Virus filtration using small pore virus filter in downstream processing of biotherapeutic products: The effect of operating pressure
Biologicals. 2023 Oct 12;84:101718. doi: 10.1016/j.biologicals.2023.101718. Online ahead of print.ABSTRACTVirus filtration is a robust and effective method to remove potential virus contaminants. Planova 20 N, a virus filter form Asahi Kasei Bioprocess, has been widely used in the manufacturing process of biotherapeutics. Previous studies have shown that parvovirus removal by Planova 20 N can be impacted by low operation pressure and depressurization. Therefore, it is critical to define an operating pressure range for robust virus removal. In this work, the effect of pressure combined with depressurization on virus removal...
Source: Biologicals : Journal of the International Association of Biological Standardization - October 14, 2023 Category: Biotechnology Authors: Na Liu Tiandan Xu Source Type: research

Virus filtration using small pore virus filter in downstream processing of biotherapeutic products: The effect of operating pressure
Biologicals. 2023 Oct 12;84:101718. doi: 10.1016/j.biologicals.2023.101718. Online ahead of print.ABSTRACTVirus filtration is a robust and effective method to remove potential virus contaminants. Planova 20 N, a virus filter form Asahi Kasei Bioprocess, has been widely used in the manufacturing process of biotherapeutics. Previous studies have shown that parvovirus removal by Planova 20 N can be impacted by low operation pressure and depressurization. Therefore, it is critical to define an operating pressure range for robust virus removal. In this work, the effect of pressure combined with depressurization on virus removal...
Source: Biologicals : Journal of the International Association of Biological Standardization - October 14, 2023 Category: Biotechnology Authors: Na Liu Tiandan Xu Source Type: research

Evolution, genetic recombination, and phylogeography of goose parvovirus
This study offers novel insights into the evolutionary state and spread of GPV, holding promise for informing preventive and containment strategies against GPV infection.PMID:37812834 | DOI:10.1016/j.cimid.2023.102079 (Source: Comparative immunology, microbiology and infectious diseases.)
Source: Comparative immunology, microbiology and infectious diseases. - October 9, 2023 Category: Allergy & Immunology Authors: Xinrui Huo Yumeng Chen Jingru Zhu Yong Wang Source Type: research

Evolution, genetic recombination, and phylogeography of goose parvovirus
This study offers novel insights into the evolutionary state and spread of GPV, holding promise for informing preventive and containment strategies against GPV infection.PMID:37812834 | DOI:10.1016/j.cimid.2023.102079 (Source: Comparative immunology, microbiology and infectious diseases.)
Source: Comparative immunology, microbiology and infectious diseases. - October 9, 2023 Category: Allergy & Immunology Authors: Xinrui Huo Yumeng Chen Jingru Zhu Yong Wang Source Type: research

Evolution, genetic recombination, and phylogeography of goose parvovirus
This study offers novel insights into the evolutionary state and spread of GPV, holding promise for informing preventive and containment strategies against GPV infection.PMID:37812834 | DOI:10.1016/j.cimid.2023.102079 (Source: Comparative immunology, microbiology and infectious diseases.)
Source: Comparative immunology, microbiology and infectious diseases. - October 9, 2023 Category: Allergy & Immunology Authors: Xinrui Huo Yumeng Chen Jingru Zhu Yong Wang Source Type: research

Viruses, Vol. 15, Pages 2068: Identification of Multiple Novel Viruses in Fecal Samples of Black-Necked Cranes Using Viral Metagenomic Methods
This study provides valuable information for understanding the viral community composition in the digestive tract of black-necked cranes in Tibet, which can be used for monitoring, preventing, and treating potential viral diseases in black-necked cranes. (Source: Viruses)
Source: Viruses - October 9, 2023 Category: Virology Authors: Qifan Zhao Ran Zhao Yijie Sun Li Ji Yuan Xi Xiaochun Wang Quan Shen Likai Ji Yan Wang Zhenqiang You Shixing Yang Wen Zhang Tags: Article Source Type: research

Lupus erythematosus cells in a bone marrow aspirate
AbstractA teenage girl presented with fevers of unknown origin and pancytopenia. Complete blood count showed anemia (hemoglobin, 9.0 g/dL), neutropenia (1.7  × 109/L), and thrombocytopenia (66  × 109/L). The bone marrow was hypocellular with left shifted hematopoiesis and myeloid hypoplasia. Aspirate smears were notable for a prominent population of neutrophils with crescentic nuclei that engulfed blue amorphous material (Fig.  1 panels A and B, Wright-Giemsa, magnification × 1000). The trephine biopsy showed similar cells with crescentic nuclei and eosinophilic material (Fig.1 panels C and D, hematoxylin...
Source: Journal of Hematopathology - October 2, 2023 Category: Pathology Source Type: research

Identification and in vitro characterization of a novel porcine parvovirus 6 in Russia
In this study, the first identification of porcine parvovirus 6 in Russia, its phylogenetic analysis, and its characterization in vitro are reported. During the investigation, 521 serum samples collected from pigs of different ages from seven regions of the Russian Federation were tested. In four regions, the DNA of the virus was detected. The overall prevalence of porcine parvovirus 6 in Russia was 9.4%. Fattening pigs were the group with the most frequent detection of the virus genome. Phylogenetic analysis of the Russian isolate detected in a domestic boar indicated high homology with strains from Spain. In vitro studie...
Source: Cell Research - September 29, 2023 Category: Cytology Authors: Alina Komina Afshona Anoyatbekova Nikita Krasnikov Anton Yuzhakov Source Type: research

Identification and in vitro characterization of a novel porcine parvovirus 6 in Russia
In this study, the first identification of porcine parvovirus 6 in Russia, its phylogenetic analysis, and its characterizationin vitro are reported. During the investigation, 521 serum samples collected from pigs of different ages from seven regions of the Russian Federation were tested. In four regions, the DNA of the virus was detected. The overall prevalence of porcine parvovirus 6 in Russia was 9.4%. Fattening pigs were the group with the most frequent detection of the virus genome. Phylogenetic analysis of the Russian isolate detected in a domestic boar indicated high homology with strains from Spain.In vitro studies ...
Source: Veterinary Research Communications - September 29, 2023 Category: Veterinary Research Source Type: research

Detection of Parvovirus B19 genome in human heart tissue samples
Identifying viral genomes in human heart tissues is critical for disease diagnosis and assessment of cardiovascular damage. Human heart tissue samples obtained during a biopsy procedure are routinely used to t... (Source: BMC Research Notes)
Source: BMC Research Notes - September 29, 2023 Category: Research Authors: Anna Kloc, Kenneth S. Campbell and Yarida A. Urbina Espinoza Tags: Research Note Source Type: research

Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated with < em > Haemophilus influenzae < /em > Meningitis in a Newborn
This report highlights the possible involvement of B19 in the occurrence of acute neurological manifestations and emphasizes that its possible involvement might be better revealed by the use of metagenomic technology to detect viral agents in clinical situations of unknown or uncertain etiology.PMID:37754223 | DOI:10.3390/cimb45090439 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Noely Evangelista Ferreira Antonio C da Costa Esper G Kallas Cassia G T Silveira Ana Carolina S de Oliveira Layla Honorato Heuder G O Pai ão Silvia H Lima Dewton de M Vasconcelos Marina F C ôrtes Silvia F Costa Tania R T Mendoza H élio R Gomes Steven S Source Type: research

Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated with < em > Haemophilus influenzae < /em > Meningitis in a Newborn
This report highlights the possible involvement of B19 in the occurrence of acute neurological manifestations and emphasizes that its possible involvement might be better revealed by the use of metagenomic technology to detect viral agents in clinical situations of unknown or uncertain etiology.PMID:37754223 | PMC:PMC10529629 | DOI:10.3390/cimb45090439 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Noely Evangelista Ferreira Antonio C da Costa Esper G Kallas Cassia G T Silveira Ana Carolina S de Oliveira Layla Honorato Heuder G O Pai ão Silvia H Lima Dewton de M Vasconcelos Marina F C ôrtes Silvia F Costa Tania R T Mendoza H élio R Gomes Steven S Source Type: research

Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated with < em > Haemophilus influenzae < /em > Meningitis in a Newborn
This report highlights the possible involvement of B19 in the occurrence of acute neurological manifestations and emphasizes that its possible involvement might be better revealed by the use of metagenomic technology to detect viral agents in clinical situations of unknown or uncertain etiology.PMID:37754223 | PMC:PMC10529629 | DOI:10.3390/cimb45090439 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Noely Evangelista Ferreira Antonio C da Costa Esper G Kallas Cassia G T Silveira Ana Carolina S de Oliveira Layla Honorato Heuder G O Pai ão Silvia H Lima Dewton de M Vasconcelos Marina F C ôrtes Silvia F Costa Tania R T Mendoza H élio R Gomes Steven S Source Type: research

Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated with < em > Haemophilus influenzae < /em > Meningitis in a Newborn
This report highlights the possible involvement of B19 in the occurrence of acute neurological manifestations and emphasizes that its possible involvement might be better revealed by the use of metagenomic technology to detect viral agents in clinical situations of unknown or uncertain etiology.PMID:37754223 | PMC:PMC10529629 | DOI:10.3390/cimb45090439 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Noely Evangelista Ferreira Antonio C da Costa Esper G Kallas Cassia G T Silveira Ana Carolina S de Oliveira Layla Honorato Heuder G O Pai ão Silvia H Lima Dewton de M Vasconcelos Marina F C ôrtes Silvia F Costa Tania R T Mendoza H élio R Gomes Steven S Source Type: research

Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated with < em > Haemophilus influenzae < /em > Meningitis in a Newborn
This report highlights the possible involvement of B19 in the occurrence of acute neurological manifestations and emphasizes that its possible involvement might be better revealed by the use of metagenomic technology to detect viral agents in clinical situations of unknown or uncertain etiology.PMID:37754223 | PMC:PMC10529629 | DOI:10.3390/cimb45090439 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Noely Evangelista Ferreira Antonio C da Costa Esper G Kallas Cassia G T Silveira Ana Carolina S de Oliveira Layla Honorato Heuder G O Pai ão Silvia H Lima Dewton de M Vasconcelos Marina F C ôrtes Silvia F Costa Tania R T Mendoza H élio R Gomes Steven S Source Type: research