasome
Presented by: Gabriel Nuñez, M.D.; Paul de Kruif Endowed Professor in Academic Pathology; Department of Pathology, University of Michigan School of MedicineCategory: ImmunologyAired date: 03/16/2016 (Source: Videocast - All Events)
Source: Videocast - All Events - March 17, 2016 Category: Journals (General) Tags: Past Events Source Type: video
