Comparative analysis reveals the long-term coevolutionary history of parvoviruses and vertebrates
by Matthew A. Campbell, Shannon Loncar, Robert M. Kotin, Robert J. Gifford Parvoviruses (familyParvoviridae) are small DNA viruses that cause numerous diseases of medical, veterinary, and agricultural significance and have important applications in gene and anticancer therapy. DNA sequences derived from ancient parvoviruses are common in animal genomes and analysis of theseendogenous parvoviral elements (EPVs) has demonstrated that the family, which includes twelve vertebrate-specific genera, arose in the distant evolutionary past. So far, however, such “paleovirological” analysis has only provided glimpses into the b...
Source: PLoS Biology: Archived Table of Contents - November 29, 2022 Category: Biology Authors: Matthew A. Campbell Source Type: research

Persistent viral infections and their role in heart disease
Viral infections are the culprit of many diseases, including inflammation of the heart muscle, known as myocarditis. Acute myocarditis cases have been described in scientific literature, and viruses, such as parvovirus B19, coxsackievirus B3, or more recently, SARS-CoV-2, were the direct cause of cardiac inflammation. If not treated, myocarditis could progress to dilated cardiomyopathy, which permanently impairs the heart and limits a person’s lifespan. Accumulated evidence suggests that certain viruses may persist in cardiac tissue after the initial infection, which could open up the door to reactivation under favorable...
Source: Frontiers in Microbiology - November 24, 2022 Category: Microbiology Source Type: research

Viruses, Vol. 14, Pages 2612: Carnivore protoparvovirus 1 (CPV-2 and FPV) Circulating in Wild Carnivores and in Puppies Illegally Imported into North-Eastern Italy
Paolo Zucca Isabella Monne Paola De De Benedictis The illegal trade of animals poses several health issues to the global community, among which are the underestimated risk for spillover infection and the potential for an epizootic in both wildlife and domestic naïve populations. We herein describe the genetic and antigenic characterization of viruses of the specie Carnivore protoparvovirus 1 detected at high prevalence in puppies illegally introduced in North Eastern Italy and compared them with those circulating in wild carnivores from the same area. We found evidence of a wide diversity of canine par...
Source: Viruses - November 23, 2022 Category: Virology Authors: Stefania Leopardi Adelaide Milani Monia Cocchi Marco Bregoli Alessia Schivo Sofia Leardini Francesca Festa Ambra Pastori Gabrita de Zan Federica Gobbo Maria Serena Beato Manlio Palei Alessandro Bremini Marie-Christin Rossmann Paolo Zucca Isabella Monne Pa Tags: Communication Source Type: research

Virome Analysis of Ticks and Tick-borne Viruses in Heilongjiang and Jilin Provinces, China
Virus Res. 2022 Nov 19:199006. doi: 10.1016/j.virusres.2022.199006. Online ahead of print.ABSTRACTTicks transmit diverse human and animal pathogens, leading to an increasing number of public health concerns. In the forest area of northeast China, the spread of tick-borne diseases (TBDs) is severe; however, little is known about the tick virome composition and evolution. Herein, we investigate the geographical distribution of tick species and related viruses in Heilongjiang and Jilin Provinces in Northeast China. To reveal the diversity of tick-borne viruses in parts of Heilongjiang and Jilin, ticks were collected at 9 coll...
Source: Virus Research - November 22, 2022 Category: Virology Authors: Xianglong Cai Xiaojing Cai Yongkang Xu Yi Shao Lian Fu Xiaoyu Men Yan Zhu Source Type: research

Do common infections trigger disease-onset or -severity in CTLA-4 insufficiency?
CONCLUSIONS: Our results show that the investigated pathogens are very unlikely to trigger the disease onset in CTLA-4-insufficient individuals, and their prevalence is not correlated with disease severity or expressivity.PMID:36405723 | PMC:PMC9667032 | DOI:10.3389/fimmu.2022.1011646 (Source: Herpes)
Source: Herpes - November 21, 2022 Category: Infectious Diseases Authors: M áté Krausz Noriko Mitsuiki Valeria Falcone Johanna Komp Sara Posadas-Cantera Hanns-Martin Lorenz Jiri Litzman Daniel Wolff Maria Kanariou Anita Heinkele Carsten Speckmann Georg H äcker Hartmut Hengel Laura G ámez-Díaz Bodo Grimbacher Source Type: research

Do common infections trigger disease-onset or -severity in CTLA-4 insufficiency?
CONCLUSIONS: Our results show that the investigated pathogens are very unlikely to trigger the disease onset in CTLA-4-insufficient individuals, and their prevalence is not correlated with disease severity or expressivity.PMID:36405723 | PMC:PMC9667032 | DOI:10.3389/fimmu.2022.1011646 (Source: Herpes)
Source: Herpes - November 21, 2022 Category: Infectious Diseases Authors: M áté Krausz Noriko Mitsuiki Valeria Falcone Johanna Komp Sara Posadas-Cantera Hanns-Martin Lorenz Jiri Litzman Daniel Wolff Maria Kanariou Anita Heinkele Carsten Speckmann Georg H äcker Hartmut Hengel Laura G ámez-Díaz Bodo Grimbacher Source Type: research

An atlat of the blood virome in healthy individuals
In conclusion, this study is the first comprehensive investigation of blood virome in healthy individuals by metatranscriptomic sequencing of VLP in China. Further investigation of potential false positives representing a major challenge for the identification of novel viruses in mNGS, will offer a systemic idea and means to reveal true viral infections of human.PMID:36402209 | DOI:10.1016/j.virusres.2022.199004 (Source: Cell Research)
Source: Cell Research - November 19, 2022 Category: Cytology Authors: Bo Feng Bo Liu Min Cheng Jie Dong Yongfeng Hu Fang Yang Qi Jin Source Type: research

An atlat of the blood virome in healthy individuals
In conclusion, this study is the first comprehensive investigation of blood virome in healthy individuals by metatranscriptomic sequencing of VLP in China. Further investigation of potential false positives representing a major challenge for the identification of novel viruses in mNGS, will offer a systemic idea and means to reveal true viral infections of human.PMID:36402209 | DOI:10.1016/j.virusres.2022.199004 (Source: Virus Research)
Source: Virus Research - November 19, 2022 Category: Virology Authors: Bo Feng Bo Liu Min Cheng Jie Dong Yongfeng Hu Fang Yang Qi Jin Source Type: research

An atlat of the blood virome in healthy individuals
In conclusion, this study is the first comprehensive investigation of blood virome in healthy individuals by metatranscriptomic sequencing of VLP in China. Further investigation of potential false positives representing a major challenge for the identification of novel viruses in mNGS, will offer a systemic idea and means to reveal true viral infections of human.PMID:36402209 | DOI:10.1016/j.virusres.2022.199004 (Source: Virus Research)
Source: Virus Research - November 19, 2022 Category: Virology Authors: Bo Feng Bo Liu Min Cheng Jie Dong Yongfeng Hu Fang Yang Qi Jin Source Type: research

Bilateral Conjunctivitis, Keratitis, and Anterior Uveitis in a Patient Co-infected with Parvovirus B19 and SARS-CoV-2
We report on a case of bilateral conjunctivitis, keratitis, and anterior uveitis that occurred in a patient co-infected by B19V and SARS-CoV-2. A young nurse developed, 20 days after the onset of asthenia and fever, a maculopapular rash and, in the following month, B19V-related arthritis. Shortly after a course of antibiotics and corticosteroids and the resolution of the arthritis, she began to complain of hearing loss and tinnitus. A polymerase chain reaction for SARS-CoV-2, previously negative, turned out positive; IgM for B19V decreased while IgG increased and antinuclear autoantibody and rheumatoid factor test results ...
Source: Case Reports in Ophthalmology - November 18, 2022 Category: Opthalmology Source Type: research

Viruses, Vol. 14, Pages 2543: Unravelling Bile Viromes of Free-Range Laying Chickens Clinically Diagnosed with Spotty Liver Disease: Emergence of Many Novel Chaphamaparvoviruses into Multiple Lineages
Petrovski Spotty liver disease (SLD) causes substantial egg production losses and chicken mortality; therefore, it is a disease that concerns Australian egg farmers. Over the last few decades, much research has been conducted to determine the etiologic agents of SLD and to develop potential therapeutics; however, SLD still remains a major issue for the chicken industries globally and remained without the elucidation of potentially multiple pathogens involved. To help fill this gap, this study was aimed at understanding the viral diversity of bile samples from which the SLD-causing bacterium, Campylobacter hepaticus, ha...
Source: Viruses - November 17, 2022 Category: Virology Authors: Subir Sarker Saranika Talukder Arif Anwar Thi Thu Hao Van Steve Petrovski Tags: Article Source Type: research

Case Report: Lupus Nephritis or a Mimic?
We present... [Read More] (Source: The Rheumatologist)
Source: The Rheumatologist - November 10, 2022 Category: Rheumatology Authors: Matthew J. Mandell, DO, Yishui Chen, MD, Prerna Rastogi, MD, PhD, & Rebecca Tuetken, MD, PhD Tags: Conditions SLE (Lupus) case report Fellows Fellows-in-Training Lupus nephritis parvovirus B19 SLE Resource Center syphilis Source Type: research

Pure red cell aplasia: Diagnosis, classification and treatment
Rev Med Interne. 2022 Nov 3:S0248-8663(22)01073-6. doi: 10.1016/j.revmed.2022.10.385. Online ahead of print.ABSTRACTPure red cell aplasia (PRCA) is a rare anemia characterised by profound reticulocytopenia caused by a marked reduction in bone marrow erythroblasts, without abnormalities in other blood lineages. Blackfan-Diamond anemia is an inherited ribosomopathy responsible for a hereditary form of PRCA. Acquired PRCA are separated in primary and secondary forms, including Parvovirus B19 infection, thymoma, lymphoproliferative disorders, autoimmune diseases (lupus) and drug-induced PRCA. The pathophysiology of PRCA is not...
Source: Revue de Medecine Interne - November 6, 2022 Category: Internal Medicine Authors: Herv é Lobbes Source Type: research

Characteristics and outcomes of acute hepatitis of unknown etiology in Egypt: first report of adult adenovirus-associated hepatitis
CONCLUSION: This is the first report describing etiologies and characteristics of AHUE cases in Egypt, and interestingly, adenovirus was detected in adults. Further studies are required to determine the prevalence of this newly emerging viral hepatitis pathogens.PMID:36334256 | DOI:10.1007/s15010-022-01945-1 (Source: Herpes)
Source: Herpes - November 5, 2022 Category: Infectious Diseases Authors: Haidi Karam-Allah Ramadan Ibrahim M Sayed Amal A Elkhawaga El-Zahraa M Meghezel Ashraf A Askar Abdelmajeed M Moussa Asmaa O B S Osman Azza Abo Elfadl Walaa A Khalifa Ahmed M Ashmawy Mohamed A El-Mokhtar Source Type: research