Viral DNAemia and DNA Virus Seropositivity and Mortality in Pediatric Sepsis
CONCLUSIONS AND RELEVANCE: The findings of this cohort study suggest that DNAemia for CMV, HAdV, BKPyV, and HHV-6 and EBV seropositivity were independently associated with increased sepsis mortality. Further investigation of the underlying biology of these viral DNA infections in children with sepsis is warranted to determine whether they only reflect mortality risk or contribute to mortality.PMID:38407904 | DOI:10.1001/jamanetworkopen.2024.0383 (Source: Herpes)
Source: Herpes - February 26, 2024 Category: Infectious Diseases Authors: Stephanie S Cabler Gregory A Storch Jason B Weinberg Andrew H Walton Karen Brengel-Pesce Zachary Aldewereld Russell K Banks Valerie Cheynet Ron Reeder Richard Holubkov Robert A Berg David Wessel Murray M Pollack Kathleen Meert Mark Hall Christopher Newth Source Type: research

Viral DNAemia and DNA Virus Seropositivity and Mortality in Pediatric Sepsis
CONCLUSIONS AND RELEVANCE: The findings of this cohort study suggest that DNAemia for CMV, HAdV, BKPyV, and HHV-6 and EBV seropositivity were independently associated with increased sepsis mortality. Further investigation of the underlying biology of these viral DNA infections in children with sepsis is warranted to determine whether they only reflect mortality risk or contribute to mortality.PMID:38407904 | PMC:PMC10897747 | DOI:10.1001/jamanetworkopen.2024.0383 (Source: Herpes)
Source: Herpes - February 26, 2024 Category: Infectious Diseases Authors: Stephanie S Cabler Gregory A Storch Jason B Weinberg Andrew H Walton Karen Brengel-Pesce Zachary Aldewereld Russell K Banks Valerie Cheynet Ron Reeder Richard Holubkov Robert A Berg David Wessel Murray M Pollack Kathleen Meert Mark Hall Christopher Newth Source Type: research

For better or worse: crosstalk of parvovirus and host DNA damage response
Parvoviruses are a group of non-enveloped DNA viruses that have a broad spectrum of natural infections, making them important in public health. NS1 is the largest and most complex non-structural protein in the parvovirus genome, which is indispensable in the life cycle of parvovirus and is closely related to viral replication, induction of host cell apoptosis, cycle arrest, DNA damage response (DDR), and other processes. Parvovirus activates and utilizes the DDR pathway to promote viral replication through NS1, thereby increasing pathogenicity to the host cells. Here, we review the latest progress of parvovirus in regulati...
Source: Frontiers in Immunology - February 23, 2024 Category: Allergy & Immunology Source Type: research

Viral clearance capability of monoclonal antibody purification
Biologicals. 2024 Feb 21;85:101751. doi: 10.1016/j.biologicals.2024.101751. Online ahead of print.ABSTRACTViral clearance steps are routinely included in monoclonal antibody purification processes to safeguard product from potential virus contamination. These steps are often experimentally studied using product-specific feeds and parameters for each project to demonstrate viral clearance capability. However, published evidence suggests that viral clearance capability of many of these steps are not significantly impacted by variations in feed material or process parameter within commonly used ranges. The current investigati...
Source: Biologicals : Journal of the International Association of Biological Standardization - February 22, 2024 Category: Biotechnology Authors: Kang Cai Jennifer Anderson Etienne Utiger Gisela Ferreira Source Type: research

Viral clearance capability of monoclonal antibody purification
Biologicals. 2024 Feb 21;85:101751. doi: 10.1016/j.biologicals.2024.101751. Online ahead of print.ABSTRACTViral clearance steps are routinely included in monoclonal antibody purification processes to safeguard product from potential virus contamination. These steps are often experimentally studied using product-specific feeds and parameters for each project to demonstrate viral clearance capability. However, published evidence suggests that viral clearance capability of many of these steps are not significantly impacted by variations in feed material or process parameter within commonly used ranges. The current investigati...
Source: Biologicals : Journal of the International Association of Biological Standardization - February 22, 2024 Category: Biotechnology Authors: Kang Cai Jennifer Anderson Etienne Utiger Gisela Ferreira Source Type: research

Viral clearance capability of monoclonal antibody purification
Biologicals. 2024 Feb 21;85:101751. doi: 10.1016/j.biologicals.2024.101751. Online ahead of print.ABSTRACTViral clearance steps are routinely included in monoclonal antibody purification processes to safeguard product from potential virus contamination. These steps are often experimentally studied using product-specific feeds and parameters for each project to demonstrate viral clearance capability. However, published evidence suggests that viral clearance capability of many of these steps are not significantly impacted by variations in feed material or process parameter within commonly used ranges. The current investigati...
Source: Biologicals : Journal of the International Association of Biological Standardization - February 22, 2024 Category: Biotechnology Authors: Kang Cai Jennifer Anderson Etienne Utiger Gisela Ferreira Source Type: research

Antiviral alternatives against important members of the subfamily Parvovirinae: a review
AbstractParvoviruses are responsible for multiple diseases, and there is a critical need for effective antiviral therapies. Specific antiviral treatments for parvovirus infections are currently lacking, and the available options are mostly supportive and symptomatic. In recent years, significant research efforts have been directed toward understanding the molecular mechanisms of parvovirus replication and identifying potential targets for antiviral interventions. This review highlights the structure, pathogenesis, and treatment options for major viruses of the subfamilyParvovirinae, such as parvovirus B19 (B19V), canine pa...
Source: Archives of Virology - February 20, 2024 Category: Virology Source Type: research

Pure Red Cell Aplasia Secondary to Parvovirus B19 Infection as a Rare Cause of Anemia in a Dialysis Patient: A Case Report
Intern Med. 2024 Feb 19. doi: 10.2169/internalmedicine.2631-23. Online ahead of print.ABSTRACTParvovirus B19 infection can cause chronic pure red cell aplasia in immunosuppressed hosts or acute and transient aplastic crises in immunocompetent hosts. In dialysis patients, only transient aplastic crisis induced by parvovirus B19 infection has been reported. We herein report the first case of an adult dialysis patient who developed chronic pure red cell aplasia associated with parvovirus B19 infection. Repeated pneumonia and heart failure may contribute to an immunocompromised status, making the patient more vulnerable to par...
Source: Internal Medicine - February 18, 2024 Category: Internal Medicine Authors: Yuequan Shi Xiaoxiao Shi Haiyun Wang Zijuan Zhou Lei Zhang Limeng Chen Source Type: research

Viruses, Vol. 16, Pages 282: Transcriptional Differential Analysis of Nitazoxanide-Mediated Anticanine Parvovirus Effect in F81 Cells
ngping Li Bing Yang Canine parvovirus (CPV) is a single-stranded DNA virus that can cause typical hemorrhagic enteritis, and it is one of the common canine lethal viruses. In previous studies, we screened the Food and Drug Administration (FDA)’s drug library and identified nitazoxanide (NTZ), which has anti-CPV capabilities. To investigate the potential antiviral mechanisms, we first reconfirmed the inhibitory effect of NTZ on the CPV by inoculating with different doses and treating for different lengths of time. Then, the differences in the transcription levels between the 0.1%-DMSO-treated virus group...
Source: Viruses - February 12, 2024 Category: Virology Authors: Xia Su Hongzhuan Zhou Ziwei Han Fuzhou Xu Bing Xiao Jin Zhang Qi Qi Lulu Lin Huanhuan Zhang Songping Li Bing Yang Tags: Article Source Type: research