Heritability and genome-wide association study of vaccine-induced immune response in Beagles: A pilot study
The objective of this study was to estimate the heritability of the antibody response to vaccination against viral and bacterial pathogens, and to identify genes driving variation of the immune response to vaccination in Beagles. Sixty puppies were immunized following a standard vaccination schedule with an attenuated combination vaccine containing antigens for canine adenovirus type 2, canine distemper virus, canine parainfluenza virus, canine parvovirus, and four strains of Leptospira bacteria. Serum antibody measurements for each viral and bacterial component were measured at multiple time points. Heritability estimatio...
Source: Vaccine - April 11, 2024 Category: Allergy & Immunology Authors: Jeanna M Blake James Thompson Harm HogenEsch Kari J Ekenstedt Source Type: research

Heritability and genome-wide association study of vaccine-induced immune response in Beagles: A pilot study
The objective of this study was to estimate the heritability of the antibody response to vaccination against viral and bacterial pathogens, and to identify genes driving variation of the immune response to vaccination in Beagles. Sixty puppies were immunized following a standard vaccination schedule with an attenuated combination vaccine containing antigens for canine adenovirus type 2, canine distemper virus, canine parainfluenza virus, canine parvovirus, and four strains of Leptospira bacteria. Serum antibody measurements for each viral and bacterial component were measured at multiple time points. Heritability estimatio...
Source: Vaccine - April 11, 2024 Category: Allergy & Immunology Authors: Jeanna M Blake James Thompson Harm HogenEsch Kari J Ekenstedt Source Type: research

Opportunistic sampling of yellow canary (Crithagra flaviventris) has revealed a high genetic diversity of detected parvoviral sequences
Virology. 2024 Apr 4;595:110081. doi: 10.1016/j.virol.2024.110081. Online ahead of print.ABSTRACTParvoviruses are known to be significant viral pathogens that infect a wide range of species globally. However, little is known about the parvoviruses circulating in Australian birds, including yellow canaries. Here, we present four parvoviral sequences including three novel parvoviruses detected from 10 yellow canaries (Crithagra flaviventris), named canary chaphamaparvovirus 1 and -2 (CaChPV1 and CaChPV2), canary dependoparvovirus 1 and -2 (CaDePV1 and CaDePV2). The whole genome sequences of CaChPV1, CaChPV2, CaDePV1, and CaD...
Source: Virology - April 10, 2024 Category: Virology Authors: Yuhao Zhang Saranika Talukder Md Safiul Alam Bhuiyan Lei He Subir Sarker Source Type: research

Opportunistic sampling of yellow canary (Crithagra flaviventris) has revealed a high genetic diversity of detected parvoviral sequences
Virology. 2024 Apr 4;595:110081. doi: 10.1016/j.virol.2024.110081. Online ahead of print.ABSTRACTParvoviruses are known to be significant viral pathogens that infect a wide range of species globally. However, little is known about the parvoviruses circulating in Australian birds, including yellow canaries. Here, we present four parvoviral sequences including three novel parvoviruses detected from 10 yellow canaries (Crithagra flaviventris), named canary chaphamaparvovirus 1 and -2 (CaChPV1 and CaChPV2), canary dependoparvovirus 1 and -2 (CaDePV1 and CaDePV2). The whole genome sequences of CaChPV1, CaChPV2, CaDePV1, and CaD...
Source: Virology - April 10, 2024 Category: Virology Authors: Yuhao Zhang Saranika Talukder Md Safiul Alam Bhuiyan Lei He Subir Sarker Source Type: research

Opportunistic sampling of yellow canary (Crithagra flaviventris) has revealed a high genetic diversity of detected parvoviral sequences
Virology. 2024 Apr 4;595:110081. doi: 10.1016/j.virol.2024.110081. Online ahead of print.ABSTRACTParvoviruses are known to be significant viral pathogens that infect a wide range of species globally. However, little is known about the parvoviruses circulating in Australian birds, including yellow canaries. Here, we present four parvoviral sequences including three novel parvoviruses detected from 10 yellow canaries (Crithagra flaviventris), named canary chaphamaparvovirus 1 and -2 (CaChPV1 and CaChPV2), canary dependoparvovirus 1 and -2 (CaDePV1 and CaDePV2). The whole genome sequences of CaChPV1, CaChPV2, CaDePV1, and CaD...
Source: Virology - April 10, 2024 Category: Virology Authors: Yuhao Zhang Saranika Talukder Md Safiul Alam Bhuiyan Lei He Subir Sarker Source Type: research

Opportunistic sampling of yellow canary (Crithagra flaviventris) has revealed a high genetic diversity of detected parvoviral sequences
Virology. 2024 Apr 4;595:110081. doi: 10.1016/j.virol.2024.110081. Online ahead of print.ABSTRACTParvoviruses are known to be significant viral pathogens that infect a wide range of species globally. However, little is known about the parvoviruses circulating in Australian birds, including yellow canaries. Here, we present four parvoviral sequences including three novel parvoviruses detected from 10 yellow canaries (Crithagra flaviventris), named canary chaphamaparvovirus 1 and -2 (CaChPV1 and CaChPV2), canary dependoparvovirus 1 and -2 (CaDePV1 and CaDePV2). The whole genome sequences of CaChPV1, CaChPV2, CaDePV1, and CaD...
Source: Virology - April 10, 2024 Category: Virology Authors: Yuhao Zhang Saranika Talukder Md Safiul Alam Bhuiyan Lei He Subir Sarker Source Type: research

Congenital Infectious Encephalopathies from the Intrapartum Period to Postnatal Life
Congenital infections are a common but often underrecognized cause of fetal brain abnormalities, as well as fetal-neonatal morbidity and mortality, that should be considered by all healthcare professionals providing neurological care to fetuses and newborns.Maternal infection with various pathogens (cytomegalovirus, Toxoplasmosis, Rubella virus, Parvovirus B19, lymphocytic choriomeningitis virus, syphilis, Zika virus, varicella zoster virus) during pregnancy can be transmitted to the developing fetus, which can cause multisystem dysfunction and destructive or malformative central nervous system lesions, which can be recogn...
Source: Seminars in Fetal and Neonatal Medicine - April 10, 2024 Category: Perinatology & Neonatology Authors: Olivier Fortin, Roberta L. DeBiasi, Sarah B. Mulkey Source Type: research

TCR αβ-depleted hematopoietic stem cell transplant and third-party CD45RA+ depleted adoptive cell therapy for treatment of post-transplant parvovirus B19 aplastic crisis
CD19 and CD22-targeted chimeric antigen receptor (CAR) T-cell therapy bridged to hematopoietic stem cell transplantation (HSCT) has emerged as an effective therapeutic approach for refractory/relapsed acute lymphoblastic leukemia [1,2]. However, despite successful therapy, patients remain vulnerable to viral infections caused by prolonged immune system deficiency. Human parvovirus (HPV) B19 infection is among the frequently encountered viral infections post-transplantation. Effective treatment for persistent HPV B19 infection in immunocompromised patients has yet to be established. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 5, 2024 Category: Infectious Diseases Authors: Manpin Zhang, Chengjuan Luo, Jianmin Wang, Hua Zhu, Changying Luo, Xia Qin, Xiaohang Huang, Yuchen Lin, Jing Chen Tags: Case Report Source Type: research

Detection and genetic characterization of circulating canine parvovirus from stray dogs in Shanghai, China
This study further confirmed the prevalence of CPV-2c and new-CPV-2b in Shanghai, and also found a new mutation site of new-CPV-2c, which provided a theoretical basis for further enriching the epidemiological data of CPV-2 in Shanghai, as well as the development of vaccines and the prevention and control of the disease.PMID:38555807 | DOI:10.1016/j.virol.2024.110041 (Source: Virology)
Source: Virology - March 31, 2024 Category: Virology Authors: Junyi Pu Yan Zhang Dengke Zhong Qiusheng Chen Source Type: research

Detection and genetic characterization of circulating canine parvovirus from stray dogs in Shanghai, China
This study further confirmed the prevalence of CPV-2c and new-CPV-2b in Shanghai, and also found a new mutation site of new-CPV-2c, which provided a theoretical basis for further enriching the epidemiological data of CPV-2 in Shanghai, as well as the development of vaccines and the prevention and control of the disease.PMID:38555807 | DOI:10.1016/j.virol.2024.110041 (Source: Virology)
Source: Virology - March 31, 2024 Category: Virology Authors: Junyi Pu Yan Zhang Dengke Zhong Qiusheng Chen Source Type: research

WSV2023 - The second meeting of the world society for virology: One health - One world - One virology
Discussions further explored SARS-CoV-2 RNA replicons as vaccine candidates, SARS-CoV-2 in humans and animals, and the significance of plant viruses in the 'One Health' paradigm. The presence of the presidents from three virology societies, namely the American, Indian, and Korean Societies for Virology, highlighted the event's significance. Additionally, past president of the American Society for Virology (ASV), formally declared the partnership between ASV and WSV during the conference.PMID:38527382 | DOI:10.1016/j.virol.2024.110049 (Source: Virology)
Source: Virology - March 25, 2024 Category: Virology Authors: Ahmed S Abdel-Moneim Modra Murovska Maria S öderlund-Venermo Vikram N Vakharia William C Wilson Douglas P Gladue Matthew D Moore Covadonga Alonso Sayed F Abdelwahab Marietjie Venter Yashpal S Malik Shi Zhengli Shailendra K Saxena Anupam Varma Richard J K Source Type: research

WSV2023 - The second meeting of the world society for virology: One health - One world - One virology
Discussions further explored SARS-CoV-2 RNA replicons as vaccine candidates, SARS-CoV-2 in humans and animals, and the significance of plant viruses in the 'One Health' paradigm. The presence of the presidents from three virology societies, namely the American, Indian, and Korean Societies for Virology, highlighted the event's significance. Additionally, past president of the American Society for Virology (ASV), formally declared the partnership between ASV and WSV during the conference.PMID:38527382 | DOI:10.1016/j.virol.2024.110049 (Source: Virology)
Source: Virology - March 25, 2024 Category: Virology Authors: Ahmed S Abdel-Moneim Modra Murovska Maria S öderlund-Venermo Vikram N Vakharia William C Wilson Douglas P Gladue Matthew D Moore Covadonga Alonso Sayed F Abdelwahab Marietjie Venter Yashpal S Malik Shi Zhengli Shailendra K Saxena Anupam Varma Richard J K Source Type: research

Viruses, Vol. 16, Pages 480: Parvovirus B19 Outbreak in Israel: Retrospective Molecular Analysis from 2010 to 2023
This study presents an analysis of the epidemiological trends of parvovirus B19 (B19V) in Israel from 2010 to 2023, with particular emphasis on the outbreak in 2023. The analysis utilized molecular diagnostic data from individual patients obtained at the Central Virology Laboratory. Between 2010 and 2022, 8.5% of PCR-tested samples were positive for B19V, whereas in 2023, this percentage surged to 31% of PCR-tested samples. Throughout the study period, annual cycles consistently peaked in early spring/summer, with the most recent prominent outbreak occurring in 2016. Predominantly, diagnoses were made in children and women...
Source: Viruses - March 20, 2024 Category: Virology Authors: Orna Mor Marina Wax Shoshana-Shani Arami Maya Yitzhaki Or Kriger Oran Erster Neta S. Zuckerman Tags: Brief Report Source Type: research

Association between Parvovirus B19 and thyroid/celiac autoantibodies among T1DM pediatric patients
CONCLUSIONS: The prevalence of autoantibodies against the thyroid was higher among the seropositive Parvovirus B19 children with T1DM. A positive association between the prevalence of autoantibodies against thyroid disease and the increase in the duration of diabetes was also noted. Hence, periodic screening of T1DM patients for B19 antibodies and autoantibodies for thyroid is crucial.PMID:38497882 | DOI:10.26355/eurrev_202403_35614 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: H C Chandramoorthy A A Shati A A Aseeri A Subramanian A Alhanshani E A H Almohseny R Ram Mani A Kumar R A Ali Moosa A Al-Hakami K Chidambaram Source Type: research

Association between Parvovirus B19 and thyroid/celiac autoantibodies among T1DM pediatric patients
CONCLUSIONS: The prevalence of autoantibodies against the thyroid was higher among the seropositive Parvovirus B19 children with T1DM. A positive association between the prevalence of autoantibodies against thyroid disease and the increase in the duration of diabetes was also noted. Hence, periodic screening of T1DM patients for B19 antibodies and autoantibodies for thyroid is crucial.PMID:38497882 | DOI:10.26355/eurrev_202403_35614 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 18, 2024 Category: Drugs & Pharmacology Authors: H C Chandramoorthy A A Shati A A Aseeri A Subramanian A Alhanshani E A H Almohseny R Ram Mani A Kumar R A Ali Moosa A Al-Hakami K Chidambaram Source Type: research